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Id: biblio-1038113
Autor: Ke, Yixin; Yu, Kaihang; Zeng, Weiliang; Lian, Guojun.
Título: Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
Fonte: Acta cir. bras;34(7):e201900706, 2019. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the protective roles of pyracantha fortune fruit extract (PFE) on acute renal toxicity induced by cadmium chloride (CdCl2) in rats. Methods: Rats were pretreated with PFE and consecutively injected with CdCl2 (6.5 mg/kg) for 5 days. Results: The concentration of Cd, kidney weight, malondialdehyde (MDA), and nitric oxide (NO) production were remarkably increased in CdCl2 group as well as the levels of plasma uric acid, urea, and creatinine (P < 0.001). However, the body weight and glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione peroxidase (GR) levels were markedly reduced by CdCl2 treatment (P < 0.001). Histological manifestations of renal tissue showed severely adverse changes. Moreover, CdCl2 treatment significantly decreased the B-cell lymphoma-2 (Bcl-2) expression while increased the Bcl-2-Associated X Protein (Bax), tumor necrosis factor-α (TNF-α) expression (P < 0.001). Additionally, the expression of Nrf2/Keap 1 related proteins Keap-1 gained a significant increase (P < 0.001), whereas the Nrf2, HO-1, γ-GCS, GSH-Px and NQO1 expression decreased by CdCl2 treatment (P < 0.05). These rats were pretreated with PFE to improve the changes caused by CdCl2 treatment. Conclusion: PFE could protect the kidney against acute renal toxicity induced by CdCl2.
Descritores: Extratos Vegetais/farmacologia
Cloreto de Cádmio/toxicidade
Pyracantha/química
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Rim/efeitos dos fármacos
Antioxidantes/farmacologia
-Superóxido Dismutase/metabolismo
Catalase/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Modelos Animais de Doenças
Frutas/química
Glutationa/metabolismo
Glutationa Peroxidase/metabolismo
Rim/patologia
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME



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