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Referências encontradas : 30 [refinar]
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Id: biblio-1052721
Autor: Acosta H, Nicolás; Tobar U, Daniel; Olivares C, Roberto; Dabanch P, Jeannette; Norambuena G, Mackarenna.
Título: Chikungunya: educación y prevención como pilares fundamentales para enfermedad sin cura / Chikungunya: education and prevention as fundamental support for disease without cure
Fonte: Rev. Hosp. Clin. Univ. Chile;30(2):109-119, 2019. ilus.
Idioma: es.
Resumo: Chikungunya virus is an alphavirus, member of the Togaviridae family, first discovered in Africa in 1952. Since then it caused sporadic outbreaks in Africa and Asia, but since 2000, outbreaks had been more frequent, being identified in Europe, America and the Caribbean. Chikungunya virus can cause chronic and incapacitating arthralgia, with an important morbidity, being considered as a relevant re-emerging public health problem. This review intends to update our knowledge in epidemiology, transmission, pathogenesis, treatment and vaccination strategies of Chikungunya virus. (AU)
Descritores: Vírus Chikungunya/patogenicidade
Febre de Chikungunya/prevenção & controle
-Alphavirus
Febre de Chikungunya/fisiopatologia
Febre de Chikungunya/terapia
Febre de Chikungunya/epidemiologia
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Revisão
Responsável: CL36.1 - Biblioteca Hospital Clínico


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Texto completo SciELO Brasil
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Id: biblio-839330
Autor: Mota, Mânlio Tasso de Oliveira; Terzian, Ana Carolina; Silva, Maria Luana Cristiny Rodrigues; Estofolete, Cássia; Nogueira, Maurício Lacerda.
Título: Mosquito-transmitted viruses - the great Brazilian challenge
Fonte: Braz. j. microbiol;47(supl.1):38-50, Oct.-Dec. 2016. graf.
Idioma: en.
Resumo: ABSTRACT Arboviruses pose a serious threat to public health worldwide, overloading the healthcare system and causing economic losses. These viruses form a very diverse group, and in Brazil, arboviruses belonging to the families Flaviviridae and Togaviridae are predominant. Unfortunately, the number of arboviruses increases in proportion with factors such as deforestation, poor sanitation, climate changes, and introduction of new viruses like Chikungunya virus and Zika virus. In Brazil, dengue is endemic, along with the presence of other arboviruses. The situation is complicated by the scarcity of diagnostic infrastructure and the absence of approved vaccines for these diseases. Disease control, thus, relies solely on vector control. Therefore, enhanced clinical knowledge and improved general awareness about these arboviruses are indispensable to tackle diagnostic inadequacies.
Descritores: Viroses/transmissão
Viroses/virologia
Insetos Vetores/virologia
Culicidae/virologia
-Brasil/epidemiologia
Viroses/diagnóstico
Viroses/epidemiologia
Infecções por Alphavirus/diagnóstico
Infecções por Alphavirus/transmissão
Infecções por Alphavirus/epidemiologia
Infecções por Alphavirus/virologia
Alphavirus/classificação
Alphavirus/fisiologia
Dengue/transmissão
Dengue/epidemiologia
Dengue/virologia
Vírus da Dengue/classificação
Vírus da Dengue/fisiologia
Infecção por Zika virus/diagnóstico
Infecção por Zika virus/transmissão
Infecção por Zika virus/epidemiologia
Infecção por Zika virus/virologia
Limites: Humanos
Animais
Responsável: BR1.1 - BIREME


  3 / 30 LILACS  
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Id: biblio-869122
Autor: Bernal-Vera, Cynthia Magdalena; Cardozo-Segovia, Fátima María; Mendoza-Torres, Laura Patricia.
Título: Estandarización de una técnica de RT-PCR anidada para detección de alfavirus / Standardization of a nested RT-PCR technique for alphavirus detection
Fonte: Mem. Inst. Invest. Cienc. Salud (Impr.);15(2):30-36, ago. 2017. ilus.
Idioma: es.
Resumo: El género Alphavirus está constituido por virus de ARN de los cuales, varias especies son causantes de enfermedades humanas y animales como los virus chikungunya, Mayaro y los virus de encefalitis equinas, por lo que son considerados un problema de salud pública a nivel regional. En Paraguay han sido reportadas infecciones humanas por chikungunya pero son necesarios más estudios para ampliar conocimientos sobre circulación y ecoepidemiología de los alfavirus. La transcripción reversa de ARN seguida de una reacción en cadena de la polimerasa (RT-PCR) anidada es de gran utilidad como herramienta diagnóstica y en la vigilancia epidemiológica. El objetivo de este estudio fue definir las condiciones óptimas de reacción y determinar el límite de detección para una RT-PCR anidada para la detección genérica de alfavirus. El límite de detección obtenido, de 0,47 UFP/mL, indica una alta sensibilidad, pudiéndose aplicar la técnica a muestras humanas y animales de suero, líquido cefalorraquídeo, órganos y a pooles de mosquitos. Este trabajo servirá de base a otros estudios de detección e identificación de especies de alfavirus circulantes en nuestro país, lo que contribuiría a fortalecer su vigilancia y prevención.

The genus Alphavirus consists of RNA viruses of which several species areresponsible for human and animal diseases, such as chikungunya, Mayaro and equineencephalitis viruses, and are therefore considered a regional public health problem. InParaguay, human infections have been reported by chikungunya, but more studies areneeded to increase knowledge on the circulation and ecoepidemiology of alphaviruses.Reverse RNA transcription followed by a nested polymerase chain reaction (RT-PCR) isvery useful as a diagnostic tool and in epidemiological surveillance. The objective ofthis study was to define optimal reaction conditions and to determine the limit ofdetection for a nested RT-PCR for generic alphavirus detection. The detection limitobtained, of 0,47 PFU/mL, indicate high sensitivity, and the possibility of applying thetechnique to human and animals samples of serum, cerebrospinal fluid, organs andmosquito pools. This work will serve as a basis for other studies of detection andidentification of alphavirus species circulating in our country, which would helpstrengthen the surveillance and prevention.
Descritores: Alphavirus
Infecções por Alphavirus
Reação em Cadeia da Polimerase Via Transcriptase Reversa
-Saúde Pública
Limites: Humanos
Responsável: PY3.1 - Biblioteca


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Texto completo SciELO Brasil
Vasconcelos, Pedro Fernando da Costa
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Id: biblio-841812
Autor: Naveca, Felipe Gomes; Nascimento, Valdinete Alves do; Souza, Victor Costa de; Nunes, Bruno Tardelli Diniz; Rodrigues, Daniela Sueli Guerreiro; Vasconcelos, Pedro Fernando da Costa.
Título: Multiplexed reverse transcription real-time polymerase chain reaction for simultaneous detection of Mayaro, Oropouche, and Oropouche-like viruses
Fonte: Mem. Inst. Oswaldo Cruz;112(7):510-513, July 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT We describe a sensitive method for simultaneous detection of Oropouche and Oropouche-like viruses carrying the Oropouche S segment, as well as the Mayaro virus, using a multiplexed one-step reverse transcription real-time polymerase chain reaction (RT-qPCR). A chimeric plasmid containing both Mayaro and Oropouche targets was designed and evaluated for the in vitro production of transcribed RNA, which could be easily used as a non-infectious external control. To track false-negative results due to PCR inhibition or equipment malfunction, the MS2 bacteriophage was also included in the multiplex assay as an internal positive control. The specificity of the multiplex assay was evaluated by Primer-Blast analysis against the entire GenBank database, and further against a panel of 17 RNA arboviruses. The results indicated an accurate and highly sensitive assay with amplification efficiency greater than 98% for both targets, and a limit of detection between two and 20 copies per reaction. We believe that the assay described here will provide a tool for Mayaro and Oropouche virus detection, especially in areas where differential diagnosis of Dengue, Zika and Chikungunya viruses should be performed.
Descritores: Orthobunyavirus/classificação
Orthobunyavirus/genética
Infecções por Bunyaviridae/diagnóstico
Infecções por Bunyaviridae/virologia
Infecções por Alphavirus/diagnóstico
Infecções por Alphavirus/virologia
Alphavirus/classificação
Alphavirus/genética
Reação em Cadeia da Polimerase Via Transcriptase Reversa
-Reação em Cadeia da Polimerase Multiplex
Limites: Humanos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
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Id: lil-796902
Autor: Hoyos-López, Richard; Suaza-Vasco, Juan; Rúa-Uribe, Guillermo; Uribe, Sandra; Gallego-Gómez, Juan Carlos.
Título: Molecular detection of flaviviruses and alphaviruses in mosquitoes (Diptera: Culicidae) from coastal ecosystems in the Colombian Caribbean
Fonte: Mem. Inst. Oswaldo Cruz;111(10):625-634, Oct. 2016. tab, graf.
Idioma: en.
Projeto: COLCIENCIAS.
Resumo: Arboviruses belonging to the genera Flavivirus and Alphavirus were detected in mosquitoes in a rural area of San Bernardo del Viento (Córdoba, Colombia). A total of 22,180 mosquitoes were collected, sorted into 2,102 pools, and tested by generic/nested reverse transcription-polymerase chain reaction. Venezuelan equine encephalitis virus, dengue virus, West Nile virus, St. Louis encephalitis virus, yellow fever virus, and Culex flavivirus were detected and identified by sequencing. The detection of arboviral pathogens in this zone represents possible circulation and indicates a human health risk, demonstrating the importance of virological surveillance activities.
Descritores: Alphavirus/genética
Culicidae/virologia
Flavivirus/genética
-Alphavirus/classificação
Alphavirus/isolamento & purificação
Região do Caribe
Colômbia
Flavivirus/classificação
Filogenia
Reação em Cadeia da Polimerase Via Transcriptase Reversa
População Rural
Limites: Humanos
Animais
Feminino
Responsável: BR1.1 - BIREME


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Id: lil-785514
Autor: Zuluaga Gómez, Mateo; Vanegas Isaza, Daniel.
Título: El virus Chikungunya en Colombia: aspectos clínicos y epidemiológicos y revisión de la literatura / Vírus chicungunha na Colômbia: aspectos clínicos e epidemiológicos e revisão da literatura / Chikungunya virus in Colombia: Clinical and epidemiological aspects, and literature review
Fonte: Iatreia;29(1):65-74, ene.-mar. 2016. tab.
Idioma: es.
Resumo: En años recientes, con el movimiento de las poblaciones y la globalización, algunas infecciones y enfermedades han cambiado su patrón endémico por uno epidémico; es el caso del virus chikungunya, un arbovirus reemergente que ha activado las alarmas mundiales. Según datos de los Centros para el Control y Prevención de Enfermedades (CDC), de los Estados Unidos, hasta enero del 2015 se habían detectado más de un millón de casos sospechosos y alrededor de treinta mil habían sido confirmados por laboratorio en 42 países del Caribe, Centroamérica, Suramérica y Norteamérica. Según el Instituto Nacional de Salud de Colombia,el número total de casos de esta infección confirmados por clínica era de 231.392; por laboratorio se habían confirmado 1.528 y había 3.848 casos sospechosos, para un total general de 236.768. En esta revisión se incluyen los siguientes aspectos de la infección por el virus chikungunya: virología, transmisión por vector, patogenia, epidemiología, manifestaciones clínicas,pruebas de laboratorio, medidas de prevención y perspectivas futuras...

In recent years, with the movement of populations and with globalization, some infections and diseases have changed from endemic to epidemic in certain regions. Such is the case of chikungunya virus (CHIKV), a re-emerging arbovirus that has triggered global alarm. According to the Center for Disease Control and Prevention (CDC), until January 2015, there had been case reports from 42 countries in the Caribbean, and Central, South, and North America, with more than one million suspected cases and about thirty thousand laboratory-confirmed cases. The latest report in Colombia by Instituto Nacional de Salud refers to a total of 231.392 clinically confirmed cases (suggestive symptoms associatedwith CHIKV), 1.528 cases confirmed by laboratory, and 3.848 suspected cases, for an overall total of 236.768. In this review, the following aspects of CHIKV infection are included: virology, transmission by vector, pathogenesis, epidemiology, clinical manifestations, laboratory tests, preventive measures and future prospects...

Nos anos recentes, com o movimento das populações e a globalização, algumas infecções e doenças mudaramseu padrão endémico por um epidêmico; é o caso do vírus chicungunha, um arbovírus reemergente que ativou os alarmes mundiais. Segundo dados do Centro para o Controle e Prevenção de Doenças (CDC), dos Estados Unidos, até janeiro de 2015 se tinham detectado mais de um milhão de casos suspeitos e ao redor de trinta mil tinham sido confirmados por laboratório em 42 países do Caribe, América Central, América do Sul e América do Norte. Segundo o Instituto Nacional de Saúde da Colômbia, o número total de casos desta infecção confirmados por clínica era de 231.392; por laboratório se tinham confirmado 1.528 e tinha 3.848 casos suspeitos, para um total geral de 236.768. Nesta revisão se incluem os seguintes aspectos da infecção pelo vírus chicungunha: virologia, transmissão por vector, patogenia, epidemiologia, manifestações clínicas, provas de laboratório, medidas de prevenção e perspectivas futuras...
Descritores: Alphavirus
Vírus Chikungunya
Colômbia
Togaviridae
-Infecções
Limites: Humanos
Responsável: CO56.1 - Biblioteca


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Id: lil-773751
Autor: Brasil. Secretaria de Saúde do Estado de Pernambuco; .Brasil. Secretaria executiva de Vigilância em Saúde.
Título: Protocolo Clinico e Epidemiológico para investigação de casos de microcefalia no estado de Pernambuco / Clinical and Epidemiological protocol for investigating cases of microcephaly in the state of Pernambuco.
Fonte: Pernambuco; s.n; nov. 2015. 28 p. ilus.
Idioma: pt.
Descritores: Anormalidades Congênitas/fisiopatologia
Microcefalia/epidemiologia
Protocolos Clínicos/normas
Monitoramento Epidemiológico/normas
Vigilância em Saúde Pública/métodos
-Alphavirus/patogenicidade
Brasil
Cefalometria/métodos
Dengue/epidemiologia
Flavivirus/patogenicidade
Microcefalia/embriologia
Nascimento Vivo/epidemiologia
Notificação de Doenças/métodos
Vírus Chikungunya/patogenicidade
Limites: Humanos
Masculino
Feminino
Recém-Nascido
Lactente
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
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Id: lil-771080
Autor: Serra, Otacília Pereira; Cardoso, Belgath Fernandes; Ribeiro, Ana Lúcia Maria; Santos, Fábio Alexandre Leal dos; Slhessarenko, Renata Dezengrini.
Título: Mayaro virus and dengue virus 1 and 4 natural infection in culicids from Cuiabá, state of Mato Grosso, Brazil
Fonte: Mem. Inst. Oswaldo Cruz;111(1):20-29, Jan. 2016. tab, graf.
Idioma: en.
Resumo: This study aimed to verify the diversity of Culicidae species and their frequency of infection with flaviviruses and alphaviruses in Cuiabá, state of Mato Grosso, Brazil. Mosquitoes were captured with Nasci aspirators and hand net in 200 census tracts, identified alive at species level and pooled in one-20 (11,090 mosquitoes, 14 species). Female pools (n = 610) were subjected to multiplex seminested-reverse transcription-polymerase chain reaction (RT-PCR) for 11 flavivirus and five alphavirus. Positive pools were tested by single RT-PCR followed by nucleotide sequencing, by RT-PCR for E1 gene [Mayaro virus (MAYV)] and by inoculation in Vero cells (MAYV) or C6/36 cells (flaviviruses). One/171 Aedes aegypti was positive for dengue virus (DENV)-1, 12/403 Culex quinquefasciatus, and four/171Ae. aegypti for MAYV, which was isolated from two pools containing two nonengorged females of Ae. aegypti and two ofCx. quinquefasciatus. DENV-4 was detected in 58/171 pools of Ae. aegytpi, 105/403 Cx. quinquefasciatus, two/five Psorophora sp., two/11 Psorophora varipes/Psorophora albigenu, one/one Sabethes chloropterus, two/five Culex bidens/Culex interfor, and one/one Aedes sp. DENV-4 was isolated from two pools containing three and 16 nonengorged Cx. quinquefasciatus females. Phylogenetic analysis revealed MAYV belongs to genotype L, clustering with human samples of the virus previously identified in the city. Cuiabá has biodiversity and ecosystem favourable for vector proliferation, representing a risk for arbovirus outbreaks.
Descritores: Alphavirus/isolamento & purificação
Culicidae/virologia
Vírus da Dengue/isolamento & purificação
Insetos Vetores/virologia
-Alphavirus/genética
Brasil
Culicidae/classificação
Vírus da Dengue/genética
Genótipo
Insetos Vetores/classificação
Reação em Cadeia da Polimerase Multiplex
Filogenia
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Estações do Ano
Limites: Animais
Feminino
Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  9 / 30 LILACS  
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Id: lil-769244
Autor: González T, Marco; Mattar V, Salim.
Título: Mayaro and Chikungunya; two alphaviruses with clinical and epidemiological similarities / Mayaro y Chikungunya; dos alfavirus con similitudes clínicas y epidemiológicas
Fonte: Rev. MVZ Córdoba;20(supl.1):4861-4863, Dec. 2015.
Idioma: en.
Resumo: In 1780, Philadelphia suffered an unusual outbreak of hemorrhagic fever, which years later was identified as dengue (1). One hundred years later, in Memphis, 1500 people died from yellow fever, which caused residents to abandoned the city (2). Even though these stories may seem anecdotes, they show how dramatic hemorrhagic arbovirus outbreaks can be. The tropic host arboviruses such as Chikungunya (CHIKV), Dengue, and Zika (ZIKV); but there are others, such as Mayaro, Oropuche, and Bussuquara, among others, which have still not been studied in depth by the public health systems of our countries.
Descritores: Alphavirus
-Vírus Chikungunya
Vírus
Responsável: CO332 - Facultad de Medicina


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Texto completo SciELO Brasil
Texto completo
Id: lil-732989
Autor: Figueiredo, Mario Luis Garcia de; Figueiredo, Luiz Tadeu Moraes.
Título: Emerging alphaviruses in the Americas: Chikungunya and Mayaro
Fonte: Rev. Soc. Bras. Med. Trop;47(6):677-683, Nov-Dec/2014. graf.
Idioma: en.
Resumo: Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are emergent arthropod-borne viruses that produce outbreaks of acute febrile illness with arthropathy. Despite their different continental origins, CHIKV and MAYV are closely related and are components of the Semliki Forest Complex of the Alphavirus (Togaviridae). MAYV and, more recently, CHIKV, which are both transmitted by Aedes mosquitoes, have resulted in severe public health problems in the Americas, including Brazil. In this review, we present aspects of the pathogenesis, clinical presentation and treatment of febrile illnesses produced by CHIKV and MAYV. We also discuss the epidemiological aspects and effects related to the prophylaxis of infections by both viruses.
Descritores: Infecções por Alphavirus/virologia
Alphavirus/genética
Doenças Transmissíveis Emergentes/virologia
-América
Infecções por Alphavirus/epidemiologia
Alphavirus/classificação
Alphavirus/fisiologia
Vírus Chikungunya/genética
Vírus Chikungunya/fisiologia
Doenças Transmissíveis Emergentes/epidemiologia
Insetos Vetores/classificação
Replicação Viral
Limites: Animais
Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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