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Pesquisa : B01.650.940.800.575.912.250.825.850 [Categoria DeCS]
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Texto completo SciELO Chile
Texto completo
Id: biblio-950783
Autor: NK, Asha Tukappa; Londonkar, Ramesh L; Nayaka, Hanumantappa B; CB, Sanjeev Kumar.
Título: Cytotoxicity and hepatoprotective attributes of methanolic extract of Rumex vesicarius L
Fonte: Biol. Res;48:1-9, 2015. ilus, graf, tab.
Idioma: en.
Resumo: BACKGROUND: To evaluate the hepatoprotective potential and invitro cytotoxicity studies of whole plant methanol extract of Rumex vesicarius L. Methanol extract at a dose of 100 mg/kg bw and 200 mg/kg bw were assessed for its hepatoprotective potential against CCl4-induced hepatotoxicity by monitoring activity levels of SGOT (Serum glutamic oxaloacetic transaminase), SGPT (Serum glutamic pyruvic transaminase), ALP (Alkaline phosphatase), TP (Total protein), TB (Total bilirubin) and SOD (Superoxide dismutase), CAT (Catalase), MDA (Malondialdehyde). The cytotoxicity of the same extract on HepG2 cell lines were also assessed using MTT assay method at the concentration of 62.5, 125, 250, 500 µg/ml. RESULTS: Pretreatment of animals with whole plant methanol extracts of Rumex vesicarius L. significantly reduced the liver damage and the symptoms of liver injury by restoration of architecture of liver. The biochemical parameters in serum also improved in treated groups compared to the control and standard (silymarin) groups. Histopathological investigation further corroborated these biochemical observations. The cytotoxicity results indicated that the plant extract which were inhibitory to the proliferation of HepG2 cell line with IC50 value of 563.33 ± 0.8 Mg/ml were not cytotoxic and appears to be safe. CONCLUSIONS: Rumex vesicarius L. whole plant methanol extract exhibit hepatoprotective activity. However the cytotoxicity in HepG2 is inexplicable and warrants further study.
Descritores: Extratos Vegetais/farmacologia
Proliferação de Células/efeitos dos fármacos
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
-Aspartato Aminotransferases/metabolismo
Superóxido Dismutase/metabolismo
Sais de Tetrazólio
Tetracloreto de Carbono
Ratos Wistar
Alanina Transaminase/metabolismo
Ingestão de Líquidos/efeitos dos fármacos
Ingestão de Alimentos/efeitos dos fármacos
Fosfatase Alcalina/metabolismo
Células Hep G2
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/patologia
Fígado/efeitos dos fármacos
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central

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Texto completo SciELO Chile
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Id: biblio-950784
Autor: Ahmad, Sajjad; Ullah, Farhat; Ayaz, Muhammad; Sadiq, Abdul; Imran, Muhammad.
Título: Antioxidant and anticholinesterase investigations of Rumex hastatus D. Don: potential effectiveness in oxidative stress and neurological disorders
Fonte: Biol. Res;48:1-8, 2015. graf, tab.
Idioma: en.
Resumo: BACKGROUND: Rumex species are traditionally used for the treatment of neurological disorders including headache, migraine, depression, paralysis etc. Several species have been scientifically validated for antioxidant and anticholinestrase potentials. This study aims to investigate Rumex hastatus D. Don crude methanolic extract, subsequent fractions, saponins and flavonoids for acetylcholinestrase, butyrylcholinestrase inhibition and diverse antioxidant activities to validate its folkloric uses in neurological disorders. Rumexhastatus crude methanolic extract (Rh. Cr), subsequent fractions; n-hexane (Rh. Hex), chloroform (Rh. Chf), ethyl acetate (Rh. EtAc), aqueous fraction (Rh. Aq), crude saponins (Rh. Sp) and flavonoids (Rh. Fl) were investigated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at various concentrations (125, 250, 500,1000 µg/mL) using Ellman's spectrophotometric analysis. Antioxidant potentials of Rh. Sp and Rh. Fl were evaluated using DPPH, H2O2 and ABTS free radical scavenging assays at 62.5, 125, 250, 500, 1000 µg/mL. RESULTS: All the test samples showed concentration dependent cholinesterase inhibition and radicals scavenging activity. The AChE inhibition potential of Rh. Sp and Rh. Fl were most prominent i.e., 81.67 ± 0.88 and 91.62 ± 1.67 at highest concentration with IC50 135 and 20 µg/mL respectively. All the subsequent fractions exhibited moderate to high AChE inhibition i.e., Rh. Cr, Rh. Hex, Rh. Chf, Rh. EtAc and Rh. Aq showed IC50 218, 1420, 75, 115 and 1210 µg/mL respectively. Similarly, against BChE various plant extracts i.e., Rh. Sp, Rh. Fl, Rh. Cr, Rh. Hex, Rh. Chf, Rh. EtAc and Rh. Aq resulted IC50 165,175, 265, 890, 92, 115 and 220 µg/mL respectively. In DPPH free radical scavenging assay, Rh. Sp and Rh. Fl showed comparable results with the positive control i.e., 63.34 ± 0.98 and 76.93 ± 1.13% scavenging at 1 mg/mL concentration (IC50 312 and 104 µg/mL) respectively. The percent ABTS radical scavenging potential exhibited by Rh. Sp and Rh. Fl (1000 µg/mL) were 82.58 ± 0.52 and 88.25 ± 0.67 with IC50 18 and 9 µg/mL respectively. Similarly in H2O2 scavenging assay, the Rh. Sp and Rh. Fl exhibited IC50 175 and 275 µg/mL respectively. CONCLUSION: The strong anticholinesterase and antioxidant activities of Rh. Sp, Rh. Fl and various fractions of R. hastatus support the purported ethnomedicinal uses and recommend R. hastatus as a possible remedy for the treatment of AD and neurodegenerative disorders.
Descritores: Butirilcolinesterase
Extratos Vegetais/farmacologia
Inibidores da Colinesterase/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Sequestradores de Radicais Livres/metabolismo
Concentração Inibidora 50
Doença de Alzheimer/tratamento farmacológico
Medicina Tradicional
Responsável: CL1.1 - Biblioteca Central

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Texto completo SciELO Chile
Texto completo
Id: biblio-950845
Autor: Ahmad, Sajjad; Ullah, Farhat; Ayaz, Muhammad; Zeb, Anwar; Ullah, Farman; Sadiq, Abdul.
Título: Antitumor and anti-angiogenic potentials of isolated crude saponins and various fractions of Rumexhastatus D. Don
Fonte: Biol. Res;49:1-9, 2016. ilus, graf, tab.
Idioma: en.
Resumo: BACKGROUND: Cancer, being the foremost challenge of the modern era and the focus of world-class investigators, gargantuan research is in progress worldwide to explore novel therapeutic for its management. The exploitation of natural sources has been proven to be an excellent approach to treat or minify the excessive angiogenesis and proliferation of cells. Similarly, based the ethnomedicinal uses and literature survey, the current study is designed to explore the anti-tumor and anti-angiogenic potentials of Rumex hastatus. Anti-tumor and anti-angiogenic activities were carried out using potato-disc model and chorioallantoic membrane (CAM) assay respectively. Moreover, R. hastatus was also assessed for antibacterial activity against Agrobacterium tumefaciens (tumor causing bacterial strain). The positive controls used in anti-tumor, anti-angiogenic and antibacterial activities were vincristine sulphate, dexamethasone and cefotaxime respectively. RESULTS: The crude saponins (Rh.Sp), methanolic extract (Rh.Cr) and other solvent extracts like n-hexane (Rh.Hex), chloroform (Rh.Chf), ethylacetate (Rh.EtAc) and aqueous fraction (Rh.Aq) exhibited notable anti-tumor and anti-angiogenic activities. In potato tumor assay, the chloroform and saponin fractions were observed to be the most effective showing 86.7 and 93.3 % tumor inhibition at 1000 µg/ml with IC50 values 31.6 and 18.1 µg/ml respectively. Similarly, these two samples i.e., chloroform and saponins also excelled among the entire test samples in anti-angiogenic evaluation exhibiting 81.6 % (IC50 = 17.9 µg/ml) and 78.9 % (IC50 = 64.9 µg/ml) at 1000 µg/ml respectively. In contrast, the antibacterial investigations revealed a negligible potential against A. tumefaciens. CONCLUSION: Based on our results we can claim that R. hastatus possesses both anti-tumor and anti-angiogenic potentials. In all of the solvent fractions, Rh.Chf and Rh.Sp were most effective against tumor and angiogenesis while having negligible activity against A. tumefaciens. It can be concluded that Rh.Chf and Rh.Sp might be potential targets in the isolation of natural product having anti-neoplastic action.
Descritores: Saponinas/farmacologia
Extratos Vegetais/farmacologia
Agrobacterium tumefaciens/efeitos dos fármacos
Inibidores da Angiogênese/farmacologia
-Tumores de Planta
Saponinas/isolamento & purificação
Fatores de Tempo
Testes de Sensibilidade Microbiana
Reprodutibilidade dos Testes
Análise de Variância
Tipo de Publ: Estudo de Avaliação
Responsável: CL1.1 - Biblioteca Central

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Texto completo
Texto completo
Id: biblio-1048649
Autor: Torres, Marina Portugal; Carlos, Lanamar de Almeida; Pedrosa, Marinalva Woods; Silva, Ana Paula Coelho Madeira; Silva, Ernani Clarete da; Ferraz, Leila de Castro Louback.
Título: Profile of phytochemistry and antioxidant activity of sorrel in function of organic fertilization and density of plantio / Perfil de fitoquímica e atividade antioxidante de azedinha em função da adubação orgânica e densidade de plantio
Fonte: Biosci. j. (Online);35(3):775-783, may./jun. 2019. tab, graf.
Idioma: en.
Resumo: The revival of non-conventional edible plants enables important gains in nutritional, social, cultural, economic, and environmental points of view. Among them, sorrel ­ Rumex acetosa L. ­ has been deemed pleasant by consumers due to its acid taste. As we do not have a lot of phytotechnical andnutritional information about this plant, the objective was to assess the influence of different spacing sets and cattle manure dosages on their physical-chemical characteristics and bioactive compounds content with antioxidant action. Randomized blocks with four repetitions was chosen as experimental design, using ascheme of subdivided plots, with five dosages of weather-beaten cattle manure in the plots and two sets of spacing in the subplots. Data was submitted to a variance analysis with two factors (two-way ANOVA). It was not verified any significant effect (P>0.05) in the interaction Dosage x Spacing. Fertilization dosages and spacing sets did not have any effect on color and total soluble solids average contents, humidity, titratable acidity, and phenolic compounds. Increasing dosages of organic fertilizer, up to 75 kg ha-1, reduced the plant's pH; above that amount, pH rose. Presence of anthocyanins and vitamin C was not detected. The total carotenoids average content was not influenced by the manure factor, and the plant presented greater total carotenoids content in the smallest spacing. Antioxidant activity [1.0 mg mL-1], although inferior to the standards that were used (BHT, vitamin C and quercetin), was quite representative. A conclusion was reached that fertilizing with weather-beaten cattle manure had an effect only on pH, and cropping spacing had an influence only on carotenoids content. Other phytochemicals and physical-chemical characteristics were not influenced in sorrel plants with different levels of fertilization and sets of spacing.

O resgate das plantas comestíveis não convencionais possibilita ganhos importantes do ponto de vista nutricional, social, cultural, econômico e ambiental. Dentre estas, a azedinha, Rumex acetosa L. tem agradado o consumidor por seu sabor ácido. Como são poucas as informações fitotécnicas e nutricionais sobre esta planta objetivou-se avaliar a influência de diferentes espaçamentos e doses de esterco bovino em suas características físico-químicas e no teor de compostos bioativos com função antioxidante. O delineamento experimental foi em blocos casualizados com quatro repetições, no esquema de parcelas subdivididas, sendo cinco doses de esterco curtido de gado nas parcelas e dois espaçamentos nas subparcelas. Os dados foram submetidos à análise de variância com dois fatores (two-way ANOVA). Não foi constatado efeito significativo (P>0,05) da interação Dose x Espaçamento. As doses de adubação e espaçamentos não afetaram a cor e os teores médios de sólidos solúveis totais, umidade, acidez titulável e compostos fenólicos. Doses crescentes de adubo orgânico, até 75 kg ha-1, reduziram o pH da planta, acima deste valor o pH elevou-se. Não foi detectada a presença de antocianinas e vitamina C. O teor médio de carotenoides totais não foi influenciado pelo fator esterco e no menor espaçamento a planta apresentou maior teor de carotenoides totais. A atividade antioxidante [1,0 mg mL-1], apesar de inferior aos padrões utilizados (BHT, vitamina C e quercetina), foi bastante representativa. Concluiu-se que a adubação com esterco de gado curtido afetou apenas o pH e que o espaçamento de cultivo exerceu influência apenas teor de carotenoides. Os demais fitoquímicos e características físico-químicas não foram influenciadas em plantas de azedinha com diferentes níveis de adubação e de espaçamento
Descritores: Plantas Comestíveis
Compostos Fitoquímicos
-Cultivos Agrícolas
Responsável: BR396.1 - Biblioteca Central

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Texto completo SciELO Brasil
Texto completo
Id: biblio-889228
Autor: Ding, Chang-hong; Wang, Qian-Bo; Guo, Shenglei; Wang, Zhen-yue.
Título: The improvement of bioactive secondary metabolites accumulation in Rumex gmelini Turcz through co-culture with endophytic fungi
Fonte: Braz. j. microbiol;49(2):362-369, Apr.-June 2018. graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Natural Science Foundation of Heilongjiang Province.
Resumo: Abstract Aspergillus sp., Fusarium sp., and Ramularia sp. were endophytic fungi isolated from Rumex gmelini Turcz (RGT), all of these three strains could produce some similar bioactive secondary metabolites of their host. However the ability to produce active components degraded significantly after cultured these fungi alone for a long time, and were difficult to recover. In order to obtain more bioactive secondary metabolites, the co-culture of tissue culture seedlings of RGT and its endophytic fungi were established respectively, and RGT seedling was selected as producer. Among these fungi, Aspergillus sp. showed the most significant enhancement on bioactive components accumulation in RGT seedlings. When inoculated Aspergillus sp. spores into media of RGT seedlings that had taken root for 20 d, and made spore concentration in co-culture medium was 1 × 104 mL-1, after co-cultured for 12 d, the yield of chrysophaein, resveratrol, chrysophanol, emodin and physcion were 3.52-, 3.70-, 3.60-, 4.25-, 3.85-fold of the control group. The extreme value of musizin yield was 0.289 mg, which was not detected in the control groups. The results indicated that co-culture with endophytic fungi could significantly enhance bioactive secondary metabolites production of RGT seedlings.
Descritores: Ascomicetos/metabolismo
Compostos Fitoquímicos/metabolismo
-Ascomicetos/isolamento & purificação
Ascomicetos/crescimento & desenvolvimento
Fatores de Tempo
Técnicas de Cocultura
Rumex/crescimento & desenvolvimento
Plântula/crescimento & desenvolvimento
Endófitos/isolamento & purificação
Endófitos/crescimento & desenvolvimento
Limites: Humanos
Responsável: BR1.1 - BIREME

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Texto completo
Id: biblio-996922
Autor: Velasquez Aliaga, Licet.
Título: Actividad antimicrobiana de extractos de franseria artemisioides, rumex palustris, baccharis latifolia, cetrum parqui y piper asperifolium frente a staphylococcus aureus, escherichia coli, pseudomonas aeruginosa y enterococcus faecalis / Antimicrobial activity of artemisioides, rumex palustris, baccharis latifolia, cetrum parqui and piper asperifolium against staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and enterococcus faecalis.
Fonte: La Paz; s.n; 2007. 1-77 p. ilus, tab, graf.
Idioma: es.
Tese: Apresentada a Universidad Mayor de San Andrés para obtenção do grau de Especialista.
Resumo: El presente trabajo tiene como finalidad la determinación de actividad antimicrobiana de extractos acuoso, etanólico, etéreo y diclorometánico de las partes aéreas de Rumex palustris (Qentu), la Baccharis latifolia (Chillka), la Franseria artemisioides (como altamisa), el Piper asperifolium (Matico) y Cestrum parqui (Andres Huaylla), frente a Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa y Enterococcus faecalis. Del trabajo realizado el extracto diclorometánico de Rumex palustris presenta actividad antimicrobiana contra Staphylococcus aureus y Enterococcus faecalis siendo inactivos frente a Escherichia coli y Pseudomonas aeruginosa. Con una concentración mínima inhibitoria para Staphylococcus aureus de 500 µg/ml y una concentración mínima bactericida de 1000 µg/ml. y se obtuvo una concentración mínima inhibitoria de 125 µg/ml y una concentración mínima bactericida de 250 µg/ml. para Enterococcus faecalis. El extracto etéreo de Franseria artemisioides presento actividad frente a Staphylococcus aureus y se obtuvo una concentración mínima inhibitoria de 500µg/ml. (AU)
Descritores: Extratos Vegetais
-Pseudomonas aeruginosa
Staphylococcus aureus
Enterococcus faecalis
Escherichia coli
Responsável: BR1.1 - BIREME

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Id: lil-159711
Autor: Moise, Micaela.
Título: Keynotes, su transcendencia y peculiaridad / Keynotes, its importance and singularity
Fonte: In: Liga Medicorum Homoeopathica Internationalis. Congreso de la Liga Medica Homeopatica Internacional. s.l, s.n, oct. 1992. p.309-13.
Idioma: es.
Conferência: Apresentado em: Congreso de la Liga Medica Homeopatica Internacional, 47, Cordoba, 27-31 oct. 1992.
Descritores: Sintomas Chaves
-Cocculus indicus/uso terapêutico
Conium/uso terapêutico
Crotalus horridus/uso terapêutico
Elaps corallinus/uso terapêutico
Ferrum Metallicum/uso terapêutico
Lycopodium clavatum/uso terapêutico
Rumex/uso terapêutico
Limites: Humanos
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR926.1 - Biblioteca Artur de Almeida Rezende Filho

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