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Id: lil-564046
Autor: Somocurcio, José G; Sotomayor, Alfredo; Álvarez, Gamero; Acurio, Vilma; Casquero, José; Luna, Teresa.
Título: Micetoma pulmonar por scedosporium sp, reporte de dos casos / Pulmonary mycetoma by scedosporium sp, report of two cases
Fonte: Rev. peru. med. exp. salud publica;26(3):395-399, jul.-sept. 2009. ilus.
Idioma: es.
Resumo: Se reporta los dos primeros casos de micetoma pulmonar por Scedosporium sp, en el Perú, tratados quirúrgicamenteen el Hospital Nacional Hipólito Unanue. Se practicó resección pulmonar debido a micetoma pulmonar de donde se tomó muestras que fueron enviadas a microbiología y anatomía patológica para cultivo y estudio histopatológico. Seidentificó el moho Scedosporium sp en dos pacientes con secuelas cavitarias por tuberculosis, quienes presentarontos y hemoptisis de dos meses y tres años de evolución, respectivamente. Radiológicamente las cavidades estabanocupadas por una bola fúngica. La histopatología indicó presencia de abundantes hifas, indistinguibles de las de Aspergillus sp, mientras que la inmunodifusión para Aspergillus fue negativa.

We report the two first cases of pulmonary mycetoma by Scedosporium sp. in Peru who underwent surgery in the Hipolito Unanue National Hospital. Pulmonary resection was made as therapy of pulmonary mycetoma, and samples were sent for microbiological cultures and pathologic examination. Scedosporium fungus was identified in two patients with post-TB cavitary sequelae who presented cough and hemoptysis, with two months and three years of evolution respectively. chest X ray showed cavitaries occupied by fungus ball. Pathologic examination showed hifae not distinguishable fromAspergillus sp and the test for aspergillum inmunodiffusion was negative.
Descritores: Aspergilose Broncopulmonar Alérgica
Pneumopatias Fúngicas
Scedosporium
Limites: Humanos
Masculino
Feminino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: PE1.1 - Oficina Universitária de Biblioteca


  2 / 11 LILACS  
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Texto completo SciELO Brasil
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Id: biblio-955111
Autor: Mello, Thaís Pereira de; Aor, Ana Carolina; Gonçalves, Diego de Souza; Seabra, Sergio Henrique; Branquinha, Marta Helena; Santos, André Luis Souza dos.
Título: Scedosporium apiospermum, Scedosporium aurantiacum, Scedosporium minutisporum and Lomentospora prolificans: a comparative study of surface molecules produced by conidial and germinated conidial cells
Fonte: Mem. Inst. Oswaldo Cruz;113(6):e180102, 2018. tab, graf.
Idioma: en.
Resumo: BACKGROUND Scedosporium/Lomentospora species are opportunistic mould pathogens, presenting notable antifungal resistance. OBJECTIVES/METHODS We analysed the conidia and germinated conidia of S. apiospermum (Sap), S. aurantiacum (Sau), S. minutisporum (Smi) and L. prolificans (Lpr) by scanning electron microscopy and exposition of surface molecules by fluorescence microscopy. FINDINGS Conidia of Sap, Smi and Sau had oval, ellipsoidal and cylindrical shape, respectively, with several irregularities surrounding all surface areas, whereas Lpr conidia were rounded with a smooth surface. The germination of Sap occurred at the conidial bottom, while Smi and Sau germination primarily occurred at the centre of the conidial cell, and Lpr germination initiated at any part of the conidial surface. The staining of N-acetylglucosamine-containing molecules by fluorescein-labelled WGA primarily occurred during the germination of all studied fungi and in the conidial scars, which is the primary location of germination. Calcofluor white, which recognises the polysaccharide chitin, strongly stained the conidial cells and, to a lesser extent, the germination. Both mannose-rich glycoconjugates (evidenced by fluoresceinated-ConA) and cell wall externally located polypeptides presented distinct surface locations and expression according to both morphotypes and fungal species. In contrast, sialic acid and galactose-containing structures were not detected at fungal surfaces. MAIN CONCLUSIONS The present study demonstrated the differential production/exposition of surface molecules on distinct morphotypes of Scedosporium/Lomentospora species.
Descritores: Esporos Fúngicos/fisiologia
Membrana Celular/ultraestrutura
Scedosporium/crescimento & desenvolvimento
-Microscopia Eletrônica de Varredura
Diferenciação Celular
Microscopia de Fluorescência
Limites: Humanos
Responsável: BR1.1 - BIREME


  3 / 11 LILACS  
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Rozental, Sonia
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Id: biblio-955107
Autor: Aor, Ana Carolina; Mello, Thaís P; Sangenito, Leandro S; Fonseca, Beatriz B; Rozental, Sonia; Lione, Viviane F; Veiga, Venício F; Branquinha, Marta H; Santos, André LS.
Título: Ultrastructural viewpoints on the interaction events of Scedosporium apiospermum conidia with lung and macrophage cells
Fonte: Mem. Inst. Oswaldo Cruz;113(10):e180311, 2018. graf.
Idioma: en.
Resumo: BACKGROUND Scedosporium apiospermum is a ubiquitous, emerging and multidrug-resistant fungal pathogen with still rather unknown virulence mechanisms. OBJECTIVES/METHODS The cellular basis of the in vitro interaction between fungi and host cells/tissues is the determinant factor for the development of a successful in vivo infection. Herein, we evaluated the interaction of S. apiospermum conidia with lung epithelial (A549), lung fibroblast (MRC-5) and RAW 264.7 macrophages by light and scanning/transmission electron microscopy. FINDINGS After 4 h of fungi-host cell contact, the percentage of infected mammalian cells and the number of fungi per infected cell was measured by light microscopy, and the following association indexes were calculated for A549, MRC-5 and macrophage cells: 73.2 ± 25.9, 69.7 ± 22.5 and 59.7 ± 11.1, respectively. Both conidia and germinated conidia were regularly observed interacting with the evaluated cells, with a higher prevalence of non-germinated conidia. Interestingly, nests of germinated conidia were evidenced at the surface of lung cells by scanning electron microscopy. Some germination projections and hyphae were seen penetrating/evading the mammalian cells. Furthermore, internalised conidia were seen within vacuoles as visualised by transmission electron microscopy. MAIN CONCLUSIONS The present study contributes to a better understanding of S. apiospermum pathogenesis by demonstrating the first steps of the infection process of this opportunistic fungus.
Descritores: Scedosporium
Macrófagos
-Carcinoma Pulmonar de Células não Pequenas
Fator C1 de Célula Hospedeira
Limites: Humanos
Responsável: BR1.1 - BIREME


  4 / 11 LILACS  
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Id: lil-787561
Autor: Mello, Thaís Pereira de; Aor, Ana Carolina; Oliveira, Simone Santiago Carvalho de; Branquinha, Marta Helena; Santos, André Luis Souza dos.
Título: Conidial germination in Scedosporium apiospermum, S. aurantiacum, S. minutisporum and Lomentospora prolificans: influence of growth conditions and antifungal susceptibility profiles
Fonte: Mem. Inst. Oswaldo Cruz;111(7):484-494tab, graf.
Idioma: en.
Resumo: In the present study, we have investigated some growth conditions capable of inducing the conidial germination in Scedosporium apiospermum, S. aurantiacum, S. minutisporum and Lomentospora prolificans. Germination in Sabouraud medium (pH 7.0, 37ºC, 5% CO2) showed to be a typically time-dependent event, reaching ~75% in S. minutisporum and > 90% in S. apiospermum, S. aurantiacum and L. prolificans after 4 h. Similar germination rate was observed when conidia were incubated under different media and pHs. Contrarily, temperature and CO2 tension modulated the germination. The isotropic conidial growth (swelling) and germ tube-like projection were evidenced by microscopy and cytometry. Morphometric parameters augmented in a time-dependent fashion, evidencing changes in size and granularity of fungal cells compared with dormant 0 h conidia. In parallel, a clear increase in the mitochondrial activity was measured during the transformation of conidia-into-germinated conidia. Susceptibility profiles to itraconazole, fluconazole, voriconazole, amphotericin B and caspofungin varied regarding each morphotype and each fungal species. Overall, the minimal inhibitory concentrations for hyphae were higher than conidia and germinated conidia, except for caspofungin. Collectively, our study add new data about the conidia-into-hyphae transformation in Scedosporium and Lomentospora species, which is a relevant biological process of these molds directly connected to their antifungal resistance and pathogenicity mechanisms.
Descritores: Antifúngicos/farmacologia
Scedosporium/efeitos dos fármacos
Esporos Fúngicos/efeitos dos fármacos
-Meios de Cultura/química
Testes de Sensibilidade Microbiana
Scedosporium/crescimento & desenvolvimento
Scedosporium/fisiologia
Esporos Fúngicos/crescimento & desenvolvimento
Esporos Fúngicos/fisiologia
Fatores de Tempo
Responsável: BR1.1 - BIREME


  5 / 11 LILACS  
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Texto completo SciELO Chile
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Id: lil-762648
Autor: Cruz, Rodrigo; Barros, Manuel; Reyes, Mirtha.
Título: Infección pulmonar no invasora por Scedosporium apiospermum / Pulmonary non invasive infection by Scedosporium apiospermum
Fonte: Rev. chil. infectol;32(4):472-475, ago. 2015. ilus.
Idioma: es.
Resumo: We reported a case of non-invasive pulmonary infection by Scedosporium apiospermum in 67 years old female with bronchiectasis and caverns secondary to tuberculosis. Diagnosis was made with lung CT and bronchial lavage cultures. The patient was initially treated with itraconazole for six weeks without success and then voriconazole for 16 weeks, with good clinical response.

Reportamos el caso clínico de una infección pulmonar no invasora por Scedosporium apiospermum en una mujer de 67 años de edad, con bronquiectasias y cavernas pulmonares secundarias a una tuberculosis. El diagnóstico se realizó con la TAC pulmonar y cultivos de lavado bronquial. La paciente fue tratada inicialmente con itraconazol oral por seis semanas sin respuesta y luego voriconazol vía oral por 16 semanas, con una buena respuesta clínica.
Descritores: Pneumopatias Fúngicas/microbiologia
Scedosporium/isolamento & purificação
-Antifúngicos/uso terapêutico
Líquido da Lavagem Broncoalveolar/microbiologia
Pneumopatias Fúngicas/tratamento farmacológico
Scedosporium/crescimento & desenvolvimento
Tomografia Computadorizada por Raios X
Triazóis/uso terapêutico
Limites: Idoso
Feminino
Humanos
Tipo de Publ: Relatos de Casos
Responsável: CL1.1 - Biblioteca Central


  6 / 11 LILACS  
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Id: lil-679658
Autor: Piontelli L., Eduardo.
Título: El complejo Pseudallescheria/Scedosporium y taxas afines en la rutina del laboratorio micológico clínico / The Pseudallescheria/Scedoporium complex and related taxa in the routine of clinic mycological laboratory
Fonte: Bol. micol. (Valparaiso En linea);27(2):65-77, dic. 2012. ilus, tab.
Idioma: es.
Resumo: El complejo Pseudallescheria/Scedosporium y taxas relacionados, pertenecientes a un grupo de microhongos con conidios viscosos e integrantes del orden Microascales, se presentan en diversos ambientes comunes asociados a las actividades humanas, ya sea en el suelo como en aguas contaminadas. Actualmente se consideran entre los mayores grupos de hongos filamentosos oportunistas causante de infecciones cutáneas y profundas en el hombre y otros mamíferos. El objetivo principal de este trabajo, consiste en reunir los datos primarios morfofisiológicos más relevantes, útiles para el micólogo médico en el laboratorio, con el aporte adicional de algunos aspectos, biológicos, ecológicos, taxonómicos y moleculares complementarios descritos en la literatura moderna.

The Pseudallescheria/Scedosporium complex and their related taxa are a group of fungus that conidia are presents in viscous mass and belong to the order Microascales. They are in several common enviroment related to human activities either in soil as in contaminated water. Nowadays they are considerated one of the most opportunistic group of filamentous fungus that may cause superficial and deep skin mycoses infections in man and other mammalian. The aim of this work is to gather the primary relevant morphophysiological aspects, usefull to the medical mycologist in the laboratory, plus the contribution of some of biological, ecological, taxonomical and moleculars complementary aspects that are describe in modern literature.
Descritores: Dermatomicoses
Micoses
Pseudallescheria/isolamento & purificação
Pseudallescheria/citologia
Pseudallescheria/classificação
Pseudallescheria/fisiologia
Scedosporium/isolamento & purificação
Scedosporium/citologia
Scedosporium/classificação
Scedosporium/fisiologia
Tipo de Publ: Revisão
Responsável: CL2.1 - Biblioteca de Medicina


  7 / 11 LILACS  
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Id: lil-556840
Autor: Nweze, E. I; Okafor, J. I.
Título: Comparative virulence of Scedosporium species in animal models
Fonte: Braz. j. infect. dis;14(3):271-276, May-June 2010. ilus, tab.
Idioma: en.
Resumo: Scedosporium species are an emerging opportunist group of fungi that have been found to cause infections in both immunocompetent and non-immunocompetent individuals. The infections are not regularly distributed among different countries of the world either because of improper identification or other geographical reasons. Strange as it may, disseminated systemic infections have only been reported in some specific countries. We used a mouse model of disseminated infection to assess if strains from Nigeria were virulent and compared it to a few other strains from other countries. S. apiospermum isolated from Nigeria were clearly less virulent than those obtained elsewhere. This may be the reason why this group of fungi has not been associated with specific clinical problems in Nigeria in pa'rticular and Africa in general.
Descritores: Micetoma/microbiologia
Scedosporium/patogenicidade
-Modelos Animais de Doenças
Nigéria
Fatores de Tempo
Virulência
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


  8 / 11 LILACS  
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Texto completo SciELO Chile
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Id: lil-532138
Autor: Chanqueo C., Leonardo; Tapia P., Cecilia; Silva V., Víctor; Razeto W., Leopoldo; Misad S., Carlos; Gutiérrez R., Catalina.
Título: Infección rinosinusal por Scedosporium apiospermum en un hospedero inmunocompetente / Scedosporium apiospermum rhinosinusal infection in an immunocompetent host
Fonte: Rev. chil. infectol;26(5):453-456, oct. 2009. ilus.
Idioma: es.
Resumo: Scedosporium species can cause colonization, superficial and deep localized infection or systemic disease, espe-cially in irnmunocompromised hosts. We report a case of localized infection due to Scedosporium apiospermum in a 47 year oíd woman, with previous nasal surgery. She consulted for recurrent mucopurulent post-nasal discharge not responding to antibiotics. Computed tomography showed opacification of right maxillary sinus. Surgery was performed to removed abnormal tissue from sinus; biopsy revealed chronic sinusitis with aggregate of tightly packed hyphae suggestive of filamentous fungi. The microbiology fungal culture reported Scedosporium apiospermum.

Las infecciones por Scedosporium sp pueden traducirse en colonización, infecciones localizadas superficiales y profundas, o enfermedad diseminada. Presentamos un caso clínico de infección rinosinusal por Scedosporium apiospermum en una paciente de 47 años, con antecedente de cirugía por cuerpo extraño en la fosa nasal derecha. Consultó por descarga posterior muco-purulenta y recurrente, sin respuesta a tratamiento antibacteriano. Las imágenes de cavidades paranasales mostraron opacidad del seno maxilar derecho. Se realizó cirugía de remoción de contenido sinusal cuyo estudio histológico reveló sinusitis crónica erosiva, colonias de hongos con morfología sugerente de hongo filamentoso y desarrollo de S. apiospermum en el cultivo.
Descritores: Imunocompetência
Micetoma/microbiologia
Rinite/microbiologia
Scedosporium/isolamento & purificação
Sinusite/microbiologia
-Doença Crônica
Micetoma/diagnóstico
Micetoma/cirurgia
Rinite/diagnóstico
Rinite/cirurgia
Sinusite/diagnóstico
Sinusite/cirurgia
Limites: Feminino
Humanos
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


  9 / 11 LILACS  
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Id: lil-521990
Autor: Lizaso, Diego; Aguilera, Karina; Yantorno, Laura; Cuitiño, Mario; Pérez, Lorena; Roccia Rossi, Inés; Fortunato, Eduardo; de la Parra, Gloria; Lares, Mónica; Maestroni, Silvana; Esposto, Amadeo.
Título: Infección Fúngica oportunista en un trabajador rural viviendo con VIH/sida / Opportunitic funal infection in a rural worker infected with HIV
Fonte: Actual. SIDA;17(63):18-23, mar. 2009. ilus, tab.
Idioma: es.
Resumo: Las infecciones fúngicas invasivas son una importante causa de morbimortalidad en los pacientes inmunocomprometidos. Diversos factores han producido, en los últimos años, un cambio en la epidemiología de éstas, con aislamiento de hongos infrecuentes hasta hace dos décadas (zygomicetos; Fusarium spp y Scedosporium spp), presentando un desafío diagnóstico y terapéutico. En este reporte describimos un paciente con diagnóstico reciente de VIH/sida, trabajador rural, con antecedentes de fiebre, diarrea y cuadro respiratorio, quien durante la internación presentó un cuadro de neutropenia febril, desarrollando una infección diseminada por Scedosporium prolificans, tratado con éxito con voriconazol.

Invasive fungal disease is a major cause of morbidity and mortality in immunocompromised patients. Over recent decades numerous factors have contributed to a change in the apidemiology of invasive mycoses. There have been increasing reports of infections due to new and emerging pathogens such as zygomycetes, Fusarium spp and Scedosporium spp, which pose a major diagnostic and therapeutic challenge...
Descritores: Antifúngicos/uso terapêutico
Fungos
Infecções Oportunistas Relacionadas com a AIDS/complicações
Infecções Oportunistas Relacionadas com a AIDS/mortalidade
Infecções Oportunistas
Scedosporium/isolamento & purificação
-Trabalhadores Rurais
Limites: Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: AR392.1 - Biblioteca


  10 / 11 LILACS  
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Texto completo SciELO Chile
Texto completo
Id: lil-358938
Autor: Díaz J., M. Cristina; Juliet L., Chrystal; Monzon De La T., Araceli; Rodríguez-Tudela, Juan Luis.
Título: Absceso de herida operatoria por Scedosporium prolificans: Primer aislamiento en Chile. Revisión de la literatura / Surgical site abscess by Scedosporium prolificans: first report in Chile and review
Fonte: Rev. chil. infectol;21(1):65-69, 2004. ilus.
Idioma: es.
Resumo: Se presenta el primer caso de infección por Scedosporium prolificans en nuestro paés. Se trata de un paciente de 27 años, sexo masculino, con insuficiencia renal crónica e hipertensión, sometido a trasplante renal, en tratamiento con ciclosporina, azatioprina y prednisona. A los 25 déas post-transplante presentó un aumento de volumen fluctuante bajo la herida operatoria. En tres muestras de exudado purulento y tejido obtenido finalmente por cirugia resolutiva se aisló S. prolificans como agente único. El estudio histológico reveló estructuras compatibles con hifas septadas. El paciente se trató con aseo quirúgico, anfotericina B e itraconazol lográndose la curación y cicatrización completa de la herida. S prolificans es un hongo filamentoso hialino resistente a anfotericina B y azoles, considerado actualmente un patógeno emergente, responsable de infecciones localizadas asociadas a cirugía y/o trauma, como también de infecciones diseminadas fatales en hospederos inmunocomprometidos especialmente pacientes neutropénicos, oncológicos y trasplantados. Es importante considerar este hongo en el diagnóstico diferencial de infecciones fúngicas emergentes.
Descritores: Abscesso
Anfotericina B
Itraconazol
Scedosporium
-Antifúngicos
Infecção da Ferida Cirúrgica
Transplante de Rim
Micoses
Limites: Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: CL1.1 - Biblioteca Central



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