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Vicente, Vânia Aparecida
Carvalho, Newton Sérgio de
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Id: lil-780822
Autor: Fornari, Gheniffer; Vicente, Vania Aparecida; Gomes, Renata Rodrigues; Muro, Marisol Dominguez; Pinheiro, Rosangela Lameira; Ferrari, Carolina; Herkert, Patricia Fernanda; Takimura, Marcos; Carvalho, Newton Sérgio de; Queiroz-Telles, Flavio.
Título: Susceptibility and molecular characterization of Candida species from patients with vulvovaginitis
Fonte: Braz. j. microbiol;47(2):373-380, Apr.-June 2016. tab, graf.
Idioma: en.
Resumo: Abstract Vulvovaginal candidiasis affects women of reproductive age, which represents approximately 15–25% of vaginitis cases. The present study aimed to isolate and characterize yeast from the patients irrespective of the presentation of clinical symptoms. The isolates were subjected to in vitro susceptibility profile and characterization by molecular markers, which intended to assess the distribution of species. A total of 40 isolates were obtained and identified through the CHROMagar, API20aux and by ITS and D1/D2 regions sequencing of DNAr gene. Candida albicans strains were genotyped by the ABC system and the isolates were divided into two genotypic groups. The identity of the C. albicans, C. glabrata, C. guilliermondii, C. kefyr and Saccharomyces cerevisiae isolates was confirmed by the multilocus analysis. The strains of Candida, isolated from patients with complications, were found to be resistant to nystatin but sensitive to fluconazole, amphotericin B and ketoconazole, as observed by in vitro sensitivity profile. The isolates from asymptomatic patients, i.e., the colonized group, showed a dose-dependent sensitivity to the anti-fungal agents, fluconazole and amphotericin B. However, the isolates of C. albicans that belong to distinct genotypic groups showed the same in vitro susceptibility profile.
Descritores: Candida/efeitos dos fármacos
Candidíase Vulvovaginal/microbiologia
Antifúngicos/farmacologia
-Pacientes/estatística & dados numéricos
Candida/isolamento & purificação
Candida/classificação
Candida/genética
Testes de Sensibilidade Microbiana
Fluconazol/farmacologia
Farmacorresistência Fúngica
Limites: Seres Humanos
Feminino
Adolescente
Adulto
Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-907840
Autor: Aguilar, Gustavo; Araujo, Patricia; Godoy, Elizabeth; Falcón, Myrian; Centurión, María Gloria; Ortíz, Rossana; Britez, Mariel; Martínez, Mario.
Título: Identificación y características de Candida spp en secreción vaginal de pacientes embarazadas y no embarazadas / Identification and characteristics of Candida spp in vaginal secretion of pregnant and non-pregnant patients
Fonte: Mem. Inst. Invest. Cienc. Salud (Impr.);15(3):6-12, Dic. 2017. tab.
Idioma: es.
Resumo: El objetivo de este estudio fue identificar las especies de Candida spp. aisladas de secreción vaginal de pacientes embarazadas y no embarazadas y relacionarlas con la microscopía, síntomas y signos característicos de la vaginitis causada por esta levadura. Se estudiaron 743 muestras de secreción vaginal de pacientes que acudieron al Departamento de Bacteriología y Micología del Laboratorio Central en el 2015. Las muestras fueron sembradas en CHROM agar Candida y agar Sabouraud. La identificación se hizo por macro y micromorfología, pruebas bioquímicas, auxonograma y método comercial. En las 522 pacientes embarazadas se aislaron 536 Candida spp.: C. albicans 463 (86,4%), C. glabrata 46 (8,6%), C. krusei 9 (1,7%), C. parapsilosis 9 (1,7%), C. tropicalis 8 (1,5%), C. lusitaniae 1 (0,1%).En las 221 pacientes no embarazadasse aislaron 222 Candida spp.: C. albicans 163 (73,4%), C. glabrata 31 (14%), C. krusei 10 (4,6%), C. parapsilosis 9 (4,1%), C. tropicalis 6 (2,7%), C. guilliermondii 1 (0,4%), C. kefyr 1 (0,4%) y C. novergensis 1 (0,4%). Se observó un mayor porcentaje de aislamiento de Candida no albicansen las no embarazadas (26,6% vs 13,6%). En 15 pacientes (2%) se aislaron dos especies de Candida.Tanto en embarazadas como no embarazadas el prurito, la reacción inflamatoria y la presencia de pseudohifas fueron más frecuentes cuando el aislamiento era C. albicans. Enfatizamos la importancia de la siembra de las muestras en agar cromogénico para identificar y diferenciar especies de Candida para la epidemiología y un tratamiento eficazde la vaginitis causada por esta levadura.

The objective of this study was to identify Candida spp. isolated from vaginal secretion of pregnant and non-pregnant women and relate them with microscopy, symptoms and signs characteristic of vaginitis caused by this yeast. A total of 743 vaginal secretion samples wasstudied from patients consulting at the Department of Bacteriology and Mycology of the Central Laboratory in 2015. All samples were cultured on CHROM agar Candida and Sabouraud agar. The identification was made by macro and micromorphology, biochemical tests, auxonogram and commercial method. In pregnant patients (n = 522), 536 Candida spp. were isolated: C. albicans 463 (86.4%), C. glabrata 46 (8.6%), C. krusei 9 (1,7%), C. parapsilosis 9 (1.7%), C. tropicalis 8 (1.5%), C. lusitaniae 1 (0.1%). In no-pregnant patients (n = 221),222 Candida spp.were isolated: C. albicans 163 (73.4%), C. glabrata 31 (14%), C. krusei 10 (4.6%), C. parapsilosis 9 (4.1%), C. tropicalis 6 (2.7%), C. guilliermondii 1 (0.4%), C. kefyr 1 (0.4%) and C. novergensis 1 (0.4%).In the non-pregnant women, a higher percentage of non-albicans Candida species isolation was observed (26.6% vs 13.6%). Fifteen patients (2%) with two Candida species were detected. In pregnant as well non pregnant women, presence of pruritus, inflammatory reactions and and presence of pseudohifas were more frequent when Candida albicans was isolated.We emphasize the importance of culturing samples in chromogenic agar to identify and differentiate Candida species for epidemiology and an effective treatment of the vaginitis caused by this yeast.
Descritores: Candidíase Vulvovaginal
Descarga Vaginal
-Infecção
Limites: Feminino
Seres Humanos
Adolescente
Adulto
Gravidez
Meia-Idade
Responsável: PY3.1 - Biblioteca


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Id: biblio-884960
Autor: Duarte, Cynthia; Soilán, Ana María.
Título: Detección de Chlamydia trachomatis, esporos micóticos y Trichomonas vaginalis en mujeres en edad fértil que acuden a los Hospitales San Pablo y Regional de San Lorenzo / Chlamydia trachomatis, fungal spores and Trichomonas vaginalis detection of childbearing age women who attend to San Pablo Hospital and Regional of San Lorenzo
Fonte: Rev. Nac. (Itauguá);3(2):36-42, dic. 2011.
Idioma: es.
Resumo: Introducción: Las infecciones vulvo-cérvico-vaginales constituyen la causa más común por la que las mujeres en edad fértil acuden al Ginecólogo. Los agentes etiológicos involucrados incluyen a Chlamydia trachomatis, Trichomonas vaginalis, Cándida albicans, entre otros. La sospecha de vulvo-cervico-vaginitis debe orientar a la realización de estudios de secreción vaginal y muestreo endocervical a fin de detectar el agente causal, establecer un tratamiento específico y disminuir la prevalencia de los mismos así como las complicaciones. Objetivos: Determinar la prevalencia de esporos micóticos, Trichomonas vaginalis y Chlamydia trachomatis en mujeres en edad fértil. Materiales y Métodos: Estudio observacional, descriptivo, de corte transversal y prospectivo, con cuestionario realizado a mujeres en edad fértil que acudieron a los hospitales Materno Infantil San Pablo y Regional de San Lorenzo entre los meses de diciembre de 2010 a febrero de 2011. Resultados: De las 148 pacientes estudiadas, se observó una prevalencia de 27,7% de esporos micóticos, 2% de Trichomonas vaginalis y 4,1% de Chlamydia trachomatis. De las pacientes estudiadas, la mayoría tenían entre 25 a 29 años (26%). Conclusión:La prevalencia de esporos micóticos fue 27,7%, Trichomonas vaginalis 2% y Chlamydia trachomatis 4,1%.

Introduction: the vulvo cervicovaginal infections are the most common reason that women of childbearing age go to the gynecologist. The ethiological agents involved are Chlamydia trachomatis, Trichomonas vaginalis, Candida albicans, among others. The suspicion of cervico-vulvo-vaginitis should guide the studies of vaginal discharge and endocervical sampling to detect the causative agent, to stablish specific treatment and reduce the prevalence of these infections and the complications. Objective: to determine the prevalence of fungal spores, Trichomonas vaginalis and Chlamydia trachomatis in women of childbearing age. Materials and Methods: observational, descriptive, cross-sectional and prospective study performed in women of childbearing age who attended the San Pablo Hospital and Regional of San Lorenzo between the months of December 2010 to February 2011. Results: 148 patients were studied, there was a 27.7% prevalence of fungal spores, 2% Trichomonas vaginalis and 4.1% Chlamydia trachomatis. Of the patients studied, most were between 25 to 29 years (26%). Conclusion: the prevalence of fungal spores was 27.7%, Trichomonas vaginalis 2% and Chlamydia trachomatis 4.1%.
Descritores: Vaginite por Trichomonas/epidemiologia
Candidíase Vulvovaginal/epidemiologia
Infecções por Chlamydia/epidemiologia
-Trichomonas vaginalis/crescimento & desenvolvimento
Candida albicans/crescimento & desenvolvimento
Chlamydia trachomatis/crescimento & desenvolvimento
Prevalência
Estudos Transversais
Estudos Prospectivos
Limites: Seres Humanos
Feminino
Adolescente
Adulto
Meia-Idade
Tipo de Publ: Estudo Observacional
Responsável: PY92.1 - Biblioteca


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Id: biblio-1017751
Autor: Soilán, A.
Título: Frecuencia de candidiasis vaginal en embarazadas del Hospital Nacional de Itauguá / Vaginal frecuency of candidiasis in pregnancy women of the National Hospital of Itauguá
Fonte: Rev. Nac. (Itauguá);1(1):19-24, 2009.
Idioma: es.
Resumo: La infección vaginal por Candida spp , frecuente durante la gestación, la mayoría de los casos de pacientes sanas su probable repercusión motiva la realización de este trabajo para conocer la frecuencia de candidiasis vaginal en embarazadas que acuden a la consulta hospitalaria y su sensibiblidad con los antifúngicos. Se estudiaron 91 embarazadas que acudieron que acudieron al Consultorio Prenatal en el Hospital Nacional desde marzo a julio del 2008. En la población estudiada de mujeres embarazadas se aisló el 21 % de las muestras de levaduras, siendo en su mayoría Candida Albicans y con más frecuencia en las que cursaban el tercer trimestre gestacional. Se encontró amplia sensibilidad a los antifúngicos y resistencia, en las que se aislaron C. Glabrata...
Descritores: Antifúngicos
Candida albicans
Candidíase
Candidíase Vulvovaginal
Complicações Infecciosas na Gravidez/diagnóstico
Complicações Infecciosas na Gravidez/epidemiologia
-Paraguai/epidemiologia
Limites: Feminino
Gravidez
Responsável: PY92.1 - Biblioteca


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Id: biblio-839344
Autor: Brandolt, Tchana Martinez; Klafke, Gabriel Baracy; Gonçalves, Carla Vitola; Bitencourt, Laura Riffel; Martinez, Ana Maria Barral de; Mendes, Josiara Furtado; Meireles, Mário Carlos Araújo; Xavier, Melissa Orzechowski.
Título: Prevalence of Candida spp. in cervical-vaginal samples and the in vitro susceptibility of isolates
Fonte: Braz. j. microbiol;48(1):145-150, Jan.-Mar. 2017. tab.
Idioma: en.
Resumo: Abstract Vulvovaginal candidiasis (VVC) is an infection of the genital mucosa caused by different species of the genus Candida. Considering the lack of data on this topic in the south of Brazil, this study aimed to assess the prevalence of Candida spp. in the cervical-vaginal mucosa of patients treated at a university hospital in southern Rio Grande do Sul, as well as the etiology and the susceptibility of the isolates against fluconazole, itraconazole, miconazole and nystatin. Samples were collected at the gynecology clinic of the Federal Hospital of the University of Rio Grande, and the isolates were identified using phenotypic and biochemical tests. The susceptibility analysis was performed according to the CLSI M27-A2 protocol. Of the 263 patients included, Candida spp. was isolated in 27%, corresponding to a prevalence of approximately 15% for both VVC and colonization. More than 60% of the isolates were identified as Candida albicans; C. non-albicans was isolated at a rate of 8.6% in symptomatic patients and 14.3% in asymptomatic patients. The prevalence of resistance against fluconazole and itraconazole was 42% and 48%, respectively; the minimal inhibitory concentration of miconazole ranged from 0.031 to 8 µg/mL, and that of nystatin ranged from 2 to >16 µg/mL. The high rate of resistance to triazoles observed in our study suggests the necessity of the association of laboratory exams to clinical diagnosis to minimize the practice of empirical treatments that can contribute to the development of resistance in the isolates.
Descritores: Candida/efeitos dos fármacos
Candidíase Vulvovaginal/microbiologia
Candidíase Vulvovaginal/epidemiologia
-Brasil/epidemiologia
Candida/isolamento & purificação
Candida/classificação
Testes de Sensibilidade Microbiana
Infecções por HIV
Prevalência
Farmacorresistência Fúngica
Antifúngicos/farmacologia
Limites: Seres Humanos
Feminino
Gravidez
Criança
Adolescente
Adulto
Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: lil-543908
Autor: Rodrigues, Marcio Tavares; Simões, Letícia Zambelli; Diniz, Cláudio Galuppo.
Título: Clinical, microbiological and therapeutic aspects of vulvovaginal candidiasis and recurrent vulvovaginal candidiasis: importance of regionalsurveys
Fonte: HU rev;35(3), jul.-set. 2009.
Idioma: pt.
Resumo: Vulvovaginal candidiasis (VVC) has a varied aetiology. The yeasts involved in this disease have presented increased resistance to the azoles and poliens, the drugs of choice for treatment. In recurrent VVC, the therapeutic difficulties are even greater. The epidemiological relevance of aetiological diagnosis and of the antifungigram in clinical treatment is discussed.
Descritores: Candidíase
Candidíase Vulvovaginal
-Candidíase Vulvovaginal/diagnóstico
Candidíase Vulvovaginal/tratamento farmacológico
Candidíase Vulvovaginal/terapia
Antifúngicos
Tipo de Publ: Relatos de Casos
Responsável: BR378.1 - Biblioteca Central


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Id: lil-543907
Autor: Zimmermmann, Juliana Barroso; Freitas, Camila Leijôto; Perígolo, Lines Ferreira; Campos, Paula Chaves; Mourão, Renara de Pinho Caldeira; Bicalho, Silvia Nascimento.
Título: Avaliação do tratamento antifúngico oral e tópicooral para a candidíase vulvovaginal / Clinical cure after treatment regimens oral, topical, oral and topical for vulvovaginal candidiasis
Fonte: HU rev;35(3), jul.-set. 2009.
Idioma: pt.
Resumo: Em avaliação clínica do tratamento oral e tópico oral para a candidíase vulvovaginal, verificou-se que não há diferença entre o tratamento oral e tópico oral (p>0,05). Desta forma, acredita-se que o tratamento oral deva ser estimulado, não associado ao medicamento tópico, pois incrementa o custo, sem benefícios adicionais.

The authors present the clinical evaluation of oral treatment, topical and oral-topic for vulvovaginal candidiasis, and ensure that there is no difference between the oral and topical oral treatment (p> 0.05). Believe that the oral treatment should be encouraged, not associated with the drug topic, it increases the cost without additional benefit. Believe that the topical medication should be limited to patients with contra-indication tooral maedication.
Descritores: Candidíase
Candidíase Vulvovaginal
-Candidíase Vulvovaginal/diagnóstico
Candidíase Vulvovaginal/tratamento farmacológico
Tipo de Publ: Relatos de Casos
Responsável: BR378.1 - Biblioteca Central


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Lima, Edeltrudes de Oliveira
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Id: biblio-966207
Autor: Medeiros, Cássio Ilan Soares; Silva, Daniele de Figueredo; Pérez, Ana Luíza Alves de Lima; Almeida Filho, Geraldo Gonçalves de; Oliveira Filho, Abrahão Alves de; Lima, Edeltrudes de Oliveira.
Título: Study of the antifungal potential of (r)-(+)-citronellal and its association with therapeutic agents used in the treatment of vulvovaginal candidiasis / Estudo do potencial antifúngico do (r)-(+)-citronelal e sua associação com agentes terapêuticos utilizados no tratamento da candidíase vulvovaginal
Fonte: Biosci. j. (Online);33(2):494-506, mar./apr. 2017. ilus, tab, graf.
Idioma: en.
Resumo: Vulvovaginal candidiasis (VVC) is a common fungal infection that affects healthy women of all ages. At least 75% of women will develop one or more infections once during their lifetime, with 6 to 9% of those individuals developing recurrent infections. In view of this context, this study sought to evaluate the antifungal potential of the isolated (R)-(+)-citronellal [(R)-(+)-CT] and associated to therapeutic agents of clinical importance. The enantiomer was solubilized in tween 80 and dimethylsulfoxide (DMSO). Posteriorly diluted in sterile distilled water up to the concentration of 2048µg/mL. The minimum inhibitory concentration (MIC) of the product was determined by microdilution in RPMI-1640 obtaining dilutions of 1024-4µg/mL. The minimum fungicidal concentration (MFC) was determined by the Sabouraud dextrose agar (SDA) depletion technique from aliquots of 1µL of the MIC, MIC × 2 and MIC × 4. The MIC and the MFC values of (R)-(+)-CT for 90% of the C. albicans strains were 16 and 32µg/mL respectively. In the susceptibility test, C. albicans presented a high resistance to fluconazole and to itraconazole, 12 (92.30%) of the strains. However, for ketoconazole and miconazole the resistance was of 4 (30.76%) and 3 (23.07%) of the strains respectively. In the combination testing of the (R)-(+)-CT with ketoconazole and miconazole, the resistance was completely reverted. For fluconazole and itraconazole, the resistance was reverted in 9 (75%) and 7 (58.33%) of the strains respectively. The (R)-(+)-CT presented fungicide activity with MFC of MIC × 2. When in combination with ketoconazole, fluconazole, itraconazole and miconazole increased the inhibition zones of these antifungal drugs, reducing the resistance against C. albicans.

Candidíase vulvovaginal (CVV) é uma infecção fúngica comum que afeta mulheres saudáveis de todas as idades. Pelo menos 75% das mulheres irão desenvolver uma ou mais infecções uma vez durante a vida, com 6 a 9% dos indivíduos desenvolvendo infecções recorrentes. Diante deste contexto, buscou-se avaliar neste estudo o potencial antifúngico do (R)-(+)-citronelal [(R)-(+)-CT] isolado e associado a agentes terapêuticos de importância clínica. O enantiômero foi solubilizado em tween 80 e dimetilsulfóxido (DMSO). Posteriormente diluiu-se em água destilada estéril até a concentração de 2048µg/mL. A concentração inibitória mínima (CIM) do produto foi determinada por microdiluição em meio RPMI-1640 obtendo diluições de 4-1024µg/mL. A concentração fungicida mínima (CFM) foi determinada pela técnica de esgotamento em agar Sabouraud dextrose (ASD) a partir de alíquotas de 1mL da CIM, CIM × 2 e CIM × 4. A CIM e a CFM do (R)-(+)-CT para 90% das cepas de C. albicans foram 16 e 32µg/mL respectivamente. No ensaio de suscetibilidade, C. albicans apresentou alta resistência ao fluconazol e ao itraconazol, 12 (92.30%) das cepas. No em tanto, para o cetoconazol e o miconazol a resistência foi de 4 (30.76%) e 3 (23.07%) das cepas respectivamente. No ensaio de combinação do (R)-(+)-CT com cetoconazol e miconazol, a resistência foi completamente revertida. Para o fluconazol e o itraconazol, a resistências foi revertida em 9 (75%) e 7 (58.33%) das cepas respectivamente. O (R)-(+)-CT apresentou atividade fungicida com CFM igual à CIM × 2. Quando em combinação com cetoconazol, fluconazol, itraconazol e miconazol ampliou as zonas de inibição desses antifúngicos, diminuindo a resistência contra C. albicans.
Descritores: Candida albicans
Candidíase Vulvovaginal
Antifúngicos
Responsável: BR396.1 - Biblioteca Central


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Id: lil-632979
Autor: Castro, María Isabel; Abratte, Oscar; Barocchi, Miguel; Musacchio, María Laura.
Título: Coloración de Papanicolaou y su importancia en el diagnóstico de las infecciones cervicovaginales / Papanicolaou-stained smears: its importance in the diagnosis of cervicovaginal infections
Fonte: Acta bioquím. clín. latinoam;38(2):199-202, mar.-jun. 2004. ilus, tab.
Idioma: es.
Resumo: La coloración de Papanicolaou, además de la detección temprana del carcinoma de cuello uterino, brinda información sobre el estado hormonal y es orientativa al diagnóstico de infecciones cervicovaginales. La importancia de su detección y tratamiento radica en que pueden evitarse complicaciones posteriores, como enfermedad pélvica inflamatoria, ruptura prematura de membranas, abortos, sepsis del recién nacido, esterilidad. Se procesaron 251 muestras. Se estudió la correlación entre la información brindada por la coloración de Papanicolaou y el examen microbiológico (observación en fresco y coloración de Gram), con el fin de verificar la utilidad que puede brindar la coloración de Papanicolaou como alerta de las infecciones cervicovaginales. Para clasificar las muestras como vaginosis bacterianas se aplicaron los criterios de Amsel. Sobre el total de las muestras se obtuvo para las vaginosis 80% de correlación. En el caso de las infecciones micóticas el porcentaje representa 69%, valor que asciende a 75% si se consideran las muestras inflamatorias. Para Trichomonas vaginalis se obtuvo 100% de concordancia. La comparación de estos dos procedimientos revela un alto porcentaje de correlación, siendo el examen de Papanicolaou un valioso auxiliar para el diagnóstico de ciertas infecciones cervicovaginales.

The Papanicolaou (Pap) smearis not only a mean of early detection of cervical cancer, but also a cytologic screening which reports on the hormonal condition and helps in the diagnosis of cervicovaginal infections. The importance of the early detection and management of this kind of infections is based on the possibility of preventing from later complications such as pelvic inflammatory disease, early breaking of water, abortions, neonatal sepsis and infertility. In order to prove the uses of the Pap-stained smears as a way of diagnosis on potential cervicovaginal infections, 251 samples have been studied focusing on the correlation between the results of Pap-stained smears and those of wet preparations and Gram-stained. The Amsel criteria has been used to classify the samples as Bacterial Vaginosis cases. Taking the Vaginosis cases, 80% of them showed correlation between cytologic and bacteriological techniques. Mycotic infections were detected in 69% of the samples, rate which increased to 75% considering the inflammatory samples. The correlation between the Pap-stained smears and wet preparations/Gram-stained was of 100% for Trichomonas vaginalis samples. In conclusion, there is a high correlation between these two methods that proves the importance of the Pap-stained smears as an auxiliary process for diagnosing specific cervicovaginal infections.
Descritores: Candidíase Vulvovaginal
Teste de Papanicolaou
Microbiologia
-Trichomonas vaginalis
Vaginose Bacteriana
Bacilos Gram-Positivos
Teste de Papanicolaou/estatística & dados numéricos
Limites: Seres Humanos
Feminino
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


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Id: lil-633063
Autor: Dalben Dota, Kelen Fátima; Shinobu, Cristiane Suemi; Patussi, Eliana Valéria; Lopes Consolaro, Marcia Edilaine; Estivalet Svidzinski, Terezinha Inez.
Título: Susceptibilidad de levaduras vaginales a los antifúngicos más utilizados en Maringá, Paraná, Brasil / Susceptibility to vaginal yeast in most used antifungal in Maringá, Paraná, Brazil
Fonte: Acta bioquím. clín. latinoam;42(4):561-566, oct.-dic. 2008. graf, tab.
Idioma: es.
Resumo: Se determinó la susceptibilidad antifúngica in vitro de 78 cepas de levaduras aisladas de mujeres de la ciudad de Maringá/Paraná, Brasil, con candidiasis vulvovaginal (CVV), atendidas en el Laboratorio de Enseñanza e Investigación en Análisis Clínicos (LEPAC) de la Universidad Estatal de Maringá, desde el 1 de enero 2005 al 31 de diciembre 2006. Su sensibilidad in vitro fue investigada por el método de microdilución frente a ketoconazol (KETO), fluconazol (FLU), itraconazol (ITRA), nistatina (NIS) y anfotericina B (AMB). Para KETO, 41,5% de las cepas de C. albicans y 96% de Candida no-albicans presentaron resistencia (100% de C. glabrata) y para FLU solamente el 3,8% de los aislamientos de C. albicans y el 8,0% de C. glabrata fueron resistentes. Sólo 1,9% de las cepas de C. albicans y 20% de las de C. no-albicans fueron resistentes a ITRA y el 5,7% de las C. albicans y el 8% de las C. no-albicans (sólo C. glabrata) fueron resistentes a AMB. No hubo aislamientos resistentes a NIST, pero sí una elevada frecuencia de sensibilidad dosis dependiente "in vitro". Estos datos avalan la creciente necesidad de la realización de pruebas de identificación y susceptibilidad in vitro a los antifúngicos para establecer el correcto tratamiento de la CVV.

In vitro antifungal susceptibility was determined in the 78 yeasts isolated from patients with vulvovaginal candidiasis (VVC) from the city of Maringá/Parana/Brazil, assisted in the Laboratory of Teaching and Research in Clinical Analysis of the State University of Maringá, from 01 January 2005 to December 31, 2006. Its sensibility in vitro was tested according to microdilution method in front of ketoconazol (KETO), fluconazole (FLU), itraconazole (ITRA), nistatin (NIS) and amphotericin B (AMB). For KET, 41.5% of the C. albicans and 96.0% of the C. non-albicans showed resistance (100.0% of C. glabrata) and for FLU, only 3.8% of the isolates of C. albicans and 8.0% of C. glabrata showed resistance. Only 1.9% of the C. albicans and 20% of the C. no-albicans were resistant. For AMB, 5.7% of the C. albicans and 8% of the C. no-albicans (only C. glabrata), were resistant. There were no isolations resistant from NIST, however, there was a high frequency of dose-dependent sensibility (SDD) in vitro. These data makes it possible to confirm the growing necessity of the performance of identification tests and in vitro antifungal susceptibility to antifungals to establish the correct treatment of CVV.
Descritores: Candidíase Vulvovaginal/terapia
Farmacorresistência Fúngica
-Técnicas In Vitro
Brasil
Candida albicans
Fluconazol
Cetoconazol
Antifúngicos
Limites: Seres Humanos
Feminino
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas



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