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Id: biblio-1054851
Autor: Rocha, Aroni; Almeida Jr, Hiram Larangeira de; Zerwes, Gustavo; Oliveira Filho, Umberto Lopes de.
Título: Capecitabine-induced Subacute Cutaneous Lupus Erythematosus
Fonte: An. bras. dermatol;94(5):618-619, Sept.-Oct. 2019. graf.
Idioma: en.
Descritores: Lúpus Eritematoso Cutâneo/induzido quimicamente
Lúpus Eritematoso Cutâneo/patologia
Capecitabina/efeitos adversos
Antimetabólitos Antineoplásicos/efeitos adversos
-Neoplasias da Mama/tratamento farmacológico
Imuno-Histoquímica
Carcinoma Ductal de Mama/tratamento farmacológico
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: lil-547665
Autor: Mundim, Fiorita G. l; Logullo, Angela F.
Título: Role of the expression of the tyrosine kinase receptor kit in invasive ductal carcinomas of the breast: a review
Fonte: Appl. cancer res;29(2):50-57, Apr.-June 2009. ilus, tab.
Idioma: en.
Resumo: Given the necessity to research new variables that identify greater disease-free survival, through appropriate therapeutic intervention among patients of the same treatment subgroup, it is necessary to find promising candidates for prognostic factors in breast cancer. Among the tyrosine kinase receptors, we can mention the membrane receptor termed c-KIT, overexpressed in gastrointestinal stromal tumors. Normal ductal breast cells and benign breast tissue highly express the c-KIT protein, while an accentuated reduction of same was observed in samples of breast cancer, varying from non-metastatic primary carcinomas to carcinomas with distant metastasis. The study analyses the literature specific to c-KIT protein expression in breast tumors, indicating that the immunohistochemical expression of c-KIT is mainly negative in stroma of primary breast neoplasms or not specifically cited, and with controversial results regarding the epithelial component. Subsequent studies of mutations of the proto-oncogene c-KIT and correlation with other prognostic factors and survival are necessary to reveal the exact action mechanism of this molecule in breast cancer.
Descritores: Neoplasias da Mama
Carcinoma Ductal de Mama
-Carcinoma Ductal de Mama/diagnóstico
Limites: Adulto
Responsável: BR30.1 - Biblioteca


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Texto completo SciELO Costa Rica
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Id: biblio-1002552
Autor: González Ramírez, Daniel; Madriz de Haan, Pedro; Viloria González, Tibisay.
Título: Carcinoma ductal in situ de la mama con características apocrinas: reporte de un caso / Ductal carcinoma in situ of the breast with apocrine characteristics: case report
Fonte: Med. leg. Costa Rica;36(1):6-13, ene.-mar. 2019.
Idioma: es.
Resumo: Resumen Se presenta el caso de una femenina de 69 años con un carcinoma ductal in situ de la mama, el cual presentaba diferenciación apocrina y alto grado nuclear. La forma de presentación clínica se hizo patente en forma de microcalcificaciones detectadas en la mamografía, y corroboradas histológicamente como comedonecrosis. La diferenciación apocrina se comprobó por medio de tinciones de inmunohistoquímica. El diagnóstico se realizó en una biopsia excisional, pero dado a que uno de los márgenes se encontraba comprometido, la paciente se sometió posteriormente a una mastectomía.

Abstract We present the case of a 69 year old female diagnosed with a ductal in situ carcinoma of the breast. The tumor had apocrine differentiation and a high nuclear grade. The clinical presentation corresponded to microcalcifications detected on mammography, which were histologically patent in the form of comedo type necrosis. The aforementioned apocrine differentiation was reassured using the aid of immunohistochemistry. The biopsy was an excisional biopsy, but due to positive quirurgical margins, the patient was later reintervened for total mastectomy.
Descritores: Neoplasias da Mama
Receptores Androgênicos
Receptores de Progesterona
Receptores Estrogênicos
Carcinoma Ductal de Mama
Costa Rica
Limites: Humanos
Feminino
Idoso
Tipo de Publ: Relatos de Casos
Responsável: CR1.1 - BINASSS - Biblioteca Nacional de Salud y Seguridad Social


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Texto completo SciELO Chile
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Id: biblio-899924
Autor: Uribe O, Alonso; Berrios L, Carla; Li Z, Yang Yi.
Título: Cáncer en mama axilar: revisión de la literatura a propósito de un caso / Axillary breast cancer: clinical case and literature review
Fonte: Rev. chil. obstet. ginecol. (En línea);82(4):416-423, oct. 2017. graf.
Idioma: es.
Resumo: El tejido mamario ectópico se desarrolla debido a la involución incompleta de la cresta mamaria, de localización más frecuente en la axila y más común en mujeres. Este tejido sufre cambios fisiopatológicos similares a los de la mama normal, entre los cuales se encuentra la malignización. El carcinoma primario de este tejido es infrecuente, y su manifestación más común es la masa palpable. Al igual que en la mama normal, la histología más frecuente del cáncer de mama ectópica es el Carcinoma Ductal Infiltrante y, por su localización atípica, suele diagnosticarse tardíamente, y tendría un curso más agresivo y de peor pronóstico, dado por la mayor cercanía a ganglios, piel y pared torácica. Debido a los pocos datos publicados, el diagnóstico y tratamiento no están bien establecidos, pero los esquemas disponibles son similares a los utilizados en el cáncer de mama normal. Se presenta el caso de una paciente de 41 años, con diagnóstico de cáncer de mama ectópica en la región axilar derecha, sin invasión a distancia, tratada con cirugía, quimioterapia y radioterapia, que evoluciona favorablemente, sin metástasis ni recidivas durante seguimiento.

Ectopic mammary tissue develops due to the incomplete involution of the mammary crest, which is more frequently located in the axilla and more common in women. This tissue undergoes pathophysiological changes similar to those of the normal breast, among which malignancy is found. The primary carcinoma of this tissue is infrequent and its most common manifestation is the palpable mass. As in the normal breast, the most frequent histology of ectopic breast cancer is the Infiltrating Ductal Carcinoma and, because of its atypical location, it is usually diagnosed late and it would have a more aggressive course and a worse prognosis, due to the greater proximity to lymph nodes, skin and chest wall. Because of the few published data, the diagnosis and treatment are not well established, but the available schemes are similar to those used in normal breast cancer. We present the case of a 41yearsold female patient with a diagnosis of ectopic breast cancer in the right axillary region, without distant invasion, treated with surgery, chemotherapy and radiotherapy, whoevolves favorably, without metastasis or relapses during follow-up.
Descritores: Axila/anormalidades
Neoplasias da Mama/diagnóstico
Neoplasias da Mama/patologia
Carcinoma Ductal de Mama/patologia
-Neoplasias da Mama/terapia
Carcinoma Ductal de Mama/diagnóstico
Carcinoma Ductal de Mama/terapia
Limites: Humanos
Feminino
Adulto
Tipo de Publ: Relatos de Casos
Revisão
Responsável: CL126.2 - Biblioteca Médica Dr. Profesor Hernán Alessandri R.


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Texto completo SciELO Cuba
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Id: lil-547058
Autor: Luna Goza, Magaly Marion; Serrano Pérez, Ana Teresa; Hechevarría Dupuy, Rafael; Lorenzo Cossio, Fidel; Armenteros Herrera, Onelio.
Título: Pesquizaje de cáncer de mama: presentación de un caso / Screening of breast cancer: a case presentation
Fonte: Rev. cuba. cir;48(4), sept.-dic. 2009.
Idioma: es.
Resumo: El pesquizaje del cáncer de mama basado en el estudio mamográfico de las mujeres entre 50 y 65 años de edad constituye el mejor medio para realizar el diagnóstico precoz de la enfermedad. A menos de un mes de reiniciado este proceso en el Policlínico Cerro, se le diagnosticó a una paciente asintomática, de 59 años de edad, un tumor en línea media de los cuadrantes superiores de la mama izquierda. Se le realizó una cirugía conservadora, y se resecó un tumor de 0,7 cm de diámetro, que resultó ser un carcinoma ductal infiltrante en estadio precoz. La paciente fue clasificada de bajo riesgo, actualmente recibe tratamiento adyuvante con poliquimioterapia y su evolución es satisfactoria. Una vez más queda demostrada la importancia del pesquizaje como alternativa para lograr el tratamiento curativo del cáncer de mama, que hoy constituye la primera causa de muerte por cáncer no sólo en la mujer cubana(AU)

Screening of breast cancer based on mammography study of women aged between 50 and 65 is the better tool to perform the early diagnosis of this disease. At less than a month of onset of this process in Cerro polyclinic, a asymptomatic patient aged 59 was diagnosed with a tumor in middle line of high of the left breast quadrants. She underwent a conservative surgery and a ductal carcinoma of 0,7 cm was resected in early stage. Patient was classified as of low risk, nowadays she receives adjuvant treatment with polychemotherapy and its course is satisfactory. Again it was demonstrated the significance of screening as a alternative to achieve the curative treatment of breast cancer, which now is the first cause of death by cancer not only in Cuban woman(AU)
Descritores: Neoplasias da Mama/diagnóstico por imagem
Carcinoma Ductal de Mama/cirurgia
-Mamografia/métodos
Quimioterapia Adjuvante/efeitos adversos
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-887092
Autor: Torraca, Pedro de Freitas Silva; Castro, Bruna Corrêa de; Hans Filho, Günter; Lima, Alexandre Moretti de.
Título: Cutaneous metastases in a patient with no previous diagnosis of cancer: diagnostic challenge
Fonte: An. bras. dermatol;92(5,supl.1):47-49, 2017. graf.
Idioma: en.
Resumo: Abstract: On rare occasions, skin lesions are the first local of metastatic manifestation of internal malignancies. In case of no previous diagnosis of these tumors, the approach of suspicious skin lesions becomes a challenge, especially in differentiating cutaneous metastases and adnexal primary neoplasms. Currently, besides epidemiologic, dermoscopic and histopathologic aspects, the evaluation also integrates immunohistochemical exams and cell markers such as p40 and p63, highly specific for skin metastases. This article describes the case of cutaneous metastases as the sole obvious sign of breast cancer in a previously asymptomatic woman. The diagnosis was made by the finding of neoplastic cells in the dermis and immunohistochemistry compatible with ductal carcinoma.
Descritores: Neoplasias Cutâneas/secundário
Neoplasias da Mama/patologia
Carcinoma Ductal de Mama/secundário
-Pele/patologia
Imuno-Histoquímica
Neoplasias de Anexos e de Apêndices Cutâneos/patologia
Diagnóstico Diferencial
Limites: Humanos
Feminino
Idoso de 80 Anos ou mais
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-887189
Autor: Vallone, María Gabriela; González, Virginia Mariana; Casas, José Gabriel; Larralde, Margarita.
Título: Dermoscopy of inflammatory breast cancer
Fonte: An. bras. dermatol;93(2):289-290, Mar.-Apr. 2018. graf.
Idioma: en.
Resumo: Abstract: Inflammatory breast cancer is an aggressive and infiltrative malignancy that is often misdiagnosed as an infection because of its symptoms and signs of inflammation, delaying proper diagnosis and treatment. We report a case of inflammatory breast cancer showing correlation between dermoscopic and histopathological diagnoses. We highlight the utility of dermoscopy for skin biopsy site selection.
Descritores: Pele/patologia
Carcinoma Ductal de Mama/patologia
Dermoscopia/métodos
Neoplasias Inflamatórias Mamárias/patologia
-Biópsia
Carcinoma Ductal de Mama/diagnóstico
Neoplasias Inflamatórias Mamárias/diagnóstico
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: lil-787299
Autor: Esposito, Ana Cláudia Cavalcante; Munhoz, Tânia; Ocanha, Juliana Polizel; Miot, Hélio Amante.
Título: Syndrome in question
Fonte: An. bras. dermatol;91(3):387-389tab, graf.
Idioma: en.
Resumo: Abstract: Dermatomyositis is a rare inflammatory disease, autoimmune, with proximal myopathy associated with characteristic dermatological manifestations. In adults, 20-50% of the cases are paraneoplastic manifestation, being mandatory the workup for malignancy Herein we report a case of a woman with classic dermatological presentation of dermatomyositis and newly diagnosed breast cancer. In general, the clinical presentation of paraneoplastic dermatomyositis is more exuberant and manifestations may precede, concur or succeed the diagnosis of neoplasia. The prognosis of cases associated with breast cancer is worse than the idiopathic form. Treatment is based mainly on the resolution of the underlying disease, beyond immunosuppressants.
Descritores: Síndromes Paraneoplásicas/diagnóstico
Neoplasias da Mama/diagnóstico
Carcinoma Ductal de Mama/diagnóstico
Dermatomiosite/diagnóstico
-Neoplasias da Mama/complicações
Carcinoma Ductal de Mama/complicações
Creatina Quinase/sangue
Eritema/diagnóstico
Exantema/diagnóstico
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-838066
Autor: Brito, Maria Helena Toda Sanches de; Dionísio, Cecília Silva Nunes de Moura; Ferreira, Joana Cintia Monteiro; Rosa, Maria Joaninha Madalena de Palma Mendonça da Costa; Cunha, Fernando Petrucci Bernardo e; Garcia, Maria Manuela Antunes Pecegueiro da Silva.
Título: Ductal eccrine carcinoma of the axilla: a diagnostic pitfall
Fonte: An. bras. dermatol;92(2):239-242, Mar.-Apr. 2017. tab, graf.
Idioma: en.
Resumo: Abstract: Ductal eccrine carcinoma (DEC) is a rare sweat gland carcinoma with ductular differentiation. Clinically, it is characterized by a slowly growing, hardened plaque or nodule predominantly located on the head and neck. Histologically, DEC shares similar features to invasive breast carcinoma, thus causing great diagnostic challenges. We report a 69-year-old woman who presented with a hardened plaque on the axilla. A skin biopsy was performed and metastatic invasive breast carcinoma could not be ruled out. Complete excision and further workup were subsequently conducted, leading to the diagnosis of estrogen receptor positive DEC with associated axillary lymph node metastases. The patient received adjuvant radiotherapy to the left axilla and was started on oral letrozole. She is disease-free 14 months after initial diagnosis.
Descritores: Neoplasias das Glândulas Sudoríparas/patologia
Carcinoma de Apêndice Cutâneo/patologia
Carcinoma Ductal de Mama/patologia
-Axila
Neoplasias das Glândulas Sudoríparas/diagnóstico
Neoplasias das Glândulas Sudoríparas/terapia
Carcinoma de Apêndice Cutâneo/diagnóstico
Carcinoma de Apêndice Cutâneo/terapia
Carcinoma Ductal de Mama/diagnóstico
Diagnóstico Diferencial
Linfonodos/patologia
Metástase Linfática
Limites: Humanos
Feminino
Idoso
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Cuba
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Id: lil-774459
Autor: Arias Beatón, Ernesto; Arias Beatón, Martha Beatriz; Tellería León, Yoryana Elena; Causa Torres, Yosvanis.
Título: Cáncer de mama en una paciente de 21 años / Breast cancer in a 21 years patient
Fonte: Medisan;20(1), ene.-ene. 2016.
Idioma: es.
Resumo: Se presenta el caso clínico de una paciente de 21 años de edad, quien acudió a la consulta de Oncología del Hospital Gubernamental de Mbabane en Suazilandia por presentar un nódulo en la mama derecha con manifestaciones de dolor intenso desde hacía 1 mes. Fue remitida a la consulta de Cirugía donde le realizaron una biopsia con aguja gruesa, cuyo resultado indicó la presencia de un carcinoma ductal invasivo, clasificado en estadio IIIB al realizar los exámenes complementarios necesarios. La paciente fue trasladada a Sudáfrica para recibir quimioterapia neoadyuvante, con la cual obtuvo mejoría evolutiva clínica y humoral, evidenciada por la reducción del tumor y las cifras del marcador tumoral CA 15-3.

The case report of a 21 years patient who went to the Oncology service in the Government Hospital of Mbabane in Suaziland is presented. She had a nodule in her right breast with manifestations of acute pain for a month. She was referred to the Surgery service where she underwent a core-needle biopsy whose result indicated the presence of a ductal invasive carcinoma, classified in IIIB stage when carrying out the necessary complementary tests. The patient was transferred to South Africa to receive neoadyuvant chemotherapy, with which clinical and humoral response was obtained which was evidenced by tumor reduction and the values of the tumoral marker CA 15-3.
Descritores: Neoplasias da Mama
Quimioterapia Adjuvante
Carcinoma Ductal de Mama/tratamento farmacológico
-Biomarcadores Tumorais
Responsável: CU418.1 - Centro Provincial de Información de Ciencias Médicas de Santiago de Cuba



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