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Texto completo SciELO Brasil
Souccar, Caden
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Id: lil-623959
Autor: Freire, Sonia M. F; Torres, Luce M. B; Roque, Nidia F; Souccar, Caden; Lapa, Antonio J.
Título: Analgesic activity of a triterpene isolated from Scoparia dulcis L. (vassourinha)
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):149-151, 1991. graf.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: Analgesic and anti-inflammatory activities of water (WE) and ethanolic (EE) extracts of Scoparia dulcis L. were investigated in rats and mice, and compared to the effects induced by Glutinol, a triterpene isolated by purification of EE. Oral adminsitration (p.o.) of either WE or EE (up to 2 g/Kg) did not alter the normal spontaneous activity of mice and rats. The sleeping time induced by sodium pentobarbital (50 mg/Kg, i.p.) was prolonged by 2 fold in mice pretreated with 0.5 g/Kg EE, p.o. Neither extract altered the tail flick response of mice in immersion test, but previous administration of EE (0.5 g/Kg, p.o.) reduced writhings induced by 0.8% acetic acid (0.1 ml/10 g, i.p.) in mice by 47% EE (0.5 and 1 g/Kg, p.o.) inhibited the paw edema induced by carrageenan in rats by respectively 46% and 58% after 2 h, being ineffective on the paw edema induced by dextran. No significant analgesic or anti-edema effects were detected in animals pretreated with WE (1 g/Kg, p.o.). Administration of Glutinol (30 mg/Kg, p.o.) reduced writhing induced by acetic acid in mice by 40% and the carrageenan induced paw edema in rats by 73%. The results indicate that the analgesic activity of S dulcis L. may be explained by explained by an anti-inflammatory activity probably related to the triterpene Glutinol.
Descritores: Plantas Medicinais
Anti-Inflamatórios
-Scoparia
Analgesia
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Costa Rica
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Id: lil-638105
Autor: Ordaz, Gabriel; D’Armas, Haydelba; Yáñez, Dayanis; Moreno, Shailili.
Título: Composición química de los aceites esenciales de las hojas de Helicteres guazumifolia (Sterculiaceae), Piper tuberculatum (Piperaceae), Scoparia dulcis (Arecaceae) y Solanum subinerme (Solanaceae), recolectadas en Sucre, Venezuela
Fonte: Rev. biol. trop;59(2):585-595, jun. 2011. ilus, graf, tab.
Idioma: es.
Resumo: Chemical composition of essential oils from leaves of Helicteres guazumifolia (Sterculiaceae), Piper tuberculatum (Piperaceae), Scoparia dulcis (Arecaceae) and Solanum subinerme (Solanaceae) from Sucre, Venezuela. Essential oils, biosynthesized and accumulated in aromatic plants, have a wide range of applications in the pharmaceutical health, cosmetics, food and agricultural industry. This study aimed to analyze the secondary metabolites in some plant species in order to contribute to their chemotaxonomy. Leaves from Helicteres guazumifolia, Piper tuberculatum, Scoparia dulcis and Solanum subinerme were collected and their essential oils were obtained by means of hydro-distillation. The oil fraction was analyzed and identified by GC/MS. The extraction yields were of 0.004, 0.032, 0.016 and 0.005%, and the oil constituents of 88.00, 89.80, 87.50 and 89.47%, respectively. The principal oils found were: non-terpenoids volatile secondary metabolites (30.28%) in H. guazumifolia; sesquiterpenoids (20.82 and 26.09%) and oxigen derivated (52.19 and 25.18%) in P. tuberculatum and S. dulcis; and oxigen diterpenoids (39.67%) in S. subinerme. The diisobuthylphtalate (13.11 %) in H. guazumifolia, (-)-spathulenol (11.37%) in P. tuberculatum and trans-phytol (8.29 and 36.00%) in S. dulcis and S. subinerme, were the principal constituents in their respective essential oils. The diisooctylphtalate were the essential oil common to all species, but the volatile compounds such as trans-pinane, L-linalool, β-ionone, isophytol, neophytadiene, trans-phytol, dibutylphtalate and methyl hexadecanoate, were only detected in three of these essences. This suggests that these plants may require similar secondary metabolites for their ecological interactions, possibly due to common environmental factors. Rev. Biol. Trop. 59 (2): 585-595. Epub 2011 June 01.

Los aceites esenciales son biosintetizados por plantas aromáticas y pueden obtenerse de cualquier órgano de la misma, tienen gran aplicación en la industria farmacéutica, sanitaria, cosmética, agrícola y de alimentos. Los aceites esenciales de las hojas de las plantas Helicteres guazumifolia, Piper tuberculatum, Scoparia dulcis y Solanum subinerme fueron obtenidos mediante hidrodestilación con rendimientos de 0.004, 0.032, 0.016 y 0.005%, respectivamente. La CG/EM permitió identificar la mayoría de los constituyentes de estos aceites esenciales (88.00, 89.80, 87.50 y 89.47%, respectivamente), encontrándose en mayor proporción metabolitos no volátiles de estructura no terpenoidal en H. guazumifolia (30.28%), sesquiterpenoides oxigenados en P. tuberculatum (52.19%), sesquiterpenos en S. dulcis (26.09%) y derivados oxigenados de diterpenos en S. subinerme (39.67%). Los constituyentes mayoritarios fueron el diisobutilftalato (13.11%) en H. guazumifolia, (-)-espatulenol (11.37%) en P. tuberculatum y el trans-fitol (8.29 y 36.00%) para S. dulcis y S. subinerme, respectivamente. El diisooctilftalato fue el constituyente común en los aceites esenciales de todas las especies y los compuestos volátiles trans-pinano, L-linalool, β-ionona, isofitol, neofitadieno, trans-fitol, dibutilftalato y hexadecanoato de metilo, fueron detectados en tres de estas esencias. Esto sugiere que dichas plantas pueden requerir metabolitos secundarios similares para su interacción ecológica, posiblemente debido a factores ambientales comunes.
Descritores: Óleos Voláteis/química
Piper/química
Folhas de Planta/química
Óleos Vegetais/química
Scoparia/química
Solanum/química
Malvaceae/química
-Óleos Voláteis/isolamento & purificação
Óleos Vegetais/isolamento & purificação
Venezuela
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CR1.1 - BINASSS - Biblioteca Nacional de Salud y Seguridad Social


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Texto completo SciELO Brasil
Agra, Maria de Fátima
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Id: lil-514651
Autor: Silva, Tania M. S; Camara, Celso A; Lins, Antonio C. S; Agra, Maria de Fátima; Silva, Eva M. S; Reis, Igor T; Freitas, Breno M.
Título: Chemical composition, botanical evaluation and screening of radical scavenging activity of collected pollen by the stingless bees Melipona rufiventris (Uruçu-amarela)
Fonte: An. acad. bras. ciênc;81(2):173-178, June 2009. ilus, tab.
Idioma: en.
Resumo: Stingless bees in Brazil are indigenous and found all over the country. Bee pollen is used for its nutritional value in the human diet. It is made up of natural flower pollen mixed with nectar and bee secretions. In order to evaluate the chemical composition, free radical scavenging activity, and botanical origin, sample of pollen loads from stingless bee, Melipona rufiventris (Uruçu amarela) was studied. The EtOAc extract of pollen of Melipona rufiventris yielded the following compounds: p-hydroxycinnamic acid, dihydroquercetin, isorhamnetin, isorhamnetin3-O-(6"-O-E-p-coumaroyl)-β-D-glucopyranoside, luteolin, and quercetin. This is the first report of the isolation of isorhamnetin3-O-(6"O-E-p-coumaroyl)β-D-glucopyranoside from pollen. The free radicalscavenging activities of different solvent extracts of pollen were determined using DPPH assay. This activity decreases in the order: EtOAc>EtOH>Hexane extract. It appears that the EtOAc extract of the pollen is a good scavenger of active oxygen species. The botanical evaluation of pollen loads showed the composition by two pollen types, with the dominant type (97.3 percent) being Scopariadulcis (L.) (Scrophulariaceae) and the minor one Senna obtusifolia (L.) Irwin & Barneby (Fabaceae). This suggests a specific foraging behavior in Melipona rufiventris bees, even in an environment with such a rich botanical diversity as the Northeastern Brazil.

As abelhas sem ferrão são espécies indígenas encontradas em todo o Brasil. Seu pólen é utilizado devido ao seu valor nutricional na dieta humana. É produzido a partir de pólen floral misturado com néctar e líquidos secretados pelas abelhas. Visando avaliar a composição química, a atividade sequestradora de radicais livres e a origem botânica foi estudado o pólencoletado pela abelha sem ferrão Melipona rufiventris (Uruçu-amarela). Do extrato acetato de etila foram isolados os compostos: ácido phidroxicinâmico, dihidroquercetina, isoramnetina, 3O(6"OEpcoumaroil)βDglicopiranosideoisoramnetina, luteolina e quercetina. Esta é a primeira vez que a 3O(6"OEpcoumaroil)βDglicopiranosideoisoramnetina é isolada de pólen apícola. A atividade sequestradora de radicais livres de vários extratos com solventes diferentes foi determinada pelo teste com DPPH (difenilpicrilhidrazida). A atividade mostrou a ordem decrescente para os extratos AcOEt>EtOH>Hexano. O extrato AcOEt apresenta melhor atividade sequestradora de radicais. A avaliação botânica palinológicamostrou que o pólen era composto de dois tipos, um majoritário(97.3 por cento) proveniente de Scoparia dulcis (L.) (Scrophulariaceae) e outro minoritário proveniente de Senna obtusifolia (L.) Irwin& Barneby (Fabaceae). Estes resultados sugerem o comportamento de forragem bastante específico exibido pela abelha Melipona rufiventris, mesmo em um ambiente tão rico em diversidade vegetal como o Nordeste do Brasil.
Descritores: Abelhas/fisiologia
Pólen/química
Scoparia
Senna (Planta)
-Depuradores de Radicais Livres/análise
Limites: Animais
Responsável: BR1.1 - BIREME



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