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Id: biblio-969026
Autor: Perú. Ministerio de Salud; .Dirección General de Salud de las Personas.
Título: Norma técnica de salud diagnóstico y tratamiento de la leishmaniosis cutánea y mucocutánea en el Perú / Technical standard of health diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis in Peru.
Fonte: lima; Perú. Ministerio de Salud; 19930000. 63 p p. ilus..
Idioma: es.
Resumo: El documento contiene normas y procedimientos, provenientes de un prolongado análisis y discusión entre representantes de entidades de diversos niveles interesados en esta dolencia, contribuye al logro de los objetivos fundamentales que son, la defensa de la salud y la vida de la población , así como la preservación del ambiente, con el propósito de mejorar el rendimiento de las medidas de control de las leishmaniasis en el Perú.
Descritores: Programas de Assistência Gerenciada
Leishmaniose Cutânea
-Atenção Primária à Saúde
Normas Técnicas
Responsável: PE18.1 - Biblioteca Central


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Id: biblio-1048683
Autor: Oliveira, Analucia Gomes Lopes.
Título: Evolução do estado nutricional e caracterização do padrão alimentar de pacientes com leishmaniose tegumentar americana / Evolution of nutritional status and characterization of the dietary pattern of patients with American cutaneous leishmaniasis.
Fonte: Rio de Janeiro; s.n; 2018. 177 p. ilus.
Idioma: pt.
Tese: Apresentada a Instituto Nacional de Infectologia Evandro Chagas para obtenção do grau de Doutor.
Resumo: A desnutrição resulta em um aumento da susceptibilidade á infecção, e esta causa a deterioração do estado nutricional, um ciclo de desnutrição-infecção. Além de seu reconhecido papel na estimulação do sistema imune, os nutrientes também participam do processo de cicatrização de feridas. A Leishmaniose Tegumentar Americana (LTA) é uma doença infecciosa, não contagiosa, endêmica no Brasil, de evolução crônica, acometendo a pele e as mucosas das vias aero-digestivas superiores. O estado nutricional tem sido associado como risco de desenvolvimento de leishmaniose mucosa (LM), além de ter sido demonstrado sua influência no curso da LTA, com um menor percentual de cura das lesões cutâneas e maior tempo de cicatrização das lesões mucosas. O objetivo desta pesquisa é caracterizar o perfil nutricional e o padrão de ingestão alimentar de pacientes com LTA, antes e após o tratamento. Foi realizado um estudo prospectivo e longitudinal nos pacientes a partir de 20 anos com leishmaniose cutânea (LC) ou com LM, atendidos no Instituto Nacional de Infectologia Evandro Chagas/Fiocruz a partir de 2011, participantes do projeto principal "Estudo para a sistematização do atendimento de pacientes com Leishmaniose Tegumentar Americana no Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses - Instituto Nacional de Infectologia Evandro Chagas - Fiocruz"

Foram realizadas consultas nutricionais compostas de avaliação nutricional antropométrica (peso, estatura, índice de massa corporal, circunferências do braço e muscular do braço e dobra cutânea triciptal) e bioquímica (albumina e transferrina) e avaliação da ingestão alimentar (recordatórios de 24h) antes, ao término, até 3 meses e 1 a 2 anos após o tratamento específico. Foram descritas as frequências simples das variáveis categóricas (sexo, grau de instrução, renda familiar e diagnóstico nutricional) e as medidas de tendência central e dispersão das variáveis contínuas (idade e parâmetros antropométricos). A estimativa da ingestão alimentar foi analisada através do programa NutriQuanti. Foi caracterizado o perfil nutricional dos pacientes com LTA e observou-se o comprometimento do estado nutricional associado á LM, que também esteve associada à idosos, sinais e sintomas como lesões orais e faríngeas, obstrução nasal, dispneia, disfagia, odinofagia, redução da ingestão alimentar e a ingestão deficiente de zinco. A maioria dos pacientes com LTA apresentou desnutrição calórica e ingestão deficiente de selênio, magnésio, cálcio e fibras. No final do tratamento, sintomas considerados efeitos adversos do tratamento da LTA foram associados à alteração do estado nutricional. Um a dois anos após o final do tratamento não se observou associação de sintomas relacionados à LM ou ao seu tratamento ao estado nutricional e houve melhora do estado nutricional dos pacientes. (AU)
Descritores: Avaliação Nutricional
Estado Nutricional
Leishmaniose Cutânea
Desnutrição
Ingestão de Alimentos
Limites: Seres Humanos
Responsável: BR15.1 - Biblioteca de Ciências Biomédicas


  3 / 1033 LILACS  
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Id: biblio-1020081
Autor: Rugani, Jeronimo Nunes; Gontijo, Célia Maria Ferreira; Frézard, Frédéric; Soares, Rodrigo Pedro; Monte-Neto, Rubens Lima do.
Título: Antimony resistance in Leishmania (Viannia) braziliensis clinical isolates from atypical lesions associates with increased ARM56/ARM58 transcripts and reduced drug uptake
Fonte: Mem. Inst. Oswaldo Cruz;114:e190111, 2019. tab, graf.
Idioma: en.
Projeto: CNPq; . CAPES; . RPS; . RLMN; . CMG; . FF; . CNPq; . RLMN.
Resumo: BACKGROUND In addition to the limited therapeutic arsenal and the side effects of antileishmanial agents, drug resistance hinders disease control. In Brazil, Leishmania braziliensis causes atypical (AT) tegumentary leishmaniasis lesions, frequently refractory to treatment. OBJECTIVES The main goal of this study was to characterise antimony (Sb)-resistant (SbR) L. braziliensis strains obtained from patients living in Xakriabá indigenous community, Minas Gerais, Brazil. METHODS The aquaglyceroporin 1-encoding gene (AQP1) from L. braziliensis clinical isolates was sequenced, and its function was evaluated by hypo-osmotic shock. mRNA levels of genes associated with Sb resistance were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Atomic absorption was used to measure Sb uptake. FINDINGS Although clinical isolates presented delayed recovery time in hypo-osmotic shock, AQP1 function was maintained. Isolate 340 accumulated less Sb than all other isolates, supporting the 65-fold downregulation of AQP1 mRNA levels. Both 330 and 340 isolates upregulated antimony resistance marker (ARM) 56/ARM58 and multidrug resistant protein A (MRPA); however, only ARM58 upregulation was an exclusive feature of SbR field isolates. CA7AE seemed to increase drug uptake in L. braziliensis and represented a tool to study the role of glycoconjugates in Sb transport. MAIN CONCLUSIONS There is a clear correlation between ARM56/58 upregulation and Sb resistance in AT-harbouring patients, suggesting the use of these markers as potential indicators to help the treatment choice and outcome, preventing therapeutic failure.
Descritores: Leishmania braziliensis/efeitos dos fármacos
Leishmania braziliensis/genética
Resistência a Medicamentos/efeitos dos fármacos
Leishmaniose Cutânea/parasitologia
Aquagliceroporinas/metabolismo
Antimônio/farmacologia
-Resistência a Medicamentos/genética
Reação em Cadeia da Polimerase em Tempo Real
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-1002683
Autor: Muñoz, Betsy Yaneth; Mantilla, Julio Cesar; Escobar, Patricia.
Título: Therapeutic response and safety of the topical, sequential use of antiseptic, keratolytic, and pentamidine creams (3-PACK) on Leishmania (Viannia) braziliensis-infected mice
Fonte: Mem. Inst. Oswaldo Cruz;114:e180535, 2019. tab, graf.
Idioma: en.
Projeto: COLCIENCIAS; . BYM; . UT EICOLEISH.
Resumo: BACKGROUND Topical treatment of New World cutaneous leishmaniasis can be affected by bacterial coinfection, hyperkeratosis, and transdermal drug delivery. OBJECTIVE The aim of this work was to evaluate the therapeutic response and safety of the topical, sequential use of antiseptic, keratolytic, and pentamidine isethionate (PMD) creams (3-PACK kit) on CL-infected BALB/c mice. METHODS A 0.5% chlorhexidine solution (CGH), 10% salicylic acid (SA), and 3% or 6% PMD were used as antiseptic, keratolytic, and antileishmanial drugs, respectively. During the first seven days, antiseptic, followed by 10% SA gel and PMD cream, were applied topically. Subsequently, treatment was performed only with the antiseptic and PMD creams. Skin irritation, reduction of lesion size (mm2), and parasitic load were observed until 30 days of treatment were completed. FINDINGS The 3-PACK treatment using 6% PMD induced a complete lesion reduction in 3/6 mice and a partial reduction in 1/6 mice, with no parasites observed. In contrast, CGH and SA alone, along with the vehicle, were not effective (p < 0.05). Moderate to severe erythema was observed at the application site. MAIN CONCLUSION The topical 3-PACK using 6% PMD was 67% effective in the treatment of CL by Leishmania (Viannia) braziliensis. Currently, work is ongoing to improve PMD isethionate formulation and to determine a dose-response.
Descritores: Pentamidina/uso terapêutico
Leishmania braziliensis/parasitologia
Leishmaniose Cutânea/prevenção & controle
-Ceratolíticos
Camundongos Endogâmicos BALB C
Anti-Infecciosos Locais/uso terapêutico
Responsável: BR1.1 - BIREME


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Id: biblio-955123
Autor: Ramalho, Dario Brock; Silva, Rosiana Estéfane da; Senna, Maria Camilo Ribeiro de; Moreira, Hugo Silva Assis; Pedras, Mariana Junqueira; Avelar, Daniel Moreira de; Saraiva, Lara; Rabello, Ana; Cota, Gláucia.
Título: Meglumine antimoniate intralesional infiltration for localised cutaneous leishmaniasis: a single arm, open label, phase II clinical trial
Fonte: Mem. Inst. Oswaldo Cruz;113(9):e180200, 2018. tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: BACKGROUND Cutaneous leishmaniasis (CL) is a world-wide health problem which currently lacks effective, affordable and easy to use therapy. Recently, the meglumine antimoniate (MA) intralesional infiltration was included among the acceptable therapies for New World leishmaniasis. While this approach is attractive, there is currently little evidence to support its use in Americas. OBJECTIVES The aim of this study was to provide information about effectiveness and safety of a standardised MA intralesional infiltration technique for the treatment of CL. METHODS It is a single-arm phase II clinical trial conducted at a Brazilian referral centre. CL cases with parasitological confirmation presenting a maximum of three CL-compatible skin lesions were treated with weekly MA intralesional infiltration by using a validated technique, up to a maximum of eight infiltrations. RESULTS A total of 53 patients (62 lesions) were included. Overall, patients received a median of seven infiltrations (IQR25-75% 5-8) over a median treatment period of 43 days (IQR25-75% 28-52 days). The definitive cure rate at D180 was 87% (95% CI:77-96%). The majority of adverse events were local, with mild or moderate intensity. Bacterial secondary infection of the lesion site was observed in 13% of the treated patients, beside two intensity-three adverse events (hypersensitivity reactions).
Descritores: Compostos Organometálicos/administração & dosagem
Leishmaniose Cutânea/tratamento farmacológico
/uso terapêutico
FROZEN SECTIONSABDOMINAL NEOPLASMS/uso terapêutico
-Injeções Intralesionais
Antiprotozoários/efeitos adversos
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-915131
Autor: Neira, Laura Fernanda; Mantilla, Julio Cesar; Stashenko, Elena; Escobar, Patricia.
Título: Toxicidad, genotoxicidad y actividad anti-Leishmania de aceites esenciales obtenidos de cuatro (4) quimiotipos del género Lippia / Toxicity, genotoxicity and anti-Leishmania activity of essential oils obtained of four chemotypes of Lippia genus
Fonte: Bol. latinoam. Caribe plantas med. aromát;17(1):68-83, ene. 2018. ilus, tab.
Idioma: es.
Projeto: Patrimonio Autónomo Fondo Nacional de Financiamiento para la Ciencia la Tecnología y la Innovación Francisco José de Caldas; . Universidad Industrial de Santander. RC-0572; RC-687-2014.
Resumo: Los aceites esenciales (AEs), pertenecientes al género Lippia, son candidatos interesantes de formulaciones tópicas en el tratamiento de la leishmaniasis cutánea (LC). El objetivo de este trabajo fue determinar el perfil toxicológico y la actividad anti-Leishmania de AEs obtenidos de plantas colombianas del género Lippia. Ratones BALB/c fueron tratados tópica u oralmente con AEs obtenidos de L. alba quimiotipo citral (AE1) y de L. origanoides quimiotipos timol (AE2), carvacrol (AE3) y felandreno (AE4). El efecto del tratamiento en la irritación de la piel, la toxicidad aguda oral, la genotoxicidad (prueba cometa y micronúcleos), los cambios en la función hepática y renal, la inducción de reacción de hipersensibilidad de contacto y en la actividad contra L. (V) panamensis y L. (V.) braziliensis fueron determinados. Todos los AEs presentaron un perfil toxicológico similar a los parámetros normales, exceptuando los aceites AE2 y AE3 los cuales fueron irritantes y presentaron algunos signos de toxicidad aguda oral al ser utilizados en altas concentraciones (concentraciones bajas no fueron tóxicas). El AE2 mostró actividad antiparasitaria en las formas parasitarias evaluadas. Concentraciones bajas de los AEs podrían utilizarse de forma segura como componentes de formulaciones farmacológicas en LC.

Essential oils (EOs) belonging to the genus Lippia are interesting candidates in pharmaceutical systems for cutaneous leishmaniasis (CL). The aim of this work was to determine both toxicological and antileishmanial activities of EOs obtained from different species of Lippia, a widely distributed Colombian plants. BALB/c mice were treated topically or orally with EOs obtained from L. alba citral chemotype (EO1) and L. origanoides thymol (EO2), carvacrol (EO3) and phellandrene (EO4) chemotypes. The skin irritation, oral acute toxicity, genotoxicity (comet assay and micronucleus test), liver and renal adverse effects, All the EOs showed a toxicological profile similar to the normal parameters, except for oils EO2 and EO3 which were irritant and showed some signs of acute oral toxicity at high concentrations (low concentration were safe). The EO2 showed antiparasitic activity. Low concentrations of the EO could be used safely as components of pharmacological formulations in CL.
Descritores: Óleos Voláteis/farmacologia
Leishmaniose Cutânea/tratamento farmacológico
Lippia/química
Leishmania/efeitos dos fármacos
Antiprotozoários/farmacologia
-Óleos Voláteis/efeitos adversos
Colômbia
Ensaio Cometa
Dermatite de Contato/etiologia
Genotoxicidade
Camundongos Endogâmicos BALB C
Antiprotozoários/efeitos adversos
Limites: Animais
Feminino
Camundongos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-894896
Autor: Silva, Rosiana Estéfane da; Carvalho, Janaína de Pina; Ramalho, Dario Brock; Senna, Maria Camilo Ribeiro De; Moreira, Hugo Silva Assis; Rabello, Ana; Cota, Erika; Cota, Gláucia.
Título: Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment
Fonte: Mem. Inst. Oswaldo Cruz;113(2):71-79, Feb. 2018. tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: BACKGROUND Despite its recognised toxicity, antimonial therapy continues to be the first-line drug for cutaneous leishmaniasis (CL) treatment. Intralesional administration of meglumine antimoniate (MA) represents an alternative that could reduce the systemic absorption of the drug and its side effects. OBJECTIVES This study aims to validate the standard operational procedure (SOP) for the intralesional infiltration of MA for CL therapy as the first step before the assessment of efficacy and safety related to the procedure. METHODS The SOP was created based on 21 trials retrieved from the literature, direct monitoring of the procedure and consultation with experts. This script was submitted to a formal computer-aided inspection to identify readability, clarity, omission, redundancy and unnecessary information (content validation). For criterion and construct validations, the influence of critical condition changes (compliance with the instructions and professional experience) on outcome conformity (saturation status achievement), tolerability (pain referred) and safety (bleeding) were assessed. FINDINGS The median procedure length was 12 minutes and in 72% of them, patients classified the pain as mild. The bleeding was also classified as mild in 96.6% of the procedures. Full compliance with the SOP was observed in 66% of infiltrations. Despite this, in 100% of the inspected procedures, lesion saturation was observed at the end of infiltration, which means that it tolerates some degree of modification in its execution (robustness) without prejudice to the result. CONCLUSIONS The procedure is reproducible and can be used by professionals without previous training with high success and safety rates.
Descritores: Injeções Intralesionais/efeitos adversos
Leishmaniose Cutânea/tratamento farmacológico
Meglumina
Antiprotozoários/administração & dosagem
-Protocolos Clínicos/normas
Reprodutibilidade dos Testes
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-894850
Autor: Campos, Taís M; Costa, Rúbia; Passos, Sara; Carvalho, Lucas P.
Título: Cytotoxic activity in cutaneous leishmaniasis
Fonte: Mem. Inst. Oswaldo Cruz;112(11):733-740, Nov. 2017. tab, graf.
Idioma: en.
Projeto: National Institutes of Health.
Resumo: Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.
Descritores: Células Matadoras Naturais/efeitos dos fármacos
Células Matadoras Naturais/parasitologia
Linfócitos T Citotóxicos/imunologia
Leishmaniose Cutânea/imunologia
Leishmaniose Cutânea/patologia
Linfócitos T CD8-Positivos/imunologia
Linfócitos T CD8-Positivos/parasitologia
Citotoxicidade Imunológica/imunologia
-Modelos Animais de Doenças
Limites: Seres Humanos
Animais
Responsável: BR1.1 - BIREME


  9 / 1033 LILACS  
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Madeira, Maria de Fátima
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Id: biblio-842767
Autor: Carvalho, Livia Martins Veloso de; Pimentel, Maria Inês Fernandes; Conceição-Silva, Fátima; Vasconcellos, Érica de Camargo Ferreira e; Valete-Rosalino, Cláudia Maria; Lyra, Marcelo Rosandiski; Salgueiro, Mariza de Matos; Saheki, Maurício Naoto; Madeira, Maria de Fátima; Mouta-Confort, Eliame; Antonio, Liliane de Fátima; Silva, Aline Fagundes da; Quintella, Leonardo Pereira; Bedoya-Pacheco, Sandro Javier; Schubach, Armando de Oliveira.
Título: Sporotrichoid leishmaniasis: a cross-sectional clinical, epidemiological and laboratory study in Rio de Janeiro State, Brazil
Fonte: Rev. Inst. Med. Trop. Säo Paulo;59:e33, 2017. tab, graf.
Idioma: en.
Projeto: CNPq; . Fundação Carlos Chagas Filho de Amparo à Pesquisa no Estado do Rio de Janeiro.
Resumo: ABSTRACT Background Atypical presentations of cutaneous leishmaniasis include sporotrichoid leishmaniasis (SL), which is clinically described as a primary ulcer combined with lymphangitis and nodules and/or ulcerated lesions along its pathway. Aims To assess the differences between patients with sporotrichoid leishmaniasis and typical cutaneous leishmaniasis (CL). Methods From January 2004 to December 2010, 23 cases of SL (4.7%) were detected among 494 CL patients diagnosed at a reference center for the disease in Rio de Janeiro State, Brazil. These 23 cases were compared with the remaining 471 patients presenting CL. Results SL predominated in female patients (60.9%, p = 0.024), with older age (p = 0.032) and with lesions in upper limbs (52.2%, p = 0.028). CL affected more men (64.5%), at younger age, and with a higher number of lesions exclusively in lower limbs (34.8%). Conclusions Differences in clinical and epidemiological presentation were found between SL patients as compared to CL ones, in a region with a known predominance of Leishmania (Viannia) braziliensis. The results are similar to the features of most of the sporotrichosis patients as described in literature, making the differential diagnosis between ATL and sporotrichosis more important in overlapping areas for both diseases, like in Rio de Janeiro State.
Descritores: Leishmania braziliensis
Leishmaniose Cutânea/diagnóstico
-Biópsia
Brasil/epidemiologia
Ensaio de Imunoadsorção Enzimática
Imuno-Histoquímica
Estudos Transversais
Leishmaniose Cutânea/patologia
Leishmaniose Cutânea/epidemiologia
Técnica Indireta de Fluorescência para Anticorpo
Limites: Seres Humanos
Masculino
Feminino
Adulto
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Calabrese, Kátia da Silva
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Id: biblio-841766
Autor: Gasparotto, Juciano; Kunzler, Alice; Senger, Mario Roberto; Souza, Celeste da Silva Freitas de; Simone, Salvatore Giovanni de; Bortolin, Rafael Calixto; Somensi, Nauana; Dal-Pizzol, Felipe; Moreira, José Claudio Fonseca; Abreu-Silva, Ana Lúcia; Calabrese, Kátia da Silva; Silva Jr, Floriano Paes; Gelain, Daniel Pens.
Título: N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis
Fonte: Mem. Inst. Oswaldo Cruz;112(2):146-154, Feb. 2017. graf.
Idioma: en.
Projeto: FAPERGS.
Resumo: BACKGROUND Leishmaniasis is a parasitosis caused by several species of the genus Leishmania. These parasites present high resistance against oxidative stress generated by inflammatory cells. OBJECTIVES To investigate oxidative stress and molecular inflammatory markers in BALB/c mice infected with L. amazonensis and the effect of antioxidant treatment on these parameters. METHODS Four months after infection, oxidative and inflammatory parameters of liver, kidneys, spleen, heart and lungs from BALB/c mice were assessed. FINDINGS In liver, L. amazonensis caused thiol oxidation and nitrotyrosine formation; SOD activity and SOD2 protein content were increased while SOD1 protein content decreased. The content of the cytokines IL-1β, IL-6, TNF-α, and the receptor of advanced glycation endproducts (RAGE) increased in liver. Treatment with the antioxidant N-acetyl-cysteine (20 mg/kg b.w) for five days inhibited oxidative stress parameters. MAIN CONCLUSIONS L. amazonensis induces significant alterations in the redox status of liver but not in other organs. Acute antioxidant treatment alleviates oxidative stress in liver, but it had no effect on pro-inflammatory markers. These results indicate that the pathobiology of leishmaniasis is not restricted to the cutaneous manifestations and open perspectives for the development of new therapeutic approaches to the disease, especially for liver function.
Descritores: Acetilcisteína/farmacologia
Leishmania mexicana
Leishmaniose Cutânea/metabolismo
Leishmaniose Cutânea/patologia
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
-Depuradores de Radicais Livres/farmacologia
Fígado/efeitos dos fármacos
Fígado/enzimologia
Camundongos Endogâmicos BALB C
Limites: Animais
Camundongos
Responsável: BR1.1 - BIREME



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