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Id: biblio-1055384
Autor: Justus, Barbara; Arana, Andrés Fernando Montenegro; Gonçalves, Melissa Marques; Wohnrath, Karen; Boscardin, Patrícia Mathias Döll; Kanunfre, Carla Cristine; Budel, Jane Manfron; Farago, Paulo Vitor; Paula, Josiane de Fátima Padilha de.
Título: Characterization and Cytotoxic Evaluation of Silver and Gold Nanoparticles Produced with Aqueous Extract of Lavandula dentata L. in Relation to K-562 Cell Line
Fonte: Braz. arch. biol. technol;62:e19180731, 2019. graf.
Idioma: en.
Projeto: CAPES.
Resumo: Abstract Metallic nanoparticles have great potential as a chemotherapeutic agent. The aim of this study was to develop and characterize silver and gold nanoparticles using a simple method, as well as evaluating the potential cytotoxic activity in relation to the K-562 cell line. For the synthesis, a solution containing the metallic ions was subjected to magnetic stirring with the aqueous extract of Lavandula dentata L. and a change of colour was observed. With the data obtained from the analyses we concluded that the nanoparticles were successfully obtained by a simple and green method using the aqueous extract of L. dentata. The obtained nanoparticles presented a reduced size, a low level of polydispersion, and a homogenous spherical shape. The nanoparticles presented intense and characteristic diffraction peaks, which could be correlated to the planes of the centred cubic structure of the silver and gold. The two formulations presented predominantly crystalline characteristics. The infrared analysis suggested that the amides and alcohols present in the samples may have been responsible for the reduction and limitation of the size and dispersion of the silver and gold nanoparticles. The cytotoxic assay showed that the nanoparticles demonstrated great potential to reduce the cell viability of the K-562 cell line, especially the gold nanoparticles.
Descritores: Leucemia Mieloide
Lamiaceae/toxicidade
Citotoxinas
Nanopartículas Metálicas/análise
Responsável: BR1.1 - BIREME


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Id: biblio-957425
Autor: Rojas-Olivos, Alejandra; Solano-Gómez, Rodolfo; Granados-Echegoyen, Carlos; Santiago-Santiago, Luis Alberto; García-Dávila, Jorge; Pérez-Pacheco, Rafael; Lagunez-Rivera, Luicita.
Título: Larvicidal effect of Clinopodium macrostemum essential oil extracted by microwave-assisted hydrodistillation against Culex quinquefasciatus (Diptera: Culicidae)
Fonte: Rev. Soc. Bras. Med. Trop;51(3):291-296, Apr.-June 2018. tab.
Idioma: en.
Projeto: Consejo Nacional de Ciencia y Tencología.
Resumo: Abstract INTRODUCTION: In the present study, we determined the chemical composition of Clinopodium macrostemum essential oil obtained by microwave-assisted hydrodistillation and its effect on the growth and development of Culex quinquefasciatus mosquito larvae. METHODS: The essential oil compounds were identified by gas chromatography-mass spectrometry analysis, and bioassays were conducted to evaluate the influence on the developmental stages of early second instar larvae of Cx. quinquefasciatus until the emergence of adults, using essential oil concentrations of 50, 100, 200, 400, and 800mg/L. RESULTS: The gas chromatography-mass spectrometry analyses revealed that the leaf essential oil of C. macrostemum contained 32 compounds and the major chemical compounds identified were linalool (55.4%), nerol (6.4%), caryophyllene (6.25%), menthone (5.8%), geraniol acetate (4.1%), terpineol (3.7%), and pulegone (2.8%). The essential oil yield obtained by microwave-assisted hydrodistillation was 0.8% at 20 min. The treatments showed lethal concentrations (LC50 and LC90) of 22.49 and 833.35mg/L, respectively, after the final measurement of the total number of dead larvae (second, third, and fourth instars), and LC50 and LC90 of 6.62 and 693.35mg/L, respectively, at the end of the experimental period. The essential oil inhibited the growth and development of the mosquito larvae by 32% (relative growth index = 0.68) at 50mg/L, and up to 47% (relative growth index = 0.53) at 800mg/L. CONCLUSION: The present study demonstrated the larvicidal effect of C. macrostemum essential oil on Cx. quinquefasciatus, which can be attributed to the oxygenate compounds obtained by the extraction method.
Descritores: Óleos Voláteis/farmacologia
Lamiaceae/química
Culex/efeitos dos fármacos
Larva/efeitos dos fármacos
-Bioensaio
Óleos Voláteis/isolamento & purificação
Óleos Voláteis/química
Lamiaceae/classificação
Culex/classificação
Dose Letal Mediana
Cromatografia Gasosa-Espectrometria de Massas
Micro-Ondas
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: biblio-1132242
Autor: Pauletti, Gabriel Fernandes; Silvestre, Wendel Paulo; Rota, Luciana Duarte; Echeverrigaray, Sergio; Barros, Ingrid Bergman Inchausti de.
Título: Poejo (Cunila galioides Benth. ) Production in Five Agroecological Regions of Rio Grande do Sul
Fonte: Braz. arch. biol. technol;63:e20190481, 2020. tab, graf.
Idioma: en.
Resumo: Abstract The objective of this study was to evaluate the biomass and essential oil production of nine populations of poejo (Cunila galioides) cultivated in five agroecological regions of the state of Rio Grande do Sul, under different edaphoclimatic conditions. The experiments were performed in field conditions in Erechim, Caxias do Sul, Pelotas, São Francisco de Paula, and Santa Vitoria do Palmar. The experimental design was completely randomized, with nine populations, eight plants per plot and four repetitions. The following were evaluated: biomass production and essential oil chemical composition and yield. The data underwent ANOVA, followed by Tukey's multiple range test. The adaptability and stability of the populations in the different environments were also evaluated by regression analysis. The results showed great differences between the populations and cultivation sites, with genotype vs. environment interaction. Most populations presented the best biomass production results at Erechim. Pelotas and Santa Vitória do Palmar were the worst locations for poejo production, mainly due to a water deficit occurred during the experiment. The Santa Lucia population presented broad stability and the greatest adaptability to the environments for biomass and essential oil production, but its average production was not satisfactory. The André da Rocha population presented the highest average production of essential oil, and was favored in favorable environments. Regarding essential oil chemical composition, the populations kept stable contents of the major compounds at all locations, with a few variations. In some populations, a higher concentration of sesquiterpenes was observed, which can be attributed to environmental stress.
Descritores: Óleos Vegetais/química
Óleos Voláteis/química
Biomassa
Lamiaceae/genética
-Sesquiterpenos
Solo/química
Clima Tropical
Análise de Regressão
Análise de Variância
Genótipo
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Id: biblio-1179406
Autor: Zelada Mallco, Diana J; Bonilla Rivera, Pablo E.
Título: Propuesta de compuestos fenólicos presentes en el extracto metanólico de hojas de Clinopodium pulchellum (Kunth) Govaerts "panisara" / Characterization of phenolic compounds of the metallolic extract of leaves of clinopodium pulchellum (kunth) govaerts «panisara¼
Fonte: Rev. peru. med. integr;5(4):135-139, 2020. tab, graf, ilus.
Idioma: es.
Resumo: Objetivos. Proponer compuestos fenólicos presentes en el extracto metanólico de hojas de Clinopodium pulchellum (Kunth) Govaerts «panisara¼. Materiales y métodos. Se preparó un extracto metanólico de las hojas de Clinopodium pulchellum (Kunth) Govaerts «panisara¼, se determinó la solubilidad por disolución de extracto en solventes de polaridad creciente. Se detectaron algunos componentes químicos mediante un screening fitoquímico empleando gelatina, tricloruro férrico, reacción de Mayer, reacción de Shinoda, entre otros. Se realizó cromatografía en capa fina, revelándose por aspersión con reactivos cromogénicos y se propone posibles estructuras de componentes mediante espectroscopía UV. Resultados. El extracto metanólico presentó buena solubilidad en solventes de alta y mediana polaridad. El screening fitoquímico dio resultados positivos para la presencia de compuestos fenólicos y compuestos nitrogenados: flavonoides, alcaloides y glicósidos. Conclusión. Se propuso la estructura química de tres flavonoides obtenidos del extracto metanólico de hojas de Clinopodium pulchellum (Kunth) Govaerts «panisara¼.

Objectives. Propose phenolic compounds present in the methanolic extract of Clinopodium pulchellum (Kunth) Govaerts "panisara" leaves. Materials and methods. A methanolic extract of the Clinopodium pulchellum (Kunth) Govaerts "panisara" leaves was prepared by maceration, the solubility was determined by dissolving the extract in solvents of increasing polarity. Some chemical components were detected by phytochemical screening using gelatin, ferric trichloride, Mayer reaction, Shinoda reaction, among others. Thin layer chromatography was performed, revealing by spray with chromogenic reagents and possible component structures by UV spectroscopy. Results. The methanolic extract showed good solubility in solvents of high and medium polarity. Phytochemical screening gave positive results for the presence of phenolic compounds and nitrogen compounds: flavonoids, alkaloids and glycosides. Conclusion. The chemical structure of three flavonoids obtained from the methanolic leaf extract of Clinopodium pulchellum (Kunth) Govaerts "panisara" was proposed.
Descritores: Lamiaceae
Compostos Fenólicos
-Peru
Flavonoides
Extratos Vegetais
Cromatografia em Camada Delgada
Responsável: BR1.1 - BIREME


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Id: biblio-1104061
Autor: Alvarado, Aurora M; García-Trejo, Fernando; Cardador-Martínez, Anaberta; Magallán-Hernández, Fabiola.
Título: Clinopodium mexicanum: potential and difficulties for the sustainable use of a Mexican medicinal plant / Clinopodium mexicanum: potencial y dificultades para el uso de una planta medicinal mexicana
Fonte: Bol. latinoam. Caribe plantas med. aromát;19(2):149-160, mar. 2020. ilus, tab.
Idioma: en.
Resumo: Clinopodium mexicanum (Benth.) Govaerts (Lamiaceae) is a native plant of Mexico. This plant is used in traditional Mexican medicine for the treatment of cultural specific syndromes such as "susto", "nervios" or "espanto", conditions related to anxiety and depression. In addition, it has a high biocultural value for its medicinal and culinary use and for its exchange value in various indigenous areas of México. This review aims to compile updated information about the ethnobotanical, phytochemistry and commercialization aspects of Clinopodium mexicanum, and it focuses on the potential use of this species as a raw material in the phytopharmaceutical industry for the treatment of anxiety and pain. Moreover, it would be a viable productive alternative for many rural communities, which could not only produce the raw material but who could also add value to the sale of the plant.

Clinopodium mexicanum (Benth.) Govaerts, es una planta nativa de México. Es usada en la medicina tradicional mexicana para tratar síndromes de filiación cultural como "susto", "nervios" o "espanto", los cuales están asociados a la ansiedad y depresión. Además, la planta presenta un alto valor biocultural por sus usos: medicinal, culinario y por el valor de cambio que tiene en áreas indígenas de México. La revisión presentada tiene como objetivo compilar información actualizada sobre aspectos etnobotánicos, fitoquímicos y comercialización de Clinopodium mexicanum. Igualmente señalar el potencial uso de esta especie como materia prima para la elaboración de productos para la ansiedad y el dolor por parte de la industria fitofarmacéutica. Además de ser una alternativa productiva para muchas comunidades rurales, las cuales pueden venderla como materia prima o como producto derivado.
Descritores: Plantas Medicinais
Etnobotânica
Lamiaceae/química
Medicina Tradicional
-Comércio
Compostos Fitoquímicos/análise
Povos Indígenas
México
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1146253
Autor: Costa, Andréa Santos da; Arrigoni-Blank, Maria de Fátima; Bacci, Leandro; Blank, Arie Fitzgerald; Alves, Péricles Barreto; Peixoto, Magna Galvão; Santos, Ane Caroline Celestino.
Título: Toxicity of the essential oil of basil cultivars and hybrids and its repellent effect on stored grain pests / Toxicidade do óleo essencial de cultivares e híbridos de manjericão e seu efeito repelente sobre pragas de grãos armazenados
Fonte: Biosci. j. (Online);36(2):341-352, 01-03-2020. tab, graf.
Idioma: en.
Resumo: Essential oils have emerged as an alternative to synthetic insecticides in the control of stored grain pests. The toxicity and repellency of the essential oils of four basil cultivars and three basil hybrids and the monoterpenes linalool, citral, and (E)-methyl cinnamate were evaluated in the stored grain pests Callosobruchus maculatus and Sitophillus zeamais. The essential oils of the cultivar Genovese and the hybrid 'Genovese' x 'Maria Bonita' were more toxic to C. maculatus. Conversely, the essential oils of the cultivar Sweet Dani and the hybrid 'Cinnamom' x 'Maria Bonita' were more toxic to S. zeamais. Among the monoterpenes, (E)-methyl cinnamate was the most toxic to both pests, taking 0.14 and 0.34 µ L.mL-1 to kill 50% of the C. maculatus and S. zeamais populations, respectively. All essential oils from cultivars, hybrids, and monoterpenes were repellent to S. zeamais, except for (E)-methyl cinnamate. For C. maculatus, this effect was lower, being citral the most repellent compound. Results demonstrate the insecticidal potential of the essential oil of O. basilicum and its monoterpenes in the control of stored grain pests.

Os óleos essenciais surgem como alternativa aos inseticidas sintéticos no controle das pragas de grãos armazenados. A toxicidade e a repelência dos óleos essenciais de quatro cultivares e três híbridos de manjericão e dos monoterpenos linalol, citral e (E)-cinamato de metila foram avaliadas nas pragas de grãos armazenados Callosobruchus maculatus e Sitophillus zeamais. Os óleos essenciais da cultivar Genovese e do híbrido 'Genovese' x 'Maria Bonita' foram mais tóxicos para C. maculatus. Já para S. zeamais, os óleos essenciais das cultivar Sweet Dani e do híbrido 'Cinnamom' x 'Maria Bonita' apresentaram maior toxicidade. Dentre os monoterpenos, o (E)-cinamato de metila foi o mais tóxico para ambas as pragas. Foram necessários 0,14 e 0,34 µ L.mL-1 para matar 50% da população de C. maculatus e S. zeamais. Todos os óleos essenciais das cultivares, dos híbridos e dos monoterpenos foram repelentes a S. zeamais, com exceção do (E)-cinamato de metila. Já para C. maculatus, este efeito foi reduzido, sendo o citral o composto mais repelente. Nos resultados demonstram o potencial inseticida dos óleos essenciais de O. basilicum e seus monoterpenos para o controle de pragas de grãos armazenados.
Descritores: Óleos Voláteis
Ocimum basilicum
Lamiaceae
-Inseticidas
Responsável: BR396.1 - Biblioteca Central


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Id: biblio-1145996
Autor: Traversa, Ignacio P.
Título: El conocimiento botánico local en áreas urbanas del norte de Uruguay / Local botanical knowledge in urban areas of northern Uruguay
Fonte: Bol. latinoam. Caribe plantas med. aromát;19(4):376-386, 2020. tab.
Idioma: es.
Resumo: Este trabajo rescata el acervo etnobotánico de la región más septentrional de Uruguay. En este país la etnobotánica, ha tenido poco desarrollo, siendo escasos los estudios y publicaciones científicas. El área de estudio comprende los departamentos de: Artigas, Rivera, Tacuarembó y Cerro Largo. Por medio de un muestreo aleatorio fueron entrevistadas 315 personas. Entre otras variables, los datos obtenidos se refieren a los usos especiales de las plantas. La información fue procesada en planilla de cálculo y listada por medio de técnicas de estadística descriptiva. Se identificaron 134 especies utilizadas, distribuidas en 57 familias botánicas. Las familias de mayor frecuencia fueron: Lamiaceae, Asteraceae, Apiaceae y Fabaceae. La medicina convencional es complementada con plantas cultivadas que presentan aplicaciones medicinales. Fueron reportadas nueve formas de usos, la infusión mostró ser la práctica más utilizada. El conocimiento relativo a las propiedades de las plantas proviene de personas de mayor edad y se trasmite por tradición oral. La metodología puede ser replicada a otras zonas del país.

This work rescues the ethnobotanical heritage of the northernmost region of Uruguay. In this country, ethnobotany has had little development, with scarce studies and scientific publications. The study area includes the departments of: Artigas, Rivera, Tacuarembó and Cerro Largo. Through random sampling, 315 people were interviewed. Among other variables, the data obtained refer to the special uses of the plants. The information was processed in the spreadsheet and listed by means of descriptive statistics techniques. 134 species used were identified, distributed in 57 botanical families. The most frequent families were: Lamiaceae, Asteraceae, Apiaceae and Fabaceae. Conventional medicine is complemented with cultivated plants that have medicinal applications. Nine forms of uses were reported, the infusion proved to be the most used practice. The knowledge related to the properties of plants comes from older people and is transmitted by oral tradition. The methodology can be replicated to other areas of the country.
Descritores: Etnobotânica/classificação
-Plantas Medicinais
Uruguai
Apiaceae
Asteraceae
Lamiaceae
Fabaceae
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-1145976
Autor: Alipio Rodríguez, Anavely; Mostacero León, José; Lopéz Medina, Eloy; De La Cruz Castillo, Anthony J; Gil Rivero, Armando Efraín.
Título: Valor de uso etnomedicinal de la flora del Cerro "La Botica" empleada por la Comunidad Andina de Cachicadán - Perú / Ethnomedicinal use value of the flora of the Hill "La Botica" used by the Andean Community of Cachicadán - Perú
Fonte: Bol. latinoam. Caribe plantas med. aromát;19(6):601-613, 2020. tab, graf, ilus.
Idioma: es.
Resumo: La presente investigación se avocó a determinar el valor de uso etnomedicinal dado a la flora del Cerro "La Botica", por la Comunidad Andina de Cachicadán, Santiago de Chuco, Perú. Se aplicaron 96 entrevistas semiestructuradas, siguiendo la técnica "bola de nieve". Se realizaron colectas mediante exploraciones botánicas. Para cada una de las especies se detallaron los datos de familia, nombre científico y común, parte utilizada, enfermedad o dolencia tratada, ubicación en UTM e índice de valor de uso (IVU). Se reportan 48 especies empleadas etnomedicinalmente por la Comunidad Andina de Cachicadán, distribuidas en 46 géneros y 26 familias, de las que destacan por su número de especies: Asteraceae (10), Rosaceae (5) y Lamiaceae (3). De estas, el 72 % (35 especies) resultan muy importantes para la cura o tratamiento de sus enfermedades, según su valor de uso (IVU). Además los pobladores de la Comunidad Andina de Cachicadán, refieren padecer de 38 enfermedades o dolencias; agrupadas en 10 categorías, donde prevalecen, las de los sistemas: respiratorio (FCI=0.88), digestivo y gastrointestinal (FCI=0.85), reproductivo (FCI=0.84), urinario (FCI= 0.84), nervioso (FCI=0.83), Músculo-esquelético (FCI=0.82), cardiovascular (FCI=0.82) y rituales (FCI=0.81).

The present investigation was aimed at determining the value of ethnomedicinal use that is given to the flora of the Hill "La Botica", by the Andean Community of Cachicadán, Santiago de Chuco, Perú. 96 semi-structured interviews were applied, following the "snowball" technique. Collections were made by botanical explorations.For each of the species, family data, scientific and common name, part used, disease or disease treated, location in UTM and use value index (IVU) were detailed. 48 species of flora are used ethnobotanically by the Andean Community of Cachicadán, distributed in 46 genera and 26 families, of which they stand out for their number of species: Asteraceae (10), Rosaceae (5) and Lamiaceae (3). Of these, 72% (35 species) are very important for the cure or treatment of their diseases, according to their use value (IVU). In addition the inhabitants of the Andean Community of Cachicadán, report suffering from 38 diseases or ailments; grouped into 10 categories, where they prevail, those of the systems: respiratory (FCI = 0.88), digestive and gastrointestinal (FCI = 0.85), reproductive (FCI = 0.84), urinary (FCI = 0.84), nervous (FCI = 0.83), Musculoskeletal (FCI = 0.82), cardiovascular (FCI = 0.82) and rituals (FCI = 0.81).
Descritores: Etnobotânica/classificação
Asteraceae
Lamiaceae
Rosaceae
-Peru
População Rural
Medicina Tradicional
Limites: Humanos
Masculino
Feminino
Adulto
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Id: biblio-912588
Autor: Carvajal, Fabiola; Huanca, Andrés; González-Teuber, Marcia; Urzúa, Alejandro; Echeverría, Javier.
Título: Uses of hazardous medicinal plants: composition of the essential oil of Clinopodium gilliesii (Benth. ) Kuntze (Lamiaceae), collected in Chile / Uso de plantas medicinales peligrosas: composición del aceite esencial de Clinopodium gilliesii (Benth. ) Kuntze (Lamiaceae), recolectada en Chile
Fonte: Bol. latinoam. Caribe plantas med. aromát;16(5):486-492, sept. 2017. tab, graf, ilus.
Idioma: en.
Projeto: Comisión Nacional de Investigación Científica y Tecnología; . Universidad de Santiago de Chile; . CONICYT PAI/ACADEMIA.
Resumo: Clinopodium gilliesii (Benth.) Kuntze, harvested in the Chilean highlands, contains a surprising 93.87% of the toxic monoterpene pulegone in the essential oil. These results show remarkable differences with studies of the same species carried out in Argentina and Peru. These dissimilarities in the monoterpene composition of essential oils should be associated with differences in toxicity and biological activity of this medicinal plant used in ethnomedicine in different countries for the treatment of similar discomforts and diseases. These results are discussed considering the risk of consuming C. gilliesii, without clear recommendations and control of at least pulegone content in essential oils.

Clinopodium gilliesii (Benth.) Kuntze, recolectada en el altiplano chileno, contiene un sorprendente 93,87% del monoterpeno toxico pulegona, en el aceite esencial. Estos resultados muestran diferencias notables con estudios de la misma especie realizados en Argentina y Perú. Estas disimilitudes, en la composición de los aceites esenciales deben estar asociadas con diferencias en la toxicidad y actividad biológica de esta especie medicinal que se utiliza en etnomedicina en diferentes lugares para el tratamiento de molestias y enfermedades similares. Estos resultados se discuten considerando el riesgo de consumir C. gilliesii, sin recomendaciones claras y control de al menos el contenido de pulegona en los aceites esenciales.
Descritores: Óleos Voláteis/efeitos adversos
Óleos Voláteis/química
Lamiaceae
Monoterpenos/análise
-Plantas Medicinais
Chile
Monoterpenos/efeitos adversos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-886755
Autor: VICTOR, MAURICIO M; DAVID, JORGE M; SAKUKUMA, MARIA C K; COSTA-LOTUFO, LETÍCIA V; MOURA, ANDREA F; ARAÚJO, ANA J.
Título: Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
Fonte: An. acad. bras. ciênc;89(3):1369-1379, July-Sept. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.
Descritores: Triterpenos/farmacologia
Lamiaceae/química
Triterpenos Pentacíclicos/farmacologia
Fabaceae/química
Antineoplásicos/farmacologia
-Triterpenos/isolamento & purificação
Triterpenos/química
Ensaios de Seleção de Medicamentos Antitumorais
Lamiaceae/classificação
Concentração Inibidora 50
Linhagem Celular Tumoral
Ésteres
Triterpenos Pentacíclicos/isolamento & purificação
Triterpenos Pentacíclicos/química
Fabaceae/classificação
Antineoplásicos/isolamento & purificação
Antineoplásicos/química
Limites: Humanos
Responsável: BR1.1 - BIREME



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