||Han, Xufeng; Shao, Haiyan; Wang, Yi; Hu, Ankang; Chen, Renjin; Chen, Quangang.|
||Composition of the bacterial community in the gastrointestinal tract of Kunming mice|
||Electron. j. biotechnol;43:16-22, Jan. 2020. tab, graf.
||Scientific Research Foundation for the Excellent Talents of Xuzhou Medical University; . Natural Science Foundation of Jiangsu province; . Nature Science Foundation of Jiangsu Higher Education Institutions of China; . Applied Basic Research Program of Xuzhou Jiangsu.
||Background: The intestinal bacterial community has an important role in maintaining human health. Dysbiosis is a key inducer of many chronic diseases including obesity and diabetes. Kunming mice are frequently used as a model of human disease and yet little is known about the bacterial microbiome resident to the gastrointestinal tract. Results: We undertook metagenomic sequencing of the luminal contents of the stomach, duodenum, jejunum, ileum, cecum, colon, and rectum of Kunming mice. Firmicutes was the dominant bacterial phylum of each intestinal tract and Lactobacillus the dominant genus. However, the bacterial composition differed among the seven intestinal tracts of Kunming mice. Compared with the small intestine, the large intestine bacterial community of Kunming mice is more stable and diverse. Conclusions: To our knowledge, ours is the first study to systematically describe the gastrointestinal bacterial composition of Kunming mice. Our findings provide a better understanding of the bacterial composition of Kunming mice and serves as a foundation for the study of precision medicine.|
||Bactérias/isolamento & purificação|
RNA Ribossômico 16S
Reação em Cadeia da Polimerase
Sequenciamento de Nucleotídeos em Larga Escala
Firmicutes/isolamento & purificação
Lactobacillus/isolamento & purificação
||CL1.1 - Biblioteca Central|