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Id: biblio-892943
Autor: Robinson, Simon Paul; Farooq, Assad; Laniado, Marc; Motiwala, Hanif.
Título: The demographic features, clinical outcomes, prognosis and treatment options for patients with sarcomatoid carcinoma of the urinary bladder: a single centre experience
Fonte: Int. braz. j. urol;44(1):45-52, Jan.-Feb. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Introduction Carcinosarcoma of the bladder is a very rare neoplasm. The pathogenesis of carcinosarcomas is not clearly understood and remains a subject of debate. Whilst there is some research conceptualizing the histopathological findings of bladder carcinosarcomas, the demographic features, clinical outcomes, prognosis and treatment options remain unclear. Materials and Methods We analyzed 12 consecutive cases of patients with sarcoma-toid bladder cancer who were treated surgically at a single Urology Department be-tween 1999 and 2015. Radiology, pathology and surgical reports were reviewed to determine the pathological staging at the time of cystectomy. These were directly compared with 230 patients having cystectomies for urothelial cell carcinoma. The sarcomatoid patients, were compared to patients with urothelial cell cancers. The other histological sub types, squamous cell (17), neuroendocrine (9), metastatic (7), mixed (4), adenocarcinoma (3), were not included. Results and conclusion Carcinosarcoma of the urinary bladder is often described in the literature as a highly malignant neoplasm that is rapidly lethal. We found that the sarcoma does not offer a worse prognosis than conventional high-grade urothelial car-cinoma. There is no significant difference in grade, stage, positive surgical margin rate, nodal involvement, associated prostate cancer or incidence rates of progression, all cause or disease specific mortality. There was a barely significant difference in carcinoma in-situ. However, carcinosarcomas are three times the volume of urothelial cell tumors which may contribute to its reputation as an aggressive tumour (44cc v 14cc). Sarcomatous elements do not appear, from our small study, to bestow a worse prognosis.
Descritores: Neoplasias da Bexiga Urinária/cirurgia
Carcinossarcoma/cirurgia
-Prognóstico
Neoplasias da Bexiga Urinária/mortalidade
Neoplasias da Bexiga Urinária/patologia
Carcinoma de Células de Transição/cirurgia
Carcinossarcoma/mortalidade
Carcinossarcoma/patologia
Cistectomia
Análise de Sobrevida
Estudos Retrospectivos
Resultado do Tratamento
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Baracat, Edmund Chada
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Id: biblio-1153955
Autor: da Costa, Leonardo Tomiatti; dos Anjos, Laura Gonzalez; Kagohara, Luciane Tsukamoto; Torrezan, Giovana Tardin; De Paula, Claudia A. Andrade; Baracat, Edmund Chada; Carraro, Dirce Maria; Carvalho, Katia Candido.
Título: The mutational repertoire of uterine sarcomas and carcinosarcomas in a Brazilian cohort: A preliminary study
Fonte: Clinics;76:e2324, 2021. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: OBJECTIVES: The present study aimed to contribute to the catalog of genetic mutations involved in the carcinogenic processes of uterine sarcomas (USs) and carcinosarcomas (UCSs), which may assist in the accurate diagnosis of, and selection of treatment regimens for, these conditions. METHODS: We performed gene-targeted next-generation sequencing (NGS) of 409 cancer-related genes in 15 US (7 uterine leiomyosarcoma [ULMS], 7 endometrial stromal sarcoma [ESS], 1 adenosarcoma [ADS]), 5 UCS, and 3 uterine leiomyoma (ULM) samples. Quality, frequency, and functional filters were applied to select putative somatic variants. RESULTS: Among the 23 samples evaluated in this study, 42 loss-of-function (LOF) mutations and 111 missense mutations were detected, with a total of 153 mutations. Among them, 66 mutations were observed in the Catalogue of Somatic Mutations in Cancer (COSMIC) database. TP53 (48%), ATM (22%), and PIK3CA (17%) were the most frequently mutated genes. With respect to specific tumor subtypes, ESS showed mutations in the PDE4DIP, IGTA10, and DST genes, UCS exhibited mutations in ERBB4, and ULMS showed exclusive alterations in NOTCH2 and HER2. Mutations in the KMT2A gene were observed exclusively in ULM and ULMS. In silico pathway analyses demonstrated that many genes mutated in ULMS and ESS have functions associated with the cellular response to hypoxia and cellular response to peptide hormone stimulus. In UCS and ADS, genes with most alterations have functions associated with phosphatidylinositol kinase activity and glycerophospholipid metabolic process. CONCLUSION: This preliminary study observed pathogenic mutations in US and UCS samples. Further studies with a larger cohort and functional analyses will foster the development of a precision medicine-based approach for the treatment of US and UCS.
Descritores: Sarcoma/genética
Neoplasias Uterinas/genética
Carcinossarcoma/genética
-Brasil
Mutação
Limites: Humanos
Feminino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-565110
Autor: Souza, Felipe Gonçalves Schröder e; Almeida, Pedro Bastos Guimarães de; Souza, Klauss Villani Teixeira; Tostes, Alexandre Vicente Timóteo; Vidigal, Fernando Mendonça; Borsato, Luiz Henrique Silva.
Título: Carcinoma de células fusiformes em terço médio esofágico: relato de caso e revisão da literatura / Spindle cell carcinoma of the middle esophagus: case report and literature review
Fonte: HU rev;36(1), jan.-mar. 2010.
Idioma: pt.
Resumo: O carcinoma de células fusiformes, também conhecido como carcinossarcoma, representa entre 0,5% e 1,5% das neoplasias malignas do esôfago e é caracterizado por volumosa lesão lobulada, causando pequena obstrução comparada ao seu volume. Este estudo apresenta um caso desta rara neoplasia em terço médio esofágico, que foi conduzida com tratamento cirúrgico e cujo diagnóstico foi confirmado por exame imunohistoquímico.

Spindle cell carcinoma, also known as carcinosarcoma, accounts for 0.5% to 1.5% of esophageal malignancies, and is characterized by a voluminous lobulated lesion leading to low-degree obstruction relative to its volume. We report a case of this rare condition in the middle esophagus, with the diagnosis confirmed through immunohistochemistry, and which was treated with surgery.
Descritores: Neoplasias Esofágicas
Carcinossarcoma
-Sarcoma
Tipo de Publ: Relatos de Casos
Responsável: BR378.1 - Biblioteca Central


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Id: biblio-978299
Autor: Garzón-Olivares, Carmen Doris; Cortés-Díaz, Daniel Otálvaro; Ángel-Müller, Edith; Riaño-Castellanos, Giovanni Enrique; Mora-Soto, Nathalia; Acosta-Forero, Bernarda Jinneth.
Título: Cervical carcinosarcoma: Case report and review of the literature / Carcinosarcoma del cuello uterino: reporte de caso y revisión de la literatura
Fonte: Rev. colomb. obstet. ginecol;69(3):208-217, July-Sept. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective: To report the case of a patient with cervical carcinosarcoma and intra-abdominal bleeding, and to review the available literature on the treatment and prognosis of this condition. Materials and methods: Case report of an 84-year-old patient who presented with an abdominal mass and urinary tract obstruction. During hospital stay, she developed intra-abdominal bleeding with signs of shock, requiring total abdominal hysterectomy with bilateral salpyngo-oophorectomy, hypogastric artery ligation and pelvic packing as interventions to control bleeding. Histology reported a diagnosis of carcinosarcoma of the uterine cervix. The patient evolved adequately and was referred for oncologic management. The search in the literature was conducted in the Medline vía PubMed, SciELO and Ovid databases, using the terms "uterine carcinosarcoma" "treatment" "cancer treatment" "treatment review" and "treatment outcome". The search was limited by language type but not by year of publication. Results: Of the references, 19 met the inclusion and exclusion criteria, and they were predominantly case reports. The clinical stage most frequently reported was FIGO IB in close to 53% of cases, and the most frequent presentation was genital bleeding associated with a pelvic mass. With an average follow-up of 15 months, survival in patients receiving radiotherapy or taken to surgery is 17% and 68%, respectively. Of the patients taken to surgery as primary treatment, 63% remained disease-free during the first two years of follow-up, with a frequency of nearly 100% during the same period when radiotherapy was given after surgery. Conclusions: Cervical carcinosarcoma is an infrequent condition whose most common clinical manifestation is the presence of genital bleeding accompanied by a pelvic mass. Surgery, radiotherapy and chemotherapy are therapeutic options available for the treatment of this entity. However, regardless of the treatment provided, survival prognosis in women with this disease is lower than in women with squamous cell carcinoma or adenocarcinoma. Further studies of high methodological quality are required to assess the safety and effectiveness of the various interventions used as therapeutic approach to this entity.

RESUMEN Objetivo: reportar el caso de una paciente con carcinosarcoma del cuello uterino con sangrado intraabdominal, y revisar la literatura disponible sobre el tratamiento y pronóstico de la entidad. Materiales y métodos: se reporta el caso de una paciente de 84 años, que consultó por masa abdominal y obstrucción del tracto urinario. Durante la estancia hospitalaria presentó sangrado intraabdominal con signos de choque, por lo que fue necesario realizar histerectomía abdominal total con salpingo-oforectomía bilateral, ligadura de hipogástricas y taponamiento de cavidad pélvica como intervenciones para controlar el sangrado. El estudio histológico reportó como diagnóstico carcinosarcoma del cérvix. La paciente evolucionó de forma adecuada y fue remitida para continuar manejo por oncología. Para la búsqueda de la literatura se realizó una pesquisa en las bases de datos Medline vía PubMed, SciELO y Ovid, utilizando los términos "uterinecarcinosarcoma" "treatment "cáncer treatment" "treatmentreview" y "treatmentoutcome". La búsqueda se limitó por tipo de idioma, pero no por año de publicación. Resultados: 19 estudios cumplieron con los criterios de inclusión y de exclusión, estas fueron predominantemente reportes de caso. El estadio clínico reportado con mayor frecuencia fue FIGO IB en cerca del 53 % de los casos, y la presentación más frecuente fue el sangrado genital acompañado de masa pélvica. Con un seguimiento promedio de 15 meses, la sobrevida para este tumor es del 17 % para las pacientes que recibieron radioterapia. El 63 % de las pacientes que recibieron cirugía como tratamiento primario permanecieron libres de enfermedad durante los dos primeros años de seguimiento, con una frecuencia cercana al 100% para este mismo periodo cuando se administró radioterapia posterior a la cirugía. Conclusiones: el carcinosarcoma de cérvix es una entidad poco frecuente, cuya manifestación clínica más común suele ser la presencia de sangrado genital acompañado de masa pélvica. Dentro de las opciones terapéuticas disponibles para tratar esta entidad se encuentran la cirugía, la radio y la quimioterapia. No obstante, independientemente del tratamiento proporcionado, el pronóstico de sobrevida para las mujeres con esta patología es inferior al de las mujeres con carcinomas escamosos o adenocarcinomas. Se requieren estudios de alta calidad metodológica que evalúen la seguridad y la efectividad de las diferentes intervenciones para el abordaje terapéutico de esta entidad.
Descritores: Carcinossarcoma
-Prognóstico
Terapêutica
Útero
Doenças do Colo do Útero
Colo do Útero
Limites: Humanos
Responsável: CO76


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Texto completo SciELO Chile
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Id: biblio-902780
Autor: Tapia C, Mario; Ortega R, Pablo; Urra B, Alexis; Ayres H, Geraldine; Sepúlveda A, Ilson.
Título: Carcinosarcoma de laringe: reporte de dos casos / Carcinosarcoma of the larynx: report of two cases
Fonte: Rev. otorrinolaringol. cir. cabeza cuello;77(3):300-306, set. 2017. ilus.
Idioma: es.
Resumo: El carcinosarcoma de laringe es un tumor bifásico raro que representa menos del 1% de todos los tumores malignos de laringe. Debido a su doble naturaleza epitelial y mesenquimal esta neoplasia ha sido denominada de distintas maneras en la literatura, siendo indispensable el estudio mediante inmunohistoquímica para establecer un diagnóstico correcto. Se presentan 2 casos de carcinosarcoma de laringe, confirmados mediante estudio con inmunohistoquímica, ambos tratados mediante laringectomía total. Se elabora una discusión de los principales aspectos clínicos, histopatológicos y terapéuticos de esta infrecuente neoplasia.

The larynx carcinosarcoma is a rare biphasic tumor that represents less than 1% of all malignant tumors of the larynx. Because of its biphasic epithelial and mesenchymal nature this neoplasm has been called in different ways in the literature being indispensable the study by immunohistochemistry to establish a proper diagnosis. We present 2 cases of larynx carcinosarcoma confirmed by immunohistochemical study, both treated with total laryngectomy. A discussion of the main clinical, histopathological and therapeutic aspects of this rare neoplasm is made.
Descritores: Carcinossarcoma/cirurgia
Carcinossarcoma/patologia
Neoplasias Laríngeas/cirurgia
Neoplasias Laríngeas/patologia
Laringectomia/métodos
-Carcinossarcoma/diagnóstico por imagem
Neoplasias Laríngeas/diagnóstico por imagem
Limites: Humanos
Masculino
Pessoa de Meia-Idade
Idoso de 80 Anos ou mais
Tipo de Publ: Relatos de Casos
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
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Id: lil-776425
Autor: Bernardes Filho, Fred; Melo, Alessandro Severo Alves de; Pires, Andréa Rodriguez Cordovil; Lupi, Omar; Neves, Daniel Gama das; Cruz, Margareth Fernandes da; Kac, Bernard Kawa.
Título: Cutaneous invasion from sarcomatoid urothelial carcinoma: clinical and dermatopathologic features
Fonte: An. bras. dermatol;91(1):73-79, Jan.-Feb. 2016. graf.
Idioma: en.
Resumo: Abstract In Brazil, without considering the non-melanoma skin tumors, bladder cancer in men is the eighth most common, and the urothelial carcinoma or transitional cell carcinoma is the most common among these. Cutaneous metastases from urothelial neoplasms appear as single or multiple erythematous, infiltrated nodules or plaques, and like other cases of distant disease, it is indicative of poor prognosis. The invasive urothelial carcinoma is recognized for its ability to present divergent differentiation and morphological variants. The sarcomatoid urothelial carcinoma is a rare cancer that consists of two different components: one composed of epithelial tissue and the other with sarcomatoid features of mesenchymal origin. The authors describe a case of cutaneous metastasis of sarcomatoid urothelial carcinoma in a 63-year-old male patient.
Descritores: Carcinoma de Células de Transição/patologia
Carcinossarcoma/patologia
Neoplasias Cutâneas/patologia
Neoplasias da Bexiga Urinária/patologia
-Evolução Fatal
Invasividade Neoplásica
Pele/patologia
Urotélio/patologia
Limites: Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Alves, Ana Paula Negreiros Nunes
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Id: lil-743351
Autor: Alves, Ana Paula Negreiros Nunes.
Título: Efeito do metotrexato e do bisfosfonato alendronato em modelo do carcinossarcoma 256 de Walker na mandíbula de ratos [Manuscrito] / The effect of methotrexate and bisphosphonate alendronate in a model of Walker 256 carcinosarcoma in the rat mandible [Manuscript].
Fonte: Fortaleza; s.n; 2005.
Idioma: pt.
Tese: Apresentada a Universidade Federal do Ceará para obtenção do grau de Doutor.
Resumo: As reabsorções patológicas do osso alveolar vistas numa variedade de neoplasias malignas são severas e graves, levando precocemente a microfraturas. A invasão tumoral óssea pode acontecer em consequência da progressão subcortical do tumor através dos alvéolos dentários. O objetivo desse estudo foi avaliar o efeito do Metotrexato (MTX) e do Bifosfonato Alendronato (ALD) em modelo do Carcinossarcoma 256 de Walker na mandíbula de ratos. Uma suspensão de células tumorais do Carcinossarcoma de Walker 256, na concentração de 10 elevado a sexta potência células/mL, foi implantada nos alvéolos de ratos, previamente abertos por exodontia. Os animais foram divididos em grupos e tratados com salina, MTX, ALD e associação do MTX com ALD. Foram observados durante todo o tratamento a sobrevivência e o peso corpóreo dos animais. Após o sacrifício, os tumores foram medidos e as mandíbulas removidas para exames radiográfico e histológico. No exame radiográfico do grupo controle foi verificado área lítica, sem evidência de reparo, na região dos alvéolos, e na microscopia, infiltração óssea periférica e central, de pequenas células tumorais com diversas áreas de necrose...
Descritores: Alendronato
Carcinossarcoma
CARCINOMA ADENOSINE KINASE DE WALKER
Neoplasias Bucais
Limites: Ratos
Responsável: BR6.1 - BCS - Biblioteca de Ciências da Saúde


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Id: lil-742648
Autor: Redondo-Bermúdez, César; Mendoza-Suárez, Liney; Ruiz-Cáez, Karina; Gómez-Villa, Jorge.
Título: Carcinosarcoma uterino con extensión pélvica: presentación de un caso y revisión de la literatura / Uterine carcinosarcoma with extension to the pelvis: Case presentation and review of the literature
Fonte: Rev. colomb. obstet. ginecol;65(4):354-360, oct.-dic. 2014. ilus.
Idioma: es.
Resumo: Objetivo: se presenta un caso de carcinosarcoma uterino para hacer una revisión de la literatura publicada acerca de la epidemiologia, el diagnóstico, tratamiento y pronóstico de esta neoplasia. Materiales y métodos: se presenta el caso de una paciente de 73 años de edad, quien consultó a un centro de referencia para atención ginecoobstétrica en Cartagena (Colombia), por sangrado vaginal, pérdida de peso y masa pélvica. El análisis microscópico reveló un carcinosarcoma endometrial/ tumor mülleriano mixto maligno. Se realizó una búsqueda sistemática en las bases de datos Medline vía PubMed, Hinari, Imbiomed, ScienceDirect y EBSCO, utilizando los términos "Carcinosarcoma", "Neoplasias uterinas", "Útero". Se buscaron estudios tipo reporte de casos, revisiones de temas u otros estudios publicados en los últimos diez años, en inglés o español. Resultados: se encontraron 350 títulos de los cuales un total de 20 artículos estaban relacionados directamente con el tema, de estos se seleccionaron 18 que correspondieron a ocho reportes de casos, siete revisiones de temas, dos cohortes retrospectivas y un ensayo clínico. El carcinosarcoma uterino es una neoplasia poco frecuente que afecta especialmente a mujeres posmenopáusicas. Histopatológicamente se observa una combinación de cambios carcinomatosos y sarcomatosos; el tratamiento estándar es quirúrgico. La profundidad de la invasión miometrial ha sido sugerida como factor pronóstico muy importante, y en un 50 % de los casos presenta extensión extrauterina que se asocia con una supervivencia general muy pobre. Conclusiones: el carcinosarcoma es una neoplasia de baja frecuencia caracterizada por su población celular bifásica y mal pronóstico.

Objective: Presentation of a case of uterine carcinosarcoma and review of the literature on the epidemiology, diagnosis, treatment and prognosis of this neoplasm. Materials and methods: A 73 year-old female patient presenting with vaginal bleeding, weight loss and a pelvic mass to a referral centre for gynaecological and obstetrical care in Cartagena, Colombia. The microscopic examination revealed a mixed malignant endometrial carcinosarcoma/ müllerian tumor. A systematic search was conducted in the Medline via PubMed, Hinari, Imbiomed, ScienceDirect and Ebsco databases, using the terms "carcinosarcoma", "uterine neoplasms", "uterus". The search included case reports, topic reviews or other studies published within the past 10 years, both in English and Spanish. Results: Overall, 350 titles were found, 20 of which were directly related to the topic. Of these, 18 were selected, including 8 case reports, 7 topic reviews, 2 retrospective cohorts, and 1 clinical trial. Uterine carcinosarcoma is an infrequent neoplasm affecting post-menopausal women in particular. The histopathology shows a combination of carcinomatous and sarcomatous changes. The standard treatment is surgery. It has been suggested that the depth of invasion into de myometrium is a very important prognostic factor, and extra-uterine extension is found in 50% of cases. It is generally associated with very poor survival. Conclusions: Carcinosarcoma is an infrequent neoplasm characterized by biphasic cell population and poor prognosis.
Descritores: Carcinossarcoma
NEOPLASIAS UTERINAS UTERO
Limites: Feminino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: CO76


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Id: lil-724127
Autor: Leiner, Rita; González, Virginia; Casas, Gabriel; Larralde, Margarita.
Título: Carcinosarcoma / Sarcomatoid carcinoma
Fonte: Dermatol. argent;17(1):70-73, ene.-feb. 2011. ilus.
Idioma: es.
Resumo: El carcinosarcoma es un tumor poco frecuente, bifásico, que ha sido comunicado en diferentes sitios del organismo. Está compuesto por un componente maligno epitelial íntimamente asociado con un componente epitelial sarcomatoide que puede ser homólogo y heterólogo. Existen carcinosarcomas cutáneos y extracutáneos. Los carcinosarcomas extracutáneos muestran un pronóstico pobre. Presentamos un paciente de 75 años, fototipo II, que consulta por presentar un tumor exofítico angiomatoide sangrante de 8 mm, de aspecto botriomicoide, de 2 meses de evolución en piel frontal derecha. Se confirma con biopsia y técnicas de inmunohistoquímica la existencia de 2 morfologías celulares típicas del carcinosarcoma. El tumor fue extirpado con un centímetro de margen de seguridad. El paciente, al año de su intervención, está libre de recurrencias y metástasis. El componente sarcomatoso del tumor es comprendido como una transformación metaplásica del componente carcinomatoso. Estos tumores son potencialmente agresivos.

Carcinosarcoma is an uncommon biphasic neoplasm that has been reported in diverseanatomical sites. This tumor is composed of two malignant epithelial components: onetypical and the other atypical, this one resembling mesenchymal tissue. Both are intimatelyassociated .The latter may be homologous or heterologous. When these tumors are locatedat extracutaneous sites, they are characteristically aggressive.We report a 75-year-old man who developed a solitary reddish bleeding nodule that quicklygrew in a two-months period. It resembled a pyogenic granuloma and was located on hisright frontal skin. Clinical, histologycal and immunohistochemical features were evaluated.The tumor was completely excised with a one-centimeter safety margin, and after a lapse ofone year he is free of local relapses or metastases.The sarcomatous component of the tumor is considered to be a metaplastic transformation ofthe carcinomatous component. These tumors are potentially aggressive if partially removed,thus complete excision is mandatory.
Descritores: Carcinossarcoma/cirurgia
Carcinossarcoma/diagnóstico
Carcinossarcoma/patologia
Neoplasias Cutâneas/patologia
-Carcinoma de Células Escamosas/patologia
Diagnóstico Diferencial
Limites: Humanos
Idoso
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco


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Texto completo SciELO Brasil
Texto completo
Id: lil-721405
Autor: Tomas, Davor; Vagic, Davor; Bedekovic, Vladimir; Kruslin, Bozo.
Título: Carcinosarcoma de novo of the parotid gland with unusual sarcomatous component / Carcinossarcoma de novo da parótida com componente sarcomatoso incomum
Fonte: Braz. j. otorhinolaryngol. (Impr.);80(4):364-365, Jul-Aug/2014. graf.
Idioma: en.
Descritores: Carcinossarcoma/patologia
Neoplasias Parotídeas/patologia
Limites: Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME



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