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Pesquisa : B01.650.940.800.575.912.250.618.100.400.500 [Categoria DeCS]
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Id: biblio-1002224
Autor: Brozzo, Natacha Pinheiro Melo; Ferreira, Efraim dos Santos; Gonçalves, Eduardo Andrade; Meneguetti, Dionatas Ulises de Oliveira; Silva, Delano Aníbal da; Cunha, Renildo Moura da.
Título: Curcuma Longa Abolishes Phenylephrine-Induced Contractions in Isolated Aortic Artery of Rats
Fonte: Int. j. cardiovasc. sci. (Impr.);32(3):207-216, May-June 2019. graf.
Idioma: en.
Projeto: CNPQ.
Resumo: Curcuma longa has biological effects. Its cardiovascular activities are yet to be scientifically studied. Objectives: To investigate the vasorelaxant effects of the aqueous extract of Curcuma longa (AECL). Methods: Aortic annuli of normotensive rats, with or without endothelium, were set up in a data storage system with nutrient solution in recipients, with scientifically recommended temperature, aeration and tension. Over contraction by Phenylephrine, the AECL (1, 3, 10, 30, 100, 300 and 1000 µg/mL) was incubated before and after incubation with atropine or L-name or indomethacin. An AECL concentration-response curve was also built over contractions caused by elevation of extracellular K+. Data were significant when p < 0.05, with GraphPad Prism 6.0 software resolutions. Results: The AECL induced 100% vasorelaxation also in the endothelium-free annuli. The part of the endothelium-dependent effect had EC50 = 4.32 ± 0.05 µg/mL. With inhibition of NO production, the EC50 increased to 126.50 ± 2.35 µg/mL; after inhibition of prostacyclin production, to 124.6 ± 0.05 µg/mL; and after muscarinic blockade, to 437.10 ± 0.2 µg/mL. Opening of K+ channels (relaxation of 56.98%) and VOCC blockade (relaxation of 31.56%) were evident. Conclusion: AECL induced significant vasorelaxation, being more significant in the presence of endothelium. The muscarinic pathway seems to be the main one involved in this effect, followed by the NO production and prostacyclin pathways. The activity in K+ channels by AECL was more significant than its VOCC blockade. The use of other models and tools to study action mechanisms will be important and elucidating
Descritores: Aorta
Fenilefrina
Curcuma/efeitos adversos
-Ratos
Vasodilatadores/uso terapêutico
Cardiotônicos
Análise Estatística
Análise de Variância
Receptores Muscarínicos
Modelos Animais
Crocus
Hipertensão
Antioxidantes
Limites: Animais
Ratos
Responsável: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt


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Id: biblio-966230
Autor: Rao, Junfeng; Lv, Weide; Yang, Jumei.
Título: Proteomic analysis of saffron (Crocus sativus L. ) grown under conditions of cadmium toxicity / Análise proteômica do açafrão (Crocus sativus L. ) cultivado sob condições de toxicidade por cádmio
Fonte: Biosci. j. (Online);33(3):713-720, may/jun. 2017. ilus, tab.
Idioma: en.
Resumo: Cd is a highly detrimental global environmental pollutant. Plants have evolved complex defense mechanisms as an adaptation to against Cd toxicity. In this study, a pot experiment was performed to evaluate the protein profile of saffron in response to Cd stress. Fifteen proteins were found to be up-regulated in the leaves of plants under Cd stress and were primarily related to metabolism, signal transduction, stress and defense response and energy. Eleven proteins were found to be down-regulated following Cd treatment, including ribulose bisphosphate carboxylase/oxygenase (Rubisco), ferredoxin-NADP reductase, a 70 kDa heat shock-related protein and three protein synthesis-associated proteins. The results provide valuable insights regarding the molecular mechanism of saffron in response to Cd toxicity and the possible utilization of genetic resources in developing Cd tolerant/low-accumulation saffron.

O cádmio (Cd) é um poluente ambiental global altamente prejudicial. As plantas desenvolveram mecanismos de defesa complexos como uma adaptação contra a toxicidade por Cd. Neste estudo, realizou-se um experimento em vaso para avaliar o perfil proteico do açafrão em resposta ao estresse por Cd. Foi descoberto que quinze proteínas foram supra-reguladas (up-regulated) nas folhas de plantas sob estresse por Cd e foram principalmente relacionados ao metabolismo, transdução de sinal, estresse e resposta de defesa e energia. Foi descoberto ainda que onze proteínas foram infra-reguladas (down-regulated) após tratamento com Cd, incluindo ribulose bifosfato carboxilase oxigenase (RuBisCO), ferredoxina-NADP redutase, uma proteína relacionada com o choque térmico de 70 kDa e três proteínas associadas à síntese de proteínas. Os resultados fornecem informações valiosas sobre o mecanismo molecular do açafrão em resposta à toxicidade do Cd e a possível utilização de recursos genéticos no desenvolvimento de açafrão tolerante ao Cd e de baixa acumulação.
Descritores: Fotossíntese
Cádmio
Metais Pesados
Proteoma
Crocus
Responsável: BR396.1 - Biblioteca Central


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Id: biblio-1005799
Autor: Brozzo, Natacha Pinheiro Melo; Ferreira, Efraim dos Santos; Gonçalves, Eduardo Andrade; Meneguetti, Dionatas Ulises de Oliveira; Silva, Delano Aníbal da; Cunha, Renildo Moura da.
Título: Curcuma longa abolishes phenylephrine-induced contractions in isolated aortic artery of rats / Curcuma longa interrompe contrações induzidas por fenilefrina em artéria aórtica isolada de ratos
Fonte: Int. j. cardiovasc. sci. (Impr.);32(3):207-216, may.-june. 2019. graf.
Idioma: en.
Resumo: Background:Curcuma longa has biological effects. Its cardiovascular activities are yet to be scientifically studied. Objectives: To investigate the vasorelaxant effects of the aqueous extract of Curcuma longa (AECL). Methods: Aortic annuli of normotensive rats, with or without endothelium, were set up in a data storage system with nutrient solution in recipients, with scientifically recommended temperature, aeration and tension. Over contraction by Phenylephrine, the AECL (1, 3, 10, 30, 100, 300 and 1000 µg/mL) was incubated before and after incubation with atropine or L-name or indomethacin. An AECL concentration-response curve was also built over contractions caused by elevation of extracellular K+. Data were significant when p < 0.05, with GraphPad Prism 6.0 software resolutions.Results: The AECL induced 100% vasorelaxation also in the endothelium-free annuli. The part of the endothelium-dependent effect had EC50 = 4.32 ± 0.05 µg/mL. With inhibition of NO production, the EC50 increased to 126.50 ± 2.35 µg/mL; after inhibition of prostacyclin production, to 124.6 ± 0.05 µg/mL; and after muscarinic blockade, to 437.10 ± 0.2 µg/mL. Opening of K+ channels (relaxation of 56.98%) and VOCC blockade (relaxation of 31.56%) were evident. Conclusion: AECL induced significant vasorelaxation, being more significant in the presence of endothelium. The muscarinic pathway seems to be the main one involved in this effect, followed by the NO production and prostacyclin pathways. The activity in K+ channels by AECL was more significant than its VOCC blockade. The use of other models and tools to study action mechanisms will be important and elucidating
Descritores: Aorta
Fenilefrina
Ratos
Curcuma
-Vasodilatadores/uso terapêutico
Cardiotônicos
Análise Estatística
Análise de Variância
Receptores Muscarínicos
Modelos Animais
Crocus
Hipertensão
Antioxidantes
Limites: Animais
Ratos
Responsável: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt


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Texto completo SciELO Brasil
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Id: lil-727207
Autor: Berni, R.F.; Chaves, F.C.M.; Pinheiro, J.B.; Vaz, A.P.A..
Título: Produção de açafrão em função de acessos e do peso de rizomas-semente / Influence of the weight of seed-rhizomes in the production of turmeric
Fonte: Rev. bras. plantas med;16(3,supl.1):765-770, 2014. tab.
Idioma: pt.
Projeto: EMBRAPA; . FINEP/FAPEAM/FDB.
Resumo: O açafrão-da-terra (Curcuma longa L.) é originário do sudeste asiático e subcontinente indiano. É uma herbácea de caule subterrâneo, alaranjado, com vários rizomas secundários aproveitados na indústria alimentícia e farmacêutica devido às características de cor, sabor, odor, produção de óleos essenciais, e corantes. Na escolha do melhor material propagativo deve-se levar em consideração o material genético, o peso, tamanho, idade, capacidade de reserva acumulada, sanidade, dentre outros fatores. O objetivo neste experimento foi avaliar a influencia de diferentes acessos e pesos de rizomas-sementes na produção de açafrão. Empregou-se o delineamento em blocos casualizados em parcelas subdivididas com quatro repetições, tendo como tratamento principal os acessos (C-06, C-36 e C-38) e como tratamento secundário as classes de rizomas-sementes (peso): pequeno, médio e grande, ±5, ±10 e ±15 g/rizoma, respectivamente. Após a colheita, os rizomas foram distribuídos sobre tela suspensa para secagem à sombra com ventilação natural, por 20 dias. Posteriormente, para avaliar a produção, os rizomas foram classificados em 4 classes: A (> 15g ), B (±10 g), C (±5 g) e D(<5g). A interação entre os acessos e o tamanho do rizoma-semente foi significativa para todas as variáveis, com exceção da Classe D. Com o uso de rizoma-semente grande os acessos C-38 e o C-06 apresentaram maior produtividade total, 0,834 e 0,812kg/planta, respectivamente. O descarte gerado foi menor no acesso C-38 do que no C-06, representando 7,8 e 12,8% da produção total, respectivamente. O uso de rizomas-semente maiores aumentou significativamente a produção total. No acesso C-06 a produção passou de 0,481 para 0,812 kg/planta, ou seja, um aumento de 70%. O ganho relativo na produção de rizoma (kg/planta) no acesso C-06 para o plantio de rizomas com ±15 g, foi de 28%.

Turmeric (Curcuma longa L) originated in Southeast Asia and the Indian subcontinent. It is an herbaceous plant with underground, orange stem with several secondary rhizomes used in the food and pharmaceutical industries, because of its characteristics of color, taste, smell, production of essential oils and dyes. In cultivation, the best choice of propagation material must take account the genetic material, weight, age, accumulated reserve capacity, sanity, among other factors. In this study, seed-rhizomes of three weight categories - small, medium and large -, ± 05, ± 10 and ± 15 g / rhizome, respectively, of three genetic materials - C-06, C-36 and C-38 - from the Germplasm Bank of the ESALQ / USP were cultured from December 2009 to August 2010, at a spacing of 0.5 mx 0.2 m. After harvest, they were distributed on canvas suspended for drying in the shade and natural ventilation for 20 days. Later, to evaluate the production, they were classified into four categories: A (> 15g), B (± 10 g), C (± 5 g) and D (<5g) .The interaction between accessions and size of seed-rhizomes was significant for all variables, except for category D. With the use of large seed-rhizomes, C-38 and C-06 had a higher total yield, with 0.834 and 0.812 kg/plant, respectively. The use of large seed-rhizomes increased significantly the total production. In C-06, the production increased from 0.481 to 0.812 kg/plant, i.e. an increase of 70%. Also in C-06, the relative gain in the production of rhizome (kg / plant) for the planting of seed-rhizomes with ± 15 g was 28%.
Descritores: Crocus/farmacologia
Rizoma/classificação
Pesos e Medidas/instrumentação
-Sementes/anatomia & histologia
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
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Id: lil-548032
Autor: Ajami, Marjan; Eghtesadi, Shahriar; Pazoki-Toroudi, Hamidreza; Habibey, Rouhollah; Ebrahimi, Soltan Ahmed.
Título: Effect of crocus sativus on gentamicin induced nephrotoxicity
Fonte: Biol. Res;43(1):83-90, 2010. graf.
Idioma: en.
Resumo: Crocus sativus, known as saffron, is used in folk medicine for treatment of different types of diseases, and its anti-inflammatory and free radical scavenging activities have been demonstrated. The present study evaluated gentamicin nephrotoxicity in saffron treated rats. Male Wistar rats (200-250g) were treated with saffron (40 or 80 mg/k/d) for 10 days, or saffron (40 or 80 mg/ kg/d) for 10 days and gentamicin 80 mg/kg/d for five days, starting from day 6. At the end of treatment, blood samples were taken for measurement of serum creatinine (SCr) and BUN. The left kidney was prepared for histological evaluation and the right kidney for Malondialdehyde (MDA) measurement. Gentamicin 80 (mg/k/d) increased SCr, BUN and renal tissue levels of MDA and induced severe histological changes. Saffron at 40 mg/k/d significantly reduced gentamicin-induced increases in BUN and histological scores (p<0.05). Gentamicin-induced increases in BUN, SCr and MDA and histological injury were significantly reduced by treatment with saffron 80 mg/k/d (p<0.05, p<0.001, p<0.05, and p<0.001 respectively). In conclusion, our results suggest that saffron treatment reduces gentamicin-induced nephrotoxicity and this effect seems to be dose dependent.
Descritores: Antibacterianos/toxicidade
Crocus/química
Gentamicinas/toxicidade
Nefropatias/induzido quimicamente
Nefropatias/tratamento farmacológico
Extratos Vegetais/uso terapêutico
-Malondialdeído/análise
Ratos Wistar
Índice de Gravidade de Doença
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME



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