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Barbosa, Dulce Aparecida
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Id: biblio-949881
Autor: Santos, Samantha Bertoncello dos; Sabadin, Clarice Elvira Saggin; Mario, Débora Nunes; Rigo, Lilian; Barbosa, Dulce Aparecida.
Título: Presence of Candida spp. and candidiasis in liver transplant patients
Fonte: An. bras. dermatol;93(3):356-361, May-June 2018. tab, graf.
Idioma: en.
Resumo: Abstract: BACKGROUND: Candidiasis is the most common opportunistic fungal infection of the oral cavity caused by fungi of the genus Candida and usually associated with immunosuppressed individuals. OBJECTIVES: To evaluate the presence of oral candidiasis and identify the presence of Candida spp. in liver transplant recipients and assess the association between the presence of the fungus and sociodemographic variables, dietary habits and environmental exposure. METHODS: A cross-sectional study was performed with 49 patients who had undergone liver transplants at Hospital São Vicente de Paulo in Passo Fundo - RS. Patient information was collected to obtain sociodemographic data, eating habits and environmental exposure. Fungal infections were screened by oral clinical examination and the presence of Candida spp by the collection of oral samples with a sterile swab, seeded in Sabouraud Dextrose Agar, incubated at 25°C and observed at 48 hours. To identify Candida albicans, the germ tube test was performed. RESULTS: In 49 patient samples, 39% had the yeast of the genus Candida isolated and, of these patients, 12% had candidiasis, 66% of atrophic type and 34% pseudomembranous. Eleven yeast species were (58%) Candida non-albicans and eight (42%) Candida albicans. STUDY LIMITATIONS: The present study presents as a limitation the inclusion of patients in different stages of immunosuppression. CONCLUSION: The high incidence of Candida non-albicans in the oral cavity of transplant patients with a long period of transplantation is warning to a more effective control of the health of these individuals, especially those with older age.
Descritores: Infecções Oportunistas/microbiologia
Candida/isolamento & purificação
Candidíase Bucal/diagnóstico
Transplante de Fígado
Boca/microbiologia
-Candida/classificação
Candidíase Bucal/patologia
Estudos Transversais
Hospedeiro Imunocomprometido
Antifúngicos/uso terapêutico
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: lil-749658
Autor: Werneck, Juliana Tristão; Costa, Taiara de Oliveira; Stibich, Christian Abreu; Leite, Cristhiane Almeida; Dias, Eliane Pedra; Silva Junior, Arley.
Título: Oral lichen planus: study of 21 cases
Fonte: An. bras. dermatol;90(3):321-326, May-Jun/2015. tab, graf.
Idioma: en.
Resumo: Abstract BACKGROUND: Lichen planus is considered to be the most common dermatological disease involving the oral mucosa. OBJECTIVE: To investigate the profile, clinical features, and the presence of dysplasia and candidiasis in patients with oral lichen planus. METHODS: A total of 21 patients were selected from 258 patients at risk for oral cancer development. RESULTS: Most of the patients were white (76,2%), female (66,6%), with mean age of 58.8 years. Eight were smokers and seven were alcohol consumers. The buccal mucosa was the most affected site, followed by the tongue and the gingiva. The reticular pattern was the most common appearance. Histopathology depicted dysplasia in nine cases and cytopathology was positive for Candida in eight cases in the first appointment. CONCLUSION: Our data are similar to the literature. Cytopathology was important for the diagnosis of candidiasis. Although the presence of dysplasia was verified, further studies are necessary to clarify the importance of this finding. .
Descritores: Candidíase Bucal/patologia
Líquen Plano Bucal/patologia
-Biópsia
Índice de Gravidade de Doença
Candidíase Bucal/complicações
Estudos Retrospectivos
Fatores de Risco
Líquen Plano Bucal/complicações
Mucosa Bucal/patologia
Limites: Seres Humanos
Masculino
Feminino
Meia-Idade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: biblio-828186
Autor: Ellepola, Arjuna N. B; Samaranayake, L. P; Khan, Z. U.
Título: Extracellular phospholipase production of oral Candida albicans isolates from smokers, diabetics, asthmatics, denture wearers and healthy individuals following brief exposure to polyene, echinocandin and azole antimycotics
Fonte: Braz. j. microbiol;47(4):911-916, Oct.-Dec. 2016. tab.
Idioma: en.
Projeto: Kuwait University Research Grant.
Resumo: Abstract Objective Candida albicans is the primary causative agent of oral candidosis, and one of its key virulent attributes is considered to be its ability to produce extracellular phospholipases that facilitate cellular invasion. Oral candidosis can be treated with polyenes, and azoles, and the more recently introduced echinocandins. However, once administered, the intraoral concentration of these drugs tend to be sub-therapeutic and rather transient due to factors such as the diluent effect of saliva and cleansing effect of the oral musculature. Hence, intra-orally, the pathogenic yeasts may undergo a brief exposure to antifungal drugs. We, therefore, evaluated the phospholipase production of oral C. albicans isolates following brief exposure to sub-therapeutic concentrations of the foregoing antifungals. Materials and methods Fifty C. albicans oral isolates obtained from smokers, diabetics, asthmatics using steroid inhalers, partial denture wearers and healthy individuals were exposed to sub-therapeutic concentrations of nystatin, amphotericin B, caspofungin, ketoconazole and fluconazole for one hour. Thereafter the drugs were removed and the phospholipase production was determined by a plate assay using an egg yolk-agar medium. Results The phospholipase production of these isolates was significantly suppressed with a percentage reduction of 10.65, 12.14, 11.45 and 6.40% following exposure to nystatin, amphotericin B, caspofungin and ketoconazole, respectively. This suppression was not significant following exposure to fluconazole. Conclusions Despite the sub-therapeutic, intra oral, bioavailability of polyenes, echinocandins and ketoconazole, they are likely to produce a persistent antifungal effect by suppressing phospholipase production, which is a key virulent attribute of this common pathogenic yeast.
Descritores: Fosfolipases/biossíntese
Candida albicans/efeitos dos fármacos
Candida albicans/metabolismo
Candidíase Bucal/microbiologia
Candidíase Bucal/tratamento farmacológico
Antifúngicos/farmacologia
-Polienos/uso terapêutico
Polienos/farmacologia
Azóis/uso terapêutico
Azóis/farmacologia
Candida albicans/isolamento & purificação
Candida albicans/patogenicidade
Fumar
Testes de Sensibilidade Microbiana
Dentaduras
Fatores de Virulência
Diabetes Mellitus
Ativação Enzimática
Espaço Extracelular
Equinocandinas/farmacologia
Antifúngicos/uso terapêutico
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-893630
Autor: BADARÓ, Maurício Malheiros; SALLES, Marcela Moreira; LEITE, Vanessa Maria Fagundes; ARRUDA, Carolina Noronha Ferraz de; OLIVEIRA, Viviane de Cássia; NASCIMENTO, Cássio do; SOUZA, Raphael Freitas de; PARANHOS, Helena de Freitas de Oliveira; SILVA-LOVATO, Cláudia Helena.
Título: Clinical trial for evaluation of Ricinus communis and sodium hypochlorite as denture cleanser
Fonte: J. appl. oral sci;25(3):324-334, May-June 2017. tab, graf.
Idioma: en.
Projeto: São Paulo Research Foundation; . São Paulo Research Foundation.
Resumo: Abstract The development of opportunistic infections due to poor denture hygiene conditions justified the search for effective hygiene protocols for controlling denture biofilm. Objective This study evaluated Ricinus communis and sodium hypochlorite solutions in terms of biofilm removal ability, remission of candidiasis, antimicrobial activity, and participant satisfaction. Material and Methods It was conducted a controlled clinical trial, randomized, double-blind, and crossover. Sixty-four denture wearers with (n=24) and without candidiasis (n=40) were instructed to brush (3 times/day) and immerse their dentures (20 min/day) in different storage solutions (S1 / S2: 0.25% / 0.5% sodium hypochlorite; S3: 10% R. communis; S4: Saline).The trial period for each solution was seven days and a washout period of seven days was used before starting the use of another solution. The variables were analyzed at baseline and after each trial period. The biofilm of inner surfaces of maxillary dentures was disclosed, photographed, and total and dyed areas were measured (Image Tool software). The percentage of biofilm was calculated. Remission of candidiasis was assessed by visual scale and score were attributed. Antimicrobial activity was assessed by the DNA-Checkerboard hybridization method. Patient satisfaction was measured using a questionnaire. Results S1 (4.41±7.98%) and S2 (2.93±5.23%) were more effective then S3 (6.95±10.93%) in biofilm remotion(P<0.0001). All solutions were different from the control (11.07±11.99%). S3 was the most effective solution in remission of candidiasis (50%), followed by S1 (46%). Concerning antimicrobial action, S1/S2 were similar and resulted in the lowest microorganism mean count (P=0.04), followed by S3. No significant differences were found with patient's satisfaction. Conclusions 10% R. communis and 0.25% sodium hypochlorite were effective in biofilm removal, causing remission of candidiasis and reducing the formation of microbial colonies in denture surfaces. All solutions were approved by patients.
Descritores: Ricinus/química
Hipoclorito de Sódio
Candidíase Bucal/tratamento farmacológico
Biofilmes/efeitos dos fármacos
Higienizadores de Dentadura
Prótese Total Superior/microbiologia
Anti-Infecciosos Locais
-Propriedades de Superfície
Fatores de Tempo
Contagem de Colônia Microbiana
Modelos Logísticos
Método Duplo-Cego
Reprodutibilidade dos Testes
Análise de Variância
Resultado do Tratamento
Satisfação do Paciente
Limites: Seres Humanos
Masculino
Feminino
Idoso
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Machado, Alcyone Artioli
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Id: biblio-842770
Autor: Lourenço, Alan Grupioni; Ribeiro, Ana Elisa Rodrigues Alves; Nakao, Cristiano; Motta, Ana Carolina Fragoso; Antonio, Luana Grupioni Lourenço; Machado, Alcyone Artioli; Komesu, Marilena Chinali.
Título: Oral Candida spp carriage and periodontal diseases in HIV-infected patients in Ribeirão Preto, Brazil
Fonte: Rev. Inst. Med. Trop. Säo Paulo;59:e29, 2017. tab, graf.
Idioma: en.
Projeto: National Counsel of Technological and Scientific Development.
Resumo: ABSTRACT The majority of HIV-infected patients develop Candida spp-associated clinical oral lesions. Studies have shown that asymptomatic oral colonization of Candida spp may lead to oral lesions or become a source of disseminated infections. The aim of this study was to verify the effects of periodontal conditions on Candida spp prevalence and Candida spp carriage in the oral cavity of HIV-infected patients compared to non-infected patients. Twenty-five patients not infected with HIV and 48 HIV-infected patients were classified according to periodontal conditions as being periodontal healthy or with periodontal disease. Candida spp carriage and classification were performed in oral rinse samples. Viral load and CD4+ T lymphocyte (CD4+L) counts were performed in blood samples from HIV-infected patients. No differences in Candida spp prevalence related to HIV status or periodontal condition were detected. However, Candida spp carriage was increased in periodontally affected HIV-infected patients when compared to periodontally healthy HIV-infected patients (p= 0.04). Periodontally healthy HIV-infected patients presented Candida spp carriage in similar levels as healthy or periodontally affected non-HIV-infected patients. Candida spp carriage was correlated with CD4+L counting in HIV-infected patients. We concluded that periodontal disease is associated with increased Candida spp carriage in HIV-infected patients and may be a predisposing factor to clinical manifestations of candidiasis.
Descritores: Doenças Periodontais/microbiologia
Candida/classificação
Candidíase Bucal/microbiologia
Infecções Oportunistas Relacionadas com a AIDS/microbiologia
-Doenças Periodontais/epidemiologia
Brasil/epidemiologia
Candida/isolamento & purificação
Candidíase Bucal/epidemiologia
Portador Sadio
Infecções Oportunistas Relacionadas com a AIDS/epidemiologia
Contagem de Linfócito CD4
Carga Viral
Boca/microbiologia
Limites: Seres Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: lil-615121
Autor: Matos Paraguassú, Gardênia; Andrade Pimentel, Poliana; Rode Santos, Aline; Araújo Silva Gurgel, Clarissa; Almeida Sarmento, Viviane.
Título: Prevalência de lesões bucais associadas ao uso de próteses dentárias removíveis em um serviço de estomatologia / Prevalencia de lesiones bucales asociadas al uso de prótesis dentales removibles, en un servicio de estomatología / Prevalence of oral lesions associated with use of removable dental prostheses in a Stomatology service
Fonte: Rev. cuba. estomatol;48(3):268-276, jul.-set. 2011.
Idioma: pt.
Resumo: As próteses dentárias removíveis restabelecem a função e estética do sistema estomatognático, embora possam causar injúrias aos tecidos bucais. O objetivo deste estudo é avaliar a prevalência de lesões bucais relacionadas ao uso de próteses dentárias removíveis. Foi realizada a revisão de prontuários dos pacientes atendidos no Serviço de Estomatologia da Faculdade de Odontologia da Universidade Federal da Bahia, no periodo de junho de 2006 à dezembro de 2007. Dos 28 indivíduos usuários de próteses dentárias removíveis, 25 (89,3 por cento) apresentaram alguma alteração na mucosa bucal, sendo que 42,8 por cento destas apresentavam-se mal-adaptadas. A hiperplasia fibrobrosa inflamatória (29,42 por cento), candidíase crônica atrófica (20,6 por cento), queilite angular (8,82 por cento) e úlcera traumática (8,82 por cento) foram as lesões mais prevalentes, e a mucosa alveolar (35,3 por cento) e o palato duro (29,4 por cento) os sítios anatômicos mais acometidos. Estes resultados reafirmam a importância da confecção de próteses adequadas, da necessidade de se realizar controles periódicos e fornecer instruções sobre higiene bucal aos pacientes que vierem fazer uso de próteses dentárias removíveis(AU)

Las prótesis dentales removibles restauran la función y la estética del sistema estomatognático, pero pueden causar daños a los tejidos bucales. El objetivo de este estudio fue evaluar la prevalencia de lesiones bucales relacionadas con el uso de prótesis removibles. Se realizó una revisión del historial de los pacientes atendidos en el Servicio de Estomatología de la Facultad de Odontología de la Universidad Federal de Bahía de Brasil, del mes de junio del año 2006 al mes de diciembre del año 2007. De los 28 individuos que usaron prótesis dentales removibles, 25 mostraron anormalidades en la mucosa bucal, para un 89,3 por ciento; y el 42,8 por ciento de estas estaban mal adaptadas. Dentro de las lesiones se encuentra la hiperplasia fibrosa inflamatoria en el 29,42 por ciento de la muestra, la candidiasis crónica atrófica en el 20,6 por ciento, la queilitis angular en el 8,82 por ciento y la úlcera traumática en el 8,82 por ciento. Los sitios anatómicos más afectados fueron la mucosa alveolar con un 35,3 por ciento y el paladar con un 29,4 por ciento. Estos resultados subrayan la importancia del uso de prótesis adecuadas, así como la necesidad de realizar controles periódicos y de proporcionar instrucciones sobre la higiene bucal en pacientes que usan prótesis removibles(AU)

The removable dental prosthesis restores the function and esthetics of stomatognathic system but may to cause damages in oral tissues. The objective of present study is to assess the prevalence of oral lesions related to the use of removable prostheses. Authors made a review of records of patients seen in the Stomatology service of the Dentistry Faculty of Bahia Federal University of Brazil, from June, 2006 to December, 2007. From the 28 subjects using removable prostheses, 25 (89.3 percent) showed abnormalities in the buccal mucosa and the 42.8 percent of them were not well adapted. The inflammatory fibrous hyperplasia (29.42 percent), atrophic chronic candidiasis (20.6 percent), angular cheilitis (8.82 percent) and traumatic ulcer (8.82 percent) were the more frequent lesions and the alveolar mucosa (35.3 percent) and palate (29.4 percent) were the anatomical sites more involved. These results emphasize la significance of an appropriate prosthesis, the need to make periodical controls and to give instructions on oral hygiene for patients that may use removable prostheses(AU)
Descritores: Higiene Bucal/métodos
Candidíase Bucal/epidemiologia
Prótese Parcial Removível/efeitos adversos
-Mucosa Bucal/anormalidades
Limites: Seres Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-1047354
Autor: Mendes, Mariana Sarmet Amiderle; Jales, Sumatra Melo da Costa Pereira; Carvalho, Ricardo Tavares de; Algranti, Bruna Mezan; Anagusko, Sergio Seiki; Andrade, Ana Carolina Porro de.
Título: Cuidados bucais em paciente com fibrose pulmonar idiopática sob cuidados paliativos. Relato de caso / Oral care in idiopathic pulmonary fibrosis patient in palliative care. Case report
Fonte: Rev. Soc. Cardiol. Estado de Säo Paulo;29(4 (Supl)):441-445, out.-dez. 2019. tab, ilus.
Idioma: pt.
Resumo: A Fibrose Pulmonar Idiopática (FPI) é uma doença crônica do interstício pulmonar que se manifesta por fibrose progressiva com alta prevalência de insuficiência respiratória. Como toda doença crônica e progressiva, a FPI necessita de acompanhamento por uma equipe multiprofissional de Cuidados Paliativos (CP) a fim de proporcionar um cuidado integral, considerando todas as queixas e necessidades do paciente. Em uma enfermaria de CP de um hospital terciário, um paciente do sexo masculino, 77 anos, foi admitido por FPI avançada para controle de sintomas e cuidados de fim de vida. Durante a oroscopia realizada pela equipe, recebeu diagnóstico de candidíase oral, onde foi solicitada avaliação do cirurgião-dentista. Na avaliação odontológica, queixou-se de língua ressecada e perda do paladar. Paciente acamado, dispneico em repouso, em uso contínuo de máscara de venturi e lábios ressecados, com presença de placas brancas ressecadas (resíduos alimentares) em palato duro e mole, mucosa jugal e gengival, língua ressecada com saburra e hipossalivação. Foi realizada a higiene oral, prescrição de substituto salivar e hidratante labial. O procedimento foi longo e intermitente devido à dificuldade do paciente de se manter sem o suporte de oxigênio. Após o procedimento, o paciente relatou melhora de 90% dos sintomas bucais. Conclusão: O caso apresentou as alterações bucais e os cuidados odontológicos em um paciente com FPI e também evidenciou a importância da avaliação especializada realizada pelo cirurgião-dentista inserido em uma equipe multiprofissional em CP, que, além do diagnóstico diferencial, proporcionou alívio dos sintomas bucais e conforto ao paciente em sua fase final de vida

Idiopathic Pulmonary Fibrosis (IPF) is a chronic interstitial lung disease manifested by progressive fibrosis with a high prevalence of respiratory failure. As all chronic and progressive diseases, IPF needs follow-up by a multidisciplinary Palliative Care (PC) team in order to provide comprehensive care considering all patient's complaints and needs. In a PC inpatient unit of a tertiary hospital, a 77-year-old male patient was admitted because of advanced IPF for symptom control and end-of-life care. During the oroscopy done by the team, he was diagnosed with oral candidiasis, where evaluation by the dentist was requested. In the dental evaluation, he complained of dry tongue and taste loss. Bedridden patient, dyspnea at rest, in continuous use of venturi mask and dry lips, dry white plaques (food residues) in hard and soft palate, jugal and gingival mucosa, dry tongue with oral coating and hyposalivation. Oral hygiene was performed, salivary substitute and lip moisturizer were prescribed. The procedure was long and intermittent due to the difficulty of the patient with staying without oxygen support. After the procedure, the patient reported 90% improvement in oral symptoms. Conclusion: The case showed the oral disorders and dental care in a patient with IPF and highlighted the importance of specialized evaluation performed by the dentist inserted in a multidisciplinary PC team which, besides the differential diagnosis, provided symptom relief of the mouth and comfort to the patient in his end of life
Descritores: Manifestações Bucais
Cuidados Paliativos
Fibrose Pulmonar Idiopática
-Higiene Bucal
Equipe de Assistência ao Paciente
Insuficiência Respiratória
Candidíase Bucal
Doença Crônica
Odontólogos
Diagnóstico Diferencial
Diagnóstico Bucal
Pneumopatias
Tipo de Publ: Relatos de Casos
Responsável: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt


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Rode, Sigmar de Mello
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Id: biblio-966755
Autor: Rode, Sigmar de Mello; Jóias, Renata Pilli; Oliveira, Jonatas Rafael de; Mattos, Maria Fernanda; Jorge, Antônio Olavo Cardoso; Silva, Michelle Perreluppi; Seixas, Ellen Cristina Libonati.
Título: Assessment of Candida SPP. proliferation in occlusal and palatal splints / Avaliação da proliferação Candida SPP. em placas oclusais e palatais
Fonte: Biosci. j. (Online);34(2):525-533, mar./apr. 2018. ilus, tab.
Idioma: en.
Resumo: Candida species inhabit the oral cavity of all individuals who wear complete denture and whose material is the same as that used in splints. Assess the growth of C. albicans in occlusal and palatal splints used for treatment of TMD so that the potential risks of oral microbiota can be assessed. The growth of Candida spp. was assessed in the saliva of 27 individuals wearing splints for treatment of TMD. They were divided into two groups: G1 (n = 14), individuals wearing occlusal splint; and G2 (n = 13), individuals wearing palatal splint. Saliva samples were collected during placement of the splints (T1) and after 4 months (T2), being stored in PBS (10 mL) after 60-second rinses. It was observed that patients wearing occlusal splints (G1) had an increase of 0.648 CFU/mL (Log 10), with statistically significant differences (P = 0.043) for C. albicans (42.33%), C. glabrata (5.52%), C. krusei (41.72%) and C. tropicalis (10.43%). In the group of patients wearing palatal splints (G2), there was a decrease of 0.101 CFU/mL (Log 10), was observed with (P = 0.964) only the presence of C. albicans. The results suggest that growth of Candida species was greater in patients wearing occlusal splints compared to those wearing palatal ones as the presence of different yeast species was found in the former.

Espécies de Candida habitam a cavidade oral de 60-100% de indivíduos usuários de prótese total, cujo material é o mesmo utilizado em placas miorrelaxante. Avaliar o crescimento de C. albicans. em placas relaxantes musculares oclusais e palatais, usadas para o tratamento de DTM, na intenção de verificar riscos em potencial à microbiota bucal. Avaliou-se o crescimento de Candida spp. na saliva de 27 indivíduos, usuários de placa miorrelaxante, em tratamento para DTM no ICT-UNESP. Os indivíduos foram divididos em dois grupos: G1(n=14) ­ placa com recobrimento oclusal; e G2 (n=13) ­ sem recobrimento. As coletas foram com PBS (10mL), em bochechos por 60seg, na instalação das placas (T1) e após 4 meses (T2). Observou-se que pacientes usuários da placa miorrelaxante com recobrimento oclusal (grupo G1) apresentaram aumento de 0,648 UFC/mL (Log10) com diferença estatisticamente significante (p=0,043) analisando-se 42,33% C. albicans, 5,52% C. glabrata, 41,72% C. krusei e 10,43% C. tropicalis. No grupo de pacientes que utilizaram a placa sem recobrimento (grupo G2), observou-se diminuição de 0,101 UFC/mL (Log10) com (p=0,954) apresentando apenas C. albicans. Os resultados sugerem que os pacientes que fizeram uso de placa miorrelaxante com recobrimento oclusal apresentaram maior crescimento de Candida spp. em relação aos usuários de placa sem recobrimento, verificando-se a presença de diferentes espécies da levedura.
Descritores: Candida
Contagem de Colônia Microbiana
-Higiene Bucal
Candidíase Bucal
Placas Oclusais
Prótese Dentária
Responsável: BR396.1 - Biblioteca Central


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Id: biblio-1025562
Autor: Bergamo, Vanessa Zafaneli.
Título: Novas tendências de combate ao biofilme de Candida em próteses dentárias / New trends to combat Candida biofilm in dental prosthetics
Fonte: Clin. biomed. res;38(2):155-166, 2018.
Idioma: pt.
Resumo: Apesar de a espécie Candida albicans ser efetivamente o microrganismo mais frequentemente associado a estomatite protética, as espécies de Candida não albicans já foram isoladas nas superfícies de dentaduras e da mucosa oral de indivíduos com essa lesão eritematosa. A virulência das espécies de Candida e a capacidade de adesão a polímeros acrílicos são condições prévias para a colonização e o desenvolvimento de biofilmes em superfícies de dentaduras. Estudos recentes focam na tentativa de modificação das resinas acrílicas para diminuir a adesão de cepas patogênicas e formadoras de biofilme do gênero Candida spp. Dentro desse aspecto, esta revisão sistematiza o atual panorama epidemiológico da estomatite protética associada ao uso de próteses dentárias, bem como as atuais e novas opções de combate ao biofilme fúngico especializado na adesão desse tipo de biomaterial. (AU)

Although the Candida albicans species is effectively the microorganism most frequently associated with prosthetic stomatitis, Candida non-albicans species have already been isolated from the denture and oral mucosal surfaces of individuals with this erythematous lesion. The virulence of Candida species and the ability to adhesion to acrylic polymers are preconditions for the colonization and development of biofilms on denture surfaces. Recent studies focus on the attempt to modify the acrylic resins to reduce the adhesion of pathogenic and biofilm forming strains of the genus Candida spp. In this aspect, this review systematizes the current epidemiological panorama of prosthetic stomatitis associated with the use of dental prostheses, as well as new options for combating the fungal biofilm specialized in the adhesion of this type of biomaterial. (AU)
Descritores: Candida albicans/patogenicidade
Infecções Relacionadas à Prótese
Prótese Dentária/efeitos adversos
Biofilmes
-Estomatite sob Prótese
Resinas Acrílicas/efeitos adversos
Candidíase Bucal
Placa Dentária/prevenção & controle
Limites: Seres Humanos
Tipo de Publ: Revisão
Responsável: BR18.1 - Biblioteca FAMED/HCPA


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Id: biblio-998255
Autor: Sankari, Sankar Leena; Mahalakshmi, Krishnan.
Título: Oral Candidal Carriage Among Patients with Oral Potential Malignant Disorders: A Case-Control Study
Fonte: Pesqui. bras. odontopediatria clín. integr;19(1):4802, 01 Fevereiro 2019. tab.
Idioma: en.
Resumo: Objective: To determine the prevalence of Candida species in the saliva of patients with clinically suspected oral potentially malignant disorders (OPMD) and healthy cohorts. Material and Methods: Unstimulated saliva was collected from patients with OPMD (n=100) and age and sex matched healthy subjects (n=170). The samples were inoculated onto Sabouraud Dextrose Agar and incubated for a week. The colonies of the isolates were enumerated using a colony counter. The isolates were identified using standard phenotypic methods. The significance of oral candidal carriage was calculated using Independent T test. Odds and Risk ratio was calculated using Pearson's Chi-square test. Results: Oral candida carriage was present in 51% of patients with OPMD while healthy cohorts had a prevalence of 20.6%. A good statistical significance was observed for the prevalence of oral candidal carriage for patients with OPMD in comparison to healthy cohorts (p=0.013). Significant Odds and risk ratio was observed for the prevalence of Candida species among OPMD. Majority of the isolates in both groups were C. albicans. Colony forming units were high among patients with OPMD. Conclusion: A significant association of oral candidal carriage to oral potentially malignant disorders in comparison to healthy cohorts was observed. Candidal species may be potent risk factor for transition of OPMD to oral Squamous Cell Carcinoma.
Descritores: Fenótipo
Candidíase Bucal/prevenção & controle
Leucoplasia Bucal
Neoplasias Bucais/patologia
Estudos de Casos e Controles
-Fibrose Oral Submucosa/patologia
Candida albicans
Distribuição de Qui-Quadrado
Índia
Limites: Seres Humanos
Masculino
Feminino
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos



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