Base de dados : LILACS
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Id: biblio-987713
Autor: López López, Lluvia Itzel; Nery Flores, Sendar Daniel; Silva Belmares, Sonia Yesenia; Sáez Galindo, Aidé.
Título: Naphthoquinones: biological properties and synthesis of lawsone and derivatives- a structured review / Naftoquinonas: propiedades biológicas y síntesis de lawsona y derivados ­ una revisión estructurada
Fonte: Vitae (Medellín);21(3):248-258, 2014. Ilustraciones.
Idioma: en.
Resumo: Background: Naphthoquinones are natural pigments that are widely distributed in nature and have important biological activities. Lawsone (2-hydroxy-1,4-naphthoquinone) and its synthetic derivatives, and especially those containing nitrogen, have promising potential for the treatment of different diseases due to their antibacterial, antifungal, antiviral, antitumor and antiparasitic effects, and for pest control via their molluscicidal and insecticidal activities. Their pharmacological activities and mechanisms of action are related to their oxide/reduction and acid/base properties, and can be modulated by directly adding a substituted to the 1,4-naphthoquinone ring. Due to this, naphthoquinones and their derivatives are at the center of multiple areas of research. In this manuscript, we present a structured review of lawsone, a hydroxyl derivative of naphthoquinone, and discuss relevant reports about the chemistry and synthesis of derivatives. Finally, we present the pharmacological activities and mechanism of action reported. Objective: The purpose of this review is to present recent reports from the literature about the chemistry, synthesis and pharmacological properties of lawsone and its amine derivatives. Methods: This structured review presents a discussion about lawsone literature over the last ten years. The most representative studies including those about the chemistry of lawsone, the synthesis of its derivatives, and pharmacological properties were identified and selected. The information has been compiled, organized and presented into logical topics in order to provide a current review for the field of lawsone chemistry. Results: A general overview of the principal aspects of lawsone chemistry, the synthesis of its derivatives and their pharmacological activities and mechanism of action has been obtained. This provides researchers in the area with a framework from which to investigate further. Conclusions: Lawsone and its derivatives have promising potential for treating several diseases due to their antibacterial, antifungal, antiviral, antitumor and antiparasitic effects and have the potential to control pests via their molluscicidal and insecticidal properties. For this reason, it would be of interest to evaluate the synthetic derivatives of this compound for their pharmacologic actions; in the future, synthetic derivatives of lawsone could potentially be used to treat disease and be used as pesticides.
Descritores: Naftoquinonas
-Controle de Pragas
Ações Farmacológicas
Lawsonia (Planta)
Limites: Seres Humanos
Tipo de Publ: Artigo Clássico
Responsável: CO56.3 - Biblioteca


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Id: lil-686902
Autor: Piloto Ferrer, Janet; Stoiber, Thomas; Vizoso Parra, Angel; Vega Hurtado, Yamile; Rodríguez Ferrada, Carlos; González Sanabria, María L; Sánchez-Lamar, Angel.
Título: Search of new Antimitotics compounds from the Cuban flora / Búsqueda de nuevos compuestos con actividad antimitótica en la flora cubana
Fonte: Bol. latinoam. Caribe plantas med. aromát;10(1):75-82, ene. 2011. ilus, tab.
Idioma: en.
Resumo: The main objective of anti-carcinogenic chemotherapy is to stop uncontrolled cellular proliferation. This has prompted us to begin a systematic survey of new effective inhibitors with ability to react with cytoskeletal components and arrest living, dividing cells. Even for traditional populations herbs-consuming, encouraging the use of species with chemopreventive actions could be helpful as part of life expectancy improvement strategies. Herbal products have significantly lower costs, exhibit little or no toxicity during long-term oral administration and are relatively available at large scale. Current work involved the screening of 85 extracts from Cuban medicinal plants, selected on the basis of traditional use, ethnobotanics and pharmacological information (antiparasitic, antitumour, abortive, etc.). Antitubulinic activity in the hydroalcoholics extracts was evaluated by using a modified version of the conventional turbidity assay of tubulin assembly/ disassembly. The activity limits of the news isolated antitubulin agents were thoroughly investigated. According to the presented results, the extracts displaying the highest antitubulinic activity were Tamarindus indica L., Lawsonia inermes L and Xanthium strumarium L.

Detener la proliferación celular es el principal propósito de la quimioterapia anticarcinogénica. Para ello se ha realizado una búsqueda a partir de fuentes naturales de nuevos inhibidores efectivos que reaccionen con los componentes del citoesqueleto y puedan detener la división celular. En poblaciones que tradicionalmente utilizan plantas medicinales se estimula el uso de aquellas especies con acción quimiopreventivas como parte de una estrategia que contribuya a la calidad de vida. Los productos herbarios tienen costos significativamente más bajos, exhiben poca o ninguna toxicidad durante la administración oral a largo plazo y están al alcance de todos. Nuestro trabajo consistió en realizar un tamizaje de 85 extractos de plantas medicinales cubanas seleccionadas en base al uso tradicional, en las encuestas etnobotánicas e información farmacológica (actividad antiparasitaria, antitumoral, abortiva, etc). La actividad antitubulínica fue evaluada mediante una versión modificada del ensayo turbimétrico del ensamblaje/desensamblaje de la tubulina. Se determinó la actividad límite de los nuevos agentes antitubulínicos siendo los extractos de Tamarindus indica L., Lawsonia inermes L and Xanthium strumarium L. los de mejor actividad antitubulínica según las condiciones ensayadas.
Descritores: Antimitóticos/farmacologia
Extratos Vegetais/farmacologia
Plantas/química
-Antineoplásicos/farmacologia
Cuba
Flora
Lawsonia (Planta)/química
Microtúbulos
Preparações de Plantas/farmacologia
Tamarindus/química
Xanthium/química
Responsável: CL1.1 - Biblioteca Central


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Id: lil-606419
Autor: Oliveira de Carvalho, Vania; Giraldi, Susana; Abagge, Kerstin T; Kamoi, Tsukyio O; Kovalhuk, Loreni; Parolin Marinoni, Leide.
Título: Dermatitis de contacto alérgica por tatuaje de henna / Allergic contact dermatitis from henna tattoo
Fonte: Dermatol. pediatr. latinoam. (Impr.);6(1):25-28, ene.-abr. 2008. ilus.
Idioma: es.
Resumo: Se presenta un caso de reacción de contacto por la realización de un tatuaje de henna en un paciente pediátrico y se alerta sobre las posibles complicaciones a corto y largo plazo de este procedimiento. Se trata de una niña de 12 años de edad que presentó una dermatitis de contacto después de haberse realizado un tatuaje temporario de henna. Realizó tratamiento con corticoide tópico con mejoría gradual y posterior aparición de una mácula hipocrómica residual post inflamatoria. El test epicutáneo realizado fue positivo para la parafenilenodiamina. La moda del tatuaje de henna se ha hecho común en la edad pediátrica y muchos casos de dermatitis por contacto por henna han sido descriptos en niños. Este procedimiento produce reacciones locales persistentes, erupciones símil eritema multiforme y secuelas pigmentarias, así como problemas con la futura utilización de las tinturas para el cabello debido a la sensibilización a la parafenilenodiamina. Consideramos que la comunicación de este caso es de importancia para alertar al pediatra y al dermatólogo sobre las posibles complicaciones de este procedimiento.

We present a pediatric case of contact reaction to henna tattoo, alerting of the possible short and long-term complications of this kind of procedure. We describe a 12-year-old girl with a contact dermatitis after applying a temporary henna tattoo. There was gradual improvement with the use of topical corticosteroid and evolution to residual hypochromy. Patch test was positive to paraphenilenodiamine. "Temporary tattomania" with henna is getting to the pediatric population and many cases of henna contact dermatitis have been described in children. They may present as long lasting local reactions, erythema multiform-like lesions and pigmentary sequels apart from problems with the future use of hair dyers as a result of sensitization by paraphenilenodiamine. Thus we believe that the presentation of this case is an opportunity to inform the pediatricians and dermatologists about the possibility of these complications.
Descritores: Dermatite de Contato/etiologia
Lawsonia (Planta)/efeitos adversos
Tatuagem/efeitos adversos
-Extratos Vegetais/efeitos adversos
Região Lombossacral
Limites: Seres Humanos
Feminino
Criança
Tipo de Publ: Relatos de Casos
Responsável: AR338.1 - Biblioteca


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Id: lil-558985
Autor: Sánchez Moya, Ana I; Gatica, María E; García Almagro, Domingo; Larralde, Margarita.
Título: Dermatitis alérgica de contacto por tatuajes temporales de henna negra / Allergic contact dermatitis for temporary black henna tattoos
Fonte: Arch. argent. pediatr;108(4):e96-e99, ago. 2010. tab, ilus.
Idioma: es.
Resumo: Cada vez es más frecuente la realización de seudotatuajes de henna de color negro en la población pediátrica y la incidencia de efectos adversos se incrementa significativamente. La henna negra no existe de forma natural; se obtiene a partir de la henna original por añadido de otros compuestos, entre ellos, la parafenilendiamina (PPD), que oscurece y facilita mayor precisión en el dibujo del tatuaje. La PPD posee un gran poder sensibilizante y es un conocido inductor de dermatitis alérgicas de contacto. Puede ocasionar reacciones locales persistentes, secuelas por hiperpigmentación/hipopigmentación, así como futuros problemas debido a que se encuentra presente en múltiples productos de la vida cotidiana. Presentamos el caso de una niña de 11 años con dermatitis alérgica de contacto a tatuaje de henna negra con pruebas epicutáneas positivas para PPD, para alertar sobre el riesgo de estetipo de seudotatuajes.

Temporary 'black henna' tattoos, an increasingly popular body decoration in pediatric population, are associated witha growing incidence of adverse events. Black henna does not exist naturally, it is obtained from original henna after the addition of other compounds, among them paraphenilendiamine (PPD), which serves to darken the tattoo and allows greater precision to the design. PPD is known to be a strong sensitizerand increases the risk of allergic contact dermatitis. They may present as long lasting local reactions, and pigmentarysequels apart from problems with the future use of many products present in the daily life, as a result of sensitization by PPD. We report the case of an eleven-year old girl with an allergiccontact dermatitis to black henna tattoo with a positive patch test to PPD, in order to warn against these types of temporary tattoos.
Descritores: Dermatite Alérgica de Contato
Lawsonia (Planta)/efeitos adversos
Tatuagem/efeitos adversos
Tatuagem
Limites: Seres Humanos
Feminino
Criança
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica



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