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Pesquisa : B01.650.940.800.575.912.250.044.666 [Categoria DeCS]
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Texto completo SciELO Cuba
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Id: lil-764370
Autor: Bello Alarcón, Adonis; Said Labeid, Brahim; Mangas Marín, Raisa; Rubio Delgado, Yalepsy.
Título: Tamizaje fitoquímico de tres especies del desierto del sahara occidental / Phytochemical screening of three species of western sahara
Fonte: Rev. cuba. plantas med;20(2):149-155, abr.-jun. 2015.
Idioma: es.
Resumo: INTRODUCCIÓN: las plantas que crecen en el desierto requieren de características especiales para adaptarse a las condiciones adversas de esta región. Dentro de estos se destacan los géneros Pergularia, Hammada y Rhus, al poseer estructuras y mecanismos que les confieren una gran versatilidad en cuanto a sus usos medicinales. Las investigaciones encaminadas al estudio de su composición química y actividad biológica son limitadas. OBJETIVO: determinar la composición química preliminar de extractos de diferente polaridad de las especies Pergularia tomentosa L. (Apocynaceae), Hammada scoparia I. (Amaranthaceae) y Rhus tripartita L. (Anarcadiaceae). MÉTODOS: los materiales vegetales empleados fueron las hojas y las ramas de las especies. En el momento de la colecta no existía ni floración, ni fructificación en estas especies vegetales. Se realizó un proceso de extracción por maceración, se empleó etanol. A partir de éste extracto se efectuó un fraccionamiento preliminar y se usó disolventes de diferente polaridad; el hexano, acetato de etilo, metanol y butanol. A todas estas fracciones se le realizó un tamizaje fitoquímico. RESULTADOS: los metabolitos secundarios encontrados en la identificación preliminar de las tres especies fueron; los alcaloides, azúcares reductores, compuestos con agrupamientos lactónicos y compuestos fenólicos. CONCLUSIONES: en las tres especies, las fracciones metanólicas fueron las que mostraron una mayor variedad de metabolitos secundarios.

INTRODUCTION: plants growing in deserts require special characteristics to survive under the extreme conditions of these regions. Inside these groups of plants are the genus Pergularia, Hammada and Rhus having a great versatility of medical uses. Investigations about chemical composition and biological activities of these genuses are limited. OBJECTIVE: to determine the preliminary chemical composition of extracts from different polarity of Pergularia tomentosa L. (Apocynaceae), Hammada scoparia (Amaranthaceae) and Rhus tripartita L. (Anarcadiaceae). METHODS: plant materials used were the leaves and branches of the species. At the time of collection there was not flowering or fruiting in these plants. Extraction procedure was carried out by maceration with methanol. From this extract preliminary fractionation was done using solvents with different polarity: hexane, ethyl acetate, methanol and buthanol. All these fractions were phytochemical screened. RESULTS: the secondary metabolites found in the preliminary identification of the three species were: alkaloids, reducing sugars, compounds with lactone groups and phenolic compounds. CONCLUSIONS: in the three species, the methanolics fractions showed the most variety of secondary metabolites.
Descritores: Rhus/efeitos dos fármacos
Preparações de Plantas/uso terapêutico
Medicamentos de Referência
Limites: Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: lil-741589
Autor: SAĞLAM, Mehmet; KÖSEOĞLU, Serhat; HATİPOĞLU, Mükerrem; ESEN, Hacı Hasan; KÖKSAL, Ekrem.
Título: Effect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in rats
Fonte: J. appl. oral sci;23(1):33-41, Jan-Feb/2015. graf.
Idioma: en.
Resumo: Objectives Sumac (Rhus coriaria L.) is widely used spice which has several properties such as antioxidant, anti-inflammatory and antimicrobial. The purpose of this animal study was to evaluate the effects of sumac extract on levels of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG) expression, serum oxidative status, and alveolar bone loss in experimental periodontitis. Material and Methods Twenty-four Wistar rats were separated into three groups: non-ligated (NL, n=8), ligature only (LO, n=8), and ligature and treated with sumac extract (S, n=8) (20 mg/kg per day for 11 days). A 4/0 silk suture was placed around the mandibular right first molars subgingivally; after 11 days, the rats were sacrificed, and alveolar bone loss was histometrically measured. The detection of RANKL and OPG were immunohistochemically performed. Levels of serum total antioxidant status (TAS)/total oxidant status (TOS), and oxidative stress index (OSI) were also analyzed. Results Alveolar bone loss was significantly greater in the LO group compared to the S and NL groups (p<0.05). The number of inflammatory cell infiltrate (ICI) and osteoclasts in the LO group was significantly higher than that of the NL and S groups (p<0.05). The number of osteoblasts in the LO and S groups was significantly higher than that of the NL group (p<0.05). There were significantly more RANKL-positive cells in the LO group than in the S and NL groups (p<0.05). OPG-positive cells were higher in S group than in LO and NL groups (p<0.05). TOS and OSI levels were significantly reduced in S group compared to LO group (P<0.05) and TAS levels were similar in S and NL group (p>0.05). Conclusions The present study showed that systemic administration of sumac extract may reduce alveolar bone loss by affecting RANKL/OPG balance, TOS and OSI levels in periodontal disease in rats. .
Descritores: Perda do Osso Alveolar/tratamento farmacológico
Osteoprotegerina/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Periodontite/tratamento farmacológico
Extratos Vegetais/farmacologia
Ligante RANK/efeitos dos fármacos
Rhus/química
-Perda do Osso Alveolar/patologia
Antioxidantes/análise
Contagem de Células
Imuno-Histoquímica
Osteoblastos
Osteoprotegerina/análise
Oxidantes/sangue
Periodontite/patologia
Distribuição Aleatória
Ligante RANK/análise
Ratos Wistar
Reprodutibilidade dos Testes
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME



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