Base de dados : LILACS
Pesquisa : B01.650.940.800.575.912.250.595.400.399 [Categoria DeCS]
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Id: biblio-1283629
Autor: Valdés, Carlos; Laurido, Claudio; Morales, Bernardo; Jaimes, Luisauris; Vinet, Raúl; Martínez, José L.
Título: Complete essential oils of Laurus nobilisinducing antinociceptiveaction by opioid mechanism in C-Reflex and spinal Wind-Up model in rat / Aceites esenciales totales de Laurus nobilis inducen acción antinociceptivamediante mecanismo opioide en el modelode Reflejo-C y Wind-Up espinal en ratas
Fonte: Bol. latinoam. Caribe plantas med. aromát;19(4):420-427, 2020. tab.
Idioma: en.
Projeto: Universidad de Santiago de Chile, project DICYT.
Resumo: The essential oil of Laurus nobilis L. was used to test their antinociceptive efficacy. It was applied intraperitoneally (i.p.) to rats subjected to a nociception test (C reflex and spinal wind-up). The results showed that the essential oil applied at higher doses (0.06 mg/Kg) causes a complete abolition of the spinal wind-up, while the C reflex was unchanged, indicating a clear antinociceptive effect. At lower concentrations (0.012 mg/Kg), there was a lowering in the wind-up by 85% within ten minutes of the essential i.p. oil application. Interestingly, there was an effect of naloxone (0.08 mg/Kg i.p.) When applied, a change occurs that almost entirely reversed the antinociception caused by the essential oil from Laurus nobilis. We conclude that there is a significant antinociceptive effect of the essential oil of Laurus nobilis subjected to electric nociception. In addition, it was observed that naloxone reversed the antinociceptive effect (wind-up) produced by Laurus nobilis.

El aceite esencial de Laurus nobilis L. se usó para probar su eficacia antinociceptiva. Se aplicó por vía intraperitoneal (i.p.) a ratas sometidas a una prueba de nocicepción (reflejo-C y wind-up espinal). Los resultados mostraron que el aceite esencial aplicado a dosis más altas (0.06 mg/Kg) abolió completamente el wind-up espinal, mientras que el reflejo-C no cambió, lo que indica un claro efecto antinociceptivo. A concentraciones más bajas (0.012 mg/Kg), hubo una disminución en el wind-up en un 85% dentro de los diez minutos del i.p. la aplicación del aceite esencial. Curiosamente, hubo un efecto de la naloxona (0.08 mg/Kg i.p.) la cual revierte casi por completo la antinocicepción causada por el aceite esencial de Laurus nobilis. Concluimos que existe un efecto antinociceptivo significativo del aceite esencial de Laurus nobilis sometido a nocicepción eléctrica. Además, se observó que la naloxona revirtió el efecto antinociceptivo (wind-up) producido por Laurus nobilis.
Descritores: Dor/tratamento farmacológico
Óleos Voláteis/administração & dosagem
Laurus/química
Analgésicos/administração & dosagem
-Reflexo/efeitos dos fármacos
Medula Espinal/efeitos dos fármacos
Ratos Sprague-Dawley
Naloxona/administração & dosagem
Limites: Animais
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: lil-623715
Autor: Ré, Liliane; Kawano, Toshie.
Título: Effects of Laurus nobilis (Lauraceae) on Biomphalaria glabrata (Say, 1818)
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):315-320, 1987. graf, tab, ilus.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Projeto: CNPq; . PIGV; . FAPESP.
Resumo: Experiments were carried out using aqueous extracts from leaves and flowers of Laurus nobilis on Biomphalaria glabrata. Treatments were performed on blastula stage (± 15 h after first cleavage) and on adult snails (11-18 mm). In both instances they were exposed for 24 h to different concentrations of the extracts on snails (200 to 2500 ppm) and embryos (20 to 300 ppm) at 25 ± 1ºC. The embryos were observed for a period of 20 days after treatment and the snails for 10 days. Results obtained with leaf aqueous extracts have shown a degree of toxicity on embryos starting at a concentration of 125 ppm, the flower extract being effective at 35 ppm. The malformation obtained with the different concentrations falls into the unespecific type category, however some cephalic and shell malformations were found in embryos treated with concentrations over 50 ppm (leaves) and 25 ppm (flowers). The LD90 on adult snails obtained by treatments with flower and leaf extract was observed at concentrations of 340 ppm and 1900 ppm respectively.
Descritores: Biomphalaria/fisiologia
Biomphalaria/parasitologia
-Lauraceae
Laurus
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: lil-648048
Autor: Montenegro, Iván; Madrid Villegas, Alejandro; Zaror, Luis; Martínez, Rolando; Werner, Enrique; Carrasco-Altamirano, Hector; Cuellar Fritis, Mauricio; Palma-Flemming, Hernán.
Título: Antimicrobial activity of ethyl acetate extract and essential oil from bark of Laurelia sempervirens against multiresistant bacteria / Actividad antimicrobiana del extracto acetato de etilo y aceite esencial de corteza de Laurelia sempervirens contra bacterias multirresistentes
Fonte: Bol. latinoam. Caribe plantas med. aromát;11(4):306-315, jul. 2012. tab, graf.
Idioma: en.
Projeto: Universidad Andres Bello; . Universidad Técnica Federico Santa María.
Resumo: Context: Laurelia sempervirens (R. et P.) Tul., is an evergreen tree that growths in southern Chile, its leaves and bark are used in folk medicine as an infusion. Objective: The antimicrobial activities of the essential oil and ethyl acetate extract obtained from the bark of Laurelia sempervirens were investigated. Materials and methods: Ethyl acetate extract and essential oil were analyzed by GC- mass and the antimicrobial activity was investigated against gram positive and gram negative bacteria. Results: The extract and essential oil showed a strong antimicrobial activity against bacteria such as Acinetobacter baumanii, a relevant world nosocomial pathogen Discussion and conclusion: These findings demonstrate that the ethyl acetate extract and essential oil of L.sempervirens bark have excellent antimicrobial activities and thus have great potential as a source for natural health products.

Contexto: Laurelia sempervirens (R. et P.) Tul., es un árbol de hoja perenne que crece en el sur de Chile, sus hojas y corteza se utilizan en medicina popular como infusión. Objetivo: Investigar la actividad antimicrobiana del aceite esencial y el extracto de acetato de etilo obtenido de la corteza de Laurelia sempervirens. Materiales y métodos: El extracto de acetato de etilo y el aceite esencial se analizaron por GC-masa y la actividad antimicrobiana se analizó contra bacterias gram positivas y gram negativas. Resultados: El extracto y aceite esencial evidenció una fuerte actividad antimicrobiana frente a la bacteria, Acinetobacter baumanii patógeno que causa infecciones nosocomiales de relevancia mundial. Discusión y conclusiones: Estos hallazgos demuestran que el extracto de acetato de etilo y aceite esencial de corteza de L.sempervirens tienen excelentes actividades antimicrobianas y por lo tanto tienen un gran potencial como fuente de productos naturales para la salud.
Descritores: Anti-Infecciosos
Óleos Voláteis/farmacologia
Bactérias
Folhas de Planta/química
Laurus/química
-Acetatos
Acinetobacter baumannii
Chile
Cromatografia
Casca de Planta/química
Extratos Vegetais/farmacologia
Responsável: CL1.1 - Biblioteca Central



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