Base de dados : LILACS
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Id: biblio-996385
Autor: Elizalde González, Valeria.
Título: Efecto in vitro antimicrobiano de commiphora myrrha mirra frente a streptococcus mutans / Antimicrobial in vitro effect of commiphora myrrha myrrh against streptococcus mutans.
Fonte: Ambato; s.n; 2018. 1-70 p. tab, graf.
Idioma: es.
Tese: Apresentada a Universidad Regional Autónoma de Los Andes para obtenção do grau de Maestría.
Resumo: La Organización Mundial de la Salud (OMS) en los últimos años ha impulsado el uso de la medicina tradicional como una alternativa en la salud primaria y sobre todo en áreas rurales donde se dificulta el acceso a la atención médica oportuna. Esta investigación plantea tres fases: Estudio etnofarmacológico realizado en la ciudad de Guayaquil, donde se obtuvo un 20% de nivel de uso significativo para Commiphora myrrha (mirra) con índice de valor de uso 0,022. Los metabolitos secundarios presentes en la mirra son Furanoeudesma-1,3-diene, Curzerene, ß-elemene, 2-O-acetyl-8,12epoxigermacrama1-1(10)-4,7,11-tetraene, además de polisacáridos, aminoácidos y flavonas. La actividad antimicrobiana in vitro del aceite esencial y extracto etanólico Commiphora myrrha fue investigada sobre Streptococcus mutans, utilizando como control blanco agua destilada y control positivo clorhexidina al 2%. Los valores promedios más altos de halo inhibitorio fueron en la concentración al 100%, presentando 12mm y 10mm para el aceite esencial y extracto etanólico respectivamente; acorte a la escala de Duraffourd se encuentran en sensibilidad límite. Los resultados obtenidos fueron evaluados por medio de la prueba ANOVA (Análisis de varianza) donde el valor de P es < 0,001 rechazando la no existencia de actividad antimicrobiana del aceite esencial y extracto etanólico. (AU)
Descritores: Streptococcus mutans
Commiphora
Anti-Infecciosos
-Plantas Medicinais
Técnicas In Vitro
Extratos Vegetais
Equador
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: lil-769831
Autor: Attia, Rasha AH; Mahmoud, Abeer E; Farrag, Haiam Mohammed Mahmoud; Makboul, Rania; Mohamed, Mona Embarek; Ibraheim, Zedan.
Título: Effect of myrrh and thyme on Trichinella spiralisenteral and parenteral phases with inducible nitric oxide expression in mice
Fonte: Mem. Inst. Oswaldo Cruz;110(8):1035-1041, Dec. 2015. tab, graf.
Idioma: en.
Resumo: Trichinellosis is a serious disease with no satisfactory treatment. We aimed to assess the effect of myrrh (Commiphora molmol) and, for the first time, thyme (Thymus vulgaris L.) against enteral and encysted (parenteral) phases of Trichinella spiralis in mice compared with albendazole, and detect their effect on inducible nitric oxide synthase (iNOS) expression. Oral administration of 500 mg/kg of myrrh and thyme led to adult reduction (90.9%, 79.4%), while 1,000 mg/kg led to larvae reduction (79.6%, 71.3%), respectively. Administration of 50 mg/kg of albendazole resulted in adult and larvae reduction (94.2%, 90.9%). Positive immunostaining of inflammatory cells infiltrating intestinal mucosa and submucosa of all treated groups was detected. Myrrh-treated mice showed the highest iNOS expression followed by albendazole, then thyme. On the other hand, both myrrh and thyme-treated groups showed stronger iNOS expression of inflammatory cells infiltrating and surrounding encapsulated T. spiralis larvae than albendazole treated group. In conclusion, myrrh and thyme extracts are highly effective against both phases of T. spiralis and showed strong iNOS expressions, especially myrrh which could be a promising alternative drug. This experiment provides a basis for further exploration of this plant by isolation and retesting the active principles of both extracts against different stages of T. spiralis.
Descritores: Antinematódeos/farmacologia
Óxido Nítrico Sintase Tipo II/metabolismo
Thymus (Planta)
Terpenos/farmacologia
Trichinella spiralis/efeitos dos fármacos
-Albendazol/farmacologia
Linhagem Celular
Commiphora/química
Fibroblastos/efeitos dos fármacos
Imuno-Histoquímica
Intestino Delgado/parasitologia
Larva/efeitos dos fármacos
Camundongos Endogâmicos BALB C
Músculo Esquelético/parasitologia
Trichinella spiralis/enzimologia
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: lil-419705
Autor: Hamed, Manal A; Hetta, Mona H.
Título: Efficacy of Citrus reticulata and Mirazid in treatment of Schistosoma mansoni
Fonte: Mem. Inst. Oswaldo Cruz;100(7):771-778, Nov. 2005. ilus.
Idioma: en.
Resumo: This work has been carried out to investigate the effect of Schistosoma mansoni infection on mice livers after treatment with the ethanolic extract of Citrus reticulata root or the oleo-resin extract from Myrrh of Commiphora molmol tree (Mirazid), as a new antishistosomal drug. Marker enzymes for different cell organelles were measured; succinate dehydrogenase (SDH); lactate dehydrogenase (LDH) and its isoenzymes; glucose-6-phosphatase (G-6-Pase); acid phosphatase (AP) and 5'- nucleotidase. Liver function enzymes; aspartate aminotransferase (AST); alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were also estimated. Parasitological studies through ova count and worm burden will also be taken into consideration. The results showed a marked reduction in SDH, LDH, AST, and ALT enzyme activities and a significant increase in G-6-Pase, AP, 5'- nucleotidase, and ALP after S. mansoni infection. A noticeable alteration in LDH subunits were also noticed. Treatment with C. reticulata or Mirazid improved all the previous enzyme activities with a noticeable reduction in ova count and worm burden.
Descritores: Citrus/química
Commiphora/química
Schistosoma mansoni/efeitos dos fármacos
Esquistossomose mansoni/tratamento farmacológico
Esquistossomicidas/farmacologia
Terpenos/farmacologia
-Biomarcadores/análise
Modelos Animais de Doenças
Fígado/enzimologia
Fígado/parasitologia
Extratos Vegetais/farmacologia
Esquistossomose mansoni/enzimologia
Limites: Camundongos
Animais
Masculino
Responsável: BR1.1 - BIREME



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