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Id: lil-555501
Autor: Celik, V. Kenan; Sari, Ismail; Engin, Aynur; Gürsel, Yildiz; Aydin, Hüseyin; Bakir, Sevtap.
Título: Determination of serum adenosine deaminase and xanthine oxidase levels in patients with crimean-congo hemorrhagic fever
Fonte: Clinics;65(7):697-702, 2010. tab.
Idioma: en.
Resumo: OBJECTIVE: Crimean-Congo hemorrhagic fever is an acute viral hemorrhagic fever with a high mortality rate. Despite increasing knowledge about hemorrhagic fever viruses, little is known about the pathogenesis of Crimean-Congo hemorrhagic fever. In this study, we measured serum adenosine deaminase and xanthine oxidase levels in Crimean-Congo hemorrhagic fever patients. METHODS: Serum adenosine deaminase levels were measured with a sensitive colorimetric method described by Giusti and xanthine oxidase levels by the method of Worthington in 30 consecutive hospitalized patients (mean age 42.6 ± 21.0). Laboratory tests confirmed their diagnoses of Crimean-Congo hemorrhagic fever. Thirty-five subjects (mean age 42.9 ± 19.1) served as the control group. RESULTS: There was a significant difference in adenosine deaminase and xanthine oxidase levels between cases and controls (p<0.05). However, neither adenosine deaminase nor xanthine oxidase levels varied with the severity of disease in the cases assessed (p>0.05). CONCLUSION: Adenosine deaminase and xanthine oxidase levels were increased in patients with Crimean-Congo hemorrhagic fever. Elevated serum xanthine oxidase activity in patients with Crimean-Congo hemorrhagic fever may be associated with reactive oxygen species generated by the xanthine/xanthine oxidase system during inflammatory responses. In addition, elevated lipid peroxidation may contribute to cell damage and hemorrhage. The association of cell damage and hemorrhage with xanthine oxidase activity should be further investigated in large-scale studies.
Descritores: Adenosina Desaminase/sangue
Vírus da Febre Hemorrágica da Crimeia-Congo/enzimologia
Xantina Oxidase/sangue
-Biomarcadores/sangue
Estudos de Casos e Controles
Distribuição de Qui-Quadrado
Colorimetria
Vírus da Febre Hemorrágica da Crimeia-Congo/imunologia
Estudos Prospectivos
Índice de Gravidade de Doença
Turquia
Limites: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: lil-317676
Autor: Pinheiro, Francisco P; Rosa, Jorge F. S. Travassos da.
Título: Febres hemorrágicas viróticas (Dengue, Ébola, Sabiá, Marburg, Hantaan e outros) / Virotic hemorrhagic fevers (Dengue, Ebola, Tacaribe complex viruses, Marburg virus disease, Hantaan viruses and others)
Fonte: In: Veronesi, Ricardo; Focaccia, Roberto. Tratado de infectologia: v.1. Säo Paulo, Atheneu, 2002. p.261-276, tab, graf. (BR)
Idioma: pt.
Símbolo: BR.
Descritores: Febres Hemorrágicas Virais
-Arenavirus do Novo Mundo
Dengue Grave
Doença pelo Vírus Ebola
Febre Hemorrágica com Síndrome Renal
Febre Hemorrágica Americana
Febre Hemorrágica de Omsk
Doença da Floresta de Kyasanur
Febre Lassa
Doença do Vírus de Marburg
Febre do Vale de Rift
Vírus da Febre Hemorrágica da Crimeia-Congo
Responsável: BR31.1 - SIDC - Serviço de Informação e Documentação Científica
BR31.1; WC100, V599t, 2.ed., v.1



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