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Id: biblio-1046492
Autor: Celik, Kiymet; Terek, Demet; Olukman, Ozgur; Gulfidan, Gamze; Calkavur, Sebnem; Devrim, lker; Arslanoglu, Sertac.
Título: Colonización e infección por un microorganismo poco frecuente en una unidad de cuidados intensivos neonatales: tres recién nacidos prematuros con Elizabethkingia meningoseptica / Colonization and infection with a rare microorganism in a neonatal intensive care unit: three preterm infants with Elizabethkingia meningoseptica
Fonte: Arch. argent. pediatr;117(6):631-634, dic. 2019.
Idioma: en; es.
Resumo: Elizabethkingia meningoseptica es un bacilo gramnegativo ampliamente distribuido en la naturaleza pero poco frecuente en humanos que se presenta en infecciones intrahospitalarias. Los avances en las instalaciones de cuidados intensivos neonatales y el uso de dispositivos médicos sofisticados fortalecen la capacidad infecciosa invasiva del microorganismo. Las manifestaciones clínicas suelen incluir bacteriemia primaria, meningitis, neumonía intrahospitalaria, bacteriemia relacionada con el uso de catéteres intravasculares e infecciones gastrointestinales y de las vías biliares. Es posible que, en entornos con recursos limitados, la falta de sistemas de diagnóstico mejorados sea una de las causas por las que no se notifican todas esas infecciones. Resulta bastante difícil distinguir entre colonización e infección, y el patrón de sensibilidad a los antibióticos es diferente. Por consiguiente, los médicos deben realizar el diagnóstico preciso para así evitar el tratamiento incorrecto. En este artículo, describimos tres casos de recién nacidos con diagnóstico de infección y colonización por E. meningoseptica con el objetivo de destacar la importancia del diagnóstico y el tratamiento oportunos de esta bacteria poco frecuente pero letal que ya está presente en las unidades de cuidados intensivos

Elizabethkingia meningoseptica is a widespread gram-negative bacillus in the environment, but a arely reported human pathogen presenting mostly as nosocomial infections. Advances in neonatal intensive care facilities and usage of sophisticated medical devices strengthen the invasive infectious potential of the microorganism. Clinical manifestations usually include primary bacteremia, meningitis, nosocomial pneumoniae, intravascular catheter-related bacteremia and gastrointestinal and biliary tract infections. Lack of improved diagnostic systems in resource constrained settings, might be a cause of underreporting of such infections. Discrimination between colonization and infection is quite difficult, and it has an unusual antibiotic susceptibility pattern. Therefore clinicians should pay special attention to accurate diagnosis in order to prevent mistreatment. Here we report three newborn cases with the diagnosis of E. meningoseptica infection and colopnization, with the aim of drawing attention to the diagnosis and management of this rare but lethal bacteria that is already present in the intensive care unit environment
Descritores: Recém-Nascido Prematuro
Unidades de Terapia Intensiva Neonatal
Infecção Hospitalar
Infecções por Bactérias Gram-Negativas
-Diagnóstico Diferencial
Limites: Seres Humanos
Masculino
Feminino
Recém-Nascido
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: lil-780828
Autor: Mohamed, Yasmine Fathy; Abou-Shleib, Hamida Moustafa; Khalil, Amal Mohamed; El-Guink, Nadia Mohamed; El-Nakeeb, Moustafa Ahmed.
Título: Membrane permeabilization of colistin toward pan-drug resistant Gram-negative isolates
Fonte: Braz. j. microbiol;47(2):381-388, Apr.-June 2016. tab, graf.
Idioma: en.
Resumo: Abstract Pan-drug resistant Gram-negative bacteria, being resistant to most available antibiotics, represent a huge threat to the medical community. Colistin is considered the last therapeutic option for patients in hospital settings. Thus, we were concerned in this study to demonstrate the membrane permeabilizing activity of colistin focusing on investigating its efficiency toward those pan-drug resistant isolates which represent a critical situation. We determined the killing dynamics of colistin against pan-drug resistant isolates. The permeability alteration was confirmed by different techniques as: leakage, electron microscopy and construction of an artificial membrane model; liposomes. Moreover, selectivity of colistin against microbial cells was also elucidated. Colistin was proved to be rapid bactericidal against pan-drug resistant isolates. It interacts with the outer bacterial membrane leading to deformation of its outline, pore formation, leakage of internal contents, cell lysis and finally death. Furthermore, variations in membrane composition of eukaryotic and microbial cells provide a key for colistin selectivity toward bacterial cells. Colistin selectively alters membrane permeability of pan-drug resistant isolates which leads to cell lysis. Colistin was proved to be an efficient last line treatment for pan-drug resistant infections which are hard to treat.
Descritores: Membrana Celular/metabolismo
Infecções por Bactérias Gram-Negativas/microbiologia
Colistina/metabolismo
Farmacorresistência Bacteriana Múltipla
Bactérias Gram-Negativas/metabolismo
Antibacterianos/metabolismo
-Testes de Sensibilidade Microbiana
Membrana Celular/efeitos dos fármacos
Permeabilidade da Membrana Celular
Infecções por Bactérias Gram-Negativas/tratamento farmacológico
Colistina/farmacologia
Bactérias Gram-Negativas/isolamento & purificação
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Negativas/ultraestrutura
Antibacterianos/farmacologia
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-983770
Autor: Berberian, Griselda; Brizuela, Martín; Rosanova, María T; Travaglianti, Mónica; Mastroiani, Alejandra; Reijtman, Vanesa; Fiorili, Graciela; Santa Cruz, Dora; Castro, Graciela.
Título: Infecciones por bacilos Gram-negativos multirresistentes en neonatología / Multidrug resistant Gram-negative infections in neonatology
Fonte: Arch. argent. pediatr;117(1):6-11, feb. 2019. tab.
Idioma: en; es.
Resumo: Introducción. Las infecciones por bacilos Gram-negativos multirresistentes (BGN-MR) constituyen un problema creciente en las unidades de cuidado intensivo neonatal. El objetivo del estudio fue conocer las características epidemiológicas, clínicas, microbiológicas, evolutivas y los factores de riesgo de infección por BGN-MR resistentes a carbapenemes en el Servicio de Neonatología de un hospital de alta complejidad. Población y método. Se realizó un estudio de cohorte retrospectivo en dicho Servicio, donde se incluyeron los pacientes con infección documentada por BGN-MR del 24/4/2013 al 29/4/2015. Resultados. Se incluyeron 21 pacientes. La mediana de edad gestacional y peso de nacimiento fue 35 semanas y 2070 gramos, respectivamente. Dieciocho pacientes (86 %) tuvieron hemocultivos positivos y el aislamiento microbiológico más frecuente fue Acinetobacter baumannii (17 pacientes, 81 %), seguido por Klebsiella pneumoniae productora de carbapenemasa (3 pacientes, 14 %) y Enterobacter cloacae (1 paciente, 5 %). La mediana de edad al momento del diagnóstico fue de 28 días y todos tenían factores de riesgo para la infección, como cirugía, asistencia respiratoria mecánica, nutrición parenteral, catéter central y antibióticos. El tratamiento antibiótico definitivo fue colistina en todos los casos, combinado en el 84 %. Cinco pacientes (24 %) fallecieron por la infección. La prematurez y el peso < 2000 g fueron factores de riesgo estadísticamente significativos asociados a la mortalidad (p = 0,03 y 0,01, respectivamente). Conclusión. Las infecciones por BGN-MR se presentaron en pacientes con factores predisponentes. Acinetobacter baumannii fue el primer agente etiológico. La mortalidad fue elevada y relacionada con prematurez y bajo peso al nacer.

Introduction. Multidrug resistant Gramnegative (MDRGN) infections are an increasing problem in neonatal intensive care units. The objective of this study was to establish the epidemiological, clinical, microbiological, and evolutionary characteristics of carbapenem-resistant MDRGN infections and the risk factors for them at the Division of Neonatology of a tertiary care hospital. Population and method. A retrospective cohort study was done in this Division in patients with a documented MDRGN infection between 4/24/2013 and 4/29/2015. Results. Twenty-one patients were included. Their median gestational age and birth weight were 35 weeks and 2070 g, respectively. Eighteen patients (86 %) had a positive blood culture; the most commonly isolated microorganism was Acinetobacter baumannii (17 patients, 81 %), followed by carbapenemase-producing Klebsiella pneumoniae (3 patients, 14 %) and Enterobacter cloacae (1 patient, 5 %). The median age at diagnosis was 28 days and all patients had risk factors for infection, including surgery, assisted mechanical ventilation, parenteral nutrition, central venous line, and antibiotics. The definite antibiotic therapy included colistin in all cases; in combination, in 84 %. Five patients (24 %) died due to the infection. Prematurity and a birth weight < 2000 g were statistically significant risk factors associated with mortality (p = 0.03 and 0.01, respectively). Conclusion. MDRGN infections were observed in patients with predisposing factors. Acinetobacter baumannii was the main etiologic agent. Mortality was high and related to prematurity and a low birth weight.
Descritores: Infecções por Bactérias Gram-Negativas/metabolismo
Infecções por Bactérias Gram-Negativas/tratamento farmacológico
Infecções por Bactérias Gram-Negativas/epidemiologia
-Epidemiologia Descritiva
Estudos Retrospectivos
Farmacorresistência Bacteriana Múltipla
Bactérias Gram-Negativas/metabolismo
Limites: Seres Humanos
Masculino
Feminino
Recém-Nascido
Tipo de Publ: Estudo Observacional
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: biblio-1049318
Autor: Amaro-Balderas, Eileen; Montiel-Jarquín, Alvaro José; Leonor-Muñoz, Mayra; Nava-Rodriguez, Irene; López-Colombo, Aurelio; Morales-Flores, Carlos Francisco; Vázquez-Cruz, Eduardo; Loria-Castellanos, Jorge.
Título: Infecciones intrahospitalarias en una unidad de cuidados intensivos: epidemiología y tratamiento empírico / Nosocomial infections at the ICU: Epidemilogy and empirical treatment
Fonte: Prensa méd. argent;104(5):252-259, jul2018. tab.
Idioma: en.
Resumo: Hon en día entre el 5-10% de los pacientes que ingresan a un hospital adquiere una infección nosocomial, 20% de estas son reportadas en la Unidad de Cuidados Intensivos. La incidencia es 2 a 5 veces más alta que en otros servicios hospitalarios. Objetivos: Describir la epidemiología de los patógenos intrahospitalarios en la Unidad de Cuidados Intensivos y su resistencia antibiótica. Material y métoos: Estudio transversal. La información se obtuvo de expedientes en la Unidad de Cuidados Intensivos siendo considerados solos los pacientes que desarrollaron una infección nosocomial. Resultados: Un total de 35 muestras fueron analizadas, dos grupos se obtuvieron, 24 gram positivos y 11 gram negativos. La edad media de los pacientes fue de 41.79 (78-18) ± 21.22 años. El principal sitio de infección reportado en ambos grupos, gram-negativos y gram-positivos fue la vía respiratoria baja en un 58,.3% y 81.1% respectivamente. Para el grupo de gram negativos los tres principales organismos aislados en los cultivos fueron: Klebsiella pneumoniae in 29.2% (n=7)., Acinetobacter baumanii en 25% (n=6) y Pseudomonas aeruginosa en 16.7% (n=4) por otra parte para el grupo de gram positivos la principal bacteria aislada fue: Enterococcus facalis in 27.3% (n=3). A su vez, con respecto al tratamiento inicial en el grupo de gram negativos fue en un 79.2% con dos o más antibióticos, 16.7% con ceftriaxona y 4.2% con cefazolina. Aunado a ello el tratamiento inicial para el grupo de gram positivos en ocho casos, dos o más antibióticos fueron usados, en 2 metropenem fue usado y en uno con ceftriaxona. En relación con la resistencia antibiótica para gram negativos el principal fue para ampicilina y ceftriaxona en un 100%, cefazolina y aztreonam en un 95.8%. A su vez par el grupo de gram positivos, los antibióticos asociados a resistencia fueron eritromicina y claritromicina en un 90.9%. Conclusión: De esta investigación, los médicos podrán orientarse en esta unidad, para el tratamiento de las infecciones nosocomiales, las guías nacionales establecen que el tratamiento empírico debe ser realizado con el conocimiento de las resistencias bacterianas a antibióticos

Nowadays, between 5-10% of the general in-patient hospital population gets a nosocomial inflection, 20% of these infections are reported in the Intensive Care Unit. It has been reportd that the incidence of nosocomial infections at the Intensive Care Unit is about 2 to 5 times higher than in other hospital services. Objectives: Describe the epidemiology of intrahospital pathogens in the Intensive Care Unit and their antimicrobial resistance. Material and methods: Cross-sectional study. Information was obtained from medical records of patients at the Intensive Care Unit considering only the ones whom developed a nosocomial infection. Thirty-five samples were considered, from these, two groups, were obtained. The period of time considered for this study was from June to December 2016 at the High Specialty Medical Unit, Hospital of Trauma and Orthopedic of the Instituto Mexicano del Seguro Social (IMSS). Results: A total of 35 samples were analyzed, two groups were obtained, 24 gram positive and 11 gram negative. The mean age of the patients was of 41.79 (78-18) ±21.22 years old. Principal site of infection reported in both groups, gram- negative and gram-positive was the respiratory low tract in a 58.3% and 81.1% respectively. For gram negative group three main organisms were isolated in cultures Klebsiella pneumoniae in 29.2% (n=7). Acinetobacter baumannii in 25% (n=6) and Pseudomonas aeruginosa in a 16.7% (n=4) besides for gram pisitive group the main bactria isolated in cultures was. Enterococcus faecalis in 27.3% (n=3). On the other band, corresponding to initial treatment in gram negative group 79.2% were treated sith two or more antibiotics, 16.7% with ceftriaxone and 4.2% with cefazolin. In addition to initial treatment for gram positive group in 8 cases, 2 or ore antibiotics were used, in 2 meropenem was used and 1 with ceftriaxone. In relation to antibiotic resistance for gram negative group the greatest was for ampicillin and ceftriaxone with a 100% resistance, cefazolin and aztreonam in a 95.8%. As well, for gram positive group, antibiotics associated with resistance were erythomycin and clarithromycin 980.9%. Conclusion: From this investigation, medical practitiioners could be oriented for the treatment of nosocomial infections in this unit, as a matter of fact national guidelines establish that empirical treatmente should be assed with the knowledge of the microorganism's resistences
Descritores: Fatores R
Infecção Hospitalar/epidemiologia
Estudos Transversais
Infecções por Bactérias Gram-Positivas
Infecções por Bactérias Gram-Negativas
Farmacorresistência Bacteriana
Limites: Adulto
Meia-Idade
Idoso
Responsável: AR392.1 - Biblioteca


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Elucir, Gir
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Id: lil-751307
Autor: Lopes, Ana Elisa Ricci; Canini, Silvia Rita Marin da Silva; Reinato, Lilian Andreia Fleck; Lopes, Letícia Pimenta; Gir, Elucir.
Título: Prevalence of gram-positive bacteria in patients with HIV in specialized services / Prevalência de bactérias gram-negativas em portadores de HIV internados em serviço especializado
Fonte: Acta paul. enferm;28(3):281-286, May-Jun/2015. tab.
Idioma: pt.
Projeto: Conselho Nacional de Desenvolvimento Científico e Tecnológico.
Resumo: Objective:To identify the prevalence of gram-positive bacteria in patients with HIV and who are hospitalized in specialized services.Methods:The present cross-sectional study approached 365 patients admitted in two specialized units of a teaching hospital located in the countryside of the state of São Paulo. The population was composed of 220 subjects. Sociodemographic and clinical data were obtained by means of individual interviews and medical record analysis. Saliva and nasal secretion were collected in the first 24 hours of the hospitalization process.Results:The prevalence of gram-negative bacteria in patients with HIV reached 14.5%, regardless of the site of their isolation. Pseudomonas aeruginosa was the most frequently isolated microorganism, followed by Klebsiella pneumoniae.Conclusion:The identification level of gram-negative bacteria was higher in the saliva (11.8%) than in the nasal secretion (3.6%), thus indicating that the collection of samples in more than one site may favor the identification of colonized and/or infected individuals...

Objetivo: Identificar a prevalência de bactérias gram-negativas em portadores de HIV internados em serviço especializado. Métodos: Trata-se de um estudo de corte transversal, foram abordados 365 indivíduos internados em duas unidades especializadas, de um hospital escola do interior paulista, sendo a população composta por 220 sujeitos. Os dados sociodemográficos e clínicos e foram obtidos por meio de entrevista individual e consulta aos prontuários. Coletaram-se também amostras de saliva e secreção nasal nas primeiras 24 horas de internação. Resultados: A prevalência de bactérias gram-negativas em portadores de HIV foi de 14,5 % independente do sítio onde foi isolado. Pseudomonas aeruginosa foi o microorganismo mais frequentemente isolado, seguida por Klebsiella pneumoniae. Conclusão: A identificação de bactérias gram-negativas foi maior na saliva (11,8%) que na secreção nasal (3,6%), indicando que coletar amostras de mais de um sítio pode favorecer a identificação de indivíduos colonizados e ou infectados...
Descritores: HIV
Cuidados de Enfermagem
Hospitais Especializados
Infecções por Bactérias Gram-Negativas/epidemiologia
Pacientes Internados
Serviço Hospitalar de Enfermagem
-Estudos Transversais
Limites: Seres Humanos
Masculino
Feminino
Meia-Idade
Adulto Jovem
Responsável: BR1.2 - Biblioteca Central


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Id: biblio-1022746
Autor: Wang, Zisheng; Hang, Panpan; Zhang, Qihuan; Xu, Qiaoqing; Qi, Zhitao.
Título: Molecular characterization and expression analysis of cathepsin C in Chinese giant salamander (Andrias davidianus) after Aeromonas hydrophila infection
Fonte: Electron. j. biotechnol;32:47-54, Mar. 2018. tab, ilus, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Jiangsu Province; . Opening Project of Jiangsu Key Laboratory of Biochemistry and Biotechnology of Marine Wetland.
Resumo: Background: Cathepsin C (CTSC) (dipeptidyl peptidase I, DPPI), is a member of the papain superfamily of cysteine proteases and involves in a variety of host reactions. However, the information of CTST in Chinese giant salamander (Andrias davidianus), an amphibian species with important evolutionary position and economic values, remained unclear. Results: The full-length salamander CTSC cDNA contained a 96 bp of 5'-UTR, a 1392 bp of ORF encoding 463 amino acids, and a 95 bp of 3'-UTR. The salamander CTSC possessed several sequence features similar to other reported CTSCs such as a signal peptide, a propeptide and a mature peptide. The active site triad of Cys, His and Asn were also found existing in salamander CTSC. Salamander CTSC mRNA was constitutively expressed in all the examined tissues with significantly variant expression level. The highest expression of CTSC was in intestine, followed with stomach, spleen, lung and brain. Following Aeromonas hydrophila infection for 12 h, salamander CTSC was significantly up-regulated in several tissues including lung, spleen, brain, kidney, heart, stomach and skin. Conclusion: CTSC plays roles in the immune response to bacterial infection, which provided valuable information for further studying the functions of CTSC in salamander.
Descritores: Urodelos/genética
Urodelos/imunologia
Infecções por Bactérias Gram-Negativas/veterinária
Catepsina C/imunologia
-Urodelos/microbiologia
Infecções por Bactérias Gram-Negativas/imunologia
Clonagem Molecular
Aeromonas hydrophila/fisiologia
Análise de Sequência
DNA Complementar
Catepsina C/genética
Catepsina C/metabolismo
Transcrição Reversa
Imunidade Inata/genética
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-976419
Autor: Prado, Ed Johnny R; Belo, Marco Antonio A; Moraes, Alessandra C; Barbuio, Roberto; Foz, Elizabeth P; Faria, Vanessa P; Sebastião, Fernanda A.
Título: Insulin favors acute inflammatory reaction in alloxan-diabetic tilapia during infectious aerocystitis / Insulina favorece a reação inflamatória aguda em tilápia do Nilo aloxano-diabéticas durante aerocistite infecciosa
Fonte: Pesqui. vet. bras = Braz. j. vet. res;38(12):2190-2193, dez. 2018. ilus.
Idioma: en.
Projeto: Fapesp.
Resumo: In vertebrates, the inflammatory reaction is responsible for modulating the initial nonspecific defense until specific immunity is acquired. In this context, numerous studies in mammals have demonstrated the participation of insulin in the inflammatory response, favoring cell proliferation and the migratory capacity of endothelial cells, vascular smooth muscle cells and monocytes, as well as mediating the expression of pro-thrombotic and pro-fibrotic factors. However, little is known about the effect of this peptidic hormone on the inflammatory reaction in teleostean fish. In order to evaluate the participation of insulin in the acute inflammatory response of Nile tilapia, Oreochromis niloticus, during aerocystitis induced by Aeromonas hydrophila, and 48 aloxane-diabetic tilapia were used, constituting two groups: diabetics treated with insulin and diabetics without treatment. After six, 24, and 48 hours of inflammatory stimulation, tilapia were submitted to deep anesthesia for euthanasia and necropsy, and thus, obtaining exudate and harvesting of the swim bladder for analysis of the inflammatory reaction. Based on this premise, the present study demonstrated the participation of insulin in the acute inflammatory reaction of alloxan-diabetic tilapia by favors the cellular accumulation in the exudate, the proliferative effect of fibrous tissue and neovascularization in the inflamed site. Such findings reinforce the old hypothesis that insulin plays an important role in the innate immune response during acute inflammatory reaction, being an important pro-inflammatory hormone. However, Nile tilapia proved to be a promising experimental model for studies and advances in research involving diabetes mellitus.(AU)

Em vertebrados, a reação inflamatória é responsável por modular a defesa inicial não-específica, até que imunidade específica seja adquirida. Neste contexto, inúmeros estudos em mamíferos têm demonstrado a participação da insulina sobre a resposta inflamatória, favorecendo a proliferação celular e a capacidade migratória das células endoteliais, células do músculo liso vascular e dos monócitos, além de mediar a expressão de fatores pró-trombótico e pró-fibrótico. Porém, pouco se conhece o efeito deste hormônio peptídico sobre a reação inflamatória em peixes teleósteos. Para avaliar a participação da insulina sobre a resposta inflamatória aguda em tilápias do Nilo, Oreochromis niloticus, na aerocistite induzida por Aeromonas hydrophila, foram utilizadas 48 tilápias aloxano-diabéticas, constituindo dois grupos: dos diabéticos tratados com insulina e diabéticos sem tratamento. Após, seis, 24 e 48 horas do estimulo inflamatório, as tilápias foram submetidas à anestesia profunda para eutanásia e necropsia, e assim, obtenção de exsudato e colheita da bexiga natatória para analise da reação inflamatória. Partindo-se desta premissa, o presente estudo demonstrou a participação da insulina na reação inflamatória aguda infecciosa de tilápias do Nilo aloxano-diabéticas por favorecer o acúmulo positivo celular no exsudato, assim como o efeito proliferativo de tecido fibroso e a neovascularização no local inflamado. Tais achados reforçam a hipótese de que a insulina desempenha importante papel na resposta imune inata na reação inflamatória aguda, sendo um importante hormônio pró-inflamatório. Contudo, a tilápia do Nilo demonstrou ser um modelo experimental promissor para estudos e avanços em pesquisas envolvendo o diabetes mellitus.(AU)
Descritores: Infecções por Bactérias Gram-Negativas/veterinária
Aeromonas hydrophila/patogenicidade
Ciclídeos
Diabetes Mellitus Experimental
Insulina
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-889236
Autor: Capizzani, Carolina Paulino da Costa; Caçador, Natália Candido; Marques, Elizabeth Andrade; Levy, Carlos Emílio; Tonani, Ludmilla; Torres, Lidia Alice Gomes Monteiro Marin; Darini, Ana Lúcia da Costa.
Título: A practical molecular identification of nonfermenting Gram-negative bacteria from cystic fibrosis
Fonte: Braz. j. microbiol;49(2):422-428, Apr.-June 2018. tab, graf.
Idioma: en.
Projeto: São Paulo Research Foundation; . National Council for Scientific and Technological Development.
Resumo: Abstract Identification of nonfermenting Gram-negative bacteria (NFGNB) of cystic fibrosis patients is hard and misidentification could affect clinical outcome. This study aimed to propose a scheme using polymerase chain reaction to identify NFGNB. This scheme leads to reliable identification within 3 days in an economically viable manner when compared to other methods.
Descritores: Reação em Cadeia da Polimerase/métodos
Infecções por Bactérias Gram-Negativas/diagnóstico
Fibrose Cística/complicações
Técnicas de Diagnóstico Molecular/métodos
Bactérias Gram-Negativas/isolamento & purificação
-Fatores de Tempo
Bactérias Gram-Negativas/genética
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Alvarez, M
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Id: biblio-1024913
Autor: Corallo, T; Aguirre, C; Lamberti, D; Colman, S; Álvarez, M; Sucin, G; Albornoz, M; Sotelo, O; Euliarte, C.
Título: Septicemia por Chromobacterium Violaceum en pediatría / Septicemia due to Chromobacterium Violaceum in pediatrics
Fonte: Med. infant;26(3):276-284, sept. 2019. Tab, ilus.
Idioma: es.
Resumo: Chromobacterium violaceum es una bacteria gram negativa anaerobia facultativa, que se encuentra ampliamente distribuida en el agua y el suelo en regiones tropicales y subtropicales, que se asocia con infecciones respiratorias, gastrointestinales, abscesos hepáticos, meningitis, endocarditis, síndrome hemofagocítico y sepsis fulminante. Se presentan 2 casos en niños: el primero es un varón de 8 años con lesiones en piel, fiebre y adenitis inguinal, que ingresó con un cuadro de sepsis severa, síndrome de distrés respiratorio agudo (SDRA) y falleció a las 3 h del ingreso. De los hemocultivos se aisló Chromobacterium violaceum. El segundo caso, es una niña de 12 años con antecedente de fiebre y adenopatía inguinal secundaria a herida cortopunzante en el pie homolateral, que ingresó con un cuadro de sepsis, con desarrollo de abscesos múltiples profundos. De la colección obtenida de piel y partes blandas y de un aspirado traqueal se aisló Chromobacterium violaceum. Recibió tratamiento antibiótico adecuado y posteriormente fue dada de alta. Se realizó una revisión bibliográfica de esta infección en niños y se encontraron 44 casos en todo el mundo. Algunos de éstos, se relacionaron con inmunodeficiencia de base, como la enfermedad granulomatosa crónica. La infección por esta bacteria es rara y se presenta como un cuadro grave que no responde a antibióticos habituales de uso empírico y tiene una alta tasa de mortalidad (AU)

Chromobacterium violaceum is a facultative anaerobic Gramnegative bacillus, widely distributed in water and soil in tropical and subtropical regions and associated with respiratory and gastrointestinal infections, liver abscesses, meningitis, endocarditis, hemophagocytic syndrome, and fulminant sepsis. Here two pediatric cases are presented: The first was an 8-year-old boy with skin lesions, fever, and inguinal adenitis, who was admitted with severe sepsis, acute respiratory distress syndrome (ARDS) and died three hours after. Chromobacterium violaceum was isolated from blood cultures. The second case was a 12-year-old girl with a history of fever and inguinal adenopathy secondary to a wound in the homolateral foot, who was admitted because of sepsis and multiple deep abscesses. From samples collected from the skin and soft tissues as well as tracheal aspirate Chromobacterium violaceum was isolated. Adequate antibiotic treatment was started and the patient was subsequently discharged. In a review of the literature, 44 cases worldwide were identified. Some of these cases were related to underlying immunodeficiency, such as chronic granulomatous disease. Infection with this bacterium is rare and presents with severe manifestations that do not respond to the common empirical antibiotics and are associated with a high mortality rate (AU)
Descritores: Chromobacterium/isolamento & purificação
Infecções por Bactérias Gram-Negativas/microbiologia
Sepse/microbiologia
Antibacterianos/uso terapêutico
-Mortalidade
Resultado do Tratamento
Infecções por Bactérias Gram-Negativas/diagnóstico
Infecções por Bactérias Gram-Negativas/tratamento farmacológico
Sepse/diagnóstico
Sepse/tratamento farmacológico
Limites: Seres Humanos
Criança
Tipo de Publ: Relatos de Casos
Responsável: AR305.1 - SID - Servicio de Información y Documentación


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Id: lil-741869
Autor: Burutaran, Matilde Boada; Guadagna, Regina; Grille, Sofia; Stevenazzi, Mariana; Guillermo, Cecilia; Diaz, Lilian.
Título: Results of high-risk neutropenia therapy of hematology-oncology patients in a university hospital in Uruguay
Fonte: Rev. bras. hematol. hemoter;37(1):28-33, Jan-Feb/2015. tab, graf.
Idioma: en.
Resumo: Background: Febrile neutropenia is an important cause of mortality and morbidity in hematology-oncology patients undergoing chemotherapy. The management of febrile neutropenia is typically algorithm-driven. The aim of this study was to assess the results of a standardized protocol for the treatment of febrile neutropenia. Methods: A retrospective cohort study (2011-2012) was conducted of patients with high-risk neutropenia in a hematology-oncology service. Results: Forty-four episodes of 17 patients with a median age of 48 years (range: 18-78 years) were included. The incidence of febrile neutropenia was 61.4%. The presence of febrile neutropenia was associated with both the duration and severity of neutropenia. Microbiological agents were isolated from different sources in 59.3% of the episodes with bacteremia iso- lated from blood being the most prevalent (81.3%). Multiple drug-resistant gram-negative bacilli were isolated in 62.5% of all microbiologically documented infections. Treatment of 63% of the episodes in which the initial treatment was piperacillin/tazobactam needed to be escalated to meropenem. The mortality rate due to febrile neutropenia episodes was 18.5%. Conclusion: The high rate of gram-negative bacilli resistant to piperacillin/tazobactam (frontline antibiotics in our protocol) and the early need to escalate to carbapenems raises the question as to whether it is necessary to change the current protocol. .
Descritores: Resistência a Medicamentos
Protocolos Clínicos
Infecções por Bactérias Gram-Negativas
Farmacorresistência Bacteriana
Doenças Hematológicas
Neutropenia
Limites: Seres Humanos
Responsável: BR408.1 - Biblioteca da Faculdade de Medicina - BFM



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