Base de dados : LILACS
Pesquisa : B01.650.940.800.575.912.250.401.300 [Categoria DeCS]
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Id: biblio-1284299
Autor: Parlar, Ali; Çam, Saliha Aysenur; Arslan, Seyfullah Oktay.
Título: Glabridin alleviates ischemia/reperfusion-induced functional failure of smooth muscle of rat ileum by upregulating the cAMP / Glabridin alivia la falla funcional inducida por isquemia/reperfusión del músculo liso de ileum murino regulando el incremento de cAMP
Fonte: Bol. latinoam. Caribe plantas med. aromát;19(6):555-568, 2020. tab, ilus.
Idioma: en.
Resumo: Despite the development of modern medicine, alternative medicine, which has not lost its timeliness, remains attractive for the treatment of various diseases. Glabridin, a major flavonoid of Glycyrrhiza glabra, is known for its antioxidant and anti-inflammatory activity. The aim of this study was: 1) to determine the possible protective role of glabridin against ischemia/reperfusion (I/R) injury of the intestine; 2) to evaluate the in vitrocontractile responses of ileum smooth muscles to acetylcholine after an intestinal I/R; and 3) to explain the underlying molecular mechanism of its effect. Rats were assigned to groups of six rats each; 1) I/R, 2) gla10, 3) gla20, 4) gla40, 5) N5-[imino(nitroamino)methyl]-L-ornithine, methyl ester monohydrochloride (L-NAME)+gla40, and 6) Sham group. The healing effect of glabridin was abolished by L-NAME. Glabridin did not cause contractility of the smooth muscles to acetylcholine-induced contractile responses in intestinal I/R. Yet, it increased to spontaneous basal activity.

A pesar del desarrollo de la medicina moderna, la medicina alternativa, sin perder su vigencia, sigue siendo atractiva para el tratamiento de varias enfermedades. Glabradina, el flavonoide mayoritario de Glycyrrhiza glabra, es conocido por su actividad antioxidante y antiinflamatoria. Los propósitos de este estudio fueron: 1) Determinar el posible rol protector de glabradina ante daños intestinales por isquemia/reperfusion (I/R) 2) Evaluar in vitrolas respuestas de contracción de los músculos lisos del ileum ante acetilcolina después de I/R intestinal; y 3) Explicar el mecanismo molecular subyacente de este efecto. Se asignaron grupos de seis ratas: 1) I/R, 2) gla10, 3) gla20, 4) gla40, 5) N5-[imino(nitroamino)metil]-L-ornithina, metil ester monohidrochloruro (L-NAME)+gla40, y 6) Grupo testigo. El efecto curativo de glabridina fue abolido por L-NAME. Glabridina no causó contracción en el músculo liso como respuesta acetilcolina-inducida I/R. Además, incrementa la actividad basal expontánea.
Descritores: Fenóis/administração & dosagem
Traumatismo por Reperfusão/tratamento farmacológico
AMP Cíclico/metabolismo
Glycyrrhiza
Isoflavonas/administração & dosagem
-Fenóis/farmacologia
Ratos Wistar
AMP Cíclico/análise
GMP Cíclico/metabolismo
Estresse Oxidativo/efeitos dos fármacos
NG-Nitroarginina Metil Éster
Íleo/efeitos dos fármacos
Íleo/química
Isoflavonas/farmacologia
Malondialdeído/análise
Músculo Liso/efeitos dos fármacos
Limites: Animais
Ratos
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
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Id: biblio-828170
Autor: Hajiaghamohammadi, Ali Akbar; Zargar, Ali; Oveisi, Sonia; Samimi, Rasoul; Reisian, Sedigheh.
Título: To evaluate of the effect of adding licorice to the standard treatment regimen of Helicobacter pylori
Fonte: Braz. j. infect. dis;20(6):534-538, Nov.-Dec. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective: The aim of this study was to evaluate the effect of licorice in H. pylori eradication in patients suffering from dyspepsia either with peptic ulcer disease (PUD) or non-ulcer dyspepsia (NUD) in comparison to the clarithromycin-based standard triple regimen. Methods: In this randomized controlled clinical trial, 120 patients who had positive rapid urease test were included and assigned to two treatment groups: control group that received a clarithromycin-based triple regimen, and study group that received licorice in addition to the clarithromycin-based regimen for two weeks. H. pylori eradication was assessed six weeks after therapy. Data was analyzed by chi-square and t-test with SPSS 16 software. Results: Mean ages and SD were 38.8 ± 10.9 and 40.1 ± 10.4 for the study and control groups, respectively, statistically similar. Peptic ulcer was found in 30% of both groups. Response to treatment was 83.3% and 62.5% in the study and control groups, respectively. This difference was statistically significant. Conclusion: Addition of licorice to the triple clarithromycin-based regimen increases H. pylori eradication, especially in the presence of peptic ulcer disease.
Descritores: Extratos Vegetais/uso terapêutico
Helicobacter pylori/efeitos dos fármacos
Infecções por Helicobacter/tratamento farmacológico
Claritromicina/uso terapêutico
Glycyrrhiza/química
Antibacterianos/uso terapêutico
-Úlcera Péptica/microbiologia
Úlcera Péptica/tratamento farmacológico
Resultado do Tratamento
Dispepsia/microbiologia
Dispepsia/tratamento farmacológico
Limites: Humanos
Masculino
Feminino
Adulto
Tipo de Publ: Estudo Comparativo
Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
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Id: lil-567820
Autor: Costa, Adilson; Moisés, Thaís Abdalla; Cordero, Tatiana; Alves, Caroline Romanelli Tiburcio; Marmirori, Juliana.
Título: Associação de emblica, licorice e belides como alternativa à hidroquinona no tratamento clínico do melasma / Association of emblica, licorice and belides as an alternative to hydroquinone in the clinical treatment of melasma
Fonte: An. bras. dermatol;85(5):613-620, set.-out. 2010. ilus, graf, tab.
Idioma: pt.
Resumo: FUNDAMENTOS: Melasma é uma melanodermia comum, cuja terapêutica representa um desafio clínico. OBJETIVOS: Avaliar a eficácia e segurança clínicas do complexo despigmentante emblica, licorice e belides, em comparação à hidroquinona 2 por cento, na abordagem do melasma. MÉTODOS: Após 60 dias de uso exclusivo de fotoprotetor FPS35, 56 mulheres com idades entre 18 e 60 anos, fotótipos I a IV, com melasma epidérmico ou misto, foram divididas em dois grupos de um estudo clínico monocego: A) creme contendo complexo despigmentante emblica, licorice e belides 7 por cento, usado duas vezes ao dia; B)creme de hidroquinona 2 por cento, usado à noite. O estudo durou 60 dias consecutivos e avaliações médica, das voluntárias (auto-avaliação) e fotográfica (Visia®) foram realizadas quinzenalmente. RESULTADOS: 89 por cento das voluntárias (50/56), 23 do Grupo A e 27 do Grupo B, concluíram o estudo. Duas voluntárias do Grupo A contra sete do Grupo B apresentaram eventos adversos leves transitórios. Houve despigmentação do melasma pelas avaliações médica (Grupo A: 78,3 por cento; Grupo B: 88,9 por cento) e auto-avaliação (Grupo A: 91,3 por cento; Grupo B: 92,6 por cento), todos estatisticamente significantes (p<0,001), sem diferenças entre os grupos (p>0,05). O mesmo padrão foi observado pelo Visia®, tanto no número (p = 0,001) quanto no tamanho e no tom (p<0,001), para ambos os grupos, e sem diferenças entre eles (p>0,05) nas manchas UV. CONCLUSÕES: Não houve diferença estatística na melhora do melasma nos dois grupos; o Grupo A apresentou menor incidência de eventos adversos. Logo, o complexo despigmentante emblica, licorice e belides é uma alternativa segura e eficaz na abordagem do melasma.

BACKGROUND: Melasma is a common skin pigment disorder with a difficult clinical response to treatment. OBJECTIVES: To evaluate the clinical efficacy and safety of the association of Belides, Emblica and Licorice 7 percent, compared to Hydroquinone 2 percent, in the treatment of melasma. METHODS: After 60 days of exclusive use of an SPF35 sunscreen, 56 women, 18 to 60 years of age, phototypes I to IV, with epidermal or mixed melasma, were divided into two different groups in a mono-blind clinical study: A) cream with Belides, Emblica and Licorice, applied twice a day; B) cream with Hydroquinone 2 percent, used at night. They were observed in a 60-day study; every 15 days, they were submitted to medical evaluation, self-evaluation, and photographic registration (Visia®). RESULTS: 50 volunteers (89 percent), 23 in Group A and 27 in Group B, concluded the study. Two volunteers in Group A and 7 in Group B had mild skin adverse events. Depigmentation was observed through medical evaluation (Group A: 78.3 percent; Group B: 88.9 percent) and volunteers' self-evaluation (Group A: 91.3 percent; Group B: 92.6 percent); these results were statistically significant (p<0.001), with no differences between groups (p>0.05). This pattern of results was observed by Visia® in the number (p = 0.001) and size and tone (p<0.001) of the uv stains, for both groups, with no differences between them (p>0.05). CONCLUSION: There were no statistic differences between groups in the improvement of melasma. Group A showed less skin adverse events. Therefore, the association of Emblica, Licorice and Belides is a safe and efficient alternative for the treatment of melasma.
Descritores: Antioxidantes/uso terapêutico
Asteraceae/química
Glycyrrhiza/química
Hidroquinonas/uso terapêutico
Melanose/tratamento farmacológico
Phyllanthus emblica/química
Extratos Vegetais/uso terapêutico
-Quimioterapia Combinada/métodos
Estudos Prospectivos
Fitoterapia/métodos
Resultado do Tratamento
Limites: Adulto
Feminino
Humanos
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Ensaio Clínico Fase IV
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
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Id: lil-522198
Autor: Mehrotra, Shakti; Kumar Kukreja, Arun; Singh Khanuja, Suman Preet; Nath Mishra, Bhartendu.
Título: Genetic transformation studies and scale up of hairy root culture of Glycyrrhiza glabra in bioreactor
Fonte: Electron. j. biotechnol;11(2):69-75, Apr. 2008. ilus, tab.
Idioma: en.
Resumo: The study was undertaken to induce hairy roots in Glycyrrhiza glabra in leaf explants and to optimize the nutritional requirement for its growth kinetics at shake flask and bioreactor level. Pathogenecity of Agrobacterium depends upon transformation ability of strain and age, type, and physiological state of explants. Agrobacterium rhizogenes strain K599 was used to infect leaf explants of G. glabra. Explants of different age groups were obtained from 2 to 5 weeks old in vitro grown cultures. Bacterial strain K599 could induce hairy roots in 3 and 4 weeks old leaf explants cultured on B5, MS, NB and WP basal semi-solid medium. Leaf explants of 2 and 5 weeks old culture were not responsive to bacterial infection in terms of hairy root induction. Maximum transformation frequency (TF) of tested bacterial strain was 47 percent obtained in 3 weeks old explants after 25 days of incubation on MS basal semi solid medium. NB and B5 both media composition showed 20 percent of transformation frequency after 28 and 38 days respectively. WP medium did not support induction of roots in cultured leaf explants infected with A. rhizogenes strain K599even after 50 days of incubation. Further, when all the four media combinations were tested for root growth it was found that though WP was not responsive for hairy root induction, yet all four basal media supported hairy root growth and a gradual increase in fresh weight biomass was observed with an increase in culture duration. However amongst all, the NB medium composition supported best growth of hairy roots followed by MS, B5 and WP media. About 20 times increase in root biomass on fresh weight basis was recorded after 45days of culture in NB medium. Initial inoculum of roots (0.18 g. F.wt./ flask) containing 50 ml of liquid culture medium produced 3.59 g (F. wt.) biomass. A fast growing hairy root clone G6 was grown in a 5 l capacity mechanically agitated bioreactor provided with a nylon mesh septum. After 30 days of sterile...
Descritores: Glycyrrhiza/genética
Raízes de Plantas/genética
Rhizobium/genética
Transformação Genética
-Reatores Biológicos
Meios de Cultura
Técnicas Genéticas
Glycyrrhiza/crescimento & desenvolvimento
Reação em Cadeia da Polimerase
Raízes de Plantas/crescimento & desenvolvimento
Responsável: CL1.1 - Biblioteca Central



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