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Id: biblio-1093419
Autor: Heredia Ruiz, Danay; Herrera Martínez, Manuela; Fernández Caraballo, Douglas; López Ocampo, Lázara Gladys; Gómez Monteagudo, María Bárbara; González Rodríguez, Emilio Francisco.
Título: Sistema antioxidante enzimático en mujeres con diagnóstico de Atipias celulares y Neoplasia Intraepitelial Cervical grado I / Enzymatic antioxidant system in women diagnosed with cell atypia and grade I cervical intraepithelial neoplasia
Fonte: Rev. cuba. invest. bioméd;38(4):e249, oct.-dic. 2019. tab, graf.
Idioma: es.
Resumo: Introducción: El virus de papiloma humano per se no es capaz de desarrollar todas las transformaciones neoplásicas en el cérvix uterino, de manera que factores de riesgo como los genéticos, ambientales, estilo de vida sexual y el desbalance oxidativo podrían contribuir a la enfermedad. Objetivo: Determinar el comportamiento del sistema enzimático antioxidante en mujeres con atipia de células escamosas de significado indeterminado y neoplasia intraepitelial cervical grado I. Métodos: Se conformaron tres grupos de estudio: el primero incluyó 30 mujeres con diagnóstico de atipias, el segundo se constituyó con 40 mujeres con neoplasia intraepitelial grado I y el tercero consistió en 30 mujeres con citología negativa tomadas como control, provenientes de la consulta de Patología de Cuello del Agustín Gómez Lubián de Santa Clara. Mediante métodos espectrofotométricos se determinaron los niveles de actividad enzimática superóxido dismutasa y catalasa así, como las concentraciones de glutatión reducido. Las comparaciones se realizaron con el programa SPSS, versión 18. Resultados: En el grupo de atipias aunque los tres parámetros tuvieron una tendencia a la disminución no hubo diferencias significativas con respecto al control. Mientras que el grupo de neoplasia grado I evidenció disminución significativa de los tres indicadores estudiados al ser comparados con el grupo control. Conclusiones: Se constató afectación del sistema antioxidante enzimático en el grupo de neoplasia grado I, lo cual podría considerarse un cofactor importante en la progresión de las lesiones en el cérvix uterino(AU)

Introduction: Human papillomavirus per se can not carry out all the neoplastic transformations occurring in the uterine cervix. Genetic and environmental risk factors as well as sexual behavior and oxidative imbalance may also play a role. Objective: Determine the behavior of the enzymatic antioxidant system in women with squamous cell atypia of indeterminate significance and grade I cervical intraepithelial neoplasia. Methods: Three study groups were formed. The first group included 30 women diagnosed with atypia, the second group was made up of 40 women with grade I intraepithelial neoplasia, and the third or control group consisted of 30 women with negative cytology from Agustín Gómez Lubián Cervical Pathology service in Santa Clara. Spectrophotometric methods were used to determine the levels of superoxide dismutase and catalase enzymatic activity, as well as the concentrations of reduced glutathione. Comparisons were made with the SPSS software, version 18. Results: In the atypia group the three parameters showed a decreasing tendency, but differences with respect to the control group were not significant. In the grade I neoplasia group, however, a significant reduction was found of the three study indicators when compared with the control group. Conclusions: Damage to the enzymatic antioxidant system was observed in the grade I neoplasia group. This could be considered to be an important cofactor in the progress of uterine cervix lesions(AU)
Descritores: Papiloma
Carcinoma in Situ/prevenção & controle
Colo do Útero
Neoplasia Intraepitelial Cervical/diagnóstico
Biologia Celular
Estilo de Vida
Antioxidantes/análise
-Comportamento Sexual
Estudos de Casos e Controles
Indicadores e Reagentes
Limites: Feminino
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-1153171
Autor: Chowdhury, Zachariah; Nongrum, Benjamin; Rajbongshi, Chandana.
Título: Synchronous eyelid oncocytoma and conjunctival intraepithelial neoplasia
Fonte: Autops. Case Rep;11:e2020235, 2021. graf.
Idioma: en.
Resumo: Oncocytoma of the eyelid is a rare neoplasm. Oncocytoma associated with an ocular surface squamous neoplasm, namely conjunctival intraepithelial neoplasia, is very hard to find in the literature. Herein we report a case of a 53-year-old male who presented with a swelling in the right lower lid over the last 6 years, along with a growth in the conjunctiva of the same eye for the last 2 years and encroaching upon the cornea for the last 4 months. Excision biopsy of the lower lid mass showed histopathological features consistent with oncocytoma. The conjunctival tissue revealed conjunctival intraepithelial neoplasia 3 (severe dysplasia). This case documents a rare synchronous dual ocular neoplasia, a very unlikely coexistence of oncocytoma with conjunctival intraepithelial neoplasia.
Descritores: Papiloma/patologia
Pterígio
Carcinoma in Situ
Adenoma Oxífilo/complicações
Neoplasias Palpebrais/complicações
Limites: Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR26.7 - Serviço de Biblioteca e Documentação Científica


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Id: biblio-1249012
Autor: Sekar, Aravind; Rana, Surinder Singh; Bardia, Anand.
Título: SMILE-like lesion in the anal canal
Fonte: Autops. Case Rep;11:e2021289, 2021. graf.
Idioma: en.
Resumo: Stratified mucin-producing intraepithelial lesion (SMILE) is an intraepithelial lesion with overlapping features of the high-grade squamous intraepithelial lesion (HSIL) and adenocarcinoma in situ (AIS). Currently, it is well described in the cervix. We present a case showing similar SMILE-like lesions in the polypectomy specimen from the anal canal along with invasive adenocarcinoma components. This lesion showed an immuno-profile characteristic of a SMILE lesion described in the cervix, such as p63 negativity, high ki67 index, and nuclear positivity for p16. It might be arising from the Human papillomavirus prone transitional region of the anal canal as described in the cervix. However, we could not assure this association and etiological link due to insufficient material in the formalin-fixed paraffin-embedded block. Notwithstanding, we strongly suggest that the HPV is the main driver for this SMILE-like lesion similar to what is described in the cervix. To our knowledge, this is the first case report of a SMILE lesion in the anal canal. Further studies will be required to elucidate the underlying pathogenetic mechanism of SMILE-like lesions described in the anal canal.
Descritores: Canal Anal/patologia
Carcinoma in Situ
Adenocarcinoma
-Pólipos
Limites: Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: BR26.7 - Serviço de Biblioteca e Documentação Científica


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Id: biblio-1134999
Autor: Aguiar, Carmen; García, Laura; Boccardo, María Belén; Vassel, Macarena; Arriola, Alejandra; Jaumandreu, Sylvia; Rodríguez, María Carmen; Alvarez, Carmen; Heard, Isabelle.
Título: Anal PAP, HPV tests and magnifying chromoendoscopy with biopsies in the diagnosis of anal intraephitelial neoplasia / Papanicolau anal, testes de HPV e cromoendoscopia de ampliação com biópsias no diagnóstico de neoplasia intraepitelial anal
Fonte: J. coloproctol. (Rio J., Impr.);40(3):220-226, July-Sept. 2020. tab, ilus.
Idioma: en.
Resumo: Abstract Introduction: Anal intraepithelial neoplasia (AIN) is the most likely precursor of squamous cells cancer which represents 90% of anal cancers. The use of biomolecular tests as a screening method has been extended by gynecology. Given the similarities that exist between the HPV disease in the lower genital tract and anorectal sectors, it is expected that HPV tests can provide information for the diagnosis, treatment and follow-up for AIN-affected patients. Objectives: Comparing the performance of anal cytology, PAP and HPV tests (Hybrid Capture and Papillocheck) against the histology of the diagnosis of low- and high-grade AIN in risk groups. Material and methods: A cross-sectional study was carried out to evaluate diagnostic methods for low- and high-grade AIN in 73 patients. Samples for anal PAP, Papillocheck and Hybrid Capture were taken from all patients who then, regardless of the results, underwent magnifying chromoendoscopy (MCE) along with biopsy. Diagnostic test performances and their 95% confidence intervals (CI: 95%) were calculated as well as the likelihood ratio for each test. Results: Of the 73 patients, 49 (67%) were women. The average age of the patients was 38 years. In 38 patients (52%), the histology was positive with 10 (14%) grade II AIN or higher. There were no statistically significant differences in sensitivity nor in specificity for low- and high-grade AINs between any of the tests. Conclusion: Anal PAP, the Hybrid Capture test (HC2, Qiagen) and PapilloCheck (Greiner Bio One) were highly sensitive but not specific for low- and high-grade AINs. Therefore, a biopsy should be conducted against a positive result of any of the tests to confirm AIN and the degree of dysplasia. The screening method selection depend on the availability but also costs of the test should be considered, since all the diagnostic tests have similar performance.

Resumo Introdução: A neoplasia intraepitelial anal é o precursor mais provável do câncer de células escamosas, que representa 90% dos tumores anais. O uso de exames biomoleculares como método de triagem foi ampliado pela ginecologia. Considerando-se as semelhanças entre as apresentações de HPV no trato genital inferior e anorretal, espera-se que os exames de HPV possam fornecer informações para o diagnóstico, tratamento e acompanhamento dos pacientes com neoplasia intraepitelial anal. Objetivo: Comparar o desempenho da citologia anal, Papanicolau, exames para HPV (teste de captura híbrida e Papillocheck) e histologia no diagnóstico de neoplasia intraepitelial anal de baixo e alto grau em grupos de risco. Material e métodos: Foi realizado um estudo transversal para avaliar métodos de diagnóstico de neoplasia intraepitelial anal de baixo e alto grau em 73 pacientes. Amostras para Papanicolau anal, Papillocheck e captura híbrida foram coletadas de todos os pacientes; independentemente dos resultados desses exames, todos foram submetidos a cromoendoscopia de ampliação (CEA) e biópsia. O desempenho dos exames e seus intervalos de confiança de 95% (95% CI) foram calculados, bem como a razão de verossimilhança para cada teste. Resultados: Dos 73 pacientes, 49 (67%) eram mulheres. A idade média dos pacientes foi de 38 anos. A histologia foi positiva em 38 pacientes (52%), dos quais dez (14%) apresentaram neoplasia intraepitelial anal grau II ou superior. Não foram observadas diferenças estatisticamente significativas na sensibilidade ou especificidade para as neoplasias intraepiteliais anal de baixo e alto grau entre qualquer um dos exames. Conclusão: O Papanicolau anal, o teste de captura híbrida (HC2, Qiagen) e o Papillocheck (Greiner Bio One) foram altamente sensíveis, mas não específicos para neoplasia intraepitelial anal de baixo e alto grau. Portanto, uma biópsia deve ser realizada após um resultado positivo em qualquer um dos testes para confirmar o diagnóstico de neoplasia intraepitelial anal e seu grau. A seleção do método de triagem depende da disponibilidade, mas os custos devem ser considerados, uma vez que todos os testes apresentam desempenho semelhante.
Descritores: Carcinoma in Situ/diagnóstico
Alphapapillomavirus
Teste de Papanicolaou
-Neoplasias do Ânus
Biópsia
Carcinoma in Situ/diagnóstico por imagem
Limites: Humanos
Masculino
Feminino
Responsável: BR545.3 - Biblioteca ICBS


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Id: biblio-1019886
Autor: Ha, Yun-Sok; Kim, Sang Won; Kwon, Tae Gyun; Chung, Sung Kwang; Yoo, Eun Sang.
Título: Decrease in skeletal muscle index one year after radical cystectomy as a prognostic indicator in patients with urothelial bladder cancer
Fonte: Int. braz. j. urol;45(4):686-694, July-Aug. 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT Purpose The present study aimed to determine whether sarcopenia after radical cystectomy (RC) could predict overall survival (OS) in patients with urothelial bladder cancer (UBC). Materials and Methods The lumbar skeletal muscle index (SMI) of 80 patients was measured before and 1 year after RC. The prognostic significance of sarcopenia and SMI decrease after RC were evaluated using Kaplan-Meier analysis and a multivariable Cox regression model. Results Of 80 patients, 26 (32.5%) experienced sarcopenia before RC, whereas 40 (50.0%) experienced sarcopenia after RC. The median SMI change was -2.2 cm2/m2. Patients with sarcopenia after RC had a higher pathological T stage and tumor grade than patients without sarcopenia. Furthermore, the overall mortality rate was significantly higher in patients with sarcopenia than in those without sarcopenia 1 year after RC. The median follow-up time was 46.2 months, during which 22 patients died. Kaplan-Meier estimates showed a significant difference in OS rates based on sarcopenia (P=0.012) and SMI decrease (P=0.025). Multivariable Cox regression analysis showed that SMI decrease (≥2.2 cm2/m2) was an independent predictor of OS (hazard ratio: 2.68, confidence interval: 1.007-7.719, P = 0.048). Conclusions The decrease in SMI after surgery might be a negative prognostic factor for OS in patients who underwent RC to treat UBC.
Descritores: Neoplasias da Bexiga Urinária/cirurgia
Carcinoma in Situ/cirurgia
Cistectomia/efeitos adversos
Sarcopenia/etiologia
-Fatores de Tempo
Neoplasias da Bexiga Urinária/complicações
Neoplasias da Bexiga Urinária/fisiopatologia
Neoplasias da Bexiga Urinária/mortalidade
Carcinoma in Situ/complicações
Carcinoma in Situ/mortalidade
Índice de Massa Corporal
Cistectomia/métodos
Cistectomia/mortalidade
Modelos de Riscos Proporcionais
Análise Multivariada
Estudos Retrospectivos
Músculo Esquelético/fisiopatologia
Estimativa de Kaplan-Meier
Sarcopenia/fisiopatologia
Limites: Humanos
Masculino
Feminino
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-1248211
Autor: Andrade, Nara Pacheco Pereira.
Título: O estudo da ressonância magnética com difusão na avaliação da resposta à quimioterapia neoadjuvante para pacientes com câncer de mama / Early prediction of pathological response using MR diffusion weighted imaging in patients with breast cancer submitted to neoadjuvant chemotherapy.
Fonte: São Paulo; s.n; 2018. 88 p. ilust, tabelas.
Idioma: pt.
Tese: Apresentada a Fundação Antônio Prudente para obtenção do grau de Doutor.
Resumo: Introdução: A Ressonância Magnética (RM) tem se mostrado eficaz na avaliação de resposta à quimioterapia neoadjuvante (QTN) para câncer de mama. A avaliação através do realce dinâmico do contraste (DCE) é a ferramenta mais utilizada na RM para este propósito, porém a aplicação das imagens ponderadas em difusão (DWI) tem recebido especial interesse na atualidade. As sequências em difusão avaliam a mobilidade de moléculas de água no tecido, através do valor do coeficiente aparente de difusão (ADC). Desta forma, após o início de um tratamento quimioterápico, a redução do número de células no leito tumoral é estimada através do aumento do ADC nos exames de RM subsequentes, auxiliando na avaliação de resposta. Objetivo: avaliar o uso da RM-DWI na predição precoce de resposta patológica em pacientes com tumores de mama submetidos ao tratamento com quimioterapia neoadjuvante. Pacientes e métodos: Estudo prospectivo e unicêntrico, em que foram incluídas 62 pacientes com diagnóstico de. câncer de mama, elegíveis para quimioterapia neoadjuvante, admitidas no departamento de Mastologia do A.C.Camargo Cancer Center, no período de janeiro de 2015 a julho de 2016, após aprovação do projeto no comitê de ética em pesquisa e consentimento informado e esclarecido assinado pelas pacientes incluídas no projeto. As pacientes incluídas neste estudo realizaram três exames de RM: um antes (RM1), um após o primeiro ciclo (RM2) e outro após o último ciclo (RM3) de quimioterapia. As taxas de. resposta obtidas pela RM foram avaliadas, considerando a resposta patológica como padrão-ouro. Resultados: A idade das 62 pacientes variou de 27 a 65 anos, com mediana de 45,5 anos. O tamanho tumoral variou de 15 mm a 92 mm, com mediana de 40 mm. Houve predomínio do carcinoma invasivo do tipo não especial (85,5%). Vinte e dois (35,5%) tumores eram triplo negativos, 10 (16,1%) eram superexpressores de HER-2 e 30 (48%). eram subtipo Luminal B. Vinte e quatro (38,7%) tumores apresentaram resposta patológica completa (pCR). A variação do ADC (ADC) entre RM1 e RM2 foi mais elevada para o grupo pCR, com a mediana do ADC de 49% para o grupo pCR e 13% para o grupo não-pCR. Utilizando um ponto de corte de 25% para variação mínima do valor do ADC entre RM1 e RM2, o método apresentou sensibilidade de 83%, especificidade de 84%, VPP de 77%, VPN de 89% e acurácia de 84%. Não houve variação significativa das maiores dimensões tumorais entre a RM1 e RM2. Conclusão: A variação do ADC após o primeiro ciclo de QTN em pacientes com câncer de mama localmente avançado correlacionou-se bem com a taxa de resposta patológica tumoral. Houve um significativo aumento do ADC precedendo a redução da dimensão tumoral. O método é capaz de discriminar com boa. acurácia, logo após o primeiro ciclo, respondedoras de não respondedoras ao tratamento, quando há uma variação mínima de 25% do seu valor

INTRODUCTION: Magnetic Resonance Imaging (MRI) has been shown to be effective in evaluating the response to neoadjuvant chemotherapy (NCT) for breast cancer. Dynamic contrast enhancement (DCE) evaluation is the most used tool in MRI for this purpose, but the application of diffusion weighted images (DWI) has received special interest in the present time. The diffusion sequences evaluate the mobility of water molecules in the tissue, through the value of the apparent diffusion coefficient (ADC). Thus, after the introduction of a chemotherapeutic treatment, the reduction of the number of cells in the tumor bed is estimated by increasing the ADC in the subsequent MR exams, aiding in the evaluation of response. PURPOSE: to evaluate the use of MR-DWI in the early prediction of pathological response in patients with breast tumors submitted to treatment with neoadjuvant chemotherapy. PATIENTS AND METHODS: A prospective and unicentric study was carried out in which 62 patients undergoing NCT admitted in the department of Mastology, were enrolled in the diagnosis of breast cancer, from January 2015 to July 2016. The patients included in this study performed three MR imagings: one before (MR1), one after the first cycle (MR2) and another after the last cycle (MR3) of chemotherapy. The response rates obtained by MR imaging were evaluated, considering the pathological response as gold standard. RESULTS: The 62 patients ranged from 27 to 65 years, with a median age of 45.5 years. The tumor size ranged from 15 to 92 mm, with a median of 40 mm. There was a predominance of invasive carcinoma of no special type (85.5%). Twenty-two (35.5%) tumors were triple negative, 10 (16.1%) were HER-2 overexpression and 30 (48%) were luminal B. Twenty-four (38.7%) tumors presented complete pathological response (pCR). The percent ADC value increase between MR1 and MR2 was higher for the pCR group, with the median ADC of 49% for the pCR group and 13% for the nonpCR group. Using a cut-off point of 25% for minimum increase of the ADC value between MR1 and MR2, the method had a sensitivity of 83%, specificity of 84%, VPP of 77%, NPV of 89% and accuracy of 84% in early prediction of responder to nonresponder to NQT. CONCLUSION: The ADC variation after the first cycle of NQT in patients with locally advanced breast cancer correlated well with the rate of tumor pathological response. There was a significant increase of the ADC value preceding the reduction of the tumor dimension measured with DCE MR images. DWI is able to discriminate with a good accuracy, shortly after the first cycle, non-responder from responders to treatment when there is a minimum variation of 25% of its value
Descritores: Biópsia por Agulha/métodos
Neoplasias da Mama/tratamento farmacológico
Imuno-Histoquímica
Carcinoma in Situ
Terapia Neoadjuvante
Imagem de Difusão por Ressonância Magnética/métodos
-Estudos Prospectivos
Limites: Humanos
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR30.1 - Biblioteca
BR30.1


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Id: lil-794905
Autor: Badan, Gustavo Machado; Roveda Júnior, Décio; Paito, Sebastião; Fleury, Eduardo de Faria Castro; Maragno, Bianca; Campos, Mario Sérgio Dantas do Amaral; Ferreira, Carlos Alberto Pecci; Ferreira, Felipe Augusto Trocoli.
Título: Ductal carcinoma in situ of the breast: Evaluation of main presentations on magnetic resonance imaging compared with findings on mammogram and histology / Carcinoma ductal in situ mamário: avaliação das principais apresentações à ressonância magnética em correlação com os achados da mamografia e histologia
Fonte: Rev. Assoc. Med. Bras. (1992);62(5):421-427, Sept.-Oct. 2016. tab, graf.
Idioma: en.
Resumo: SUMMARY Objective: The purpose of this study was to evaluate the various morphologies and kinetic characteristics of the ductal carcinoma in situ (DCIS) on breast magnetic resonance imaging (MRI) exam, to establish which are the most prevalent and to determine the effectiveness of the method in the detection of DCIS. Method: A prospective observational study, starting in May 2014. We evaluated 25 consecutive patients with suspicious or highly suspicious microcalcifications on mammography screening, BI-RADS categories 4 and 5, who underwent breast MRI and then surgery with proven diagnosis of pure DCIS. Surgery was considered the gold standard for correlation between histologic findings and radiological findings obtained on MRI. Results: The most frequent morphological characteristic of DCIS on MRI was non-mass-like enhancement (NMLE), p<0.001, observed in 22/25 (88%) patients (95CI 72.5-100). Of these, segmental distribution was the most prevalent, represented by 9/22 (40.91%) cases (95CI 17.4-64.4), p=0.306, and a clumped internal enhancement pattern was most commonly characterized in DCIS, observed in 13/22 (50.09%) cases. Conclusion: DCIS has a wide variety of imaging features on MRI and being able to recognize these lesions is crucial. Its most common morphological presentation is non-mass-like enhancement, while segmental distribution and a clumped internal enhancement pattern are the most common presentations. Faced with the combined analysis of these findings, percutaneous core needle biopsy (core biopsy) or vacuum-assisted biopsy (VAB) should be encouraged.

RESUMO Objetivo: avaliar as várias morfologias e características cinéticas do carcinoma ductal in situ (CDIS) ao exame de ressonância magnética (RM) de mama, estabelecer as mais prevalentes e determinar a eficácia do método na detecção do CDIS. Método: estudo prospectivo e observacional, com início em 2011 e duração de 24 meses. Foram avaliadas 25 pacientes consecutivas que apresentaram microcalcificações suspeitas ou altamente suspeitas ao exame mamográfico de rastreamento, categorias 4 e 5 de BI-RADS, que realizaram RM mamária e, posteriormente, foram submetidas à cirurgia com resultado comprovado de CDIS puro. A cirurgia foi considerada padrão-ouro para correlação entre os resultados histológicos e os achados radiológicos obtidos à RM. Resultados: a característica morfológica do CDIS mais frequente à RM foi o realce não nodular (p<0,001), observada em 22/25 (88%) casos (IC 95% 72,5-100). Dentre estes, a distribuição segmentar foi a mais prevalente, representada por 9/22 (40,91%) casos (IC 95% 17,4-64,4), p=0,306, e o realce interno tipo clumped foi o padrão mais frequentemente caracterizado no CDIS, observado em 13/22 (50,09%) casos. Conclusão: o CDIS tem uma grande variedade de características imaginológicas à RM e é fundamental reconhecê-las. A apresentação morfológica mais comum é o realce não nodular, sendo a distribuição segmentar e o padrão interno de realce tipo clumped as apresentações mais frequentes. Diante da análise combinada desses achados, a biópsia percutânea por agulha grossa (core biopsy) ou assistida a vácuo (mamotomia) deve ser encorajada.
Descritores: Neoplasias da Mama/patologia
Neoplasias da Mama/diagnóstico por imagem
Carcinoma in Situ/patologia
Carcinoma in Situ/diagnóstico por imagem
Carcinoma Ductal de Mama/patologia
Carcinoma Ductal de Mama/diagnóstico por imagem
-Neoplasias da Mama/cirurgia
Calcinose/patologia
Calcinose/diagnóstico por imagem
Imageamento por Ressonância Magnética/métodos
Mamografia/métodos
Carcinoma in Situ/cirurgia
Aumento da Imagem
Estudos Prospectivos
Reprodutibilidade dos Testes
Carcinoma Ductal de Mama/cirurgia
Gradação de Tumores
Biópsia com Agulha de Grande Calibre
Pessoa de Meia-Idade
Limites: Humanos
Feminino
Adulto
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Estudo Observacional
Responsável: BR1.1 - BIREME


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Id: lil-753581
Autor: Peñaloza-Ramírez, Arecio; Kuan-Casas, Hernando; Sánchez-Pignalosa, Carlos; Sabogal-Gómez, Carlos; Aponte-Ordóñez, Pedro.
Título: Curva de aprendizaje en disección endoscópica de la submucosa en un hospital universitario latinoamericano / Learning curve in the endoscopic submucosal dissection at a Latin American university hospital
Fonte: Rev. colomb. cir;30(2):99-105, abr.-jun. 2015. ilus, tab.
Idioma: es.
Resumo: Introduction: The endoscopic submucosal dissection (ESD) is a technique used in the treatment of early gastric cancer that was developed in Japan in the early 90's. When compared with mucosectomy it shows clear benefits, as lower local recurrence with the resection of lesions greater than 2 cm, yet with larger number of complications, especially bleeding and perforation. There is little experience with ESD in the West, because of the low incidence of early gastric cancer and the lack of screening programs; ESD reports are scarce in Colombia. Objective: To report the experience with the endoscopic dissection of the gastric submucosa in the period between March 2012 and January 2014 at Hospital de San José, Bogotá, Colombia. Methods: ESD was performed in eight patients (four men and four women) that fulfilled the Vienna criteria for this procedure. Results: Eight ESD were performed, three in the body and five in the antrum, with a mean size of 3.4 cm; complications included bleeding in one patient and perforation in one patient. En bloc resection was achieved in all eight cases with R0 (margins free of tumor) in seven patients. Conclusion: Gastric ESD is a complex technique and infrequent technique in our evironment. The procedure was performed in a safe manner with acceptable complication rates and achieving en bloc resection in all patients.

Introduction: The endoscopic submucosal dissection (ESD) is a technique used in the treatment of early gastric cancer that was developed in Japan in the early 90's. When compared with mucosectomy it shows clear benefits, as lower local recurrence with the resection of lesions greater than 2 cm, yet with larger number of complications, especially bleeding and perforation. There is little experience with ESD in the West, because of the low incidence of early gastric cancer and the lack of screening programs; ESD reports are scarce in Colombia. Objective: To report the experience with the endoscopic dissection of the gastric submucosa in the period between March 2012 and January 2014 at Hospital de San José, Bogotá, Colombia. Methods: ESD was performed in eight patients (four men and four women) that fulfilled the Vienna criteria for this procedure. Results: Eight ESD were performed, three in the body and five in the antrum, with a mean size of 3.4 cm; complications included bleeding in one patient and perforation in one patient. En bloc resection was achieved in all eight cases with R0 (margins free of tumor) in seven patients. Conclusion: Gastric ESD is a complex technique and infrequent technique in our evironment. The procedure was performed in a safe manner with acceptable complication rates and achieving en bloc resection in all patients.
Descritores: Neoplasias Gástricas
-Carcinoma in Situ
Endoscopia Gastrointestinal
Dissecação
Responsável: CO113


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Id: biblio-1151906
Autor: Martínez, Carolina; Olivares, Paulina; Martínez, Benjamín; Fernández, Alejandra.
Título: Characterization of patients with epithelial dysplasia and carcinoma in situ in the oral cavity, 2000 to 2014 / Caracterización de pacientes con displasia epitelial y carcinoma in situ en cavidad oral, entre 2000 y 2014
Fonte: J. oral res. (Impresa);9(2):111-115, abr. 30, 2020. tab.
Idioma: en.
Resumo: Objetive: To characterize patients diagnosed with oral epithelial dysplasia and carcinoma in situ, according to their severity, location, age, sex and smoking habits. Materials and Methods: A descriptive study, based on 126 histopathological reports of biopsies diagnosed with mild, moderate, severe epithelial dysplasia and carcinoma in situ, with information regarding anatomical location, age and gender of the patient, recorded in the biopsy reports of the histopathology services of the Faculty of Dentistry of Andrés Bello University and Major University, between the years 2000 and 2014. The dichotomous qualitative variables were described based on percentage and age using the Shapiro-Wilk test, presenting as average and standard deviation, in the STATA 12® program (StataCorpLP, Texas, USA). Result: A similar frequency was found for men and women diagnosed with OED, 53.17% and 46.83% respectively. A mild degree of OED was the most diagnosed in both sexes. The group most affected by OED was between 50 and 69 years old (57.94%) and the most frequent anatomic location was the lateral border of the tongue (34.13%). Conclusion: Most of the analyzed cases corresponded to mild degrees of dysplasia; however, it is important to always carry out a histopathological diagnosis of the lesion, patient follow-up and education regarding risk habits.

Objetivo: Caracterizar a pacientes con diagnóstico de displasia epitelial oral (DEO) y carcinoma in situ (CIS) según su severidad, localización, edad, género y hábito tabáquico. Materiales and Métodos: Se realizó un estudio descriptivo, en base a 126 informes histopatológicos de biopsias diagnosticadas con displasia epitelial leve, moderada, severa y carcinoma in situ, que contaban con información relativa a localización del diagnóstico, edad y género del paciente, registrados en los informes de biopsias de los servicios de histopatología de la Facultad de Odontología de la Universidad Andrés Bello y Universidad Mayor, entre los años 2000 y 2014. Las variables cualitativas dicotómicas se describieron en base a porcentaje y la edad mediante el test de Shapiro-Wilk, presentándose como media y desviación estándar, en el programa STATA 12 ® (StataCorpLP, Texas, USA). Resultados: Se encontró una frecuencia levemente aumentada de mujeres y hombres con diagnóstico de DEO, 67 (53,17%) y 59 (46,83%), respectivamente. El grado leve de DEO fue el más diagnosticado en ambos sexos. El grupo más afectado por DEO fue entre los 50 a 69 años (57,94%) y la localización anatómica más frecuente fue el borde lateral de la lengua (34,13%). Conclusión: La mayoría de los casos analizados correspondieron a grados leve de displasia; no obstante, es importante realizar siempre un diagnóstico histopatológico de la lesión, seguimiento al paciente y educación en cuanto a hábitos de riesgo.
Descritores: Lesões Pré-Cancerosas/patologia
Tabagismo
Neoplasias Bucais/patologia
-Carcinoma in Situ
Fumar
Epidemiologia Descritiva
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: CL30.1 - Biblioteca


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Id: biblio-1056650
Autor: Almeida, Gian Francisco; Heráclio, Sandra; Souza, Alex Sandro Rolland; Amorim, Melania M.
Título: Profile of women with anal neoplasia associated with cervical neoplasia receiving care at a tertiary healthcare facility in northeastern Brazil / Perfil de mulheres com neoplasia anal associada à neoplasia cervical atendidas em um serviço de saúde terciário do nordeste do Brasil
Fonte: J. coloproctol. (Rio J., Impr.);39(4):297-302, Oct.-Dec. 2019. tab.
Idioma: en.
Resumo: Abstract Objective: To describe the epidemiological, clinical and laboratory profiles of women with anal neoplasia associated with cervical neoplasia attending a tertiary healthcare facility in northeastern Brazil. Methods: This epidemiological, descriptive study was conducted using a database from a cross-sectional study carried out between December 2008 and January 2016. Women with a diagnosis of cervical neoplasia associated with anal neoplasia were included in the present study. Results: Of the women with cervical neoplasia, 14% were found to have an anal intraepithelial lesion or anal cancer. Median age was 33 years, 68% were non-white, and 70% were from urban regions, had little schooling and low income. Most reported having had anoreceptive (73%) and unprotected intercourse (84%). Regarding symptoms, 7% reported bleeding and 11% pruritus. Overall, 10% of the sample tested positive for the human immunodeficiency virus. Anal cytology was abnormal in 92%. High-resolution anoscopy was abnormal in all cases. Histopathology revealed three cases of invasive carcinoma and high-grade lesions in 32% of the cases. Conclusion: Women with a diagnosis of anal and cervical neoplasia are often young, non-white women, who initiated their sexual life at an early age, were exposed to unprotected anoreceptive intercourse, live in urban centers, have little schooling and a low-income level.

Resumo Objetivo: Descrever os perfis epidemiológico, clínico e laboratorial de mulheres com neoplasia anal associada à neoplasia cervical atendidas em uma unidade de saúde terciária no nordeste do Brasil. Métodos: Este estudo epidemiológico e descritivo usou um banco de dados de um estudo transversal realizado entre dezembro de 2008 e janeiro de 2016. Mulheres com diagnóstico de neoplasia cervical associada à neoplasia anal foram incluídas no presente estudo. Resultados: Das mulheres com neoplasia cervical, 14% apresentaram lesão intra-epitelial anal ou câncer anal. A mediana de idade foi de 33 anos; 68% das pacientes não eram brancas e 70% eram provenientes de regiões urbanas, com baixa escolaridade e baixa renda. A maioria relatou histórico de relações sexuais anoreceptivas (73%) e desprotegidas (84%). Quanto aos sintomas, 7% relataram sangramento e 11% prurido. No geral, 10% das pacientes apresentaram serologia positiva para o vírus da imunodeficiência humana. A citologia anal foi anormal em 92% da amostra. A anuscopia de alta resolução foi anormal em todos os casos. A histopatologia revelou três casos de carcinoma invasivo e lesões de alto grau em 32% dos casos. Conclusão: As mulheres com diagnóstico de neoplasia anal e cervical geralmente são jovens, não brancas, que iniciaram sua vida sexual em idade precoce, foram expostas a relações sexuais anoreceptivas desprotegidas, moram em centros urbanos e têm baixa escolaridade e baixo nível de renda.
Descritores: Neoplasias do Ânus/epidemiologia
Perfil de Saúde
Carcinoma in Situ/epidemiologia
Neoplasias do Colo do Útero/epidemiologia
-Neoplasias do Ânus/diagnóstico
Fatores Socioeconômicos
Brasil
Carcinoma in Situ/diagnóstico
Neoplasias do Colo do Útero/diagnóstico
Neoplasia Intraepitelial Cervical/diagnóstico
Neoplasia Intraepitelial Cervical/epidemiologia
Centros de Atenção Terciária
Limites: Humanos
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Adulto Jovem
Responsável: BR545.3 - Biblioteca ICBS



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