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Mariano, Mário
Silva, Maria Regina Regis
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Id: biblio-983752
Autor: Ogawa, Marilia Marufuji; Mariano, Mario; Silva, Maria Regina Regis; Enokihara, Milvia Maria Simões e Silva; Michalany, Nilceo Schwery; Nishikaku, Angela Satie; Silvestre, Agenor Messias; Tomimori, Jane.
Título: Study of tissue inflammatory response in different mice strains infected by dematiaceous fungi Fonsecaea pedrosoi
Fonte: An. bras. dermatol;94(1):29-36, Jan.-Feb. 2019. graf.
Idioma: en.
Resumo: Abstract: Background: Diseases caused by melanized fungi include mycetoma, chromoblastomycosis and phaeohyphomycosis. This broad clinical spectrum depends on the dynamic interactions between etiologic agent and host. The immune status of the host influences on the development of the disease, as, an exemple. phaeohyphomicosis is more frequently observed in immunocompromised patients. Objectives: Examine the histological inflammatory response induced by Fonsecaea pedrosoi in several different strains of mice (BALB/c, C57BL/6, Nude and SCID, and reconstituted Nude). Methods: Fonsecaea pedrosoi was cultivated on agar gel and a fragment of this gel was implanted subcutaneously in the abdominal region of female adult mice. After infection has been obtained, tissue fragment was studied histopathologically. Results: There were significant changes across the strains, with the nodular lesion more persistent in Nude and SCID mice, whereas in immunocompetent mice the lesion progressed to ulceration and healing. The histopathological analysis showed a significant acute inflammatory reaction which consisted mainly of neutrophils in the initial phase that was subsequently followed by a tuberculoid type granuloma in immunocompetent mice. Study limitations: There is no a suitable animal model for chromoblastomycosis. Conclusions: The neutrophilic infiltration had an important role in the containment of infection to prevent fungal spreading, including in immunodeficient mice. The fungal elimination was dependent on T lymphocytes. The re-exposure of C57BL/6 mice to Fonsecaea pedrosoi caused a delay in resolving the infection, and appearance of muriform cells, which may indicate that re-exposure to fungi, might lead to chronicity of infection.
Descritores: Ascomicetos
Dermatomicoses/imunologia
Imunocompetência
Inflamação/imunologia
Inflamação/microbiologia
-Especificidade da Espécie
Fatores de Tempo
Contagem de Células Sanguíneas
Doença Crônica
Cromoblastomicose/imunologia
Cromoblastomicose/patologia
Camundongos SCID
Dermatomicoses/patologia
Modelos Animais de Doenças
Inflamação/patologia
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Camundongos Nus
Neutrófilos
Limites: Animais
Feminino
Responsável: BR1.1 - BIREME


  2 / 495 LILACS  
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Id: lil-749650
Autor: Dias, Maria Fernanda Reis Gavazzoni.
Título: Counter-reply
Fonte: An. bras. dermatol;90(3):438-439, May-Jun/2015.
Idioma: en.
Descritores: Dermatomicoses/tratamento farmacológico
Antifúngicos/uso terapêutico
Limites: Seres Humanos
Tipo de Publ: Comentário
Carta
Responsável: BR1.1 - BIREME


  3 / 495 LILACS  
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Takita, Luiz Carlos
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Id: biblio-837990
Autor: Sacht, Gabriely Lessa; Lima, Alexandre Moretti de; Perdomo, Yuri Chiarelli; Boigues, Rafaela Suguimoto; Takita, Luiz Carlos; Hans Filho, Günter.
Título: Disseminated cryptococcosis with cutaneous involvement in an immunocompetent patient
Fonte: An. bras. dermatol;91(6):832-834, Nov.-Dec. 2016. graf.
Idioma: en.
Resumo: Abstract Cryptococcosis is a fungal infection of opportunistic behavior that is unusual in immunocompetent patients. We report a rare case of disseminated cryptococcosis with cutaneous involvement in an immunocompetent individual. During hospitalization, Cryptococcus gattii was isolated from skin lesions, lung and spinal fluid. The diagnosis of disseminated cryptococcosis was confirmed and treatment was established. The patient showed improvement. Due to the probable clinical severity of the disease and the possibility that skin lesions may be the first manifestation of this illness, prompt diagnosis must be established and treatment provided.
Descritores: Criptococose/imunologia
Criptococose/patologia
Dermatomicoses/imunologia
Dermatomicoses/patologia
Cryptococcus gattii/isolamento & purificação
Imunocompetência
-Pele/microbiologia
Pele/patologia
Resultado do Tratamento
Criptococose/tratamento farmacológico
Dermatomicoses/tratamento farmacológico
Linfocitose/complicações
Pulmão/microbiologia
Antifúngicos/uso terapêutico
Limites: Seres Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-837926
Autor: Amaral, Danielle Mechereffe do; Rocha, Ritha de Cássia Capelato; Carneiro, Luiz Euribel Prestes; Vasconcelos, Dewton Moraes; Abreu, Marilda Aparecida Milanez Morgado de.
Título: Disseminated cryptococcosis manifested as a single tumor in an immunocompetent patient, similar to the cutaneous primary forms
Fonte: An. bras. dermatol;91(5,supl.1):29-31, Sept.-Oct. 2016. graf.
Idioma: en.
Resumo: Abstract Cryptococcosis is a fungal infection caused by Cryptococcus neoformans that tends to affect immunocompromised individuals. The fungi are mostly acquired by inhalation, which leads to an initial pulmonary infection. Later, other organs - such as the central nervous system and the skin - can be affected by hematogenous spread. In addition, cutaneous contamination can occur by primary inoculation after injuries (primary cutaneous cryptococcosis), whose diagnosis is defined based on the absence of systemic involvement. The clinical presentation of cutaneous forms typically vary according to the infection mode. We report an unusual case of disseminated cryptococcosis in an immunocompetent patient with cutaneous lesions similar to those caused by primary inoculation. This clinical picture leads us to question the definition of primary cutaneous cryptococcosis established in the literature.
Descritores: Hospedeiro Imunocomprometido
Criptococose/patologia
Dermatomicoses/patologia
-Pele/microbiologia
Pele/patologia
Biópsia
Infecções Oportunistas/microbiologia
Criptococose/imunologia
Criptococose/microbiologia
Cryptococcus neoformans/isolamento & purificação
Dermatomicoses/imunologia
Dermatomicoses/microbiologia
Limites: Seres Humanos
Masculino
Idoso
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


  5 / 495 LILACS  
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Id: lil-787298
Autor: Oliveira, Patricia Botini de; Abreu, Marilda Aparecida Milanez Morgado de; Mattos, Antônio Luiz de Arruda.
Título: Importance of multidisciplinary approach in diagnosis of histoplasmosis
Fonte: An. bras. dermatol;91(3):362-364graf.
Idioma: en.
Resumo: Abstract: A patient with systemic involvement, initially treated as tuberculosis, is presented in this report. There were only two painful subcutaneous nodules, from which we arrived at the correct diagnosis of histoplasmosis. The patient was attended by several experts in the fields of infectious diseases, nephrology and internal medicine, but the diagnosis was only possible after dermatological examination and skin biopsy. This case values multidisciplinary interaction between dermatologists and other medical areas for diagnosis of cases with atypical manifestations.
Descritores: Tela Subcutânea/microbiologia
Dermatomicoses/diagnóstico
Histoplasmose/diagnóstico
-Braço
Biópsia
Comunicação Interdisciplinar
Diagnóstico Diferencial
Erros de Diagnóstico/prevenção & controle
Limites: Seres Humanos
Masculino
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


  6 / 495 LILACS  
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Id: biblio-884652
Autor: Aguilar Fernández, Gustavo; Araújo López, Patricia; Arce, Nilfo; Martínez Mora, Mario.
Título: Dermatofitos: casuística en la Sección de Micología del Laboratorio Central de Salud Pública, Asunción - Paraguay (2000 - 2016) / Dermatophytes: casuistry in the Mycology Section of the Central Public Health Laboratory, Asunción - Paraguay (2000 - 2016)
Fonte: Rev. Nac. (Itauguá);9(2):04-11, 2017.
Idioma: es.
Resumo: Introducción: los dermatofitos son las principales causas de micosis superficial. Su epidemiología es poco conocida en Paraguay. Objetivos: describir las especies prevalentes, tipos de tiñas y características según sexo y edad de pacientes que acudieron al Laboratorio Central de Salud Pública, Asunción- Paraguay,en el período 2000-2016. Materiales y Métodos: se estudiaron pacientes de todas las edades con diagnóstico de micosis superficiales. Las muestras procesadas fueron uñas, pelos y escamas epidérmicas Se realizaron exámenes directos con KOH y cultivos. La identificación fue por macro y microscopía de las colonias. Resultados: de 6.652 pacientes con sospecha de micosis superficiales, 803 (12%) fueron positivas para dermatofitos. Los aislamientos fueron Microsporumcanis (33,9%), Trichophytonrubrum (23,8%), Trichophytonmentagrophytes (22%), Trichophytontonsurans (12,6%), Microsporumgypseum (6,2%), Trichophytonverrucosum (1,4%), un aislamiento para Microsporummanuumy Epidermophytonfloccosum respectivamente. Los tipos de tiñas fueron: capitis (54,3%), corporis (27,1%) yunguium (9,8%), pedís (3,8%), cruris (3%) y manuum (2%). Conclusión: el hongo prevalente fue Microsporumcanis (33,9%) y la tiña más frecuente fue capitis.

Introduction: dermatophytes are the main causes of superficial mycosis. Its epidemiology is less known in Paraguay. Objectives: to describe the prevalent species, types of tinea and features according to sex and age of patients who attended the Central Laboratory of Public Health, Asunción-Paraguay, in the period 2000-2016. Materials and Methods: patients of all ages with a diagnosis of superficial mycosis were studied. The samples processed were nails, hairs and epidermal scales. Direct tests were carried out with KOH and cultures. The identification was by macro scopy and microscopy of the colonies. Results: of 6,652 patients with suspected superficial mycoses, 803 (12%) were positive for dermatophytes. The isolates were Microsporum canis (33.9%), Trichophyton rubrum (23.8%), Trichophyton mentagrophytes (22%), Trichophyton tonsurans (12.6%), Microsporum gypseum (6.2%), Trichophyton verrucosum (1,4%), isolation for Microsporum manuum and Epidermophyton floccosum respectively. The types of tinea were: capitis (54.3%), corporis (27.1%) and unguium (9.8%), pedis (3.8%), cruris (3%) and manuum (2%). Conclusion: The prevalent fungus was Microsporum canis (33.9%) and the most frequent tinea was capitis.
Descritores: Dermatomicoses/epidemiologia
-Paraguai/epidemiologia
Tinha/epidemiologia
Tinha do Couro Cabeludo/epidemiologia
Estudos Transversais
Estudos Retrospectivos
Microsporum/isolamento & purificação
Limites: Seres Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: lil-384686
Autor: Aldama Caballero, Arnaldo; Rivelli, Victoria; Correa, Julio; Mendoza, Gloria.
Título: Tiña de la cabeza: comuncación de 54 casos / Tinea capitis: communication of 54 cases
Fonte: Pediatr. (Asunción);29(1):10-15, ene.-jun. 2002. ilus, tab.
Idioma: es.
Resumo: La tiña de la cabeza (o tínea capitis) es una dermatofitosis producida por hongos de los gérmenes trichophyton o mentagrophytes. Presenta varias formas clínicas es casi exclusiva de los niños. Objetivos: Conocer las características de los casos de tiña de la cabeza observados en el servicio de Dermatología del Hospital Nacional en los periodos: 1990-1992 y 1999-2001. Material y Método: Estudio restrospectivo, descriptivo y observacional. Se determinan porcentajes y se comparan con otras series. Todos los casos tienen estudios micológicos directos y varios de ellos cultivos. Resultados: Se observan 54 casos siendo 19 del periodo 1990-1992 y 35 del periodo 1999-2001. Hay ligero predominio del sexo femenino y la edad promedio de presentación es de 5.6 años. En los casos en que se determinó la especie del hongo predomina el trichophyton mentagrophytes (10 casos, principal agente en el primer periodo), el trichophyton rubrum (9 casos, obsevado exclusivamente en el segundo periodo) y el microsporum canis (8 casos). En el periodo 1999-2001 el 7.5 porciento de las primeras consultas son por dermatofitosis, siendo el 37 porcientos niños y de éstos 50 porciento tiña de la cabeza. Conclusiones: La tiña de la cabeza es la principal dermatofitosis de la niñez en nuestro servicio y muestra una tendencia al aumento de la prevalencia. Además hay aumento de las formas inflamatorias (20 porciento del total) y surgimiento del Trichophyton rubrum como agente etiológico
Descritores: Paraguai
Dermatomicoses
Tinha
Tinha do Couro Cabeludo
Responsável: PY30.1 - Biblioteca


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Id: biblio-884957
Autor: Aldama Caballero, A; Acosta Sens, R; RivelIi, V; Insaurralde, S; Mendoza de Sánchez, G; Celías, L.
Título: Aspergilosis diseminada con importante afectación cutánea / Disseminated aspergillosis with significant skin involvement
Fonte: An. Fac. Cienc. Méd. (Asunción);49(2):87-96, jul-dic. 2016.
Idioma: es.
Resumo: La Aspergilosis es una infección micótica oportunista que afecta principalmente a pacientes inmunodeprimidos con neutropenia, en quienes produce a menudo enfermedad invasiva de curso fulminante. Las manifestaciones cutáneas de la Aspergilosis son infrecuentes, apareciendo en el 5 a 10% de los casos diseminados. Comunicamos un caso de Aspergilosis en una mujer adulta con neutropenia severa por enfermedad hematológica, con afectación pulmonar y sinusal, que presenta múltiples lesiones ulceronecróticas en piel y mucosas, con evolución fatal. Las lesiones mucocutáneas de la Aspergilosis no son específicas, obligan a varios diagnósticos diferenciales y, como en este caso, la biopsia para estudio histopatológico y micológico es necesaria para el diagnóstico.

Aspergillosis is an opportunistic fungal infection that primarily affects immunocompromised patients with neutropenia, in whom invasive disease often results in fulminant course. Cutaneous manifestations of aspergillosis are rare, occurring in 5-10% of cases scattered. We report a case of aspergillosis in an adult woman with severe neutropenia for hematologic disease, lung and sinus disease, having multiple ulceronecróticas skin lesions and mucous membranes, with fatal outcome. The mucocutaneous lesions of aspergillosis are nonspecific, forcing several differential diagnoses, and as in this case, the biopsy for histopathological and mycological study is required for diagnosis.
Descritores: Aspergilose/complicações
Aspergilose/diagnóstico
Úlcera Cutânea/diagnóstico
Úlcera Cutânea/microbiologia
Dermatomicoses/diagnóstico
Dermatomicoses/microbiologia
-Pele/patologia
Evolução Fatal
Necrose/diagnóstico
Necrose/microbiologia
Limites: Seres Humanos
Feminino
Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: PY40.1 - Biblioteca


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Id: lil-787305
Autor: Marques, Silvio Alencar; Lastória, Joel Carlos; Camargo, Rosangela Maria Pires de; Marques, Mariangela Esther Alencar.
Título: Paracoccidioidomycosis: acute-subacute clinical form, juvenile type
Fonte: An. bras. dermatol;91(3):384-386graf.
Idioma: en.
Resumo: Abstract: The authors report aspects of paracoccidioidomycosis, acute-subacute clinical form, juvenile type, in a 19-year-old female patient. Paracoccidioidomycosis, juvenile type, classically occurs in young patients, both sexes, with lymphoma-like aspects as initial presentation. However, following the natural history of the disease the lymph nodes assume patterns of infectious disease, as an abscess and fistulae. Systemic dissemination of the disease can occur and lethality and morbidity are significant in this clinical presentation.
Descritores: Paracoccidioidomicose/diagnóstico
Dermatomicoses/diagnóstico
-Paracoccidioidomicose/complicações
Doença Aguda
Dermatomicoses/microbiologia
Fotografias
Linfangite/complicações
Pescoço
Limites: Seres Humanos
Feminino
Adulto Jovem
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: lil-787301
Autor: Furlan, Karina Colossi; Pires, Mario Cezar; Kakizaki, Priscila; Chartuni, Juliana Cabral Nunes; Valente, Neusa Yuriko Sakai.
Título: Primary cutaneous aspergillosis and idiopathic bone marrow aplasia
Fonte: An. bras. dermatol;91(3):381-383graf.
Idioma: en.
Resumo: Abstract: We describe the case of a 9-year-old boy with idiopathic bone marrow aplasia and severe neutropenia, who developed skin ulcers under cardiac monitoring electrodes. The diagnosis of primary cutaneous aspergillosis was made after the second biopsy and culture. Imaging investigation did not reveal internal fungal infection. The child was treated, but did not improve and died 3 months after admission. The report highlights and discusses the preventable risk of aspergillus skin infection in immunocompromised patients.
Descritores: Aspergilose/microbiologia
Aspergillus niger/isolamento & purificação
Úlcera Cutânea/microbiologia
Dermatomicoses/microbiologia
Anemia Aplástica/imunologia
-Aspergilose/complicações
Aspergilose/patologia
Úlcera Cutânea/patologia
Evolução Fatal
Hifas/isolamento & purificação
Dermatomicoses/complicações
Dermatomicoses/patologia
Eletrodos/efeitos adversos
Anemia Aplástica/complicações
Necrose
Neutropenia/complicações
Limites: Seres Humanos
Masculino
Criança
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME



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