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Id: biblio-1025855
Autor: Torno Cafasso, Omar; Visciarelli, Elena; Prat, María Inés; García, S; Barbieri, Gustavo; Suárez, L; Ledesma, Oscar.
Título: Leishmaniasis Tegumentaria Americana en la Provincia de Santiago del Estero, Argentina / American Tegumentary Leishmaniasis in the Province of Santiago del Estero, Argentina
Fonte: Rev. Asoc. Med. Bahía Blanca;5(1):20-27, Jul. 1995.
Idioma: es.
Resumo: Se estudiaron tres casos de Leishmaniasis Tegumentaria Americana (LTA) en pacientes con formas clínicas cutáneas en la provincia de Santiago del Estero, Argentina. Para el aislamiento de las cepas a partir de la lesión primaria se realizó: examen directo, cultivos e inoculación en animales receptivos. Para la tipificación de género y especie: biometría y utilización de anticuerpos monoclonales. Se realizaron exámenes serológicos de Inmunoglorescencia Indirecta y ELISA, como así mismo la aplicación de la Intradermorreacción de Montenegro (IRM), empleando antígenos diferentes. En los tres casos estudiados de cepa aislada por Leishmania Viannia braziliensis.

The autors describe a study of three patients with American Tegumentary Leishmaniasis (LTA) with cutaneous lesions in the providence of Santiago del Estero - Argenina. Direct examination, cultures and innoculation in receptive animals were performed in order to isolate the differents strains from the primary lesion, biometric studis and techniques with monoclonal antibodies in otder to know the genus and specific epithet. Serological indirect inmunofluorescence examination and ELISA, as well as the intradermal reaction of Montenegro (IRM) using different antigens. In the three examples studied the isolated strain was Leishmania Viannia braziliensis.
Descritores: Leishmaniose Cutânea
Responsável: AR393.1 - Centro de Información y Documentación Dr H. Urquiola


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Id: biblio-1008627
Autor: Oddone C, Rolando.
Título: Rol del Consultorio de Leishmaniosis en las investigaciones del IICS / Leishmaniasis Consulting Room at the IICS: its role in research
Fonte: Mem. Inst. Invest. Cienc. Salud (Impr.);15(1):88-91, abr. 2017.
Idioma: es.
Resumo: La leishmaniosis tegumentaria es una enfermedad desatendida y descontrolada que afecta a sectores sensibles de la población. El IICS, a través de este consultorio especializado, brinda los servicios de establecer el diagnóstico y acompañar el tratamiento de los casos que se presentan, así como de realizar seguimiento de los casos curados. Esta labor aporta permanentemente datos y suscita discusiones científicas que se convierten en fuentes de trabajos de investigación para la Institución. Y estamos hablando de una enfermedad con bastantes aspectos aún desconocidos, que amerita ser estudiada con prioridad en nuestro país

Tegumentary leishmaniasis is a neglected and uncontrolled disease affecting sensitive sectors of the population. The IICS, through this specialized practice, provides the services of establishing the diagnosis and to accompany the treatment of the cases presented, as well as to follow up the cured cases. This work provides data permanently and raises scientific discussions that become sources of research to the institution. And we are talking about a disease with many still unknown aspects that deserve to be studied with priority in our country.
Descritores: Leishmaniose Cutânea/diagnóstico
-Paraguai
Pesquisa
Leishmaniose Cutânea/tratamento farmacológico
Leishmaniose Cutânea/epidemiologia
Academias e Institutos
Limites: Seres Humanos
Responsável: PY3.1 - Biblioteca


  3 / 1032 LILACS  
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Id: biblio-1024944
Autor: Araújo, Francisco Rodrigues de Freitas; André, Weibson Paz Pinheiro; Reis, Paulo Fernando Cisneiros da Costa; Fernandes, Taciana de Melo Fernandes; Batista, Jael Soares.
Título: Leishmaniose tegumentar americana canina na zona rural do município de São Miguel, Rio Grande do Norte / Leishmaniasis Tegumentary American dog in rural area of the county of São Miguel, Rio Grande do Norte
Fonte: Rev. bras. ciênc. vet;21(4):188-191, out.-dez.2014. il..
Idioma: pt.
Resumo: Leishmaniose Tegumentar Americana (LTA) constitui um problema de saúde pública emergente no Rio Grande do Norte, com relatos de casos humanos principalmente na Região Serrana do Alto Oeste do estado, uma vez que o cão tem um importante papel na manutenção da doença neste ambiente. O presente estudo teve por objetivo analisar prevalência da LTA canina em quatro localidades localizadas na Zona Rural do município de São Miguel, RN. Foram realizados exames clínicos e diagnóstico sorológico através das técnicas de ELISA e RIFI em 100 cães de diferentes sexo, idade e categorias companhia e de caça. Todas as localidades apresentaram cães soropositivos com resultados de 21% de positividade para a técnica de ELISA e 10% para a de RIFI. Maiores prevalências foram observadas em cães machos, assintomáticos, na faixa etária de dois anos de idade e de caça. O presente estudo confirma a importância epidemiológica como reservatório da infecção e poderá auxiliar nas medidas de prevenção e controle da doença no município. P

American Cutaneous Leishmaniasis ( ACL) is an emerging public health problem in Rio Grande do Norte , with reports of human cases mainly in the mountainous region of the Upper Midwest state . Once the dog has an important role in maintaining the disease in this environment the present study aimed to evaluate the prevalence of canine ACL at four sites located in the Rural Area of São Miguel , RN . Clinical and serological diagnosis through ELISA and IFA in 100 dogs of different sex, age and company categories and hunting were performed . All towns had seropositive dogs with results of 21 % positivity for ELISA and 10 % for the IFA. Highest prevalence rates were observed in males , healthy dogs aged two years old and hunting . The present study confirms the epidemiological importance as a reservoir of infection and may assist in the prevention and control of disease in the city
Descritores: Parasitos
Cães
-Testes Sorológicos
Leishmaniose Cutânea
Limites: Cães
Responsável: BR409.1 - Biblioteca


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Id: lil-294508
Autor: Aldama Caballero, Arnaldo B; Correa Martínez, Julio; Rivelli, Victoria; Mendoza, Gloria.
Título: Dermatología tropical en la infancia / Tropical dermatology in childhood
Fonte: Pediatr. (Asunción);28(1):25-32, jul. 2001. ilus, tab, graf.
Idioma: en; es.
Resumo: La dermatología tropical comprende un grupo de enfermedades con manifestaciones cutáneas predominantes o importantes, en que las condiciones ambientales propias de los trópicos influyen en sus características. Objetivo: conocer las caracteristicas en la infancia de 5 enfermedades tropicales: lepra, esporotricosis, leishmaniasis tegumentaria Americana, Pénfigo Foliáceo Endémico (PFE) y paracoccidiodomicosis, en el Hospital Nacional, en el periodo noviembre 1990-mayo 2001. Material y Métodos: estudio retrospectivos, descriptivo, observacional. Se determinaron porcentajes y se comparan con otras series. Resultados: en el mencionado periodo se observaron 282 casos de las citadas patologías correspondiendo 15 casos (5,3 porcientos) al grupo etario 0-15 años. Predominan Lepra, esporotricosis y PFE con 4 casos, 10 son de sexo masculino y todos proceden de áreas rurales. No se registró ningún óbito. Conclusión: la frecuencia de la patología tropical en la niñez no es elevada, pero la mortalidad y secuelas en un grupo etario numeroso y vulnerable justifica la importancia del tema
Descritores: Paracoccidioidomicose
Esporotricose
Leishmaniose
Hanseníase
Leishmaniose Cutânea
Criança
Pênfigo
Responsável: PY30.1 - Biblioteca


  5 / 1032 LILACS  
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Id: biblio-1021446
Autor: Araújo, Francisco de Freitas; André, Weibson Paz Pinheiro; Reis, Paulo Fernando Cisneiros da Costa; Fernandes, Taciana de Melo; Batista, Jael Soares.
Título: Leishmaniose tegumentar americana canina na zona rural do município de São Miguel, Rio Grande do Norte* / Leishmaniasis Tegumentary American dog in rural area of the county of São Miguel, Rio Grande do Norte Francisco Rodrigues de Freitas Araújo,** Weibson Paz Pinheiro Andre,*** Paulo Fernando Cisneiros da Costa Reis,****
Fonte: Rev. bras. ciênc. vet;21(4):188-191, out.-dez.2014. il..
Idioma: pt.
Resumo: Leishmaniose Tegumentar Americana (LTA) constitui um problema de saúde pública emergente no Rio Grande do Norte, com relatos de casos humanos principalmente na Região Serrana do Alto Oeste do estado, uma vez que o cão tem um importante papel na manutenção da doença neste ambiente. O presente estudo teve por objetivo analisar prevalência da LTA canina em quatro localidades localizadas na Zona Rural do município de São Miguel, RN. Foram realizados exames clínicos e diagnóstico sorológico através das técnicas de ELISA e RIFI em 100 cães de diferentes sexo, idade e categorias companhia e de caça. Todas as localidades apresentaram cães soropositivos com resultados de 21% de positividade para a técnica de ELISA e 10% para a de RIFI. Maiores prevalências foram observadas em cães machos, assintomáticos, na faixa etária de dois anos de idade e de caça. O presente estudo confirma a importância epidemiológica como reservatório da infecção e poderá auxiliar nas medidas de prevenção e controle da doença no município. .

American Cutaneous Leishmaniasis ( ACL) is an emerging public health problem in Rio Grande do Norte , with reports of human cases mainly in the mountainous region of the Upper Midwest state . Once the dog has an important role in maintaining the disease in this environment the present study aimed to evaluate the prevalence of canine ACL at four sites located in the Rural Area of São Miguel , RN . Clinical and serological diagnosis through ELISA and IFA in 100 dogs of different sex, age and company categories and hunting were performed . All towns had seropositive dogs with results of 21 % positivity for ELISA and 10 % for the IFA. Highest prevalence rates were observed in males , healthy dogs aged two years old and hunting . The present study confirms the epidemiological importance as a reservoir of infection and may assist in the prevention and control of disease in the city.
Descritores: Testes Sorológicos
Prevalência
Leishmaniose Cutânea
Cães
-Epidemiologia
Limites: Animais
Responsável: BR409.1 - Biblioteca


  6 / 1032 LILACS  
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Calabrese, Kátia da Silva
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Id: biblio-841766
Autor: Gasparotto, Juciano; Kunzler, Alice; Senger, Mario Roberto; Souza, Celeste da Silva Freitas de; Simone, Salvatore Giovanni de; Bortolin, Rafael Calixto; Somensi, Nauana; Dal-Pizzol, Felipe; Moreira, José Claudio Fonseca; Abreu-Silva, Ana Lúcia; Calabrese, Kátia da Silva; Silva Jr, Floriano Paes; Gelain, Daniel Pens.
Título: N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis
Fonte: Mem. Inst. Oswaldo Cruz;112(2):146-154, Feb. 2017. graf.
Idioma: en.
Projeto: FAPERGS.
Resumo: BACKGROUND Leishmaniasis is a parasitosis caused by several species of the genus Leishmania. These parasites present high resistance against oxidative stress generated by inflammatory cells. OBJECTIVES To investigate oxidative stress and molecular inflammatory markers in BALB/c mice infected with L. amazonensis and the effect of antioxidant treatment on these parameters. METHODS Four months after infection, oxidative and inflammatory parameters of liver, kidneys, spleen, heart and lungs from BALB/c mice were assessed. FINDINGS In liver, L. amazonensis caused thiol oxidation and nitrotyrosine formation; SOD activity and SOD2 protein content were increased while SOD1 protein content decreased. The content of the cytokines IL-1β, IL-6, TNF-α, and the receptor of advanced glycation endproducts (RAGE) increased in liver. Treatment with the antioxidant N-acetyl-cysteine (20 mg/kg b.w) for five days inhibited oxidative stress parameters. MAIN CONCLUSIONS L. amazonensis induces significant alterations in the redox status of liver but not in other organs. Acute antioxidant treatment alleviates oxidative stress in liver, but it had no effect on pro-inflammatory markers. These results indicate that the pathobiology of leishmaniasis is not restricted to the cutaneous manifestations and open perspectives for the development of new therapeutic approaches to the disease, especially for liver function.
Descritores: Acetilcisteína/farmacologia
Leishmania mexicana
Leishmaniose Cutânea/metabolismo
Leishmaniose Cutânea/patologia
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
-Depuradores de Radicais Livres/farmacologia
Fígado/efeitos dos fármacos
Fígado/enzimologia
Camundongos Endogâmicos BALB C
Limites: Animais
Camundongos
Responsável: BR1.1 - BIREME


  7 / 1032 LILACS  
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Casanova, Cláudio
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Id: biblio-841765
Autor: Aires, Juliana; Casanova, Claudio; Vernal, Sebastian; Nascimento, Margarida; Rodrigues, Sandra; Lerner, Ethan A; Roselino, Ana Maria.
Título: Maxadilan-simile expression in Nyssomyia neivai, a sandfly vector in an endemic region of Brazil, and its immunogenicity in patients with American tegumentary leishmaniasis
Fonte: Mem. Inst. Oswaldo Cruz;112(2):116-122, Feb. 2017. tab, graf.
Idioma: en.
Resumo: BACKGROUND Maxadilan (Max) is a salivary component in the sandfly Lutzomyia longipalpis (Lutz & Neiva 1912), a vector of visceral leishmaniasis. Max has a powerful vasodilatory effect and is a candidate vaccine that has been tested in experimental leishmaniasis. Nyssomyia neivai (Pinto 1926) is a vector of the pathogen responsible for American tegumentary leishmaniasis (ATL) in Brazil. OBJECTIVE We searched for Max expression in Ny. neivai and for antibodies against Max in ATL patients. METHODS cDNA and protein were extracted from the cephalic segment, including salivary glands, of Ny. neivai and analysed by polymerase chain reaction, DNA sequencing, and blotting assays. The results were compared with data obtained from Lu. longipalpis samples. We quantified antibodies against Max in serum samples from 41 patients with ATL (31 and 10 with the cutaneous and mucocutaneous forms, respectively) and 63 controls from the endemic northeastern region of São Paulo state, using enzyme-linked immunosorbent assay. FINDINGS Recognition of a Max-simile peptide by specific antibodies confirmed expression of a Max sequence in Ny. neivai (GenBank EF601123.1). Compared to controls, patients with ATL presented higher levels of antibodies against Max (p = 0.004); 24.4% of the patients with ATL and 3.2% of the controls presented anti-Max levels above the cutoff index (p = 0.014). The anti-Max levels were not associated with the specific clinical form of ATL, leishmanin skin test response, absence or presence of amastigotes in histopathologic exam, results of indirect immunofluorescence testing for leishmaniasis, or duration of cutaneous form disease. MAIN CONCLUSION High serum anti-Max levels did not protect patients against ATL, but confirmed previous natural exposure to Ny. neivai bites in this ATL endemic region.
Descritores: Leishmaniose Cutânea/imunologia
Leishmaniose Cutânea/sangue
Proteínas de Insetos/imunologia
Insetos Vetores/classificação
Anticorpos/imunologia
Anticorpos/sangue
-Psychodidae/química
Brasil
Ensaio de Imunoadsorção Enzimática
Immunoblotting
Estudos de Casos e Controles
Reação em Cadeia da Polimerase
Proteínas de Insetos/análise
Doenças Endêmicas
Limites: Animais
Masculino
Feminino
Coelhos
Responsável: BR1.1 - BIREME


  8 / 1032 LILACS  
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Brazil, Reginaldo Peçanha
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Id: biblio-841757
Autor: Araujo-Pereira, Thais de; Pita-Pereira, Daniela de; Boité, Mariana Côrtes; Melo, Myllena; Costa-Rego, Taiana Amancio da; Fuzari, Andressa Alencastre; Brazil, Reginaldo Peçanha; Britto, Constança.
Título: First description of Leishmania (Viannia) infection in Evandromyia saulensis, Pressatia sp. and Trichophoromyia auraensis (Psychodidae: Phlebotominae) in a transmission area of cutaneous leishmaniasis in Acre state, Amazon Basin, Brazil
Fonte: Mem. Inst. Oswaldo Cruz;112(1):75-78, Jan. 2017. graf.
Idioma: en.
Projeto: CNPq; . FAPERJ.
Resumo: Studies on the sandfly fauna to evaluate natural infection indexes are still limited in the Brazilian Amazon, a region with an increasing incidence of cutaneous leishmaniasis. Here, by using a multiplex polymerase chain reaction directed to Leishmania kDNA and hybridisation, we were able to identify L. (Viannia) subgenus in 12 out of 173 sandflies captured in the municipality of Rio Branco, Acre state, revealing a positivity of 6.94%. By sequencing the Leishmania 234 bp-hsp70 amplified products from positive samples, infection by L. (V.) braziliensis was confirmed in five sandflies: one Evandromyia saulensis, three Trichophoromyia auraensis and one Pressatia sp. The finding of L. (Viannia) DNA in two Ev. saulensis corresponds to the first record of possible infection associated with this sandfly. Moreover, our study reveals for the first time in Brazil, Th. auraensis and Pressatia sp. infected by L. (Viannia) parasites.
Descritores: Psychodidae/classificação
Psychodidae/parasitologia
Leishmaniose Cutânea/transmissão
Insetos Vetores/classificação
Insetos Vetores/parasitologia
Leishmania/isolamento & purificação
Leishmania/classificação
-Brasil
Reação em Cadeia da Polimerase Multiplex
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: biblio-841754
Autor: Espiau, Benoît; Vilhena, Virginia; Cuvillier, Armelle; Barral, Aldina; Merlin, Gilles.
Título: Phenotypic diversity and selection maintain Leishmania amazonensis infectivity in BALB/c mouse model
Fonte: Mem. Inst. Oswaldo Cruz;112(1):44-52, Jan. 2017. tab, graf.
Idioma: en.
Resumo: Leishmania are protozoan parasites that show remarkable diversity, as revealed by the various clinical forms of leishmaniasis, which can range from mild skin lesions to severe metastatic cutaneous/mucosal lesions. The exact nature and extent of Leishmania phenotypic diversity in establishing infection is not fully understood. In order to try to understand some aspects of this diversity, we subcutaneously infected BALB/c mice with first and second generation subclones of a L. amazonensis strain isolated from a patient (BA125) and examined in vivo lesion growth rate and antimony susceptibility. In vivo fast-, medium- and slow-growing subclones were obtained; moreover, fast-growing subclones could generate slow-growing subclones and inversely, revealing the continuous generation of diversity after passage into mice. No antimony-resistant subclone appeared, probably a rare occurrence. By tagging subclone cells with a L. amazonensis genomic cosmid library, we found that only a very small number of founding cells could produce lesions. Leishmania clones transfected with in vivo selected individual cosmids were also diverse in terms of lesion growth rate, revealing the cosmid-independent intrinsic characteristics of each clone. Our results suggest that only a few of the infecting parasites are able to grow and produce lesions; later, within the cell mixture of each lesion, there coexist several parasite populations with different potentialities to grow lesions during the next infection round. This may reflect a sort of programmed heterogeneity of individual parasites, favoring the survival of some individuals in various environmental conditions.
Descritores: Leishmania mexicana/genética
Leishmania mexicana/patogenicidade
Leishmaniose Cutânea/parasitologia
Modelos Animais de Doenças
-Fenótipo
Fatores de Tempo
Camundongos Endogâmicos BALB C
Limites: Animais
Feminino
Responsável: BR1.1 - BIREME


  10 / 1032 LILACS  
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Id: biblio-1020081
Autor: Rugani, Jeronimo Nunes; Gontijo, Célia Maria Ferreira; Frézard, Frédéric; Soares, Rodrigo Pedro; Monte-Neto, Rubens Lima do.
Título: Antimony resistance in Leishmania (Viannia) braziliensis clinical isolates from atypical lesions associates with increased ARM56/ARM58 transcripts and reduced drug uptake
Fonte: Mem. Inst. Oswaldo Cruz;114:e190111, 2019. tab, graf.
Idioma: en.
Projeto: CNPq; . CAPES; . RPS; . RLMN; . CMG; . FF; . CNPq; . RLMN.
Resumo: BACKGROUND In addition to the limited therapeutic arsenal and the side effects of antileishmanial agents, drug resistance hinders disease control. In Brazil, Leishmania braziliensis causes atypical (AT) tegumentary leishmaniasis lesions, frequently refractory to treatment. OBJECTIVES The main goal of this study was to characterise antimony (Sb)-resistant (SbR) L. braziliensis strains obtained from patients living in Xakriabá indigenous community, Minas Gerais, Brazil. METHODS The aquaglyceroporin 1-encoding gene (AQP1) from L. braziliensis clinical isolates was sequenced, and its function was evaluated by hypo-osmotic shock. mRNA levels of genes associated with Sb resistance were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Atomic absorption was used to measure Sb uptake. FINDINGS Although clinical isolates presented delayed recovery time in hypo-osmotic shock, AQP1 function was maintained. Isolate 340 accumulated less Sb than all other isolates, supporting the 65-fold downregulation of AQP1 mRNA levels. Both 330 and 340 isolates upregulated antimony resistance marker (ARM) 56/ARM58 and multidrug resistant protein A (MRPA); however, only ARM58 upregulation was an exclusive feature of SbR field isolates. CA7AE seemed to increase drug uptake in L. braziliensis and represented a tool to study the role of glycoconjugates in Sb transport. MAIN CONCLUSIONS There is a clear correlation between ARM56/58 upregulation and Sb resistance in AT-harbouring patients, suggesting the use of these markers as potential indicators to help the treatment choice and outcome, preventing therapeutic failure.
Descritores: Leishmania braziliensis/efeitos dos fármacos
Leishmania braziliensis/genética
Resistência a Medicamentos/efeitos dos fármacos
Leishmaniose Cutânea/parasitologia
Aquagliceroporinas/metabolismo
Antimônio/farmacologia
-Resistência a Medicamentos/genética
Reação em Cadeia da Polimerase em Tempo Real
Limites: Seres Humanos
Responsável: BR1.1 - BIREME



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