Base de dados : LILACS
Pesquisa : B01.650.940.800.575.912.250.885.444 [Categoria DeCS]
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Texto completo SciELO Brasil
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Id: biblio-886660
Autor: LOURITH, NATTAYA; KANLAYAVATTANAKUL, MAYUREE; CHAIKUL, PUXVADEE; CHANSRINIYOM, CHAISAK; BUNWATCHARAPHANSAKUN, PICHAPORN.
Título: In vitro and cellular activities of the selected fruits residues for skin aging treatment
Fonte: An. acad. bras. ciênc;89(1,supl):577-589, May. 2017. tab, graf.
Idioma: en.
Projeto: National Research Council of Thailand.
Resumo: ABSTRACT Peel extracts of litchi and rambutan, and that of tamarind seed coat were investigated in relation to their utility in skin-aging treatments. Standardized extracts of tamarind were significantly (p < 0.05) more efficient at O2 •- scavenging (IC50 = 27.44 ± 0.09) than those of litchi and rambutan (IC50 = 29.57 ± 0.30 and 39.49 ± 0.52 μg/ml, respectively) and the quercetin standard (IC50 = 31.88 ± 0.15 μg/ml). Litchi extract proved significantly (p < 0.05) more effective for elastase and collagenase inhibition (88.29 ± 0.25% and 79.46 ± 0.92%, respectively) than tamarind (35.43 ± 0.68% and 57.69 ± 5.97%) or rambutan (31.08 ± 0.38% and 53.99 ± 6.18%). All extracts were safe to human skin fibroblasts and inhibit MMP-2, with litchi extract showing significantly (p < 0.01) enhanced inhibition over the standard, vitamin C (23.75 ± 2.74% and 10.42 ± 5.91% at 0.05 mg/ml, respectively). Extracts suppress melanin production in B16F10 melanoma cells through inhibition of tyrosinase and TRP-2, with litchi extract being the most potent, even more so than kojic acid (standard). These results highlight the potential for adding value to agro-industrial waste, as the basis for the sustainable production of innovative, safe, anti-aging cosmetic products.
Descritores: Extratos Vegetais/farmacologia
Envelhecimento da Pele/efeitos dos fármacos
Tamarindus/química
Sapindaceae/química
Litchi/química
Antioxidantes/farmacologia
-Fenóis/farmacologia
Administração Cutânea
Depuradores de Radicais Livres/farmacologia
Cosméticos
Fibroblastos/efeitos dos fármacos
Frutas/química
Antioxidantes/isolamento & purificação
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-886889
Autor: QUEIROZ, ESTELA R; ABREU, CELESTE M P DE; ROCHA, DENISE A; SOUSA, RAIMUNDO V DE; FRÁGUAS, RODRIGO M; BRAGA, MARIANA A; CÉSAR, PEDRO H S.
Título: Lychee (Litchi chinensis Sonn) peel flour: effects on hepatoprotection and dyslipidemia induced by a hypercholesterolemic diet
Fonte: An. acad. bras. ciênc;90(1):267-281, Mar. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Dyslipidemias are associated with the incidence of cardiovascular diseases, obesity, diabetes, hypertension and hepatic steatosis, being the cause of morbidity and mortality. This study investigated the effects of lychee peel flour (PF) on serum levels of total cholesterol (TC), low-density lipoprotein (LDL-c), triacylglycerols (TAG) and various parameters related to obesity, in rats fed a hypercholesterolemic diet. Therefore, 20 male rats were used. In the first 21 days, the animals were fed a hypercholesterolemic diet, except for control group. In the following 21 days, their diets were modified, and they received a standard diet (Control); hypercholesterolemic (Hyper); hypercholesterolemic + 5% PF (PF5) and hypercholesterolemic + 10% PF (PF10). The results revealed that PF intake attenuated weight gain, reduced body mass index, glucose and the levels of TAG, TC, LDL-c, hepatic enzymes and leptin, besides the percentage of hepatic lipids, liver lipid peroxidation and frequency of severe steatosis. Histological studies of the aorta did not show the formation of the atheromatous plaque. These results reinforce its potential to reduce the risk of diseases associated with obesity.
Descritores: Litchi/química
Fígado Gorduroso/prevenção & controle
Dieta Hiperlipídica
Hipercolesterolemia/prevenção & controle
Fígado/efeitos dos fármacos
-Aspartato Aminotransferases/sangue
Peroxidação de Lipídeos
Colesterol/sangue
Ratos Wistar
Substâncias Protetoras/farmacologia
Alanina Transaminase/sangue
Fígado Gorduroso/dietoterapia
Fígado Gorduroso/sangue
Hipercolesterolemia/dietoterapia
Hipercolesterolemia/sangue
Lipoproteínas LDL/sangue
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME



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