Base de dados : LILACS
Pesquisa : B01.650.940.800.575.912.250.618.100.970 [Categoria DeCS]
Referências encontradas : 1 [refinar]
Mostrando: 1 .. 1   no formato [Detalhado]

página 1 de 1

  1 / 1 LILACS  
             
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-949367
Autor: Karaoğlan, Esen Sezen; Albayrak, Abdulmecit; Kutlu, Zerrin; Bayır, Yasin.
Título: Gastroprotective and antioxidant effects of Eremurus spectabilis Bieb. methanol extract and its isolated component isoorientin on indomethacin induced gastric ulcers in rats
Fonte: Acta cir. bras;33(7):609-618, July 2018. graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the gastroprotective effect of methanol extract of E. spectabilis and its major component isoorientin. Methods: Effects of isoorientin and methanol extract of E. spectabilis were investigated in indomethacin-induced gastric damage model on rats. Famotidine was used as the standard antiulcer drug. Numerical density of ulcer areas and oxidative status were determined on stomach tissues of rats. Results: All doses of isoorientin and methanol extract decreased MDA level and increased SOD activity and GSH levels in the stomach tissue of rats. When numerical density of ulcer areas were analized, the 500 mg/kg dose of methanol extract (84%) exhibited a similar effect to 20 mg/kg dose of standart drug famotidine (87%). Conclusions: The gastroprotective effects of E. spectabilis and its major constituent isoorientin in rats for the first time. Detailed analyses suggested that potential antioxidant activity of both plant extract and isoorientin mediates the gastroprotective effect.
Descritores: Úlcera Gástrica/tratamento farmacológico
Extratos Vegetais/farmacologia
Luteolina/farmacologia
Metanol/farmacologia
Xanthorrhoeaceae/química
Antiulcerosos/farmacologia
Antioxidantes/farmacologia
-Úlcera Gástrica/patologia
Superóxido Dismutase/análise
Superóxido Dismutase/efeitos dos fármacos
Índice de Gravidade de Doença
Indometacina
Reprodutibilidade dos Testes
Resultado do Tratamento
Ratos Wistar
Relação Dose-Resposta a Droga
Glutationa/análise
Glutationa/efeitos dos fármacos
Malondialdeído/análise
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME



página 1 de 1
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde