Base de dados : LILACS
Pesquisa : B01.650.940.800.575.912.250.825.700 [Categoria DeCS]
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Texto completo SciELO Brasil
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Id: biblio-951893
Autor: Chen, Zhonghua; Shen, Li; Yang, Changyong; Jiang, Jinghui; Liu, Xing.
Título: Metabolic analysis of the effect of rheum on a taurocholate-induced acute pancreatitis rat model
Fonte: Braz. J. Pharm. Sci. (Online);53(2):e15022, 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT The effects of rheum on serum parameters in a taurocholate-induced acute pancreatitis (AP) rat model were investigated using pathological and biochemical tests, and a proton nuclear magnetic resonance (1H NMR)-based metabonomic strategy. Healthy rats and rats with AP were either treated with rheum (7.5% at a dose of 1.5 g/kg) or left untreated. Serum samples were collected from the AP and rheum-treated groups at 6, 12, and 24 h after treatment. The effect of rheum on pathological changes in the pancreatic was investigated to validate the AP model. We obtained 1H NMR spectra and analyzed the results using the partial least squares discriminant method. The results of the pathological and metabolic analyses revealed an amelioration of multiple metabolic abnormalities and an increase in the aerobic respiration ratio after treatment, compared with the AP groups. These results were attributed to improvements in energy supply and the elimination of metabolic products. The study also promoted NMR-based metabonomic analysis as a feasible method of assessing traditional Chinese drugs.
Descritores: Pancreatite/patologia
Rheum/efeitos adversos
Ácido Taurocólico/administração & dosagem
-Metabolômica
Espectroscopia de Prótons por Ressonância Magnética/instrumentação
Limites: Animais
Masculino
Ratos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-1011643
Autor: Wei, Hongwei; Chang, Jinhua; Liu, Pei; Li, Zhongsi; Miao, Guangxin; Liu, Xigang; Liu, Cuizhe; Zhang, Xiangrong.
Título: Design and evaluation of rhubarb total free anthraquinones oral colon-specific drug delivery granules to improve the purgative effect
Fonte: Braz. J. Pharm. Sci. (Online);55:e17110, 2019. tab, graf.
Idioma: en.
Resumo: Rhubarb is commonly used as a cathartic in Asian countries. However, researchers have devotedextensive concerns to the quality control and safety of rhubarb and traditional Chinese preparations composed of rhubarb due to the instable purgative effect and potential nephrotoxicity of anthraquinones. In this study, we aimed to prepare rhubarb total free anthraquinones (RTFA) oral colon-specific drug delivery granules (RTFA-OCDD-GN) to delivery anthraquinones to colon to produce purgative effect. RTFA-OCDD-GN were prepared using chitosan and Eudragit S100 through a double-layer coating process and the formulation was optimized. Continuous release studies were performed in a simulated gastric fluid (pH 1.2), followed by a small-intestinal fluid (pH 6.8) and a colonic fluid (pH 7.4, containing rat cecal contents). The purgative effect test was performed in rats. The dissolution profile of RTFA-OCDD-GN showed that the accumulative dissolution rate of RTFA was about 83.0% in the simulated colonic fluid containing rat cecal contents and only about 9.0% in the simulated gastrointestinal fluids. And the RTFA-OCDD-GN could produce the comparative purgative activity as rhubarb, suggesting it could deliver the free AQs to the colon. The RTFA-OCDD-GN was a useful media to enhance the purgative activity of free anthraquinones after administered orally.
Descritores: Rheum/efeitos adversos
Preparações Farmacêuticas
Antraquinonas/efeitos adversos
Colo
Projetos
-Catárticos/análise
Limites: Animais
Masculino
Feminino
Ratos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: lil-710933
Autor: Paudel, Babita; Bhattarai, Hari Datta; Chan Kim, Il; Lee, Hyoungseok; Sofronov, Roman; Ivanova, Lena; Poryadina, Lena; Yim, Joung Han.
Título: Estimation of antioxidant, antimicrobial activity and brine shrimp toxicity of plants collected from Oymyakon region of the Republic of Sakha (Yakutia), Russia
Fonte: Biol. Res;47:1-6, 2014. tab.
Idioma: en.
Projeto: Korea Polar Research Institute.
Resumo: BACKGROUND: Several plants are reported to be produced various biological active compounds. Lichens from the extreme environments such as high altitude, high UV, drought and cold are believed to be synthesized unique types of secondary metabolites than the other one. Several human pathogenic bacteria and fungi have been muted into drug resistant strains. Various synthetic antioxidant compounds have posed carcinogenic effects. This phenomenon needs further research for new effective drugs of natural origin. This manuscript aimed to screen new source of biological active compounds from plants of subarctic origin. RESULTS: A total of 114 plant species, including 80 species of higher plants, 19 species of lichens and 15 species of mosses, were collected from Oymyakon region of the Republic of Sakha (Yakutia), Russia (63˚20′N, 141˚42′E - 63˚15′N, 142˚27′E). Antimicrobial, DPPH free radical scavenging and brine shrimp (Artemia salina) toxicity of all crude extract were evaluated. The obtained result was analyzed and compared with commercial standards. A total of 28 species of higher plants showed very strong antioxidant activity (DPPH IC50, 0.45-5.0 µg/mL), 13 species showed strong activity (DPPH IC50, 5-10 µg/mL), 22 species showed moderate antioxidant activity (DPPH IC50,10-20 µg/mL) and 17 species showed weak antioxidant activity (DPPH IC50 more than 20 µg/mL). Similarly, 3 species of lichen showed strong antioxidant activity, one species showed moderate and 15 species showed weak DPPH reducing activity. In addition, 4 species of mosses showed moderate antioxidant activity and 11 species showed weak antioxidant activity. Similarly, extracts of 51 species of higher plants showed antimicrobial (AM) activity against Staphylococcus aureus and 2 species showed AM activity against Candida albicans. Similarly, 11 species of lichen showed AM activity against S. aureus and 3 species showed AM activity against Escherichia coli. One species of moss showed AM activity against S. aureus. And finally, one species of higher plant Rheum compactum and one species of lichen Flavocetraria cucullata showed the toxicity against Brine shrimp larvae in 100 µg/mL of concentration. CONCLUSION: The experimental results showed that subarctic plant species could be potential sources of various biologically active natural compounds.
Descritores: Anti-Infecciosos/farmacologia
Antioxidantes/farmacologia
Artemia/efeitos dos fármacos
Fungos Mitospóricos/efeitos dos fármacos
Extratos Vegetais/farmacologia
-Anti-Infecciosos/análise
Antioxidantes/análise
Aspergillus niger/efeitos dos fármacos
Produtos Biológicos/farmacologia
Compostos de Bifenilo/farmacologia
Candida albicans/efeitos dos fármacos
Escherichia coli/efeitos dos fármacos
INHIBITORY CONCENTRATION ACADEMIES AND INSTITUTES
Líquens/metabolismo
Picratos/farmacologia
Federação Russa
Rheum/química
Rhododendron/química
Rosaceae/química
Staphylococcus aureus/efeitos dos fármacos
Testes de Toxicidade
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: lil-177385
Autor: Guaita, Mercedes María.
Título: Irritabilidad en el niño hasta los dos años de edad / Irritability in the small child
Fonte: Homeopatía (Argent.);61(1/2):15-8, 1996.
Idioma: es.
Resumo: El propósito de este trabajo es analizar el síntoma irritabilidad del lactante y del niño pequeño, y buscar las modalizaciones que nos ayuden a prescribir el remedio correspondiente. Se hace un breve resumen de los síntomas más característicos de los remedios más usados en este período de la vida
Descritores: Pré-Escolar
Sintomas Afetivos/terapia
Temperamento/efeitos dos fármacos
-Calcarea Carbonica/uso terapêutico
Chamomilla/uso terapêutico
Emodina/uso terapêutico
Lycopodium clavatum/uso terapêutico
Moluscos
Rheum
Rheum palmatum/uso terapêutico
Sepia succus/uso terapêutico
Limites: Humanos
Lactente
Pré-Escolar
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco



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