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Id: biblio-950741
Autor: Hossain, Mohammad Mobarak; Ahamed, Sayed Koushik; Dewan, Syed Masudur Rahman; Hassan, Md Mahadi; Istiaq, Arif; Islam, Mohammad Safiqul; Moghal, Md Mizanur Rahman.
Título: In vivo antipyretic, antiemetic, in vitro membrane stabilization, antimicrobial, and cytotoxic activities of different extracts from Spilanthes paniculata leaves
Fonte: Biol. Res;47:1-9, 2014. graf, tab.
Idioma: en.
Resumo: BACKGROUND: The study was conducted to evaluate the in vitro antimicrobial activity, cytotoxic, and membrane stabilization activities, and in vivo antiemetic and antipyretic potentials of ethanolic extract, n-hexane and ethyl acetate soluble fractions of Spilanthes paniculata leaves for the first time widely used in the traditional treatments in Bangladesh. RESULTS: In antipyretic activity assay, a significant reduction (P < 0.05) was observed in the temperature in the mice tested. At dose 400 mg/kg-body weight, the n-hexane soluble fraction showed the effect (36.7 ± 0.63°C ) as like as the standard (dose 150 mg/kg-body weight) after 5 h of administration. Extracts showed significant (P < 0.001) potential when tested for the antiemetic activity compared to the standard, metoclopramide. At dose 50 mg/kg-body weight, the standard showed 67.23% inhibition, whereas n-hexane and ethyl acetate soluble fractions showed 37.53% and 24.93% inhibition of emesis respectively at dose 400 mg/kg-body weight. In antimicrobial activity assay, the n-hexane soluble fraction (400 µg/disc) showed salient activity against the tested organisms. It exerts highest activity against Salmonella typhi (16.9 mm zone of inhibition); besides, crude, and ethyl acetate extracts showed resistance to Bacillus cereus and Bacillus subtilis, and Vibrio cholera respectively. All the extracts were tested for lysis of the erythrocytes. At the concentration of 1mg/ml, ethanol extract, and n-hexane and ethyl acetate soluble fractions significantly inhibited hypotonic solution induced lysis of the human red blood cell (HRBC) (27.406 ± 3.57, 46.034 ± 3.251, and 30.72 ± 5.679% respectively); where standard drug acetylsalicylic acid (concentration 0.1 mg/ml) showed 77.276 ± 0.321% inhibition. In case of heat induced HRBC hemolysis, the plant extracts also showed significant activity (34.21 ± 4.72, 21.81 ± 3.08, and 27.62 ± 8.79% inhibition respectively). In the brine shrimp lethality bioassay, the n-hexane fraction showed potent (LC50 value 48.978 µg/ml) activity, whereas ethyl acetate fraction showed mild (LC50 value 216.77 µg/ml) cytotoxic activity. CONCLUSIONS: Our results showed that the n-hexane extract has better effects than the other in all trials. In the context, it can be said that the leaves of S. paniculata possess remarkable pharmacological effects, and justify its folkloric use as antimicrobial, antipyretic, anti-inflammatory, and antiemetic agent. Therefore, further research may be suggested to find possible mode of action of the plant part.
Descritores: Asteraceae/química
Citotoxinas/farmacologia
Membrana Eritrocítica/efeitos dos fármacos
Antipiréticos/farmacologia
Antibacterianos/farmacologia
Antieméticos/farmacologia
-Artemia/efeitos dos fármacos
Salmonella typhi/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
Bacillus cereus/efeitos dos fármacos
Bacillus subtilis/efeitos dos fármacos
Vibrio cholerae/efeitos dos fármacos
Bioensaio/mortalidade
Extratos Vegetais/farmacologia
Testes de Sensibilidade Microbiana
Galinhas
Folhas de Planta/química
Asteraceae/classificação
Etanol
Membrana Eritrocítica/fisiologia
Escherichia coli/efeitos dos fármacos
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Temperatura Alta
Hexanos
Medicina Tradicional
Acetatos
Limites: Humanos
Animais
Camundongos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950751
Autor: Raju, Golam Sarwar; Moghal, Md Mizanur Rahman; Hossain, Mohammad Salim; Hassan, Md Mahadi; Billah, Md Mustahsan; Ahamed, Sayed Koushik; Rana, SM Masud.
Título: Assessment of pharmacological activities of two medicinal plant of Bangladesh: Launaea sarmentosa and Aegialitis rotundifolia roxb in the management of pain, pyrexia and inflammation
Fonte: Biol. Res;47:1-11, 2014. graf, tab.
Idioma: en.
Resumo: BACKGROUND: The current study aims at evaluating the analgesic, anti-pyretic and anti-inflammatory properties of methanolic extract of the stem, bark and leaves of Launaea sarmentosa and Aegialitis rotundifolia roxb. RESULTS: The AELS and AEAR extract presented a significant (***p < 0.001) dose dependent increase in reaction time in writhing method and showed inhibition of 63.1% and 57.1% respectively at the doses of 400 mg/kg body weight while standard drug showed (P < 0.001) inhibition of 69.23%. In tail immersion method, AELS and AEAR showed maximum time of tail retention at 30 min in hot water i.e. 6.93 sec and 6.54 sec respectively at highest doses of 400 mg/kg body weight than lower dose while standard pentazocine showed reaction time of 7.62 sec. The AELS and AEAR extract also exhibited promising anti-inflammatory effect as demonstrated by statistically significant inhibition of paw volume by 32.48% and 26.75% respectively at the dose of 400 mg/kg body weight while the value at the dose of 200 mg/kg body weight were linear to higher dose at the 3rd hour of study. On the other hand, Standard indomethacin inhibited 40.13% of inflammation (***P < 0.001). In Cotton-pellet granuloma method, AELS and AEAR extract at the dose of 400 mg/kg body weight exhibited inhibition of inflammation of 34.7% and 29.1% respectively while standard drug showed (P < 0.001) inhibition of 63.22%. Intraperitoneal administration of AELS and AEAR showed dose dependent decrease in body temperature in brewer's yeast induced hyperthermia in rats at both doses. However, AELS significantly decreased body temperature (***p < 0.001) at 400 mg/kg compared to control. CONCLUSIONS: Present work propose that the methanolic extract of Launaea sarmentosa and Aegialitis rotundifolia roxb possesses dose dependent pharmacological action which supports its therapeutic use in folk medicine possibly mediated through the inhibition or blocking of release of prostaglandin and/or actions of vasoactive substances such as histamine, serotonin and kinins.
Descritores: Asteraceae/química
Plumbaginaceae/química
Antipiréticos/uso terapêutico
Febre/tratamento farmacológico
Manejo da Dor
Fitoterapia
-Fatores de Tempo
Bangladesh
Extratos Vegetais/uso terapêutico
Anti-Inflamatórios não Esteroides/uso terapêutico
Aspirina/uso terapêutico
Indometacina/uso terapêutico
Ratos Wistar
Folhas de Planta/efeitos dos fármacos
Folhas de Planta/metabolismo
Testes de Toxicidade Aguda
Edema/induzido quimicamente
Edema/tratamento farmacológico
Analgésicos/uso terapêutico
Inflamação/tratamento farmacológico
Limites: Animais
Masculino
Feminino
Camundongos
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950765
Autor: Park, Hee-Sook; Choi, Hye-Young; Kim, Gun-Hee.
Título: Preventive effect of Ligularia fischeri on inhibition of nitric oxide in lipopolysaccharide-stimulated RAW 264. 7 macrophages depending on cooking method
Fonte: Biol. Res;47:1-6, 2014. graf, tab.
Idioma: en.
Projeto: Globalization of Korean Foods R& D program; . Ministry of Agriculture, Food, and Rural Affairs, Republic of Korea; . National Research Foundation of Korea; . Ministry of Education. Basic Science Research Program.
Resumo: BACKGROUND: Ligularia fischeri (common name Gomchwi) is known for its pharmaceutical properties and used in the treatment of jaundice, scarlet-fever, rheumatoidal arthritis, and hepatic diseases; however, little is known about its anti-inflammatory effect. In this study the influence of blanching and pan-frying on the anti-inflammatory activity of Ligularia fischeri (LF) was evaluated. RESULTS: Fresh LF and cooked LF showed no significant effect on the viability of macrophages after 24 h incubation. Fresh LF was found to be the most potent inhibitor of nitric oxide (NO) production at 100 µg/ml, while pan-fried LF showed little inhibitory effect on lipoloysaccharide (LPS) stimulated murine machrophage RAW264.7 cells. In contrast with its effect on NO production, pan-fried LF showed significant attenuation of the expression of inducible nitiric oxide synthase (iNOS) compared with fresh LF. In the cooking method of LF, PGE2 production was not affected in the LPS-induced RAW 264.7 cells. In LPS-induced RAW 264.7 cells, pretreatment by fresh and cooked LF increased COX2 mRNA expression. The 3-O-caffeoylquinic acid content of blanching and pan-frying LF increased by 4.92 and 9.7 fold with blanching and pan-frying respectively in comparison with uncooked LF. CONCLUSIONS: Regardless of the cooking method, Ligularia fischeri exhibited potent inhibition of NO production through expression of iNOS in LPS-induced RAW264.7 cells.
Descritores: Culinária/métodos
Asteraceae/química
Preparações de Plantas/farmacologia
Óxido Nítrico Sintase Tipo II/metabolismo
Macrófagos/efeitos dos fármacos
Óxido Nítrico/biossíntese
-Ácido Quínico/análise
Ácido Quínico/análogos & derivados
Ácido Quínico/classificação
RNA Mensageiro/efeitos dos fármacos
RNA Mensageiro/metabolismo
Dinoprostona/análise
Dinoprostona/biossíntese
Sobrevivência Celular
Lipopolissacarídeos
Cromatografia Líquida de Alta Pressão
Asteraceae/classificação
Ciclo-Oxigenase 2/análise
Ciclo-Oxigenase 2/metabolismo
Células RAW 264.7
Temperatura Alta
Macrófagos/fisiologia
Anti-Inflamatórios/farmacologia
Limites: Animais
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1224582
Autor: Egashira, Gilmar Ossamu; Matos, Ricardo Luis Nascimento de; Arakawa, Nilton Syogo.
Título: Isolamento do estigmasterol do extrato hexânico das folhas de Sphagneticola trilobata Pruski (Asteraceae) / Isolation of stigmaterol from hexanic extract of the leaves of Sphagneticola trilobata Pruski (Asteraceae)
Fonte: Semina cienc. biol. saude;41(1):43-54, jan./jun.2020. Tab, Ilus.
Idioma: pt.
Resumo: O interesse de pesquisadores e da população geral é bastante evidente, e tem crescido bastante na atualidade, no uso de plantas medicinais. A espécie de interesse deste trabalho, a Sphagneticola trilobata Pruski é uma planta herbácea pertencente à família Asteraceae. Alguns relatos têm mostrado a presença de diversos constituintes químicos nesta planta, principalmente diterpenos. O presente trabalho realizou o estudo fitoquímico de uma fração do extrato hexânico, devido ao baixo rendimento da fração diclorometânica, através da utilização de diversos métodos cromatográficos, na qual isolouse o fitoesterol estigmasterol. Este composto foi confirmado por meio de dados espectroscópicos e de literaturas, e o isolamento de compostos desta classe de substâncias indicam uma nova vertente para o uso medicinal desta planta como um futuro hipocolesterolêmico. Para isto, estudos serão direcionados para o isolamento de fitoesteróis, com posterior realização de ensaios biológicos (AU)

The interest of researchers and the general population is quite evident, and has grown considerably today, in the use of medicinal plants. The species of interest in this work, Sphagneticola trilobata Pruski is a herbaceous plant, belonging to Asteraceae family. Some reports have shown the presence of several chemical constituents in this plant, mainly diterpenes. The present work carried out the phytochemical study of a fraction of the hexane extract, due to the low yield of the dichloromethane fraction, by several chromatographic methods, in which the phytosterol estigmasterol was isolated. This compound has been confirmed by means of spectroscopic and literature data, and the isolation of compounds of this class of substances indicates a new strand for the medicinal use of this plant as a hypocholesterolemic future. For this, studies will be directed to the isolation of phytosterols, with subsequent biological tests (AU)
Descritores: Plantas Medicinais/efeitos adversos
Pesquisadores
Estigmasterol
Asteraceae
-Fitosteróis
Métodos
Responsável: BR512.1 - Biblioteca Setorial do Centro de Ciências da Saúde


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Id: biblio-950815
Autor: Mamun, Md. Abdullah Al; Islam, Kamrul; Alam, Md. Jahangir; Khatun, Amina; Masihul Alam, M; Al-Bari, Md. Abdul Alim; Alam, Md. Jahangir.
Título: Flavonoids isolated from Tridax procumbens (TPF) inhibit osteoclasts differentiation and bone resorption
Fonte: Biol. Res;48:1-7, 2015. ilus, graf, tab.
Idioma: en.
Projeto: Shahjalal University of Science and Technology; . Bangladesh Research.
Resumo: BACKGROUND: The Tridax procumbens flavonoids (TPF), are well known for their medicinal properties among local natives. The TPF are traditionally used for dropsy, anaemia, arthritis, gout, asthma, ulcer, piles, and urinary problems. It also used in treating gastric problems, body pain, and rheumatic pains of joints. The TPF have been reported to increase osteogenic functioning in mesenchymal stem cells. However, their effects on osteoclastogenesis remain unclear. The TPF isolated from T. procumbens and investigated the effects of the TPF inhibit on osteoclast differentiation and bone resorption activities using primary osteoclastic cells. Osteoclast formation was assessed by counting the number of tartrate resistant acid phosphatase (TRAP) positive multinucleated cells and by measuring both TRAP activities. RESULTS: The TPF significantly suppressed the RANKL-induced differentiation of osteoclasts and the formation of pits in primary osteoclastic cells. The TPF also decreased the expression of mRNAs related to osteoclast differentiation, including Trap, Cathepsin K, Mmp-9, and Mmp-13 in primary osteoclastic cells. The treatment of primary osteoclastic cells with the TPF decreased Cathepsin K, Mmp-9, and Mmp-13 proteins expression in primary osteoclastic cells. CONCLUSION: These results indicated that TPF inhibit osteoclastogenesis and pits formation activities. Our results suggest that the TPF could be a potential anti-bone resorptic agent to treat patients with bone loss-associated diseases such as osteoporosis.
Descritores: Osteoclastos/efeitos dos fármacos
Flavonoides/farmacologia
Reabsorção Óssea
Diferenciação Celular/efeitos dos fármacos
Asteraceae/química
-Flavonoides/isolamento & purificação
RNA Mensageiro
Fosfatase Ácida Resistente a Tartarato/efeitos dos fármacos
Camundongos Endogâmicos C57BL
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Barros, Claudio S. L
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Id: lil-624087
Autor: Driemeier, David; Irigoyen, Luiz Francisco; Loretti, Alexandre Paulino; Colodel, Edson Moleta; Barros, Claudio S. L.
Título: Intoxicação espontânea pelos frutos de Xanthium cavanillesii (Asteraceae) em bovinos no Rio Grande do Sul / Spontaneous poisoning by the burs of Xanthium cavanillesii (Asteraceae) in cattle in Rio Grande do Sul, southern Brazil
Fonte: Pesqui. vet. bras = Braz. j. vet. res;19(1):12-18, Jan. 1999. ilus.
Idioma: pt.
Resumo: Two outbreaks of Xanthium cavanillesii poisoning in feedlot cattle in the counties of Casca and Cachoeira do Sul, Rio Grande do Sul, southern Brazil, are described. The disease occurred on two farms in late April and mid August 1996. On one farm, 17 heifers out of 310 cattle died. On the other, 11 out of 83 yearling calves died. Clinical signs included depression, anorexia, progressive dehydration, sunken eyes, tenesmus and slight rectal prolapse, muscle tremors, incoordination of gait, blindness, aggressivity and recumbency. Blindness was present in the terminal stages prior to death that occurred within 3 to 24 hours after the onset of the clinical signs. Necropsy findings included accentuation of the lobular pattern of the liver with pinpoint hemorrhages on capsular and cut surfaces; perirenal edema, hydropericardium, and translucent and gelatinous edema of the gall bladder wall, mesentery, abomasal ligaments and folds. The feces were scant, dry and formed balls coated by mucus and streaks of clotted blood. There were widespread petechiae, ecchymoses and suffusions. Burs of X. cavanillesii were found mixed with the solid and dried contents of the rumen and reticulum. The main histopathological findings were marked centrilobular coagulative hepatocellular necrosis associated with congestion and hemorrhages, surrounded or not by a narrow rim of markedly swollen and vesicular hepatocytes. The animals were being fed with whole or milled leftovers from soybean crops contaminated with large amounts of burs of X. cavanillesii. Deaths stopped after the feeding with the soybean leftovers was discountinued. The diagnosis was based on epidemiological data, clinical signs, necropsy findings, histological lesions and experimental reproduction of the toxicosis in cattle and sheep. The morphology and pathogenesis of the hepatic lesion and the clinical and pathological aspects of the toxicosis are discussed and compared with other reports of Xanthium spp poisoning and other acute hepatotoxicoses in cattle.(AU)

Descreve-se a ocorrência de dois surtos de intoxicação espontânea de bovinos pelos frutos de Xanthium cavanillesii em dois estabelecimentos dos municípios de Casca e Cachoeira do Sul, RS, no final de abril e meados de agosto de 1996. Em um dos estabelecimentos, morreram 17 novilhas de um total de 310 bovinos e no outro, morreram 11 de um total de 83 terneiros de 12 a 18 meses de idade. O curso clínico variou de 3 a 24 horas e caracterizou-se por apatia, anorexia, desidratação progressiva, retração dos globos oculares, tenesmo associado a discreto prolapso retal, tremores musculares, incoordenação motora, agressividade, decúbito, cegueira na fase terminal, e morte. As principais lesões macroscópicas nos animais necropsiados incluíam fígado com acentuação do padrão lobular e hemorragias puntiformes na superfície capsular e de corte; hidropericárdio, edema gelatinoso e translúcido na parede da vesícula biliar, no mesentério, nos ligamentos e dobras do abomaso e na região perirrenal; fezes ressequidas, em pequena quantidade, sob a forma de esferas e recobertas por muco e estrias de sangue coagulado; petéquias, equimoses e sufusões disseminadas em diferentes tecidos e órgãos; e frutos de X. cavanillesii misturados a conteúdo firme e ressecado do rúmen e do retículo. A principal lesão microscópica consistia em acentuada necrose coagulativa hepatocelular centrolobular associada à congestão e hemorragias, circundadas ou não por uma estreita faixa de hepatócitos marcadamente tumefeitos e vesiculares. Nas propriedades, os bovinos confinados eram alimentados com resíduo de lavoura de soja, inteiro ou moído, contaminado acidentalmente por grande quantidade de frutos de X. cavanillesii. Após a retirada do resíduo da suplementação alimentar desses animais, as mortes cessaram. O diagnóstico baseou-se em dados epidemiológicos, clínicos, de necropsia e histopatológicos e na reprodução experimental da enfermidade em bovinos e ovinos. A morfologia e a patogenia da lesão hepática e o quadro clínico-patológico observados são discutidos e comparados com outros relatos de intoxicação por Xanthium spp descritos na literatura e com outras hepato-toxicoses agudas em bovinos.(AU)
Descritores: Intoxicação por Plantas/veterinária
Bovinos/fisiologia
Asteraceae
Hepatócitos
-Patologia Veterinária
Plantas Tóxicas/toxicidade
Envenenamento
Limites: Animais
Bovinos
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-1124215
Autor: Fernandes-Rocha, Lucas; Ribeiro-Paula, Natália; Gonçalves-Nazareno, Alison; Carvalho, Dulcinéia de.
Título: Development and characterization of nuclear microsatellite markers for Eremanthus erythropappus and their transferability across related species
Fonte: Biol. Res;53:30, 2020. tab.
Idioma: en.
Projeto: FAPEMIG (Fundação de Amparo à Pesquisa do Estado de Minas Gerais); . Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES).
Resumo: BACKGROUND: We developed simple sequence repeats (SSR) for Eremanthus erythropappus (DC.) MacLeish, an endangered tree species endemic to the Brazilian Savanna and Atlantic Forest biomes, and tested their transferability to two closely related Eremanthus species. RESULTS: Using a genomic library enriched with tandem repeat motifs, we identified 16 primer pairs, and characterized them in two populations. Nine primers amplified the expected size fragments and seven SSRs were polymorphic, providing a total of 38 alleles and an average of 4.22 alleles per marker. The polymorphic information content (PIC) ranged from 0.44 to 0.94 with an average of 0.65. The average observed heterozygosity across all loci varied from 0.61 to 1.00. The observed ( HO ) and expected ( HE ) heterozygosity within the two populations varied from 0.65 to 1.00 and from 0.31 to 1.00, respectively. CONCLUSIONS: These newly developed SSR markers are a powerful tool for population genetic analyses and may be useful in studies on species ecology, evolution, and taxonomy.
Descritores: Espécies em Perigo de Extinção
Repetições de Microssatélites/genética
Asteraceae/genética
-Brasil
Alelos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1153299
Autor: Alper, Mehlika; Özay, Cennet; Güneş, Hatice; Mammadov, Ramazan.
Título: Assessment of Antioxidant and Cytotoxic Activities and Identification of Phenolic Compounds of Centaurea solstitialis and Urospermum picroides from Turkey
Fonte: Braz. arch. biol. technol;64:e21190530, 2021. tab, graf.
Idioma: en.
Resumo: HIGHLIGHTS The phenolic composition, antioxidant activity and cytotoxic potential of the extracts of C. solstitialis and U. picroides were investigated. Caffeic acid was found as the most abundant phenolic compound in the extracts. Both species showed promising antioxidant activity towards different assays. The highest cytotoxic potential was observed in the extract of C. solstitialis.

Abstract It is known that some genera of the Asteraceae family are commonly used in Turkish folk medicine. Several studies have investigated the biological effects of different extracts of Centaurea and Urospermum species, but studies involving the phenolic composition of C. solstitialis and U. picroides extracts are very limited. This study aimed to investigate the phenolic composition and antioxidant activity of C. solstitialis and U. picroides and evaluate their possible cytotoxic effect. RP-HPLC analysis was used to elucidate the phenolic profiles of the ethanolic extracts of flowering parts of C. solstitialis and U. picroides.The both ethanolic extracts were assessed for their antioxidant properties using DPPH, FRAP, phosphomolybdenum and metal chelating assays. Furthermore, the effect of the extracts on cell viability was evaluated against MCF-7 and PC-3 cancer cells and HEK293 cell line using the MTT assay. The most abundant phenolic compound in both extracts was determined to be caffeic acid, and the amount of this compound was 24078.03 and 14329.59 µg g-1 in the extracts of C. solstitialis and U. picroides, respectively. The antioxidant activity of the extracts was found similar. Compared with U. picroides extract, C. solstitialis extract had higher potential on the inhibition of cell viability. The IC50 value of C. solstitialis on MCF cells was found as 58.53 µg mL-1. These data suggest that the extracts of C. solstitialis and U. picroides may be considered as novel and alternative natural antioxidant and anticancer sources.
Descritores: Asteraceae/química
Citotoxinas/farmacologia
Centaurea/química
Compostos Fenólicos/análise
Antioxidantes/farmacologia
-Fenóis/farmacologia
Plantas Medicinais
Turquia
Ácidos Cafeicos/farmacologia
Extratos Vegetais/farmacologia
Cromatografia Líquida de Alta Pressão
Células HEK293
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-950829
Autor: Mamun, Md. Abdullah Al; Hosen, Mohammad Jakir; Islam, Kamrul; Khatun, Amina; Masihul Alam, M; Al-Bari, Md. Abdul Alim.
Título: Tridax procumbens flavonoids promote osteoblast differentiation and bone formation
Fonte: Biol. Res;48:1-8, 2015. graf, tab.
Idioma: en.
Projeto: Shahjalal University of Science and Technology; . Bangladesh Research.
Resumo: BACKGROUND: Tridaxprocumbens flavonoids (TPFs) are well known for their medicinal properties among local natives. Besides traditionally used for dropsy, anemia, arthritis, gout, asthma, ulcer, piles, and urinary problems, it is also used in treating gastric problems, body pain, and rheumatic pains of joints. TPFs have been reported to increase osteogenic functioning in mesenchymal stem cells. Our previous study showed that TPFs were significantly suppressed the RANKL-induced differentiation of osteoclasts and bone resorption. However, the effects of TPFs to promote osteoblasts differentiation and bone formation remain unclear. TPFs were isolated from Tridax procumbens and investigated for their effects on osteoblasts differentiation and bone formation by using primary mouse calvarial osteoblasts. RESULTS: TPFs promoted osteoblast differentiation in a dose-dependent manner demonstrated by up-regulation of alkaline phosphatase and osteocalcin. TPFs also upregulated osteoblast differentiation related genes, including osteocalcin, osterix, and Runx2 in primary osteoblasts. TPFs treated primary osteoblast cells showed significant upregulation of bone morphogenetic proteins (BMPs) including Bmp-2, Bmp-4, and Bmp-7. Addition of noggin, a BMP specific-antagonist, inhibited TPFs induced upregulation of the osteocalcin, osterix, and Runx2. CONCLUSION: Our findings point towards the induction of osteoblast differentiation by TPFs and suggested that TPFs could be a potential anabolic agent to treat patients with bone loss-associated diseases such as osteoporosis.
Descritores: Osteoblastos/efeitos dos fármacos
Osteogênese/efeitos dos fármacos
Flavonoides/farmacologia
Diferenciação Celular/efeitos dos fármacos
Asteraceae/química
-Osteoblastos/citologia
Osteoblastos/metabolismo
Crânio/citologia
Crânio/efeitos dos fármacos
Fatores de Transcrição/genética
Flavonoides/análise
Calcificação Fisiológica/efeitos dos fármacos
Osteocalcina/efeitos dos fármacos
Osteocalcina/genética
Regulação para Cima/genética
Proteínas Morfogenéticas Ósseas/metabolismo
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Fosfatase Alcalina/efeitos dos fármacos
Fosfatase Alcalina/metabolismo
Subunidade alfa 1 de Fator de Ligação ao Core/genética
Subunidade alfa 1 de Fator de Ligação ao Core/metabolismo
Cultura Primária de Células
Fator de Transcrição Sp7
Medicina Tradicional
Camundongos Endogâmicos C57BL
Limites: Animais
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1104063
Autor: Trendafilova, Antoaneta; Kutova, Nikolina; Ozek, Gulmira; Todorova, Milka; Yur, Suleyman; Ozek, Temel; Dimitrov, Dimitar.
Título: Phenolic profile and antioxidant, acetylcholinesterase, and tyrosinase inhibitor activities of Jurinea tzar-ferdinandii Davidov, an endemic plant of the Balkans / Perfil fenólico y actividad antioxidante, acetilcolinesterasa e inhibidora de tirosinasa de Jurinea tzar-ferdinandii Davidov, planta endémica de los Balcanes
Fonte: Bol. latinoam. Caribe plantas med. aromát;19(2):161-166, mar. 2020. tab, ilus.
Idioma: en.
Projeto: Bulgarian Academy of Sciences; . TUBITAK.
Resumo: The methanol extract of the Balkan endemic species Jurinea tzar-ferdinandii Davidov demonstrated weak antioxidant activity against DPPH• and ABTS+• and low inhibitory potential against acetylcholinesterase (8.3% Inh.) and tyrosinase (IC50 = 208 ± 8 µg/mL) enzymes. Phytochemical investigation of the extract led to isolation and identification of apigenin, luteolin, apigenin-7-O-glucoside, apigenin-4'-O-glucoside, apigenin-7-O-gentiobioside, luteolin-4'-O-glucoside, rutin, narcissin, chlorogenic and 1,5-dicaffeoylquinic acid. With exception of apigenin and rutin, all isolated compounds are reported for the first time in the representatives of genus Jurinea. The distribution of flavonoids was discussed from chemotaxonomic point of view.

El extracto de metanol de la especie endémica de los Balcanes Jurinea tzar-ferdinandii Davidov demostró una actividad antioxidante débil contra DPPH• y ABTS+• y un bajo potencial inhibidor contra las enzimas acetilcolinesterasa (8.3% Inh.) tirosinasa (IC50 = 208 ± 8 µg/mL). La investigación fitoquímica del extracto condujo al aislamiento e identificación de apigenina, luteolina, apigenina-7-Oglucósido, apigenina-4'-O-glucósido, apigenina-7-O-gentiobiósido, luteolina-4'-O-glucósido, rutina, narcissin, clorogénico y ácido 1,5- dicafeoilquinico. Con excepción de la apigenina y la rutina, todos los compuestos aislados se informan por primera vez en el género Jurinea. La distribución de flavonoides se discute desde el punto de vista quimiotaxonómico.
Descritores: Asteraceae/química
Antioxidantes/farmacologia
Antioxidantes/química
-Fenóis/análise
Flavonoides/análise
Inibidores da Colinesterase
Monofenol Mono-Oxigenase/antagonistas & inibidores
Metanol
Península Balcânica
Responsável: CL1.1 - Biblioteca Central



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