Base de dados : LILACS
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Id: biblio-888983
Autor: Ju, J; Chen, W; Lai, Y; Wang, L; Wang, H; Chen, WJ; Zhao, X; Ye, H; LI, Y; Zhang, Y.
Título: Astragalus polysaccharides improve cardiomyopathy in STZ-induced diabetic mice and heterozygous (SOD2+/-) knockout mice
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(8):e6204, 2017. tab, graf.
Idioma: en.
Projeto: Commission of Shanghai Municipality STCSM; . Chinese State Natural Science Funds Commission (NSFC).
Resumo: Oxidative stress plays an important role in the development of diabetic cardiomyopathy. In the present study, we determined whether the effect of astragalus polysaccharides (APS) on diabetic cardiomyopathy was associated with its impact on oxidative stress. Streptozotocin (STZ)-induced diabetic mice and heterozygous superoxide dismutase (SOD2+/-) knockout mice were administered APS. The hemodynamics, cardiac ultrastructure, and the apoptosis, necrosis and proliferation of cardiomyocytes were assessed to evaluate the effect of APS on diabetic and oxidative cardiomyopathy. Furthermore, H2O2 formation, oxidative stress/damage, and SOD activity in cardiomyocytes were evaluated to determine the effects of APS on cardiac oxidative stress. APS therapy improved hemodynamics and myocardial ultrastructure with reduced apoptosis/necrosis, and enhanced proliferation in cardiomyocytes from both STZ-induced diabetic mice and heterozygous SOD2+/- knockout mice. In addition, APS therapy reduced H2O2 formation and oxidative stress/damage, and enhanced SOD activity in both groups of mice. Our findings suggest that APS had benefits in diabetic cardiomyopathy, which may be partly associated with its impact on cardiac oxidative stress.
Descritores: Astrágalo (Planta)/química
Diabetes Mellitus Experimental/tratamento farmacológico
Cardiomiopatias Diabéticas/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Polissacarídeos/uso terapêutico
Superóxido Dismutase/genética
-Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Diabetes Mellitus Experimental/patologia
Cardiomiopatias Diabéticas/patologia
Camundongos Endogâmicos C57BL
Camundongos Knockout
Microscopia Eletrônica de Transmissão
Miócitos Cardíacos/efeitos dos fármacos
Miócitos Cardíacos/ultraestrutura
Estresse Oxidativo/efeitos dos fármacos
Estreptozocina
Limites: Animais
Masculino
Camundongos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
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Id: lil-683996
Autor: Li, Xu Ting; Wang, Bin; Li, Jin Liang; Yang, Rui; Li, Si Cong; Zhang, Min; Huang, Wei; Cao, Liang.
Título: Effects of Dangguibuxue Tang, a Chinese herbal medicine, on growth performance and immune responses in broiler chicks
Fonte: Biol. Res;46(2):183-188, 2013. graf, tab.
Idioma: en.
Projeto: Sichuan Animal Science Academy.
Resumo: The effects of Dangguibuxue Tang (DBT) on growth performance and immunity response in immunosuppressed broiler chicks were investigated in this study. 240 one-d-old broiler chicks (DaHeng S01) were randomly divided into 4 groups, 2.0% DBT-treatment (A), 0.5% DBT-treatment (B), cyclophosphamide-control (C), and control group (D). From 4 d to 7 d of age, chicks in group A, B and C were given cyclophosphamide (CY) at a dosage of 100mg/kg body weight (BW) daily by intraperitoneal injection to induce immunosuppression. Chicks in group D were given an equal volume of physiological saline daily by intraperitoneal injection and considered normal chicks. Groups A and B were supplemented with 2.0% or 0.5% of DBT in the drinking water from 8 d to 42 d of age. Groups C and D did not receive any additional medication. The results revealed that chicks from group B had lower feed:gain rate (FGR), lower total mortality, higher immunity organ indexes, higher levels of Newcastle disease (ND) antibody and infectious bursal disease (IBD) antibody, higher interleukin-2 and interleukin-6 levels, and greater lymphocyte proliferative responses to concanavalin A (ConA) during the experiment than those from group C. However, no significant difference in the immunity status in the two levels of DBT-treatment was observed. These results indicate that supplementation of 0.5% of DBT can improve both cellular immunity and humoral immunity in immunosuppressed broiler chicks.
Descritores: Infecções por Birnaviridae/veterinária
Galinhas
Medicamentos de Ervas Chinesas/farmacologia
Vírus da Doença Infecciosa da Bursa/imunologia
Doença de Newcastle/imunologia
-Angelica sinensis
Astrágalo (Planta)
Infecções por Birnaviridae/imunologia
Galinhas/crescimento & desenvolvimento
Galinhas/imunologia
Ciclofosfamida/farmacologia
Imunossupressão/métodos
Imunossupressão/veterinária
Imunossupressores/farmacologia
/sangue
INTERLEUKIN-ABDOMEN, ACUTE/sangue
/sangue
INTERLEUKIN-TEMEFOS/sangue
Distribuição Aleatória
Limites: Animais
Feminino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: lil-591917
Autor: Erisen, Semiha; Yorgancilar, Mustafa; Atalay, Emine; Babaoglu, Mehmet; Duran, Ahmet.
Título: Callus induction and plant regeneration of the endemic Astragalus nezaketae in Turkey
Fonte: Electron. j. biotechnol;13(6):13-14, Nov. 2010. ilus, tab.
Idioma: en.
Projeto: The Scientific and Technological Research Council of Turkey. Tissue Culture and Cytogenetic Studies in Some Endemic Astragalus L. Species (Leguminosae) for Germplasm Preservation and Agricultural Uses.
Resumo: A callus induction and plant regeneration protocol was developed from leaf and petiole explants of the endemic Astragalus nezaketae. Explants were cultured on Murashige and Skoog medium (MS) supplemented with different plant growth regulators (PGRs) [a-naphthaleneacetic acid (NAA), benzyladenine (BA), 2,4-dichlorophenoxyacetic acid (2,4-D), kinetin (Kin), thidiazuron (TDZ)]. The combinations and concentrations of PGRs were shown significant variations for the frequency of callus formation, appearence of callus and the potential of callus differentiation. NAA x BA have been found highly affective in callusing and plant regeneration. Other PGRs have not resulted in callus differentiation for shoot formation. The highest number of shoots (6/explants) was obtained from leaf explants cultured on MS with 0.5 mg/l NAA and 4 mg/l BA. The regenerated shoots transferred to rooting medium (MS with 0.5 mg/l indole-3-butyric acid) were successfully rooted (100 percent) and showed rapid elongation. Rooted plantlets were acclimatized in pots containing 1:1 mixture of peat and perlite.
Descritores: Astrágalo (Planta)/crescimento & desenvolvimento
Astrágalo (Planta)
Reguladores de Crescimento de Planta/farmacologia
-Aclimatação
Astrágalo (Planta)/embriologia
Brotos de Planta/crescimento & desenvolvimento
Técnicas de Cultura
Organogênese
Regeneração
Sementes/crescimento & desenvolvimento
Responsável: CL1.1 - Biblioteca Central



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