Base de dados : LILACS
Pesquisa : B04.613.807.124.500 [Categoria DeCS]
Referências encontradas : 21 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 3 ir para página          

  1 / 21 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: lil-734411
Autor: Pogo, Beatriz GT.
Título: El virus del tumor de mama humano (HMTV) en 2014
Fonte: Medicina (B.Aires);74(5):415-417, oct. 2014.
Idioma: es.
Descritores: Adenocarcinoma/virologia
Neoplasias da Mama/virologia
Vírus do Tumor Mamário do Camundongo/genética
Infecções por Retroviridae/virologia
Infecções Tumorais por Vírus/virologia
-Retrovirus Endógenos/genética
Neoplasias Mamárias Animais/virologia
Homologia de Sequência do Ácido Nucleico
Limites: Animais
Feminino
Seres Humanos
Camundongos
Tipo de Publ: Editorial
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


  2 / 21 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Id: lil-354252
Autor: Ecuador. Ministerio de Salud Pública.
Título: Manual de normas técnicas y procedimientos de planificación familiar y detección oportuna de cáncer cérvico uterino y mamario / Manual of practical standardses and procedures of familiar planning and opportune detection of uterine and mammary cérvico cancer.
Fonte: Quito; MSP; 1992. 171 p. tab.
Idioma: es.
Descritores: Anticoncepção
Equador
Planejamento Familiar
Infertilidade
Vírus do Tumor Mamário do Camundongo
Responsável: EC1.1 - BICME - Banco de Información Científico-Médica
EC111.2; 614+618.1, M665


  3 / 21 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Id: lil-325250
Autor: Aliaga Bruch, SandraF.
Título: ¿Es la salud sexual y reproductiva un tema clave en las PROPUESTAS POLITICAS? Los partidos responden / Is a key subject in the POLITICAL PROPASALS the sexual and reproductive health? The parties answer.
Fonte: La Paz; PROCOSI; mayo 1997. [21] p. tab.
Idioma: es.
Resumo: El documento trata sobre la salud sexual y reproductiva,derechos sexuales,mortalidad materna,planificacion familiar,prenatal,posnatal,cancer cervico,sida,educacion sexual.
Descritores: Planejamento Familiar
Mortalidade Materna
Cuidado Pós-Natal
Diagnóstico Pré-Natal
Educação Sexual
-Síndrome de Imunodeficiência Adquirida
Bolívia
Vírus do Tumor Mamário do Camundongo
Neoplasias
Limites: Seres Humanos
Masculino
Feminino
Responsável: BO2.1 - Centro de Información y Documentación
BO2; WQ205 A398s


  4 / 21 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Id: lil-321743
Autor: Anon.
Título: Retrovirus-host interactions. The mouse mammary tumor virus model
Fonte: Medicina (B.Aires);57(supl.2):43-52, 1997.
Idioma: en.
Resumo: Mouse mammary tumor virus (MMTV) is a retrovirus which can induce mammary carcinomas in mice late in life by activation of proto-oncogenes after integration in their vicinity. Surprisingly, it requires a functional immune system to achieve efficient infection of the mammary gland. This requirement became clear when it was discovered that it has developed strategies to exploit the immune response. Instead of escaping immune detection, it induces a vigorous polyclonal T-B interaction which is required to induce a chronic infection. This is achieved by activating and then infecting antigen presenting cells (B cells), expressing a superantigen on their cell surface and triggering unlimited help by the large number of superantigen-specific T cells. The end result of this strong T-B interaction is the proliferation and differentiation of the infected B cells leading to their long term survival.
Descritores: Infecções por Retroviridae/imunologia
Infecções Tumorais por Vírus/imunologia
Integração Viral/imunologia
Neoplasias Mamárias Experimentais/imunologia
Vírus do Tumor Mamário do Camundongo/imunologia
-Linfócitos B
Proto-Oncogenes
Superantígenos/imunologia
Linfócitos T
Limites: Animais
Feminino
Camundongos
Responsável: BR1.1 - BIREME


  5 / 21 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Id: lil-320010
Autor: Ross, Susan R; Dzuris, John L; Golovkina, Tatyana V; Clemmons, Wayne C; van den Hoogen, Bernadette.
Título: Mouse mammary tumor virus (MMTV), a retrovirus that exploits the immune system. Genetics of susceptibility to MMTV infection
Fonte: Medicina (B.Aires);57(Supl.2):34-42, Aug. 1997.
Idioma: en.
Resumo: All animals, including humans, show differential susceptibility to infection with viruses. Study of the genetics of susceptibility or resistance to specific pathogens is most easily studied in inbred mice. We have been using mouse mammary tumor virus (MMTV), a retrovirus that causes mammary tumors in mice, to study virus/host interactions. These studies have focused on understanding the mechanisms that determine genetic susceptibility to MMTV-induced mammary tumors, the regulation of virus gene expression in vivo and how the virus is transmitted between different cell types. We have found that some endogenous MMTVs are only expressed in lymphoid tissue and that a single base pair change in the long terminal repeat of MMTV determines whether the virus is expressed in mammary gland. This expression in lymphoid cells is necessary for the infectious cycle of MMTV, and both T and B cells express and shed MMTV. Infected lymphocytes are required not only for the initial introduction of MMTV to the mammary gland, but also for virus spread at later times. Without this virus spread, mammary tumorigenesis is dramatically reduced. Mammary tumor incidence is also affected by the genetic background of the mouse and at least one gene that affects infection of both lymphocytes and mammary cells has not yet been identified. The results obtained from these studies will greatly increase our understanding of the genetic mechanisms that viruses use to infect their hosts and how genetic resistance to such viruses in the hosts occurs.
Descritores: Predisposição Genética para Doença
Infecções por Retroviridae/genética
Infecções Tumorais por Vírus/genética
Nucleotídeos/genética
Vírus do Tumor Mamário do Camundongo/genética
Gammaretrovirus/genética
-Linfócitos B
CAMUNDONGOS ENDOGAMICOS CABDOMENABDOMINAL INJURIESBL
Infecções por Retroviridae/imunologia
Infecções Tumorais por Vírus/imunologia
Integração Viral/genética
Integração Viral/imunologia
Sequência de Carboidratos/genética
Linfócitos T
Vírus do Tumor Mamário do Camundongo/imunologia
Gammaretrovirus/imunologia
Limites: Animais
Camundongos
Responsável: BR1.1 - BIREME


  6 / 21 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Id: lil-320007
Autor: Pogo, Beatriz G. T; Holland, James F; Wang, Yue; Melana, Stella M; Pelisson, Isabelle; Liu, Bingren; Go, Vera; Bleiweiss, Ira.
Título: En busca de secuencias retrovirales relacionadas con el cáncer de mama humano / Searching for retroviral sequences related to human breast cancer
Fonte: Medicina (B.Aires);57(Supl.2):75-80, Aug. 1997.
Idioma: es.
Resumo: The participation of viruses in mammary carcinogenesis has been largely studied in animals. A model similar to the mouse mammary tumor virus (MMTV) was previously proposed. Several lines of research supported the participation of MMTV in human breast cancer, but these evidences were contradicted when further research was performed. One major issue was the presence of human endogenous retroviral sequences that confounded results reporting MMTV-like sequences in human breast cancer. To overcome this problem we selected a 660 bp sequence of the MMTV env gene with low homology to endogenous sequences and search for a sequence to it using the polymerase chain reaction (PCR). The sequence was found in 38 of the human breast cancers and in 2 of the normal breasts studied. The sequence was not present in tumors from other organs. It was 90-98 homologous to MMTV and only 18 to human endogenous retrovirus (HERV) K-10. It was also detected in some of the positive tumors by Southern blot hybridization using one of the cloned 660 bp as a probe. Using reverse transcriptase PCR, it was possible to demonstrate that the 660 bp sequence is expressed in the majority of the tumors. Also, preliminary experiments revealed that sequences related to the LTR and gag genes of MMTV were present in the DNA of breast tumors. The origin of the MMTV-like sequences in tumor DNA could be the result of integrated MMTV-like sequences derived from a human mammary virus or may represent unknown endogenous sequences that can only be detected in breast tumors.
Descritores: Neoplasias da Mama
Infecções por Retroviridae/genética
Infecções Tumorais por Vírus/genética
Neoplasias Mamárias Experimentais/genética
Vírus do Tumor Mamário do Camundongo/genética
-Neoplasias da Mama
Substâncias de Crescimento/genética
Limites: Seres Humanos
Animais
Camundongos
Responsável: BR1.1 - BIREME


  7 / 21 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: lil-317323
Autor: Melana, Stella M; Picconi, Maria Alejandra; Rossi, Carlos; Mural, Juan; Alonio, Lidia Virginia; Teyssie, Angelica; Holland, James F; Pogo, Beatriz G. T.
Título: Deteccion de secuencias homologas al gen env del virus del Tumor Mamario Murino (MMTV) en cancer de mama de pacientes argentinas / Detection of murine mammary tumor virus (MMTV) env gene-like sequences in breast cancer from Argentine patients
Fonte: Medicina (B.Aires);62(4):327-323, 2002. ilus, tab.
Idioma: es.
Resumo: In the last years research on the possible viral etiology of human breast cancer has been revised. Previous studies have demonstrated the presence of a Mouse Mammary Tumor Virus (MMTV) env gene-like sequence in about 38% of breast cancers from American and Italian women; these sequences are generally absent in other tumors and in normal mammary tissue. In the present study we have analyzed the presence of a 250-bp sequence of the MMTV env gene in breast cancer biopsies from Argentine patients. The retroviral fragment was present in 31% (23/74) of the tumors, only in one normal mammary tissue and in none of the fibroadenomas analYzed. Peripheral blood mononuclear cells (PBMC) from 46 cancer patients were also analyzed; the sequence was found in 17% (2/12) of the PBMC from env positive tumor patients and in 3% (1/34) of the env negatives. The results from Argentine samples are similar to those from USA and Italy, where the breast cancer incidence is alike. These findings support the hypothesis of a viral agent involved in the genesis of this neoplasia and encourage the continuation of these studies
Descritores: Neoplasias da Mama
Genes env
Vírus do Tumor Mamário do Camundongo
Infecções por Retroviridae
Infecções Tumorais por Vírus
-Argentina
Sequência de Bases
Homologia de Sequência
Limites: Seres Humanos
Animais
Feminino
Camundongos
Responsável: BR1.1 - BIREME


  8 / 21 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Id: lil-275050
Autor: Pasqualini, Christiane Dosne.
Título: Nuevos descubrimientos en cancer experimental / New breakthroughs in cancer research
Fonte: Medicina (B.Aires);60(supl.2):1-3, 2000.
Idioma: es.
Conferência: Apresentado em: Simposio Internacional: Nuevas Perspectivas en Oncología, Buenos Aires, 7-8 ago. 2000.
Descritores: Neoplasias Mamárias Experimentais/imunologia
Vírus do Tumor Mamário do Camundongo/imunologia
Infecções por Retroviridae/imunologia
Limites: Animais
Camundongos
Responsável: BR1.1 - BIREME


  9 / 21 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Id: lil-263180
Autor: Selgrad Farago, Stefan; García Tamayo, Jorge.
Título: Carcinoma mamario murino transplantable (Ca.-MMT-INHRR-984): modelo biológico para el estudio de la oncogénesis viral / Transplantation muridae mammary (Ca.-MMT-INHRR-984): biological model to viral oncogenesis study
Fonte: Rev. Inst. Nac. Hig;28:9-14, 1997. ilus.
Idioma: es.
Resumo: En este trabajo se describe la citología, histología y ultraestructura del tumor mamario transplantable (Ca-MMt-INHRR-984) de la cepa de ratones N: NIH (s) desarrollado a nivel intraperiritoneal y subcutáneo. Las células tumorales muestran cambios ultraestructurales relacionados con su actividad metabólica y se identificaron en el tejido signos de necrosis y degeneración en algunas células. Tanto en el tumor ascítico como en las células del tumor subcutáneo se vieron partículas virales correspodientes a retrovirus tipo B. Se discute la importancia de los hallazgos en relación con el conocimiento sobre la relación entre el MMTV y partículas similares detectadas en la leche y en las células del cáncer mamario humano, por lo que se plantea la utilidad del modelo biológico presentado para el estudio de la oncogénesis
Descritores: Gammaretrovirus
Camundongos/anatomia & histologia
Modelos Biológicos
Oncogenes
Vírus do Tumor Mamário do Camundongo/ultraestrutura
Limites: Animais
Camundongos
Tipo de Publ: Relatos de Casos
Responsável: VE1.1 - Biblioteca Humberto Garcia Arocha


  10 / 21 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Id: lil-241293
Autor: Pasqualini, Christiane Dosne.
Título: Cuatro décadas de oncoinmunología experimental / Four decades of experimental oncoimmunology
Fonte: Bol. Acad. Nac. Med. B.Aires;76(2):429-44, jul.-dic. 1998.
Idioma: es.
Conferência: Apresentado em: Sesión Pública Ordinaria, Buenos Aires, 2 nov. 1998.
Resumo: En nuestro laboratorio, trabajando principalmente con ratones endocriados en un bioterio propio y adaptándonos a los sucesivos descubrimientos en cáncer experimental, se fueron añadiendo distintos subtemas, los cuales fueron surgiendo de los resultados obtenidos. Así fue que empezando con la inducción de leucemia en ratones por diversos procedimientos en vista a descubrir un virus leucemogénico humano, se llegó a estudiar el crecimiento tumoral y la relación tumor-huésped con especial énfasis en la resistencia concomitante. La comparación con la relación materno-fetal llevó al estudio de la tolerancia inmunológica en el recién nacido y de la inmunorregulación como base de la ontogenia del sistema inmune. Se contemplaron luego las alteraciones inmunológicas provocadas por estimulaciones antigénicas crónicas tanto en la madre como en el recién nacido, con el afán de encontrar una explicación al pico de leucemia observado en niños de poca edad. Estudiando los superantígenos asociados al MMTV (murine mammary tumor virus) se detectó una variante viral con deleción de determinados antígenos Vß del receptor T y fuerte inducción de tumores de mama en multipreñadas. Por otro lado, y por serendipismo, se descubrió que en ratones los progestágenos inducen cáncer de mama, dando origen a un modelo experimental que permite comparar el crecimiento neoplásico hormono-dependiente con el hormono-independiente o autónomo. De esta manera, después de tantos años, se reencuentran los subtemas tumorales y virales con los inmunológicos.
Descritores: Transformação Celular Neoplásica
Imunidade Inata
Inibidores da Angiogênese
Leucemia Experimental/imunologia
Vírus do Tumor Mamário do Camundongo/imunologia
-Testes de Carcinogenicidade
Citotoxicidade Imunológica
Reação Enxerto-Hospedeiro
Imunidade Materno-Adquirida
Ativação Viral
Limites: Seres Humanos
Animais
Gravidez
Camundongos
Responsável: AR1.1 - Biblioteca Rafael Herrera Vegas



página 1 de 3 ir para página          
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde