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Coelho, Humberto Eustáquio
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Id: biblio-1012003
Autor: Magalhães, Fernanda Oliveira; Uber-Bucek, Elizabeth; Ceron, Patricia Ibler Bernardo; Name, Thiago Fellipe; Coelho, Humberto Eustáquio; Barbosa, Claudio Henrique Gonçalves; Carvalho, Tatiane; Groppo, Milton.
Título: Chronic treatment with hydroalcoholic extract of Plathymenia reticulata promotes islet hyperplasia and improves glycemic control in diabetic rats / Tratamento crônico com extrato hidroalcoólico de Plathymenia reticulata promove hiperplasia de ilhotas e controle glicêmico em ratos diabéticos
Fonte: Einstein (Säo Paulo);17(3):eAO4635, 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective: To investigate the anti-hyperglycemic effects of Plathymenia reticulata hydroalcoholic extract and related changes in body weight, lipid profile and the pancreas. Methods: Diabetes was induced in 75 adult male Wistar rats via oral gavage of 65mg/Kg of streptozotocin. Rats were allocated to one of 8 groups, as follows: diabetic and control rats treated with water, diabetic and control rats treated with 100mg/kg or 200mg/kg of plant extract, and diabetic and control rats treated with glyburide. Treatment consisted of oral gavage for 30 days. Blood glucose levels and body weight were measured weekly. Animals were sacrificed and lipid profile and pancreatic tissue samples analyzed. Statistical analysis consisted of ANOVA, post-hoc Tukey-Kramer, paired Student's t and χ2 tests; the level of significance was set at 5%. Results: Extract gavage at 100mg/kg led to a decrease in blood glucose levels in diabetic rats in the second, third (198.71±65.27 versus 428.00±15.25) and fourth weeks (253.29±47.37 versus 443.22±42.72), body weight loss (13.22±5.70 versus 109.60±9.95) and lower cholesterol levels (58.75±3.13 versus 80.11±4.01) in control rats. Extract gavage at 200mg/Kg led to a decrease in glucose levels on the fourth week in diabetic rats, body weight loss in the second, third and fourth weeks in control rats, and lower cholesterol levels in diabetic and control rats. Islet hyperplasia (p=0.005) and pancreatic duct dilation (p=0.047) were observed in diabetic and control rats. Conclusion: Plathymenia extract reduced blood glucose levels in diabetic rats, and body weight in control rats, and promoted pancreatic islet hyperplasia in diabetic and control rats.

RESUMO Objetivo: Avaliar o efeito anti-hiperglicêmico do extrato hidroalcoólico de Plathymenia reticulata, alterações no peso, lipídeos e efeito sobre o pâncreas. Métodos: O diabetes foi induzido pela administração de estreptozotocina 65mg/kg, em 75 ratos Wistar adultos machos, divididos em 8 grupos diferentes: ratos diabéticos e controle + água, ratos diabéticos e controle + 100mg/kg ou 200mg/kg de extrato, ratos diabéticos e controle + gliburida. O tratamento foi realizado por gavagem (oral) por 30 dias. Níveis de glicose e peso foram verificados semanalmente. Os animais foram sacrificados, e amostras de lipídeos e do pâncreas foram analisadas. A análise estatística incluiu ANOVA, post-hoc Tukey-Kramer, teste t de Student pareado e teste do χ2, com nível de significância de 5%. Resultados: O extrato 100mg/kg promoveu redução nos níveis de glicose sanguínea em ratos diabéticos na segunda, terceira (198,71±65,27 versus 428,00±15,25) e quarta semanas (253,29±47,37 versus 443,22±42,72), perda de peso (13,22±5,70 versus 109,60±9,95) e diminuição do colesterol (58,75±3,13 versus 80,11±4,01) em ratos controle. Com extrato de 200mg/kg, houve redução dos níveis de glicose na quarta semana, nos ratos diabéticos; de peso na segunda, terceira e quarta semanas, nos ratos controle; e de colesterol nos animais diabéticos e controle. Ocorreram hiperplasia de ilhotas (p=0,005) e dilatação dos ductos pancreáticos (p=0,047) em ratos diabéticos e controles. Conclusão: O extrato de Plathymenia reduziu os níveis de glicose em ratos diabéticos e de peso em ratos controle, além de ter promovido hiperplasia de ilhotas pancreáticas em diabéticos e controles.
Descritores: Extratos Vegetais/farmacologia
Diabetes Mellitus Experimental/tratamento farmacológico
Hipoglicemiantes/farmacologia
Fabaceae
-Glicemia/análise
Peso Corporal/efeitos dos fármacos
Colesterol
Ratos Wistar
Estreptozocina
Folhas de Planta
Diabetes Mellitus Experimental/induzido quimicamente
Modelos Animais de Doenças
Hiperplasia/patologia
Fitoterapia
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1047367
Autor: Qureshi, M. Amjad; Tariq Pervez, Muhammad; Ellahi Babar, Masroor; Hussain, Tanveer; Shoaib, Muhammad; Shah Mohammad, Syed.
Título: Genomic comparisons of Rhizobium species using in silico AFLP-PCR, endonuclease restriction, and AMPylating enzymes
Fonte: Electron. j. biotechnol;34:67-75, july. 2018. graf, tab.
Idioma: en.
Resumo: Background: The whole-genome sequences of nine Rhizobium species were evaluated using different in silico molecular techniques such as AFLP-PCR, restriction digest, and AMPylating enzymes. The entire genome sequences were aligned with progressiveMauve and visualized by reconstructing phylogenetic tree using NTSYS pc 2.11X. The "insilico.ehu.es" was used to carry out in silico AFLP-PCR and in silico restriction digest of the selected genomes. Post-translational modification (PTM) and AMPylating enzyme diversity between the proteome of Rhizobium species were determined by novPTMenzy. Results: Slight variations were observed in the phylogeny based on AFLP-PCR and PFGE and the tree based on whole genome. Results clearly demonstrated the presence of PTMs, i.e., AMPylation with the GS-ATasE (GlnE), Hydroxylation, Sulfation with their domain, and Deamidation with their specific domains (AMPylating enzymes) GS-ATasE (GlnE), Fic, and Doc (Phosphorylation); Asparagine_hydroxylase and Collagen_prolyl_lysyl_hydroxylase; Sulfotransferase; and CNF (Cytotoxic Necrotizing Factors), respectively. The results pertaining to PTMs are discussed with regard to functional diversities reported in these species. Conclusions: The phylogenetic tree based on AFLP-PCR was slightly different from restriction endonuclease- and PFGE-based trees. Different PTMs were observed in the Rhizobium species, and the most prevailing type of PTM was AMPylation with the domain GS-ATasE (GlnE). Another type of PTM was also observed, i.e., Hydroxylation and Sulfation, with the domains Asparagine_hydroxylase and Collagen_prolyl_lysyl_hydroxylase and Sulfotransferase, respectively. The deamidation type of PTM was present only in Rhizobium sp. NGR234. How to cite: Qureshi MA, Pervez MT, Babar ME, et al. Genomic comparisons of Rhizobium species using in silico AFLP-PCR, endonuclease restrictions and ampylating enzymes.
Descritores: Rhizobium/genética
-Filogenia
Rhizobium/enzimologia
Rhizobium/fisiologia
Simbiose
Simulação por Computador
Enzimas de Restrição do DNA
Reação em Cadeia da Polimerase/métodos
Análise de Sequência
Proteoma
Genômica
Análise do Polimorfismo de Comprimento de Fragmentos Amplificados
Fabaceae/microbiologia
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1038028
Autor: Teixeira, Renan Kleber Costa; Costa, Felipe Lobato da Silva; Calvo, Faustino Chaves; Santos, Deivid Ramos dos; Yasojima, Edson Yuzur; Brito, Marcus Vinicius Henriques.
Título: Effect of copaiba oil in intestinal mucosa of rats submitted to hypovolemic shock / Efeito do óleo de copaíba na mucosa intestinal de ratos submetidos ao choque hipovolêmico
Fonte: ABCD arq. bras. cir. dig;32(3):e1451, 2019. tab.
Idioma: en.
Resumo: ABSTRACT Background: Hypovolemic shock is a common disease in polytrauma patients and may develop ischemia in various organs, increasing morbidity and mortality. The bowel is usually most affected by this condition. Aim: To evaluate the effects of copaiba oil on the intestinal mucosa's injury of rats submitted to hypovolemic shock. Method: Fifteen rats were divided into three groups: sham - simulated surgery; ischemia - animals submitted to hypovolemic shock; and copaiba - animals submitted to hypovolemic shock previously treated with copaiba oil. Mean blood pressure, arterial blood gas after shock induction, degree of intestinal lesion and villus length were evaluated. Results: The sham presented the lowest values of lactate and PaCO2 and the highest values of mean arterial pressure, pH and bicarbonate in relation to the other groups. The degree of mesenteric lesion was zero in the sham group; 3.00±1.00 in the ischemia group; and 3.00±0.71 in the copaiba group. The villus length was 173.60±8.42 in the sham, 142.77±8.33 in the ischemia and 143.01±9.57 in the copaiba group. There was a significant difference between the sham and the other groups (p<0.05); however, there not significant difference between groups Ischemia and copaiba. Conclusion: Administration of copaiba oil did not reduce the intestinal mucosa lesion of rats after hypovolemic shock.

RESUMO Racional: O choque hipovolêmico é situação comum em pacientes politraumatizados, podendo acarretar isquemia de vários órgãos, aumentando a morbimortalidade. O intestino é geralmente um dos órgãos mais afetados por essa condição. Objetivo: Avaliar os efeitos do óleo de copaíba na lesão da mucosa intestinal de ratos submetidos ao choque hipovolêmico. Métodos: Quinze ratos foram distribuídos em três grupos: Sham - operação simulada; isquemia - submissão ao choque hipovolêmico; e copaíba - submissão ao choque hipovolêmico previamente tratados com óleo de copaíba. A pressão arterial média, a gasometria arterial após a indução do choque, o grau da lesão intestinal e o tamanho das vilosidades foram avaliados. Resultados: O grupo sham apresentou os menores valores de lactato e PaCO2 e os maiores valores de pressão arterial média, pH e bicarbonato em relação aos demais grupos. O grau de lesão mesentérica foi de zero no sham; 3,0±1,00 no grupo isquemia; e 3,0±0,71 no da copaíba. O comprimento dos vilos foi de 173,60±8,42 no grupo sham, 142,77±8,33 no da isquemia e 143,01±9,57 no da copaíba. Houve diferença significante entre o grupo sham e os demais grupos (p<0.05); contudo, não houve diferença estatística entre os grupos submetidos ao choque hipovolêmico. Conclusão: A administração do óleo de copaíba não reduziu a lesão da mucosa intestinal de ratos submetidos ao choque hipovolêmico.
Descritores: Choque/tratamento farmacológico
Óleos Vegetais/farmacologia
Mucosa Intestinal/efeitos dos fármacos
Fabaceae/química
Anti-Inflamatórios/farmacologia
-Óleos Vegetais/uso terapêutico
Óleos Vegetais/química
Distribuição Aleatória
Ratos Wistar
Modelos Animais de Doenças
Íleo/patologia
Mucosa Intestinal/patologia
Isquemia/tratamento farmacológico
Anti-Inflamatórios/uso terapêutico
Anti-Inflamatórios/química
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-1141905
Autor: Rós, Adriana de Souza; Santos, Carlos Henrique Marques dos; Dourado, Doroty Mesquita; Silva-Neto, Moisés Soares da; Caldeira, Isabela; Furtado, Leandro de Oliveira.
Título: Can stryphnodendron adstringens extract improve the results of fistulotomy followed by primary sphincteroplasty in the treatment of transsphincteric fistulae? / Extrato de stryphnodendron adstringens pode melhorar os resultados da fistulotomia seguida por esfincteroplastia primária no tratamento de fístulas transesfincterianas?
Fonte: ABCD arq. bras. cir. dig;33(3):e1540, 2020. tab, graf.
Idioma: en.
Resumo: ABSTRACT Background: There is still a need for progress in the treatment of transsphincteric anal fistulae and the use of herbal medicines seems promising. Aim: To evaluate the efficacy of Stryphnodendron adstringens associated with fistulotomy and primary sphincteroplasty in the treatment of transsphincteric fistulae in rats. Methods: Thirty Wistar rats were used, which were submitted to transsphincteric fistulas with steel wire 0; after 30 days a treatment was performed according to the group. Group A (n=10) was submitted to fistulotomy; group B (n=10), fistulotomy followed by primary sphincteroplasty with "U" stitch with polyglactin 911 4-0; group C(n=10) , similar to group B, but with the interposition between the muscular stumps of hemostatic sponge soaked in Stryphnodendron adstringens extract. Euthanasia was performed after 14 days, resecting a segment of the anal canal for histological analysis, which aimed to evaluate the closure of the fistula, the area of separation of the muscle cables, the inflammatory process and the degree of fibrosis. Results: No animal had a remaining fistulous tract. About the spacing between the muscle cables, an average of 106.3 µm2 was observed in group A, 82.8 µm2 in group B and 51.8 µm2 in group C (p<0.05). There was no difference between the groups regarding the inflammatory process and, in relation to fibrosis, in group A there was a mean of 0.6, in group B 0.7 and in group C 0.2 (p<0.05). Conclusions: Stryphnodendron adstringens extract was able to allow less spacing between muscle cables in rats submitted to fistulotomy followed by primary sphincteroplasty, in addition to providing less local fibrosis.

RESUMO Racional: Há ainda necessidade de avanço no tratamento das fístulas transesfincterianas e o uso de fitoterápicos parece promissor. Objetivo: Avaliar a eficácia da Stryphnodendron adstringens associada à fistulotomia e esfincteroplastia primária no tratamento de fístulas transesfincterianas em ratos. Métodos: Utilizou-se 30 ratos Wistar submetidos à confecção de fístulas transesfincterianas com fio de aço 0; após 30 dias realizou-se tratamento de acordo com o grupo. O grupo A (n=10) foi submetido à fistulotomia; o grupo B (n=10) fistulotomia seguida de esfincteroplastia primária com ponto em "U" com poliglactina 911 4-0; o grupo C (n=10), semelhante ao grupo B, porém com a interposição entre os cotos musculares de esponja hemostática embebida em extrato de Stryphnodendron adstringens. Realizou-se eutanásia após 14 dias, ressecando-se segmento do canal anal para análise histológica, que objetivou avaliar o fechamento da fístula, a área de afastamento dos cabos musculares, o processo inflamatório e o grau de fibrose. Resultados: Nenhum animal apresentou trajeto fistuloso remanescente. Quanto ao afastamento entre os cabos musculares observou-se média 106,3 µm2 no grupo A, 82,8 µm2 no grupo B e 51,8 µm2 no grupo C (p<0,05). Não houve diferença entre os grupos quanto ao processo inflamatório e, em relação à fibrose; no grupo A observou-se média 0,6, no grupo B 0,7 e no grupo C 0,2 (p<0,05). Conclusões: O extrato de Stryphnodendron adstringens foi capaz de permitir menor afastamento entre os cabos musculares em ratos submetidos à fistulotomia seguida por esfincteroplastia primária, além de proporcionar menor fibrose local.
Descritores: Procedimentos Cirúrgicos do Sistema Digestório
Extratos Vegetais/uso terapêutico
Fístula Retal/cirurgia
Fabaceae/química
-Canal Anal/cirurgia
Resultado do Tratamento
Ratos Wistar
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-892983
Autor: Feitosa Junior, Denilson José Silva; Carvalho, Luan Teles Ferreira de; Rocha, Ingrid Rodrigues de Oliveira; Brito, Camila Noura de; Moreira, Rodrigo Alencar; Barros, Charles Alberto Villacorta de.
Título: Effects of Copaiba oil in the healing process of urinary bladder in rats
Fonte: Int. braz. j. urol;44(2):384-389, Mar.-Apr. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Introduction The appropriate closure of the urinary bladder is important to many urologic procedures to avoid the formation of fistulas and strictures by excessive fibrosis. This paper presents the alterations in the bladder healing process of rats after the topical use of Copaiba oil (Copaifera reticulata). Material and Methods Ten male Wistar rats were used and randomly divided into two groups: Control group (CG): injected 1ml/kg of saline solution on the suture line; and Copaiba group (CpG): 0.63ml/kg of copaiba oil applied to the suture line. Euthanasia was performed on the seventh day after surgery. The criteria observed were adherences formation, histopathological modifications and stereology for collagen. Results Both groups showed adhesions to the bladder, with no statistically significant difference (p=0.1481). The microscopic evaluation revealed a trend to more severe acute inflammation process on the CpG, but there was statistical difference only in the giant cells reaction (p=0.0472) and vascular proliferation (p=0.0472). The stereology showed no difference. Conclusion The copaiba oil modified the healing process, improving the quantity of giant cells and vascular proliferation, but not interfered in the collagen physiology.
Descritores: Cicatrização/efeitos dos fármacos
Bexiga Urinária/efeitos dos fármacos
Óleos Vegetais/farmacologia
Fabaceae/química
-Bexiga Urinária/cirurgia
Bexiga Urinária/patologia
Óleos Vegetais/administração & dosagem
Distribuição Aleatória
Administração Tópica
Ratos Wistar
Modelos Animais de Doenças
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-950719
Autor: Zia-Ul-Haq, Muhammad; Ahmad, Shakeel; Bukhari, Shazia Anwer; Amarowicz, Ryszard; Ercisli, Sezai; Jaafar, Hawa ZE.
Título: Compositional studies and biological activities of some mash bean (Vigna mungo (L) Hepper) cultivars commonly consumed in Pakistan
Fonte: Biol. Res;47:1-14, 2014. graf, tab.
Idioma: en.
Resumo: BACKGROUND: In recent years, the desire to adopt a healthy diet has drawn attention to legume seeds and food products derived from them. Mash bean is an important legume crop used in Pakistan however a systematic mapping of the chemical composition of mash bean seeds is lacking. Therefore seeds of four mash bean (Vigna mungo (L.) Hepper, family Leguminoseae) cultivars (NARC-Mash-1, NARC-Mash-2, NARC-Mash-3, NARC-Mash-97) commonly consumed in Pakistan have been analyzed for their chemical composition, antioxidant potential and biological activities like inhibition of formation of advanced glycation end products (AGE) activity and tyrosinase inhibition activity. RESULTS: The investigated cultivars varied in terms of biochemical composition to various extents. Mineral composition indicated potassium and zinc in highest and lowest amounts respectively, in all cultivars. The amino acid profile in protein of these cultivars suggested cysteine is present in lowest quantity in all cultivars while fatty acid distribution pattern indicated unsaturated fatty acids as major fatty acids in all cultivars. All cultivars were found to be rich source of tocopherols and sterols. Fourier transform infrared spectroscopy (FTIR) fingerprints of seed flour and extracts indicated major functional groups such as polysaccharides, lipids, amides, amines and amino acids. Results indicated that all investigated cultivars possessed appreciable antioxidant potential. CONCLUSIONS: All cultivars are rich source of protein and possess sufficient content of dietary fiber, a balanced amino acid profile, low saturated fatty acids and antioxidant capacity that rationalizes many traditional uses of seeds of this crop besides its nutritional importance. The collected data will be useful for academic and corporate researchers, nutritionists and clinical dieticians as well as consumers. If proper attention is paid, it may become an important export commodity and may fetch considerable foreign exchange for Pakistan.
Descritores: Sementes/química
Produtos Agrícolas/química
Fabaceae/química
-Paquistão
Fenóis/análise
Riboflavina/análise
Sementes/metabolismo
Esteróis/análise
Taninos/análise
Tiamina/análise
Oligoelementos/análise
Flavonoides/análise
Extratos Vegetais/química
Sequestradores de Radicais Livres
Monofenol Mono-Oxigenase/antagonistas & inibidores
Produtos Finais de Glicação Avançada/metabolismo
Produtos Agrícolas/metabolismo
Substâncias Redutoras/metabolismo
Cisteína/análise
Tocoferóis/análise
Fabaceae/metabolismo
Niacina/análise
Antioxidantes/metabolismo
Valor Nutritivo
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1138623
Autor: Guerrero Wyss, Leonardo; Durán-Agüero, Samuel.
Título: Consumo de legumbres y su relación con enfermedades crónicas no transmisibles / Legume consumption and relationships with chronic noncommunicable diseases
Fonte: Rev. chil. nutr;47(5):865-869, set. 2020.
Idioma: es.
Resumo: RESUMEN Las legumbres son un alimento de origen vegetal, con gran variedad en el aporte de nutrientes; contienen proteínas, minerales, fibra y antioxidantes. Se realizó una revisión bibliográfica en las bases de datos PUBMED y SCIELO, que incluyó artículos entre 2013 y 2019, bajo los términos claves "legumbres", "obesidad", "enfermedad cardiovascular" y "síndrome metabólico" y se incluyeron estudios que concluyeron una asociación beneficiosa entre consumo de legumbres y ECNT, síndrome metabólico y riesgo cardiovascular. Entre los resultados destacó que el consumo regular de legumbres aporta beneficios para la salud cardiovascular, el control de glicemia y la liberación de insulina, regulación de presión arterial, entre otros. Como conclusión esta revisión destaca que existen beneficios directos para mejorar la salud cardiometabólica provenientes del consumo regular de legumbres.

ABSTRACT Legumes are natural foods from plants with a high quantity of different nutrients, such as proteins, minerals, fiber and antioxidants. An investigation was conducted in the PUBMED and SCIELO databases, between 2013 and 2019 using the following key words: "legumes/beans", "obesity", "cardiovascular disease", and "metabolic syndrome". Articles identified showed a beneficial association between legume intake and chronic disease, metabolic syndrome, and cardiovascular risk. An important result was that regular legume intake contributes to cardiovascular health, glycemic control, insulin liberation, and control of the arterial pressure. In conclusion, this review highlighted the direct benefits of regular legume intake and improved metabolic and cardiovascular health.
Descritores: Dieta
Doenças não Transmissíveis/prevenção & controle
Fabaceae
-Doenças Cardiovasculares/prevenção & controle
Síndrome Metabólica/prevenção & controle
Obesidade/prevenção & controle
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Id: lil-696590 LILACS-Express
Autor: ESCOBAR ESCOBAR, NATALIA; MORA DELGADO, JAIRO; ROMERO JOLA, NÉSTOR.
Título: RESPUESTA AGRONÓMICA DE Zea mays L. y Phaseolus vulgaris L. A LA FERTILIZACIÓN CON COMPOST / AGRONOMIC RESPONSE OF Zea mays L. and Phaseolus vulgaris L. TO COMPOST FERTILIZATION
Fonte: Rev. luna azul;(37):18-29, jul.-dic. 2013. ilus, tab.
Idioma: es.
Resumo: El compostaje es una tecnología ecológica, la cual constituye una vía para la reutilización y biotransformación de materiales orgánicos así como su posterior aplicación en suelos. La calidad de un abono orgánico se determina a partir del contenido nutricional y de la capacidad de proveer nutrientes a un cultivo. Con base en un compostaje de material orgánico en mezcla (pulpa de café, residuos de banano, gallinaza y bovinaza), proveniente de fincas cafeteras ubicadas en el departamento de Cundinamarca, se determinaron y compararon indicadores químicos y biológicos. Además, mediante un bioensayo, usando dos especies con alto potencial alimentario y forrajero: maíz (Zea mays L.) y fríjol (Phaseolus vulgaris L.), se evaluó el efecto del compost sobre parámetros agronómicos y productividad en ambos cultivos. Siete tratamientos fueron evaluados [Abono químico (Q), Mezcla 1 (Mz1), Mezcla 2 (Mz2), Mezcla 3 (Mz3), Testigo sin fertilización (SF), Abono orgánico comercial (AOC)], con base en la determinación de parámetros químicos (MO, macro y micronutrientes). En el bioensayo con maíz (Zea mays L.), Q y Mz1 obtuvieron los parámetros más altos durante la etapa vegetativa; en la etapa de floración la Mz3 obtuvo los mejores valores en los parámetros. En fríjol (Phaseolus vulgaris L.), en la etapa vegetativa, los tratamientos Q y Mz1 fueron los mejores sin presentar diferencias significativas entre sí; en las etapas de floración y rendimiento Mz2 fue la que obtuvo mejor respuesta. En conclusión, los abonos orgánicos son una alternativa viable y sostenible probada bajo condiciones de campo.

Composting is an ecological technology which constitutes a way to reusing and biotransforming organic materials as well as their subsequent application in soil. The quality of organic fertilizer is determined from the nutritional content and the ability to provide nutrients to a crop. Based on an organic material composting mix, (coffee pulp, banana waste, chicken and cattle manure) coming from the coffee farms located in the department of Cundinamarca, chemical and biological indicators were determined and compared. In addition, through a bioassay, using two species with high food and feed potential, corn (Zea mays L.) and bean (Phaseolus vulgaris L.), the effect of compost on agronomic parameters and productivity in both crops was assessed. Seven treatments were evaluated [chemical fertilizer (Q), mixture 1 (Mz1), mixture 2 (Mz2), mixture 3 (Mz3), control without fertilizer (SF), commercial organic fertilizer (AOC)], based on the determination of chemical parameters (MO, CO, macro and micronutrients). In the bioassay with corn (Zea mays L.), Q and Mz1 obtained the highest parameters during the vegetative stage; in the flowering stage, Mz3 obtained the best values in the parameters. In beans (Phaseolus vulgaris L.) in the vegeteative stage treatments, Q and Mz1 were the best, without showing statistical differences among them. In the flowering and harvesting phase, Mz2 obtained a better response. In conclusion, organic fertilizers are a viable and sustainable alternative tested under field conditions.
Descritores: Compostagem
-Phaseolus
Eficiência
Fabaceae
Limites: Humanos
Tipo de Publ: Artigo Clássico
Responsável: CO54.1 - Centro de Biblioteca e Información Científica


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Id: biblio-950804
Autor: Guo, Jian-Ru; Chen, Qian-Qian; Lam, Christopher Wai-Kei; Zhang, Wei.
Título: Effects of karanjin on cell cycle arrest and apoptosis in human A549, HepG2 and HL-60 cancer cells
Fonte: Biol. Res;48:1-7, 2015. ilus, graf, tab.
Idioma: en.
Projeto: Macao Science and Technology Development Fund.
Resumo: BACKGROUND: We have investigated the potential anticancer effects of karanjin, a principal furanoflavonol constituent of the Chinese medicine Fordia cauliflora, using cytotoxic assay, cell cycle arrest, and induction of apoptosis in three human cancer cell lines (A549, HepG2 and HL-60 cells). RESULTS: MTT cytotoxic assay showed that karanjin could inhibit the proliferation and viability of all three cancer cells. The induction of cell cycle arrest was observed via a PI (propidium iodide)/RNase Staining Buffer detection kit and analyzed by flow cytometry: karanjin could dose-dependently induce cell cycle arrest at G2/M phase in the three cell lines. Cell apoptosis was assessed by Annexin V-FITC/PI staining: all three cancer cells treated with karanjin exhibited significantly increased apoptotic rates, especially in the percentage of late apoptosis cells. CONCLUSION: Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis. This compound may be effective clinically for cancer pharmacotherapy.
Descritores: Benzopiranos/farmacologia
Extratos Vegetais/farmacologia
Apoptose/efeitos dos fármacos
Proliferação de Células/efeitos dos fármacos
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Fabaceae/química
Antineoplásicos Fitogênicos/farmacologia
-Benzopiranos/isolamento & purificação
Células HL-60
Células Hep G2
Células A549
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: lil-624090
Autor: Tokarnia, Carlos Hubinger; Döbereiner, Jürgen; Dutra, Iveraldo S; Brito, Ilson S; Chagas, Bionô R; França, Ticiana N; Brust, Luis A. G.
Título: Experimentos em bovinos com as favas de Enterolobium contortisiliquum e E. timbouva para verificar propriedades fotossensibilizantes e/ou abortivas / Experiments in cattle with the pods of Enterolobium contortisiliquum e E. timbouva to determine photosensitive and abortive properties
Fonte: Pesqui. vet. bras = Braz. j. vet. res;19(1):39-45, Jan. 1999. tab.
Idioma: pt.
Resumo: The pods of Enterolobium spp (Leg.Mimosoideae) are said to cause photsensitivity and abortion in cattle. The pods of E. contortisiliquum and E. timbouva ("tamboril" or "timbaúba"), collected at various localities, in two occasions during outbreaks of photosensitization and abortions, were fed in single and repeated doses to young bovines and to cows in calf. In all experiments the animals showed only diarrhoea and loss of apetite, as it had been already seen in previous experiments with E. contortisiliquum performed in Fortaleza, northeastern Brazil. Also it was seen again that the animals become tolerant to the toxicity of the pods if they get successive doses. The experiments did not reveal possible conditions necessary for the pods of Enterolobium contortisiliquum and E. timbouva to cause photosensitization and/or abortion.(AU)

Em função de históricos obtidos, no presente estudo tentou-se reproduzir, em bovinos, fotossensibilização e/ou aborto com as favas de Enterolobium spp (Leg. Mimosoi-deae). As favas de E. contortisiliquum e E. timbouva ("tamboril" ou "timbaúba"), de diversas procedências, inclusive as colhidas durante dois surtos de intoxicação caracterizados por fotossensiblilização e aborto, foram administradas em doses únicas e repetidas, a bovinos jovens e a vacas em gestação. Em todos os experimentos realizados, a resposta à ingestão das favas independentemente da procedência, sempre foi caracterizada por diarréia e diminuição do apetite, passageiras. Também ficou evidente que os animais mostram menor sensibilidade, à medida que ingerem as favas seguidamente. Os experimentos não revelaram possíveis fatores envolvidos ou eventuais condições necessárias para que as favas de Enterolobium contortisiliquum e E. timbouva causem fotossen-siblização e/ou aborto.(AU)
Descritores: Plantas Tóxicas/toxicidade
Bovinos/microbiologia
Fármacos Fotossensibilizantes/efeitos adversos
Fabaceae/toxicidade
-Aborto
Limites: Animais
Bovinos
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice



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