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Id: biblio-998791
Autor: Shamala, Anas; Al-Hajri, Manal; Al-Wesabi, Mohammed Ali.
Título: Risk factors for periodontal diseases among Yemeni type II diabetic patients: a case-control study
Fonte: J. oral res. (Impresa);6(7):176-181, July 2017. tab.
Idioma: en.
Resumo: BACKGROUND: chronic periodontal diseases are one of diabetes mellitus complications. The present study aims to compare the periodontal status of type II diabetic patients to a control group and assess the role of risk factors in both groups. MATERIALS AND METHODS: A case-control study was conducted of 270 individuals (132 type II diabetics and 138 non-diabetics). Full mouth periodontal examination including plaque index, gingival bleeding, gingival recession, clinical attachment loss (CAL), tooth mobility, furcation involvement and the number of missing teeth. The case group was subdivided according to glycosylated hemoglobin (HbA1c) status (poorly controlled HbA1c >8 and well controlled HbA1c≤8) Likewise, the duration of diabetes mellitus as short or long duration (DM≤10 or >10). The diabetic group was also subdivided according to smoking and Khat chewing habits. RESULT: The severity of periodontal disease among type II diabetic patients were significantly higher compared to the control group regarding the plaque index 2.6 (1.6-4.3), bleeding on probing 3.5 (2.3-13.0), gingival recession 2.0 (1.2-3.4), furcation involvement 4.0 (2.3-6.7), clinical attachment loss 5.7 (3.1-10.5), tooth mobility 2.0 (1.2-3.4), and number of missing teeth 4.4 (2.3-8.5). In addition, poorly controlled type II DM and long duration had higher CAL and number of missing teeth than well-controlled DM and short duration. No significant differences were found between smokers/nonsmokers and Khat chewers/non-chewers among the diabetic group. CONCLUSION: Type II diabetic patients have severe periodontal destruction and tooth loss compared to non-diabetic people and there were no differences within the diabetic group in regards to smoking and Khat chewing habits.(
Descritores: Doenças Periodontais
Diabetes Mellitus Tipo 2/complicações
-Doenças Periodontais
Doenças Periodontais/etiologia
Fumar/efeitos adversos
Estudos de Casos e Controles
Índice de Placa Dentária
Hemorragia Gengival
Doença Crônica
Inquéritos e Questionários
Fatores de Risco
Catha
Retração Gengival
Limites: Seres Humanos
Masculino
Adulto
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Chile
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Id: biblio-954235
Autor: Abou-Elhamd, Alaa Sayed; Ageely, Hussein; Abu-Elmagd, Muhammad; Zayed, Ahmed Elzuhry.
Título: Catha edulis forsk mediates embryotoxic effects in rats: an experimental study / Catha edulis forsk modera los efectos embriotóxicos en ratas: un estudio experimental
Fonte: Int. j. morphol;36(3):1087-1094, Sept. 2018. graf.
Idioma: en.
Projeto: Jazan University.
Resumo: Catha edulis Forsk leaves (Khat) is a flowering plant. A high proportion of the adult population in the Arabian Peninsula and the Horn of Africa chews it for its mild stimulant effect. The aim of the current study was to investigate the embryotoxic and teratogenic effects of the Khat extract using 60 female pregnant rats. These were divided to a Khat extract-treated group and a control group. Methanolic extract of Khat was orally given to the treated group 4 days before mating and up to day 16 of pregnancy with a dose of 100 mg/kg. Our results showed that significant number of embryos of the Khat-treated mothers were malformed and different in size and shape compared to embryos from the mothers of the control group. At day 8 of pregnancy, malformed embryos had ill developed primitive layers. By day 10 of pregnancy, neural tube and the somite were not formed compared to the control embryos. At later stages of pregnancy, embryos of the Khat-treated mothers appeared severely abnormal with opened neural groove and visceral pouches. Disrupted normal neural tube development, undifferentiated brain vesicles, incomplete closure of the brain flexures were also observed in these embryos. Highly significant increase in the number of the resorbed embryos of the Khat-treated mothers were observed (P < 0.01). The resorbed embryos appeared as a cellular collection in their placenta with some of their decidua had no visible embryonic tissues. In conclusions, Khat induced embryotoxic effects as well as severely affected the early normal embryonic development in rat.

Catha edulis (Khat) es una planta floreciente. Una alta proporción de la población adulta en la Península Arábiga y el Cuerno de África la mastica por su efecto estimulante. El objetivo del presente estudio fue investigar los efectos embriotóxicos y teratogénicos del extracto de Khat utilizando 60 ratas hembras preñadas. Estas se dividieron en un grupo tratado con extracto de Khat y un grupo control. El extracto metanólico de Khat se administró por vía oral al grupo tratado 4 días antes del apareamiento y hasta el día 16 de preñez con una dosis de 100 mg / kg. Los resultados mostraron que una cantidad significativa de embriones de las madres tratadas con Khat tenían malformaciones y eran diferentes en tamaño y forma en comparación con los embriones de las madres del grupo control. En el día 8 de preñez, los embriones malformados tenían capas primitivas mal desarrolladas. Para el día 10 de preñez, el tubo neural y el somito no se formaron en comparación con los embriones del grupo control. En etapas posteriores de la preñez, los embriones de las madres tratadas con Khat parecían severamente anormales con surcos neurales abiertos y bolsas viscerales. También se observaron alteraciones en el desarrollo normal del tubo neural, vesículas cerebrales indiferenciadas y el cierre incompleto de las flexiones cerebrales en estos embriones. Se observó un aumento altamente significativo en el número de embriones reabsorbidos de las madres tratadas con Khat (P <0,01). Los embriones reabsorbidos aparecieron como una colección celular en su placenta con algunas de sus deciduas sin tejidos embrionarios visibles. Khat indujo efectos embriotóxicos y afectó severamente el desarrollo embrionario normal temprano en la rata.
Descritores: Extratos Vegetais/toxicidade
Catha/química
Embrião de Mamíferos/efeitos dos fármacos
-Teratogênios
Ratos Sprague-Dawley
Limites: Animais
Feminino
Gravidez
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-907732
Autor: Al-Wesabi, Mohammed Ali; Al-Hajri, Manal; Shamala, Anas; Al-Sanaani, Saba.
Título: Tongue lesions and anomalies in a sample of Yemeni dental patients: a cross-sectional study
Fonte: J. oral res. (Impresa);6(5):121-126, May 2017. tab.
Idioma: en.
Resumo: Background: Tongue examination helps considerably in diagnosing the underlying health state of the patient, especially in the cases of chronic diseases. The aim of this study is to determine the prevalence and association of tongue lesions with risk factors among Yemeni dental patients. Materials and methods: An oral medicine specialist examined all 713 patients attending the dental polyclinics at the University of Sciences and Technology (Sana'a, Yemen). The examination sheet was designed to include information related to patient characteristics, medical history, dental history, habits, and tongue lesions. Results: The prevalence of tongue lesions among the examined participants was 76.5 percent. The prevalence rate was 83.4 percent for males and 69.2 percent for females. Fissured tongue was the most common condition. Logistic regression analysis indicated that older age (p<0.001), gender (p=0.007), khat chewing (p<0.001), and smoking (p=0.001) were associated with fissured tongue; gender (p<0.001), khat chewing (p<0.001), and smoking (p<0.001) were associated with hairy tongue; and older age (p<0.001), khat chewing (p=0.001), and smoking (p=.021) were associated with coated tongue. Conclusion: The prevalence of tongue lesions among this sample of Yemeni population was 76.5 percent; fissured tongue and hairy tongue were the most prevalent lesions. Khat chewing, smoking, and older age were the associated risk factors for many of studied lesions and anomalies.
Descritores: Língua Fissurada/epidemiologia
Língua Pilosa/epidemiologia
-Distribuição por Idade e Sexo
Estudos Transversais
Catha/efeitos adversos
Modelos Logísticos
Análise Multivariada
Prevalência
Fatores de Risco
Fumar/efeitos adversos
Doenças da Língua/epidemiologia
Iêmen/epidemiologia
Limites: Masculino
Feminino
Seres Humanos
Adolescente
Adulto
Pré-Escolar
Criança
Adulto Jovem
Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: CL30.1 - Biblioteca


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Texto completo SciELO Brasil
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Id: lil-605922
Autor: Hagel, Jillian M; Krizevski, Raz; Kilpatrick, Korey; Sitrit, Yaron; Marsolais, Frédéric; Lewinsohn, Efraim; Facchini, Peter J.
Título: Expressed sequence tag analysis of khat (Catha edulis) provides a putative molecular biochemical basis for the biosynthesis of phenylpropylamino alkaloids
Fonte: Genet. mol. biol;34(4):640-646, 2011. ilus.
Idioma: en.
Resumo: Khat (Catha edulis Forsk.) is a flowering perennial shrub cultivated for its neurostimulant properties resulting mainly from the occurrence of (S)-cathinone in young leaves. The biosynthesis of (S)-cathinone and the related phenylpropylamino alkaloids (1S,2S)-cathine and (1R,2S)-norephedrine is not well characterized in plants. We prepared a cDNA library from young khat leaves and sequenced 4,896 random clones, generating an expressed sequence tag (EST) library of 3,293 unigenes. Putative functions were assigned to > 98 percent of the ESTs, providing a key resource for gene discovery. Candidates potentially involved at various stages of phenylpropylamino alkaloid biosynthesis from L-phenylalanine to (1S,2S)-cathine were identified.
Descritores: Catha
Fenilpropanolamina
-Sequência de Bases
Plantas Medicinais
Sitios de Sequências Rotuladas
Responsável: BR1.1 - BIREME


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Texto completo SciELO Cuba
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Id: lil-507107
Autor: Fernández Pérez, Felipe Segundo; Lorié González, Alfredo F; Arias Gallardo, Ana Isis.
Título: Algunas consideraciones farmacológicas y medicolegales relativas al consumo de Catha edulis Forsk (Khat) / Some pharmacological and medicolegal considerations related to the consumption of Catha edulis Forsk (Khat)
Fonte: Rev. cuba. estomatol;45(1), ene.-mar 2008.
Idioma: es.
Resumo: Se realiza una revisión bibliográfica acerca de la historia y antecedentes históricos del consumo de la Catha edulis, Khat (Chat en amárico) en Etiopía (hoy Eritrea), un análisis botánico-farmacológico de sus componentes químicos y sus efectos sobre el organismo humano, tanto del punto de vista farmacológico como medicolegal y social.

A bibliographic review of the history and antecedents of the consumption of Catha edulis, Khat (Chat in Amaric) in Ethiopia (Erithrea today), a botanical and pharmacological analysis of its chemical components and of its effects on the human body, from the pharmacological, medicolegal and social point of view, are made.
Descritores: Catha/efeitos adversos
Catha/química
Responsável: CU1.1 - Biblioteca Médica Nacional



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