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Id: biblio-952067
Autor: Herrera, Daniel Rodrigo; Durand-Ramirez, Jorge Enrique; Falcão, Amanda; Silva, Emmanuel João Leal Nogueira da; Santos, Elizabete Brasil dos; Gomes, Brenda Paula Figueiredo de Almeida.
Título: Antimicrobial activity and substantivity of Uncaria tomentosa in infected root canal dentin
Fonte: Braz. oral res. (Online);30(1):e61, 2016. tab, graf.
Idioma: en.
Projeto: Paulo; . Conselho Nacional de Desenvolvimento Científico e Tecnológico.
Resumo: Abstract The aim of this study was to analyze the antimicrobial activity and substantivity of Uncaria tomentosa Willd DC (cat's claw, CC) in root dentin contaminated with Enterococcus faecalis. Forty-eight human premolars were contaminated with E. faecalis (ATCC 29212) and randomly divided into four groups according to the irrigant used during chemomechanical preparation (CMP): CC group: 2% CC gel; CHX group: 2% chlorhexidine digluconate gel (CHX); NaOCl group: 5.25% sodium hypochlorite (NaOCl); and SS group: sterile saline (SS). Microbiological samples were collected before (S1) and after (S2) CMP and after 7 days (S3). Colony-forming units (CFU/mL) at the different sampling times and comparisons among the groups were statistically analyzed by Wilcoxon and Kruskal-Wallis tests (p < 0.05). Significant bacterial reduction was achieved in all groups after CMP (p < 0.05). Results show no significant difference between S3 and S2 (p > 0.05) in the CC and CHX groups. Bacterial load was higher in S3 than in S2 samples (p < 0.05) in the NaOCl and SS groups. Our results suggest antibacterial effect of 2% CC gel against E. faecalis in infected dentin, in addition to antibacterial substantivity of 2% CC and 2% CHX up to 7 days.
Descritores: Enterococcus faecalis/efeitos dos fármacos
Unha-de-Gato/química
Cavidade Pulpar/efeitos dos fármacos
Cavidade Pulpar/microbiologia
Dentina/efeitos dos fármacos
Dentina/microbiologia
Anti-Infecciosos/farmacologia
-Valores de Referência
Irrigantes do Canal Radicular/farmacologia
Hipoclorito de Sódio/farmacologia
Fatores de Tempo
Contagem de Colônia Microbiana
Distribuição Aleatória
Clorexidina/análogos & derivados
Clorexidina/farmacologia
Estatísticas não Paramétricas
Carga Bacteriana/efeitos dos fármacos
Limites: Humanos
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-1285724
Autor: Caldas, Nathália Lima; Prado, Marina Carvalho; Carvalho, Nancy Kudsi; Senna, Plinio Mendes; Silva, Emmanuel João Nogueira Leal da.
Título: Cytotoxicity, and antimicrobial and physicochemical properties of sealers incorporated with Uncaria tomentosa
Fonte: Braz. oral res. (Online);35:e086, 2021. tab, graf.
Idioma: en.
Resumo: Abstract This study evaluated the cytotoxicity, the antimicrobial and physicochemical properties of root canal sealers incorporated with phytotherapic Uncaria tomentosa (UT). Unmodified AH Plus (Dentsply, DeTrey, Germany) and MTA Fillapex (Angelus, Londrina, Brazil) were used as controls. UT was incorporated into AH Plus and MTA Fillapex, at concentrations of 2% and 5% of the total weight of these sealers (w/w). Flowability, setting time, and solubility were evaluated following ISO requirements. The pH values were measured at periods of 12, 24, 48 hours, and 7 days. The antimicrobial activity of the sealers against Enterococcus faecalis was analyzed by both direct contact tests in freshly prepared sealers, and after 7 days. The cytotoxicity of the samples was evaluated by the MTT assay, to check Balb/c 3T3 cell viability. The statistical analysis was performed by one-way ANOVA and Tukey's test (p < 0.05). The incorporation of UT was associated with a decrease in flow, for both sealers, an increase in AH Plus setting time, increase in MTA Fillapex pH values, and solubility (after 14 days), for both sealers (p < 0.05). Regarding the antibacterial evaluation, bacterial reduction was reported after incorporation of UT into both AH Plus and MTA Fillapex, up to 7 days after handling of the material (P<0.05). UT incorporation decreased the cytotoxic effects of both AH Plus and MTA Fillapex sealers in a way directly proportional to their respective concentrations (p < 0.05). In conclusion, UT can be added to both sealers to reduce their cytotoxicity, and improve their antibacterial effects, without compromising their original physicochemical properties.
Descritores: Materiais Restauradores do Canal Radicular/toxicidade
Unha-de-Gato
-Óxidos
Teste de Materiais
Silicatos
Compostos de Cálcio
Combinação de Medicamentos
Resinas Epóxi/toxicidade
Antibacterianos/toxicidade
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: lil-437677
Autor: Pollito, Percy A. Zevallos; Tomazello, Mario.
Título: Anatomia do lenho de Uncaria guianensis e U. tomentosa (Rubiaceae) do estado do Acre, Brasil / Wood anatomy of Uncaria guianensis e U. tomentosa (Rubiaceae) from the State of Acre, Brazil
Fonte: Acta amaz;36(2):169-175, abr.-jun.2006. ilus, tab.
Idioma: pt.
Resumo: As plantas de Uncaria guianensis e U. tomentosa são lianas trepadeiras, arbustos trepadores ou rasteiros ascendentes que ocorrem em amplas áreas da Amazônia brasileira e países da América Central e do Sul. Possuem excepcional importância medicinal, com sua casca, lenho e folhas utilizadas pelos povos amazônicos e pela indústria farmacêutica. Face a necessidade da identificação das plantas em condições de campo e de laboratório, o presente trabalho descreveu a estrutura anatômica do lenho de Uncaria guianensis e U. tomentosa, ocorrentes no Estado do Acre, Brasil. Os resultados mostraram que o lenho das espécies é característico da família Rubiaceae, a exceção dos vasos arredondados, grandes e solitários, parenquima axial difuso e largura dos raios que são próprios das lianas.

Uncaria guianensis and U. tomentosa are climbing lianas, bush lianas occuring in large areas of Brazilian Amazon and Central and South America countries. The species presented exceptional medicinal importance, with its bark, wood and leaves used by Amazon native people and pharmaceutical industries. Considering the importance of the species identification in field and laboratory conditions, the present work described the anatomical structure of Uncaria guianensis and U. tomentosa, which occurs in State of Acre, Brazil. The results showed that the wood of the species was characteristic of the Rubiaceae family, except the rounded vessel, greater and solitary, parenchyma axial diffuse and width of the rays, proper of lianas.
Descritores: Unha-de-Gato
Mikania
Uncaria
Responsável: BR6.1 - BCS - Biblioteca de Ciências da Saúde


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Id: lil-790772
Autor: Núñez, César; Lozada-Requena, Iván; Ysmodes, Tíndara; Zegarra, Daniel; Saldaña, Fatima; Aguilar, José.
Título: Inmunomodulación de Uncaria tomentosa sobre células dendríticas, IL-12 y perfil TH1/TH2/TH17 en cáncer de mama / Immunomodulation of Uncaria tomentosa over dendritic cells, IL-12 and profile TH1/TH2/TH17 in breast cancer
Fonte: Rev. peru. med. exp. salud publica;32(4):643-651, oct.-dic. 2015. graf.
Idioma: es.
Resumo: Evaluar el efecto inmunomodulador del extracto estandarizado (5,03%, alcaloides oxindólicos pentacíclicos) de Uncaria tomentosa (UT-POA) sobre el inmunofenotipo de células dendríticas (DC) y IL-12/Th1/Th2/Th17 en pacientes con cáncer de mama estadio II (BCII) y mujeres sanas (H). Materiales y métodos. Se obtuvó sangre de 11 H y 7 BCII, se aislaron y cultivaron PBMC por 2 h con/sin distintas concentraciones de UT-POA y se estimularon o no con LPS por 24 h. Las PBMC fueron marcadas con anticuerpos específicos para DC y en el sobrenadante se midió las citoquinas Th1/Th2/Th17, ambos por citometría de flujo. Además, se midió IL-12 por ELISA. Resultados. UT-POA no alteró a las DC o la expresión de moléculas accesorias en BCII. Sin embargo, en H mostró una disminución en el porcentaje de DC mieloides (mDC) con incremento de HLA-DR y CD86 a 1000 ug/mL. La secreción de IL-12 fue modificada solo en H, incrementando la subunidad p70 y disminuyendo la p40. UT-POA incremento Th1 (IFN-y y IL-2), Th2 (IL-4) y Th17 (IL-17) en BCII y H. Conclusiones. UT-POA incrementa la producción de citoquinas relacionadas con la respuesta antitumoral a concentraciones entre el rango de 500-1000 ug/mL. Este efecto positivo debería ser evaluado no solo sistemicamente sino también en el microambiente tumoral. La UT-POA puede ser un fitoquímico útil en la quimioprevención y en el uso alternativo con terapias contra el cáncer...

This study aimed to research the in vitro immunomodulatory effects of an Uncaria tomentosa hydroalcoholic extract standardized (5.03%, pentacyclic oxindole alkaloids) (UT-POA) on the immunophenotype of dendritic cells (DC) subsets, Th1, Th2, Th17 and IL-12 cytokines from patients with stage II breast cancer (BCII) and healthy women (H). Materials and methods. Blood of 11 H and 7 BCII was obtained, PBMC were isolated and cultured for 2h with/without various concentrations of UT-POA and stimulated or not with LPS for 24h. PBMC were labeled with specific antibodies for DC and in the supernatant we measured Th1/Th2/Th17 cytokines, both by flow cytometry. Furthermore IL-12 was measured by ELISA. Results. UT-POA did not alter DC or accessory molecules expression in BCII. However, H exhibited a decrease in the percentage of mDC (myeloid DC) and an increase in HLA-DR and CD86 expression at 1000 ug/mL. IL-12 secretion was modified only in the H group, increasing p70 subunit and decreasing p40 subunit. UT-POA increased Th1 (IFN-y and IL-2), Th2 (IL-4) and Th17 (IL-17) secretion in both groups. Conclusions. UT-POA increased the production of cytokines related with anti-tumoral response at concentrations of 500-1000 ug/mL. This positive effect should be evaluated not only systemically but also in the tumor microenvironment in further studies. UT-POA may be a useful phytochemical in chemoprevention and in the alternative use in cancer therapies...
Descritores: Anti-Inflamatórios
Células Dendríticas
Neoplasias da Mama
Unha-de-Gato
Limites: Humanos
Adolescente
Adulto
Feminino
Criança
Adulto Jovem
Pessoa de Meia-Idade
Responsável: PE14.1 - Biblioteca de la Sede Central


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Id: lil-790771
Autor: Lozada-Requena, Iván; Núñez, César; Alvárez, Yubell; Kahn, Laura; Aguilar, José.
Título: Poblaciones linfocitarias, células dendríticas y perfil de citoquinas en ratones con melanoma tratados con Uncaria tomentosa / Lymphocyte subsets, dendritic cells and cytokine profiles in mice with melanoma treated with Uncaria tomentosa
Fonte: Rev. peru. med. exp. salud publica;32(4):633-642, oct.-dic. 2015. ilus, tab, graf.
Idioma: es.
Resumo: Evaluar el efecto inmunomodulador sobre poblaciones linfocitarias, células dendríticas (DC), citoquinas Th1/Th2/Th17 (T-helper) e inflamatorias en el ámbito sistémico y/o en el microambiente tumoral de ratones con o sin melanoma. Materiales y métodos. Se obtuvieron muestras de sangre periférica y/o de tumores primarios de ratones con melanoma B16 tratados o no con un extracto hidroalcohólico de Uncaria tomentosa (UT) con 5,03% de alcaloides oxindólicos pentacíclicos (UT-POA) obtenido de la corteza de la planta. Todos los ensayos de medición de células y citoquinas fueron realizados por citometría de flujo. Resultados. UT-POA a nivel sistémico incrementa la relación CD4/CD8a (Cluster of Differenciation), mientras que la activación celular es inversamente proporcional; incrementa la proporción de DCm (DC mieloides); induce un perfil Th1 proinflamatorio y reduce la respuesta Th17. TNF-a (tumor necrosis factor alpha) y IL-17A (interleuquina) correlacionan positiva y negativamente con la relación CD4/CD8a. Conclusiones. El incremento de Th1 (TNF-a) puede tener como consecuencia el incremento de linfocitos CD4 o la activación de macrófagos M1. Aunque UT-POA muestra un incremento de DCm, este no es dosis-dependiente. La disminución de Th17 (IL-17A) puede favorecer el funcionamiento de los linfocitos CD8a. UT-POA muestra mejores efectos inmunomoduladores en el ámbito sistémico que intratumoral...

To evaluate the immunomodulatory effect on lymphocyte subsets, dendritic cells (DC), Th1 / Th2 / Th17 and inflammatory cytokines on systemic level and/or in the tumor microenvironment of mice with or without melanoma. Materials and methods: Peripheral blood and/or primary tumors samples were obtained of mice with B16 melanoma treated or not with a hydroalcoholic extract of Uncaria tomentosa (UT) with 5.03% of pentacyclic oxindole alkaloids (UT-POA) obtained from the bark of the plant. All cell assays and cytokine measurements were performed by flow cytometry. Results. UT-POA systemically increased CD4/CD8a relation while cell activation was inversely proportional; increased the proportion of DCm; induced a pro-inflammatory Th1 profile and reduced Th17 response. TNF-a and IL-17A positively and negatively correlated with CD4/CD8a relation. Conclusions. The increase of Th1 (TNF-a) may result in the increase of CD4 or M1 macrophage activation. Although UT-POA shows increased DCm, is not dose-dependent. Th17(IL-17A) decreased can support the function of CD8a lymphocytes. UT-POA shows better systemic immunomodulatory effects than intratumoral...
Descritores: Ativação Linfocitária
Células Dendríticas
Unha-de-Gato
Limites: Animais
Camundongos
Responsável: PE14.1 - Biblioteca de la Sede Central


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Id: lil-790744
Autor: Lozada-Requena, Ivan; Núñez, César; Aguilar, José Luis.
Título: Inmunoterapia en melanoma: vacunas de células dendríticas / Melanoma immunotherapy: dendritic cell vaccines
Fonte: Rev. peru. med. exp. salud publica;32(3):555-564, jul.-sep. 2015. ilus.
Idioma: es.
Resumo: La presente es una revisión narrativa que muestra la información accesible a la comunidad científica sobre melanoma e inmunoterapia. Las células dendríticas tienen la capacidad de participar en la inmunidad innata y adaptativa, pero no son ajenas a la evasión inmune de los tumores. Conocer su biología y rol ha llevado a generar in vitro varios prospectos de vacunas celulares autólogas contra diversos tipos de cáncer en humanos y modelos animales; sin embargo, en vista de la poca eficiencia que han mostrado, se deben implementar estrategias para potenciar su capacidad natural ya sea a través de la coexpresión de moléculas clave para activar o reactivar al sistema inmune, en combinación con biosimilares o drogas quimioterapeúticas y no se debe descartar la acción de productos naturales como alternativa inmunoestimulante o adyuvante. Todos los tipos de inmunoterapía deberían medir el impacto de las células supresoras de origen mieloide, las que pueden atacar al sistema inmune y ayudar a la progresión tumoral, respectivamente. Esto puede reducir la actividad de las vacunas celulares y/o sus combinaciones pudiendo ser la diferencia entre el éxito o no de la inmunoterapia. Aunque en melanoma existen biosimilares aprobados por la Food and Drug Administration (FDA) no todos tienen el éxito esperado por lo que es necesario evaluar otras estrategias que incluyan vacunas celulares cargadas con péptidos antigénicos tumorales expresados exclusivamente o antígenos provenientes de extractos tumorales y sus respectivos adyuvantes...

This is a narrative review that shows accessible information to the scientific community about melanoma and immunotherapy. Dendritic cells have the ability to participate in innate and adaptive immunity, but are not unfamiliar to the immune evasion of tumors. Knowing the biology and role has led to generate in vitro several prospects of autologous cell vaccines against diverse types of cancer in humans and animal models. However, given the low efficiency they have shown, we must implement strategies to enhance their natural capacity either through the coexpression of key molecules to activate or reactivate the immune system, in combination with biosimilars or chemotherapeutic drugs. The action of natural products as alternative or adjuvant immunostimulant should not be ruled out. All types of immunotherapy should measure the impact of myeloid suppressor cells, which can attack the immune system and help tumor progression, respectively. This can reduce the activity of cellular vaccines and/or their combinations, that could be the difference between success or not of the immunotherapy. Although for melanoma there exist biosimilars approved by the Food and Drug Administration (FDA), not all have the expected success. Therefore it is necessary to evaluate other strategies including cellular vaccines loaded with tumor antigenic peptides expressed exclusively or antigens from tumor extracts and their respective adjuvants...
Descritores: Células Dendríticas/imunologia
Imunoterapia
Melanoma
Unha-de-Gato/imunologia
Vacinas
Limites: Humanos
Tipo de Publ: Revisão
Responsável: PE14.1 - Biblioteca de la Sede Central


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Id: lil-564000
Autor: Lozada-Requena, Iván; Núñez, César; Álvarez, Yubell; Aguilar, José Luis.
Título: Efecto de un extracto hidroalcohólico de uncaria tomentosa (uña de gato) sobre la población de células dendríticas y sus moléculas hla-dr y cd86 ante el estímulo con lipopolisacáridos / Effect of an hydro-alcoholic extract of uncaria tomentosa (cat´s claw) over dendritic cell subsets and hla-dr/cd86 molecules by lipopolysacarides stimulus
Fonte: Rev. peru. med. exp. salud publica;26(2):168-174, abr.-jun. 2009. graf.
Idioma: es.
Resumo: Objetivo. Determinar el efecto de un extracto hidroalcohólico de uña de gato, Uncaria tomentosa (UG) sobre célulasdendríticas (DC) de sangre periférica y la expresión de HLA-DR y CD86 en muestras de sangre periférica de individuos sanos tratadas con lipopolisacáridos (LPS). Materiales y métodos. El polvo de la corteza de UG se preparó como una decocción estéril a 30g/L por 30 minutos. Se obtuvo muestras de sangre periférica de individuos sanos. Las célulasmononucleares de sangre periférica (CMSP) fueron separadas por gradiente de centrifugación, pretratadas o no durante dos horas con distintas concentraciones de UG y estimuladas 24 h con LPS, luego fueron marcadas con anticuerpos monoclonales fluorescentes específicos para HLA-DR, Linaje tipo 1 (Lin1), CD11c y CD86 y preparadas para la citometría de flujo. Resultados. Comparando con el grupo de CMSP con LPS pero sin UG se observó, de maneradosis dependiente, una disminución en el porcentaje de DC mieloides (DCm) (p menor que 0,05) y una tendencia a incrementar el porcentaje de DC plasmacitoides (DCp). En las DCp se observó una disminución de la intensidad de fluorescencia media (IFM) de HLA-DR sólo a 500 y 1000 μg/mL de UG (p menor que 0,001); mientras que hubo un incremento de la IFM de CD86en todo el rango (p menor que 0,05). En DCm a las mismas concentraciones no se observó efecto de UG sobre la IFM de HLA-DR y CD86. Conclusiones. Este extracto estandarizado de UG tiende a incrementar el porcentaje de DCp y disminuye el porcentaje de DCm. UG no afecta la expresión de HLA-DR y CD86 en DCm. Este estudio demuestra que este extracto de UG favorece la activación/diferenciación de DCp, la cual participa en mecanismos de respuesta inmune adaptativa.

Objective. To determine the effect of an hydro-alcoholic extract of cat´s claw Uncaria tomentosa (UG) overlipopolysaccharides û treated dendritic cells (DC) and HLA-DR and CD86 molecules expression of peripheral bloodsamples obtained from healthy individuals. Materials and methods. Peripheral blood samples were collected from healthy individuals. Peripheral Blood Mononuclear Cells (PBMC) were isolated by centrifugation over density gradient, pre-treated with and without the addition of UG, and then stimulated for 24 h with lipopolysaccharides (LPS), then the cells were labelled with specific fluorescent monoclonal antibodies to HLA-DR, Linage type 1 (Lin1), CD11c and CD86 and prepared for flow. Results. Compared to PBMC with LPS but without UG group, we found a decrease of myeloid DC (mDC) percentage (p minor that 0.05) and a tendency to increase plasmacytoid DC (pDC) percentage, both in a dose-dependent manner. There was a decrease in media fluorescence intensity (MFI) of HLA-DR in DCp between 500 and 1000 μg/mL of CC (p minor that 0,001), but we found a increase in MFI of CD86 at all concentrations (p<0,05). There was no effect of UG overMFI of the HLA-DR or CD86 expression in mDC. Conclusions. UG showed a tendency to increase pDC percentage and decreased mDC percentage. UG did not affect the expression of CD86 and HLA-DR from mDC. This study demonstrates that UG promotes activation/differentiation of pDC, which has a demonstrated involvement in the adaptive immune response mechanisms.
Descritores: ANTIGENOS CDACETAMINOPHEN
Células Dendríticas
Plantas Medicinais
Uncaria
Unha-de-Gato
Limites: Humanos
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: lil-515253
Autor: Núñez Ponce, César Eduardo; Lozada Requena, Iván; Akamine Panez, Isabel; Carbajal Arroyo, Luz Aurora; Aguilar Olano, José Luis.
Título: Efecto de Uncaria tomentosa (Uña de gato) sobre la población y activación decélulas dendríticas en sangre periférica de pacientes con artritis reumatoidea / Effect of Uncaria tomentosa (Catïs claw) over dendritic cells population and activation in peripheral blood of rheumatoid arthritis patients
Fonte: Acta méd. peru;25(3):135-139, jul.-sept. 2008. graf.
Idioma: es.
Resumo: Introducción: la artritis reumatoide (AR) es una enfermedad autoinmune caracterizada por un proceso inflamatorio crónico articular. En los últimos años se está resaltando la importancia de las células dendríticas en AR, debido a su capacidad de presentar autoantígenos y estimular a linfocitos T autoreactivos. En este estudio se ensayó la capacidad de Uncaria tomentosa (Uña de Gato, UG), una planta peruana con propiedades inmunomoduladoras, sobre la población de células dendríticas circulantes y sobre la expresión de sus moléculas de maduración y coestimulación. Objetivos: determinar la población de células dendríticas (DC) de origen mieloide (DCm) y plasmocitoide (DCp) por citometría de flujo en pacientes con AR. Evaluar la variación en la expresión de moléculas HLA-DR y CD86 en ambas subpoblaciones celulares expuestas a diferentes concentraciones de un extracto hidroalcohólico de UG con 5 por ciento de alcaloides oxindólicos pentacíclicos (UG-POA). Material y método: se evaluaron DC a partir de muestras de sangre periférica de pacientes con AR y adultos controles sanos, enfrentadas a diferentes concentraciones de UG. Las muestras fueron marcadas con anticuerpos monoclonales específicos, evaluadas por citometría de flujo y analizadas con el software Summit 4.3. El análisis estadístico fue realizado mediante Test de rangos de Friedman para muestras relacionadas, Test T de student y Prueba de Tendencias y Análisis de Medidas Repetidas. Resultados: encontramos que UG-POA disminuyó de manera dosis dependiente la subpoblación de DCm de sangre periférica de pacientes con AR, sin afectar la subpoblación de DCp y aumentó la expresión de las moléculas HLA-DR y CD86 en DCm. Conclusiones: la UG-POA disminuye la subpoblación de DCm, mientras incrementa la expresión de moléculas HLA-DR y CD86 en pacientes con AR definida. Estos hallazgos añadirían un mecanismo adicional al efecto inmuno-modulador de la UG en procesos inflamatorios crónicos.

Introduction: Rheumatoid arthritis (RA) is an autoimmune disease characterized by a chronic inflammatory process with in the joints. Recently, the importance of dendritic cells (DC) has been emphasized in this condition due to their remarkable ability for presenting autoantigens and for stimulating auto-reactive T-cells. The ability of Uncariatomentosa (CatÆs claw), a native Peruvian plant with immune-modulating properties on the circulating dendritic cell population and on their maturation and co-stimulation capacities was assessed. Objectives: To determine subsets of myeloid and plasmacytoid dendritic cells (mDC and pDC, respectively) in patients with RA with the use of flow cytometry. To evaluate variations in the expression of HLA-DRand CD86 molecules in both subsets of DC in response to different concentrations of a hydro-alcoholic extract of Catïs claw with 5 per cent of pentacyclic oxindole alkaloids. Materials and methods: Peripheral blood dendritic cells were taken from RA patients and healthy controls, and they were incubated with different concentrations of Catïs claw. Then, cells were labeled with specific monoclonal antibodies and they were separated using flow cytometry and they were analyzed with a Summit 4.3. software. Statistical analysis was performed using Friedmanïs, T-student, trends and repeat measure analysis tests. Results: We found that Catïs claw extract decreased in a dose-dependent fashion mDC population in the peripheral blood of RA patients without affecting pDC, and it also increased HLA-DR and CD86 expression on mDC. Conclusions: Catïs claw reduced the mDC subset, while it increased HLA-DR and CD86 expression in RA patients. This is an additional mechanism for the known immune-modulating effect of Catïs claw in chronic inflammatory conditions.
Descritores: Artrite Reumatoide
Células Dendríticas
Unha-de-Gato
Unha-de-Gato
Limites: Humanos
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: biblio-871280
Autor: EsSalud.
Título: Estudio de prefactibilidad económica: producción de fitofármacos en base a extractos deshidratados de uña de gato y sangre de grado / Economic feasibility study: production of herbal medicines based on dried extracts of cat's claw and sangre de grado.
Fonte: Lima; EsSalud; 2007. 37 p.
Idioma: es.
Descritores: Croton/classificação
Plantas Medicinais/classificação
Unha-de-Gato/classificação
Responsável: PE355.1 - Centro de Documentación e Información
PE355.1; WB 925, E


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Id: biblio-1114219
Autor: EsSalud.
Título: Uncaria tomentosa (Willd.) D.C., Uncaria guianensis (Aubl.) Gmel. ®Uña de gato¼ / Uncaria tomentosa (Willd. ) DC, Uncaria guianensis (Aubl. ) Gmel.
Fonte: s.l; EsSalud; s.f. [44] p. tab.
Idioma: es.
Descritores: Plantas Medicinais
Unha-de-Gato/classificação
Unha-de-Gato/toxicidade
Limites: Animais
Tipo de Publ: Estudo de Avaliação
Responsável: PE355.1 - Centro de Documentación e Información
PE355.1; WB 925, U



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