Base de dados : LILACS
Pesquisa : B01.650.940.800.575.912.250.198.500.937 [Categoria DeCS]
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Id: biblio-889396
Autor: Ammar, Ouahab.
Título: In silico pharmacodynamics, toxicity profile and biological activities of the Saharan medicinal plant Limoniastrum feei
Fonte: Braz. J. Pharm. Sci. (Online);53(3):e00061, 2017. tab, graf, ilus.
Idioma: en.
Resumo: ABSTRACT In-silico study was performed to find the pharmacodynamics, toxicity profiles and biological activities of three phytochemicals isolated from Limoniastrum feei (Plumbagenaceae). Online pharmacokinetic tools were used to estimate the potential of Quercetin, kaempferol-3-O-ß-D-glucopyranoside (astragalin) and quercitin-7-O-ß-D-glucopyranoside as specific drugs. Then the prediction of potential targets of these compounds were investigated using PharmMapper. Auto-Dock 4.0 software was used to investigate the different interactions of these compounds with the targets predicted earlier. The permeability of quercetin was found within the range stated by Lipinski ׳s rule of five. Hematopoietic prostaglandin (PG) D synthase (HPGDS), farnesyl diphosphate synthetase (FPPS) and the deoxycytidine kinase (DCK) were potential targets for quercetin, astragalin and quercetin 7, respectively. Quercetin showed antiallergic and anti-inflammatory activity, while astragalin and quercetin 7 were predicted to have anticancer activities. The activity of Astragalin appeared to be mediated by FPPS inhibition. The inhibition of DCK was predicted as the anticancer mechanisms of quercetin 7. The compounds showed interesting interactions and satisfactory binding energies when docked into their targets. These compounds are proposed to have activities against a variety of human aliments such as allergy, tumors, muscular dystrophy, and diabetic cataracts.
Descritores: Plantas Medicinais/metabolismo
Simulação por Computador/estatística & dados numéricos
Plumbaginaceae/classificação
-Quercetina/análise
Fatores Biológicos
Ações Farmacológicas
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: lil-687013
Autor: Moncada Ascencio, Natali; Farcio Villarreal, Manuel; Rojas Idrogo, Consuelo; Trevisan Ferreira, Dalva; Horna Dávila, Oscar; Pereira, Jurandir; Delgado Paredes, Guillermo E.
Título: Actividad biológica de Plumbago scandens L. sobre cepas multidrogoresistente de Mycobacterium tuberculosis / Biological activity of Plumbago scandens L. against multidrug-resistance strains of Mycobacterium tuberculosis
Fonte: Bol. latinoam. Caribe plantas med. aromát;10(3):233-245, mayo 2011. ilus, tab.
Idioma: es.
Resumo: Tuberculosis control is a high priority for the Ministry of Health from Peru. In the present work the inhibitory effect of both metanolic (MeOH) and ethyl acetate (AcOEt) crude extracts and the minimum inhibitory concentration (MIC) of both wild plants and in vitro plantlets of Plumbago scandens L. -Plumbaginaceae- against multidrug-resistance (MDR) strains of Mycobacterium tuberculosis were determined. The plant material was constituted by roots and seeds, collected in the Motupe (Lambayeque) area. The in vitro plantlets were obtained from seedlings and micropropagated by shoot tips and nodal segments in Murashige and Skoog (MS) culture medium. The microbiological material consisting of one control strain and two strains of Mycobacterium tuberculosis resistant to isoniazid (INH) and rifampicin (RIF) was cultivated using the Lowenstein–Jensen culture medium. The MIC values varied from 0,65 to 1,3 mg/mL. Bacterial strains showed more sensitivite to the AcOEt crude extract. The GC analysis of the plant material showed the presence of the naphtoquinone plumbagin and other aromatic compounds. In conclusion, the MeOH y AcOEt crude extracts from roots of the wild plants and MeOH crude extract of in vitro plantlets of P. scandens showed a strong inhibitory activity against MDR strains of M. tuberculosis.

El control de la tuberculosis es un objetivo de alta prioridad para el Ministerio de Salud del Perú. En el presente trabajo se determinó el efecto inhibitorio de los extractos crudos metanólico (MeOH) y de acetato de etilo (AcOEt), expresados como concentración mínima inhibitoria (CMI) de plantas silvestres y plántulas in vitro de Plumbago scandens L. (Plumbaginaceae) sobre cepas multidrogoresistente (MDR) de Mycobacterium tuberculosis. El material vegetal estuvo constituido por raíces de plantas silvestres, en tanto que las plántulas in vitro fueron obtenidas de semillas y micropropagadas en medio de cultivo Murashige y Skoog (MS). El material microbiológico, constituido por una cepa control y dos cepas resistentes a isoniacida (INH) y rifampicina (RIF), fue cultivado en medio de cultivo Lowenstein-Jensen. Los valores CMI variaron entre 0,65 y 1,3 mg/mL, mostrándose más sensibles las cepas bacterianas frente al extracto crudo de AcOEt de plantas silvestres. El análisis cromatografía de gases (GC) determinó la presencia de la naftoquinona plumbagina y otros compuestos aromáticos. En conclusión, los extractos crudos de MeOH y AcOEt de raíces de plantas silvestres y extracto crudo de MeOH de plántulas in vitro de P. scandens ejercieron una fuerte acción inhibitoria sobre cepas MDR de M. tuberculosis.
Descritores: Antibacterianos/farmacologia
Extratos Vegetais/farmacologia
Mycobacterium tuberculosis
Plumbaginaceae/química
-Cromatografia Gasosa
Testes de Sensibilidade Microbiana
Raízes de Plantas/química
Técnicas de Cultura de Tecidos
Tuberculose Resistente a Múltiplos Medicamentos
Responsável: CL1.1 - Biblioteca Central


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Id: lil-607420
Autor: Paiva, Selma R; Lima, Lucilene A; Figueiredo, Maria Raquel; Kaplan, Maria Auxiliadora C.
Título: Chemical composition fluctuations in roots of Plumbago scandens L. in relation to floral development
Fonte: An. acad. bras. ciênc;83(4):1165-1170, Dec. 2011. ilus, tab.
Idioma: en.
Resumo: Plumbago scandens L. is a Brazilian tropical/subtropical species that occurs along the coast. Chemically it is mainly represented by naphthoquinones, flavonoids, terpenoids and steroids. The aim of the present work is to study quantitative changes in the root metabolic production of Plumbago scandens during different physiologic developmental stages relative to floration. The results indicated the presence of four substances in the extracts: plumbagin, epi-isoshinanolone, palmitic acid and sitosterol, independent on developmental stage. The naphthoquinone plumbagin has always showed to be the major component of all extracts. Naphthoquinones exhibited their highest content during floration, while the content of the two others components decreased during this stage, revealing an inverse profile. The chemical composition changed depending on the plant requirements.

Plumbago scandens L. é uma espécie brasileira tropical/subtropical que ocorre ao longo da costa. Quimicamente, é principalmente representada por naftoquinonas, flavonóides, terpenóides e esteróides. objetivo do presente trabalho é estudar mudanças quantitativas da produção metabólica nas raízes de Plumbago scandens durante diferentes estágios de desenvolvimento fisiológico, relativos à floração. Os resultados indicaram a presença de quatro substâncias nos extratos: plumbagina, epi-isoshinanolona, ácido palmítico e sitosterol, independente do estágio de desenvolvimento. A naftoquinona plumbagina tem sempre mostrado ser o componente majoritário de todos os extratos. Naftoquinonas exibiram seus maiores conteúdos durante a floração, enquanto o conteúdo dos dois outros componentes decresceu durante este estágio, revelando um perfil inverso. A composição química modificou dependendo das necessidades da planta.
Descritores: Naftoquinonas/química
Ácido Palmítico/química
Raízes de Plantas/química
Plumbaginaceae/química
Sitosteroides/química
Tetra-Hidronaftalenos/química
-Cromatografia Gasosa
Naftoquinonas/metabolismo
Ácido Palmítico/metabolismo
Raízes de Plantas/crescimento & desenvolvimento
Raízes de Plantas/metabolismo
Plumbaginaceae/crescimento & desenvolvimento
Plumbaginaceae/metabolismo
Sitosteroides/metabolismo
Tetra-Hidronaftalenos/metabolismo
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-529551
Autor: Maniafu, Barasa M; Wilber, Lwande; Ndiege, Isaiah O; Wanjala, Cornelius C; Akenga, Teresa Ayuko.
Título: Larvicidal activity of extracts from three Plumbago spp against Anopheles gambiae
Fonte: Mem. Inst. Oswaldo Cruz;104(6):813-817, Sept. 2009. ilus, tab.
Idioma: en.
Projeto: WHO/TDR/MIM.
Resumo: Three Plumbago spp have been tested for mosquito larvicidal activity. The crude extracts exhibiting the highest larvicidal activity against Anopheles gambiae were hexane (LC50 = 6.4 μg/mL) and chloroform (LC50 = 6.7 μg/mL) extracts from Plumbago zeylanica Linn, chloroform (LC50 = 6.7 ug/mL) extract from Plumbago stenophylla Bull and ethyl acetate (LC50 = 4.1 μg/mL) extract from Plumbago dawei Rolfe. These LC50 values were within 95 percent confidence limits. 5-hydroxy-2-methyl-1,4-naphthoquinone (plumbagin) 1 (LC50 = 1.9 μg/mL) and β-sitosterol 2 were characterised from ethyl acetate extract of root bark of P. dawei, a native medicinal plant growing in Kenya, based on spectral analysis and comparisons with data in literature.
Descritores: Anopheles
Inseticidas
Extratos Vegetais/farmacologia
Plumbaginaceae/química
-Larva/efeitos dos fármacos
Plumbaginaceae/classificação
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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