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Id: biblio-990877
Autor: Rojo Novo, Sara; Albalat Fernández, Rosa; Montaño Serrano, María; Cordón Gámiz, Antonio; La Calle Marcos, Manolo; Gutiérrez Domingo, Álvaro.
Título: Osteosarcoma primario de mama en una paciente con antecedentes de tratamiento radioterápico loco-regional por carcinoma in situ mamario / Primary breast osteosarcoma in a patient with a history of locoregional radiotherapy treatment for breast carcinoma in situ
Fonte: Rev. chil. obstet. ginecol. (En línea);83(6):621-629, 2018. ilus.
Idioma: es.
Resumo: RESUMEN El cáncer de mama es el tumor más prevalente a nivel mundial entre las mujeres. A pesar de que la supervivencia global alcanza cifras cercanas al 90%, sigue suponiendo un importante problema sanitario y económico para la población. Los sarcomas primarios de mama suponen menos del 1% de estas neoplasias, pero sus tasas de recidiva y mortalidad son elevadas. Dado que no existen pruebas de imagen específicas para el diagnóstico, la confirmación de dicha entidad supone un reto a nivel histopatológico. El tratamiento del osteosarcoma de mama es principalmente quirúrgico, con la extirpación de la tumoración con márgenes adecuados, que será trascendental para el pronóstico de las pacientes. No se ha demostrado que sea necesaria una disección axilar, ni un tratamiento adyuvante estándar de quimioterapia ni radioterapia, salvo casos indicados. Presentamos el caso de una paciente postmenopaúsica que tras haber desarrollado un carcinoma ductal in situ de mama tratado de forma satisfactoria, desarrolla dos años posterior a la finalización del tratamiento radioterápico, y en la misma localización del tumor inicial, un osteosarcoma primario de mama de rápido crecimiento atribuible al efecto de la radioterapia administrada.

ABSTRACT Breast cancer is the most prevalent tumor worldwide among women. Despite the fact that overall survival reaches figures close to 90%, it continues to be an important health and economic problem for the population. Primary breast sarcomas account for less than 1% of these neoplasms but their rates of recurrence and mortality are high. Given that there are no specific imaging tests for diagnosis, confirmation of this entity is a challenge at the histopathological level. The treatment of the OSM is mainly surgical with the removal of the tumor with adequate margins, which will be transcendental for the prognosis of the patients. It has not been demonstrated that an axillary dissection is required, nor a standard adjuvant treatment of chemotherapy or radiotherapy, unless indicated. We present the case of a postmenopausal patient who, after having developed a ductal carcinoma in situ of the breast (DCIS) successfully treated, developed two years after the end of the radiotherapy treatment, and in the same location of the initial tumor, an osteosarcoma primary breast of rapid growth attributable to the effect of radiotherapy administered.
Descritores: Neoplasias da Mama/diagnóstico por imagem
Osteossarcoma/diagnóstico por imagem
Neoplasias Induzidas por Radiação
-Sarcoma/etiologia
Neoplasias da Mama/radioterapia
Neoplasias da Mama/terapia
Mastectomia
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: CL126.2 - Biblioteca Médica Dr. Profesor Hernán Alessandri R.


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Id: biblio-990875
Autor: Ortega Marcilla, S; Adiego Calvo, I; Villalobos Salguero, FJ; Laborda Gotor, R; Gutierrez Y, José; Gómez I, Vicente.
Título: Cáncer de metaplásico de mama: revisión de dos casos clínicos / Metaplastic breast cancer: review of two clinical cases
Fonte: Rev. chil. obstet. ginecol. (En línea);83(6):606-613, 2018. graf, ilus.
Idioma: es.
Resumo: RESUMEN El carcinoma metaplásico de mama es un tipo de cáncer infiltrante que asemeja un carcinoma de alto grado histológico, pero cuya incidencia es muy baja (< 1%). Desde el punto de vista anatomopatológico presenta un componente mixto epitelial y mesenquimal; siendo lo más característico su comportamiento clínico altamente agresivo junto con unas características anatomopatológicas, inmunohistoquímicas concordantes, como son el HER2/neu negativo, los receptores hormonales negativos, el tamaño tumoral grande y el alto grado histológico. Por todo ello, resulta de especial interés conocer esta entidad, con la finalidad de realizar un diagnóstico preciso y llevar a cabo un tratamiento adecuado en estas pacientes. En el presente artículo se presenta la revisión de dos casos clínicos de cáncer de mama metaplásico, diagnosticados y tratados en nuestro Hospital durante el año 2015 y 2018.

ABSTRACT The metaplastic breast cancer is a subtype of an infiltranting breast cancer and it's usually high grade. However it is a rare subtype of cancer (incidence <1%). This cancer has an epithelial and connective tissues, which has an epithelial invasor ductal breast cancer with high grade and sarcomas breast. The main characteristic of the metaplastic breast cancer is their high agressive behavior as clinical as anatomopathological, which immunohistochemical expression is like a triple negative breast cancer. Because of this we consider that their knowledge is very important with the purpose of being diagnosed in women. In this paper it is showed a revision of two cases of metaplastic breast cancer, whose diagnostic and treatment were reported in our Centre.
Descritores: Neoplasias da Mama/patologia
Carcinoma/patologia
Metaplasia/patologia
-Sarcoma
Neoplasias da Mama/terapia
Neoplasias da Mama/diagnóstico por imagem
Carcinoma/terapia
Carcinoma/diagnóstico por imagem
Mastectomia
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Idoso
Tipo de Publ: Relatos de Casos
Responsável: CL126.2 - Biblioteca Médica Dr. Profesor Hernán Alessandri R.


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Id: biblio-1249005
Autor: Batool, Sajida; Ahuja, Arvind; Chauhan, Devender Singh; Bhardwaj, Minakshi; Meena, Atul Kumar.
Título: Epithelioid inflammatory myofibroblastic sarcoma: the youngest case reported
Fonte: Autops. Case Rep;11:e2021288, 2021. tab, graf.
Idioma: en.
Resumo: Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a rare variant of the inflammatory myofibroblastic tumor. It has an aggressive clinical course and a high rate of recurrence. EIMS primarily affects children and young adults. Hereby, we report this entity in a 4-month-old infant who presented with an abdominal mass. Imaging studies revealed a large hypodense mesentery-based lesion involving the right half and mid-region of the abdomen. The mass with an attached segment of the small bowel was excised in toto. Grossly, a large encapsulated tumor was identified arising from the mesentery of the small bowel. The histological examination showed a tumor consisting of epithelioid to spindle cells loosely arranged in a myxoid background with numerous blood vessels and lymphoplasmacytic inflammatory infiltrate. On immunohistochemistry, the tumor cells showed positivity for ALK1 (nuclear), desmin, SMA, CD68, and focal positivity for CD30. A final diagnosis of EIMS of the small intestine was rendered. To the best of our knowledge, this case is the youngest reported case in literature.
Descritores: Sarcoma
Neoplasias Intestinais/patologia
-Imuno-Histoquímica
Células Epitelioides/patologia
Quinase do Linfoma Anaplásico
Intestino Delgado
Mesentério
Limites: Humanos
Feminino
Lactente
Tipo de Publ: Relatos de Casos
Responsável: BR26.7 - Serviço de Biblioteca e Documentação Científica


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Id: biblio-1254750
Autor: Andrade, Rhavena Brasil; Lima, Carlos José Mota; Freitas, Ingrid Alves; Corrêa, Larissa Chagas; Lino, Danielli Oliveira da Costa; Alcantâra, Ana Carolina Brito.
Título: Sarcoma Cardíaco Intimal: uma Entidade Rara Dentre os Tumores Cardíacos / Cardiac Intimal Sarcoma: A Rare Cardiac Tumor Entity
Fonte: ABC., imagem cardiovasc;34(1), 2021.
Idioma: pt.
Descritores: Sarcoma/cirurgia
Sarcoma/diagnóstico por imagem
Átrios do Coração/fisiopatologia
Cardiopatias/fisiopatologia
Neoplasias Cardíacas/diagnóstico por imagem
Ventrículos do Coração/fisiopatologia
-Marca-Passo Artificial
Fibrilação Atrial/complicações
Raios X
Bradicardia/complicações
Ecocardiografia/métodos
Tomografia/métodos
Seguimentos
Doenças Raras/reabilitação
Tratamento Farmacológico/tendências
Eletrocardiografia
Coração/fisiopatologia
Antiarrítmicos/farmacologia
Limites: Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt


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Id: biblio-1115607
Autor: Facundo Navia, Helena; Rendón-Hernández, Juliana; Mesa, Jorge.
Título: Sarcoma gástrico primario: reporte de caso y revisión de la literatura / Primary gastric sarcoma: Case report and literature review
Fonte: Rev. colomb. gastroenterol;35(1):118-122, 2020. tab, graf.
Idioma: es.
Resumo: Resumen El cáncer gástrico, patología neoplásica de innegable importancia, corresponde en el 90 % de los casos a un adenocarcinoma. Dentro del 10 % restante, los linfomas y los tumores estromales gastrointestinales (Gastrointestinal Stromal Tumor, GIST) constituyen la mayoría. Sin embargo, los sarcomas no GIST siguen siendo un diagnóstico diferencial posible para tener en cuenta y configuran una patología neoplásica de tratamiento fundamentalmente quirúrgico. En particular, el leiomiosarcoma representa menos del 1 % de los tumores malignos del estómago y la literatura disponible al respecto consiste en reportes de caso o serie de casos. Por su rareza, presentamos este caso clínico y revisamos la literatura relacionada.

Abstract Gastric cancer, a neoplastic pathology of undeniable importance, accounts for 90% of cases to adenocarcinoma. GIST lymphomas and gastrointestinal stromal tumors are the majority of the other 10%. However, non-GIST sarcomas remain a possible differential diagnosis to keep in mind and constitute a neoplastic pathology whose treatment is fundamentally surgical. Leiomyosarcoma represents less than 1% of malignant stomach tumors, and the available literature consists of case reports or case series. Because of its rarity, we present this clinical case and review the literature.
Descritores: Sarcoma
Neoplasias Gástricas
Adenocarcinoma
-Tumores do Estroma Gastrointestinal
Literatura
Limites: Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: CO354 - Sociedad Colombiana de Gastroenterología


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Id: biblio-1254955
Autor: Brito, Manuel; Cerrada, Luis.
Título: Liposarcoma intramuscular del muslo tratado con braquiterapia de alta tasa de dosis. Reporte de un caso / Intramuscular thigh liposarcoma treated with high dose rate brachytherapy. A case report
Fonte: Rev. venez. cir. ortop. traumatol;46(1), jun 2014. ilus.
Idioma: es.
Resumo: El liposarcoma es un tumor maligno de origen mesenquimal. Comparado con otros tipos de neoplasias malignas, los sarcomas de partes blandas son tumores relativamente raros. Representan el 1% de todas las neoplasias y supone del 9 al 18% del total de sarcomas de partes blandas. Es una neoplasia propia de pacientes adultos, con mayor incidencia entre los 40 y los 60 años, con ligera preferencia del sexo masculino. Hasta hace tres décadas, la tendencia ante la presencia de este tipo de lesiones en las extremidades era la cirugía radical. Presentamos el caso de paciente femenino de 37 años quien presenta una tumoración en el muslo izquierdo. La biopsia incisional reportó una neoplasia maligna poco diferenciada. Ante la sospecha clínica y radiológica de la presencia de un liposarcoma fue llevada a quirófano donde se realizó compartamentectomía medial del muslo izquierdo, con colocación intraoperatoria de 12 catéteres para braquiterapia y linfadenectomía inguinofemoral izquierda. La braquiterapia es una forma de radioterapia adyuvante interna y una alternativa útil y atractiva(AU)

Liposarcoma is a malignant tumor of mesenchymal origin. Compared with other types of malignancies, soft tissue sarcomas are relatively rare tumors. Represent 1% of all malignancies and is from 9 to 18% of soft tissue sarcomas. Its an adult patients tumor, with the highest incidence between 40 and 60 years and with a slight prevalence of males. Until three decades ago, the trend in the presence of these lesions in the extremities was radical surgery. We report the case of a 37 years old female patient who has a growth on the thigh. Incisional biopsy reported a poorly differentiated malignant neoplasm. Suspecting a liposarcoma was taken to the operating room where left medial thigh compartamentectomy was made and intraoperative placement of 12 brachytherapy catheters and left inguinofemoral lymphadenectomy. Brachytherapy is a form of internal radiation and an alternative, useful and attractive adjuvant therapy(AU)
Descritores: Sarcoma
Braquiterapia
Lipossarcoma
Neoplasias
-Coxa da Perna
Extremidades
Crescimento
Limites: Humanos
Feminino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: VE1.1 - Biblioteca Humberto Garcia Arocha


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Id: biblio-989958
Autor: Vuruskan, Berna Aytac; Ozsen, Mıne; Coskun, Burhan; Yalcinkaya, Ulviye.
Título: Evaluation of incidence and histolopathological findings of soft tissue sarcomas in genitourinary tract: Uludag university experience
Fonte: Int. braz. j. urol;45(1):68-73, Jan.-Feb. 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT Purpose: In this study we aimed to review urological soft tissue sarcomas of genitourinary tract that were diagnosed in our institution and their prognostic factors for survival. Materials and Methods: The clinical and pathological records of 31 patients who had diagnosis of soft tissue sarcomas primarily originating from the genitourinary tract between 2005-2011 were reviewed. Results: The most common site was kidney (17 cases, 54.8%), and most common diagnosis was leiomyosarcoma (11 cases, 35.4%). A total of 24 patients (77.4%) had surgical excision. The surgical margins were positive in 7 patients who presented with local recurrence after primary resection. Twelve patients developed metastatic disease. During follow-up (range 9-70 month), 26 of the 31 patients (88.9%) were alive. Significant survival differences were found according to histological type (p: 0.001), with lower survival rates for malignant fibrous histiocytoma. The tumor size, the presence of metastasis at the time of diagnosis and tumor localization were not statistically significant for overall survival. Conclusions: In our series, prostate sarcomas, paratesticular rhabdomyosarcoma and malignant fibrous histiocytoma had poor prognosis, especially in patients presenting with metastatic disease.
Descritores: Neoplasias da Próstata/patologia
Sarcoma/patologia
Neoplasias Testiculares/patologia
Neoplasias da Bexiga Urinária/patologia
Neoplasias Renais/patologia
-Prognóstico
Neoplasias da Próstata/mortalidade
Sarcoma/mortalidade
Neoplasias Testiculares/mortalidade
Neoplasias da Bexiga Urinária/mortalidade
Incidência
Estudos Retrospectivos
Seguimentos
Estimativa de Kaplan-Meier
Neoplasias Renais/mortalidade
Pessoa de Meia-Idade
Metástase Neoplásica
Limites: Humanos
Masculino
Adulto
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1251345
Autor: Szostakowski, Bartlomiej; Staals, Eric; Onwordi, Lyris; Pollock, Robin; Skinner, John A.
Título: Reconstruction with a Custom made Prosthetic Wrist Arthrodesis after Bone Tumor Resections of the Distal Radius. Single Centre Experience / Reconstrução com implante metálico personalizado de artrodese após ressecções de tumor ósseo do rádio distal. Experiência em um único centro
Fonte: Rev. bras. ortop;56(2):224-229, Apr.-June 2021. tab, graf.
Idioma: en.
Resumo: Abstract Objective The present study aimed at analyzing the clinical, radiological and functional results of the reconstruction of the distal radius after tumor resection with a custom-made metal arthrodesis implant and compare them with other types of distal radius reconstruction, as presented in the literature. To our best knowledge, this is the first article describing this particular type of implant and patient functionality. Methods Functional outcomes of reconstruction of the distal radius were assessed in a series of 4 patients. Three of the patients having had resection of giant cell tumors (GCTs), one patient having had resection of osteosarcoma. Results There were no major implant-related complications like infection, nonunion or loosening. Two patients had to undergo further surgery for protruding metalwork. Overall function was good according to the Musculoskeletal Tumor Society MSTS and Disabilities of the Arm, Shoulder, and Hand (DASH) scores. Conclusion The present study shows that custom-made metal arthrodesis implant benefits from the fact that it can be used as a salvage option when other treatments have failed, or it can be used as a primary option in cases in which there is limited bone stock after distal radius tumor resection.

Resumo Objetivo O presente estudo teve como objetivo analisar os resultados clínicos, radiológicos e funcionais da reconstrução do rádio distal após a ressecção do tumor com implante metálico personalizado de artrodese e compará-los com outros tipos de reconstrução do rádio distal, conforme apresentado na literatura. Pelo que conhecemos, este é o primeiro artigo descrevendo esse tipo particular de implante e funcionalidade no paciente. Métodos Os desfechos funcionais de reconstrução do rádio distal foram avaliados em uma série de 4 pacientes. Três dos pacientes tiveram ressecção de tumores de células gigantes (TCGs), sendo um paciente com ressecção de osteossarcoma. Resultados Não houve complicações relacionadas ao implante, como infecção, não sindicalidade ou afrouxamento. Dois pacientes tiveram que passar por uma nova cirurgia para a protusão da prótese metálica. A função geral foi boa de acordo com as pontuações da Musculoskeletal Tumor Society (MSTS) e Disabilities of the Arm, Shoulder, and Hand (DASH). Conclusão O estudo mostra que o implante metálico personalizado de artrodese se beneficia do fato de que pode ser usado como opção de salvamento quando outros tratamentos falharam, ou pode ser usado como opção primária nos casos em que há estoque ósseo limitado após a ressecção do tumor do rádio distal.
Descritores: Artrodese
Próteses e Implantes
Rádio (Anatomia)/cirurgia
Sarcoma
Punho
Osteossarcoma
Tumores de Células Gigantes
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR26.1 - Biblioteca Central


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Baracat, Edmund Chada
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Id: biblio-1153955
Autor: da Costa, Leonardo Tomiatti; dos Anjos, Laura Gonzalez; Kagohara, Luciane Tsukamoto; Torrezan, Giovana Tardin; De Paula, Claudia A. Andrade; Baracat, Edmund Chada; Carraro, Dirce Maria; Carvalho, Katia Candido.
Título: The mutational repertoire of uterine sarcomas and carcinosarcomas in a Brazilian cohort: A preliminary study
Fonte: Clinics;76:e2324, 2021. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: OBJECTIVES: The present study aimed to contribute to the catalog of genetic mutations involved in the carcinogenic processes of uterine sarcomas (USs) and carcinosarcomas (UCSs), which may assist in the accurate diagnosis of, and selection of treatment regimens for, these conditions. METHODS: We performed gene-targeted next-generation sequencing (NGS) of 409 cancer-related genes in 15 US (7 uterine leiomyosarcoma [ULMS], 7 endometrial stromal sarcoma [ESS], 1 adenosarcoma [ADS]), 5 UCS, and 3 uterine leiomyoma (ULM) samples. Quality, frequency, and functional filters were applied to select putative somatic variants. RESULTS: Among the 23 samples evaluated in this study, 42 loss-of-function (LOF) mutations and 111 missense mutations were detected, with a total of 153 mutations. Among them, 66 mutations were observed in the Catalogue of Somatic Mutations in Cancer (COSMIC) database. TP53 (48%), ATM (22%), and PIK3CA (17%) were the most frequently mutated genes. With respect to specific tumor subtypes, ESS showed mutations in the PDE4DIP, IGTA10, and DST genes, UCS exhibited mutations in ERBB4, and ULMS showed exclusive alterations in NOTCH2 and HER2. Mutations in the KMT2A gene were observed exclusively in ULM and ULMS. In silico pathway analyses demonstrated that many genes mutated in ULMS and ESS have functions associated with the cellular response to hypoxia and cellular response to peptide hormone stimulus. In UCS and ADS, genes with most alterations have functions associated with phosphatidylinositol kinase activity and glycerophospholipid metabolic process. CONCLUSION: This preliminary study observed pathogenic mutations in US and UCS samples. Further studies with a larger cohort and functional analyses will foster the development of a precision medicine-based approach for the treatment of US and UCS.
Descritores: Sarcoma/genética
Neoplasias Uterinas/genética
Carcinossarcoma/genética
-Brasil
Mutação
Limites: Humanos
Feminino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: biblio-958391
Autor: Boyacioglu, Kamil; Ak, Adnan; Dönmez, Arzu Antal; Çayhan, Burçin; Aksüt, Mehmet; Tunçer, Mehmet Altug.
Título: Outcomes after surgical resection of primary non-myxoma cardiac tumors
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);33(2):162-168, Mar.-Apr. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Objective: Primary cardiac tumors are rare lesions with different histological type. We reviewed our 17 years of experience in the surgical treatment and clinical results of primary non-myxoma cardiac tumors. Methods: Between July 2000 and February 2017, 21 patients with primary cardiac tumor were surgically treated in our institution. The tumors were categorized as benign non-myxomas and malignants. Data including the demographic characteristics, details of the tumor histology and grading, cardiac medical and surgical history, surgical procedure of the patients were obtained from the hospital database. Results: Eleven patients were diagnosed with benign non-myxoma tumor (male/female:7/4), ranging in age from 10 days to 74 years (mean age 30.9±26.5 years). Papillary fibroelastoma was the most frequent type (63.6%). There were two early deaths in benign group (all were rhabdomyoma), and mortality rate was 18%. The mean follow-up period was 69.3±58.7 months (range, 3 to 178 months). All survivals in benign group were free of tumor-related symptoms and tumor relapses. Ten patients were diagnosed with malignant tumor (sarcoma/lymphoma:8/2, male/female:3/7), ranging in age from 14 years to 73 years (mean age 44.7±18.9 years). Total resection could be done in only three (30%) patients. The mean follow-up period was 18.7±24.8 months (range, 0-78 months). Six patients died in the first 10 months. Conclusion: Complete resection of the cardiac tumors, whenever possible, is the main goal of surgery. Surgical resection of benign cardiac tumors is safe, usually curative and provides excellent long-term prognosis. On the contrary, malignant cardiac tumors still remain highly lethal.
Descritores: Neoplasias Cardíacas/cirurgia
Neoplasias Cardíacas/patologia
-Rabdomioma/cirurgia
Rabdomioma/mortalidade
Rabdomioma/patologia
Sarcoma/cirurgia
Sarcoma/mortalidade
Sarcoma/patologia
Fatores de Tempo
Estudos Retrospectivos
Resultado do Tratamento
Carga Tumoral
Estimativa de Kaplan-Meier
Fibroma/cirurgia
Fibroma/mortalidade
Fibroma/patologia
Neoplasias Cardíacas/mortalidade
Angiomatose/cirurgia
Angiomatose/mortalidade
Angiomatose/patologia
Linfoma/cirurgia
Linfoma/mortalidade
Linfoma/patologia
Limites: Humanos
Masculino
Feminino
Recém-Nascido
Pré-Escolar
Criança
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME



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