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Id: biblio-1090558
Autor: Rianto, Bambang Udji Djoko; Wibowo, Anton Sony; Herdini, Camelia.
Título: The Difference in Thyroid Stimulating Hormone Levels between Differentiated Carcinoma and Benign Enlargement
Fonte: Int. arch. otorhinolaryngol. (Impr.);24(1):73-79, Jan.-Mar. 2020. tab.
Idioma: en.
Resumo: Abstract Introduction Papillary and follicular thyroid carcinoma are common head and neck cancers. This cancer expresses a thyroid stimulating hormone (TSH) receptor that plays a role as a cancer stimulant substance. This hormone has a diagnostic value in the management of thyroid carcinoma. Objective The present study aimed to determine the difference in TSH levels between differentiated thyroid carcinoma and benign thyroid enlargement. Methods The present research design was a case-control study. The subjects were patients with thyroid enlargement who underwent thyroidectomies at the Dr. Sardjito General Hospital, Yogyakarta, Indonesia. Thyroid stimulating hormone levels were mea- sured before the thyroidectomies. The inclusion criteria for the case group were: 1) differentiated thyroid carcinoma, and 2) complete data; while the inclusion criteria for the control group were: 1) benign thyroid enlargement, and 2) complete data. The exclusion criteria for both groups were: 1) patients suffering from thyroid hormone disorders requiring therapy before thyroidectomy surgery, 2) patients receiving thyroid suppression therapy before the thyroidectomy was performed, and 3) patients suffering from severe chronic diseases such as renal insufficiency, and severe liver disease. Results There were 40 post-thyroidectomy case group patients and 40 post-thyroidect- omy control group patients. There were statistically significant differences in TSH levels between the groups with differentiated thyroid carcinoma and benign thyroid enlargement (p = 0.001; odds ratio [OR] = 8.42; 95% confidence interval [CI]: 3.19-36.50). Conclusion Based on these results, it can be concluded that there were significant differences in TSH levels between the groups with differentiated thyroid carcinoma and benign thyroid enlargement.
Descritores: Neoplasias da Glândula Tireoide/diagnóstico
Tireotropina/sangue
Adenocarcinoma Folicular/diagnóstico
Câncer Papilífero da Tireoide/diagnóstico
-Tireoidectomia
Neoplasias da Glândula Tireoide/cirurgia
Neoplasias da Glândula Tireoide/patologia
Biomarcadores Tumorais/sangue
Estudos de Casos e Controles
Adenocarcinoma Folicular/patologia
Diagnóstico Diferencial
Câncer Papilífero da Tireoide/patologia
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: BR66.1 - Divisão de Biblioteca e Documentação


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Id: biblio-975576
Autor: Iftikhar, Haissan; Ikram, Mubasher; Nathani, Karim Rizwan; Muhammad, Adnan Yar.
Título: Papillary Thyroid Carcinoma within Thyroglossal Duct Cyst: Case Series and Literature Review
Fonte: Int. arch. otorhinolaryngol. (Impr.);22(3):253-255, July-Sept. 2018. tab.
Idioma: en.
Resumo: Abstract Introduction Thyroglossal duct cyst (TGDC) is themost common congenital anomaly of the neck, and approximately 7% of all the adult population presents it. Ectopic thyroid tissue is found in the thyroglossal duct cyst wall in up to 65% of cases. This thyroid tissue has the potential to develop some type ofmalignancy, themost common of which is the papillary carcinoma of the thyroid. There are just over 270 cases of thyroglossal duct cyst malignancy reported in the literature. Objectives We aimed to study our population of patients in order to identify cases with thyroglossal duct cyst malignancy. Methods A retrospective chart review was conducted in the section of otolaryngology/ head and neck surgery at a hospital in Karachi, Pakistan, from January of 2004 to December of 2014 on patients with the diagnosis of thyroglossal duct cyst. Results Fifty-eight patients were diagnosed with TGDC, two of whom also presented with thyroglossal duct cyst carcinoma. Both patients revealed papillary thyroid carcinoma on histopathology. Case 1 had an open biopsy before undergoing definitive surgery. Both patients underwent subsequent total thyroidectomy after Sistrunk procedure, and case 2 had selective neck dissection revealing lymph node metastasis. Conclusion Thyroglossal duct cyst carcinoma is a rare finding that comes as a surprise to both the patient and the surgeon. We report 2 out of 58 cases diagnosed with thyroglossal duct cyst carcinoma.
Descritores: Cisto Tireoglosso/complicações
Neoplasias da Glândula Tireoide/etiologia
Câncer Papilífero da Tireoide/etiologia
-Paquistão
Cisto Tireoglosso/cirurgia
Cisto Tireoglosso/diagnóstico
Cisto Tireoglosso/patologia
Tireoidectomia/métodos
Registros Médicos
Estudos Retrospectivos
Ultrassonografia
Técnicas de Ablação
Limites: Humanos
Masculino
Adulto
Tipo de Publ: Revisão
Responsável: BR66.1 - Divisão de Biblioteca e Documentação


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Id: biblio-1087931
Autor: Pedrozo, MG; Giménez, G; Rojas, T; Grossling, B; Núñez, J; Galván, P.
Título: Determinación de las características funcionales de los nódulos tiroideos mediante imágenes de medicina nuclear en pacientes que acudieron al Instituto de Investigaciones en Ciencias de la Salud - UNA, en el periodo 2016-2019 / Determination of the functional characteristics of thyroid nodules through nuclear medicine images in patients, who attended the Instituto de Investigaciones en Ciencias de la Salud - UNA, in the period 2016-2019
Fonte: Rev. salud pública Parag;10(1):[P59-P65], mar. 2020.
Idioma: es.
Resumo: nuclear permiten visualizar la estructura y función de un órgano, tejido, hueso o sistema dentro del cuerpo, entre ellos la glándula tiroidea, la cual puede presentar un nódulo tiroideo y este es importante diagnosticar por su potencial malignidad. Objetivo: Determinar las características funcionales de los nódulos tiroideos en 183 pacientes que asistieron al Servicio de Medicina Nuclear del Instituto de Investigaciones en Ciencias de la Salud - UNA durante el período de noviembre del 2016 - noviembre del 2019. Metodología: Fue utilizada la gammacámara SPECT doble cabezal, siguiendo protocolo estandarizado, con administración de pertecnetato de sodio. Resultados: Se observó que la gran mayoría de los pacientes corresponden al sexo femenino 89%, así como que el 64% provienen de la capital y del departamento central; las patologías detectadas corresponden a bocio en 82%, 15% a nódulos (hipercaptantes, hipocaptantes y autónomos) y casos particulares de tiroiditis, tiroides ectópica y adenoma tóxico. La medicina nuclear está directamente involucrada tanto en el diagnóstico como en el tratamiento de la enfermedad tiroidea, por lo que se requiere una comprensión de la fisiopatología y el manejo de los trastornos de la tiroides, de manera a que las políticas de salud pública sean implementadas para el fortalecimiento de la lucha contra estas enfermedades. Conclusión: El trabajo de investigación realizado comprobó que un mayoritario porcentaje de participantes de sexo femenino (89%), con enfermedades tiroideas asistieron al IICS/UNA, y que la frecuencia de bocio entre la totalidad de pacientes que participaron de este estudio fué de 151/183 (82%), los pacientes provenían en su mayoría de hospitales de referencia del departamento Central y coinciden con la localización geográfica de los domicilios de los pacientes, quienes provenían principalmente del mismo departamento Central 118/183 (64%), no obstante también participaron del trabajo de investigación pacientes provenientes de otros departamentos del país. Palabras claves: Diagnóstico, medicina nuclear, tiroides, tecnología nuclear en salud, SPECT

Introduction: The images obtained by nuclear medicine allow to visualize the structure and function of an organ, tissue, bone or system inside the body, including the thyroid gland, which can present a thyroid nodule and this is important to diagnose for its potential malignancy. Objective: To determine the functional characteristics of the thyroid nodules were determined in 183 patients, who attended the Nuclear Medicine Service at the Instituto de Investigaciones en Ciencias de la Salud during the period of November 2016 - November 2019. Methodology: It was used the dual head SPECT gamma camera following a standardized protocol with administration of sodium pertechnetate. Result: It was observed that most of the patients corresponded to the female sex 89 %, as well as that 64% came from the capital and the central department. The pathologies detected corresponded to goiter in 82%, 15% to nodules (hypercaptant, hypocaptant and autonoms) and particular cases of thyroiditis, ectopic thyroid and toxic adenoma. Nuclear medicine is directly involved both in the diagnosis and in the treatment of thyroid disease, therefore it requires an understanding of the pathophysiology and management of thyroid disorders in order that public health policies are implemented for strengthening the fight against these diseases. Conclusion: The research carried out showed that a majority percentage of female participants (89%), with thyroid diseases attended IICS / UNA, and the frequency of goiter among all patients who participated in this study was 151/183 ( 82%), the patients mostly they came the reference hospitals in the Central department and coincide with the geographic location of the patients' homes, who tested mainly from the same Central department 118/183 (64%), also participate in the research work patients from other departments of the country. Keywords: Diagnosis, nuclear medicine, thyroid, health technology, SPECT.
Descritores: Neoplasias da Glândula Tireoide/diagnóstico por imagem
Tomografia Computadorizada de Emissão de Fóton Único/métodos
-Paraguai
Doenças da Glândula Tireoide
Medicina Nuclear
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: PY40.1 - Biblioteca


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Id: biblio-975574
Autor: Battoo, Azhar Jan; Haji, Altaf Gauhar; Sheikh, Zahoor Ahmad; Thankappan, Krishnakumar; Mir, Wahid Abdul.
Título: Efficacy of Drainless Total Thyroidectomy in Intrathyroidal Lesions of Thyroid
Fonte: Int. arch. otorhinolaryngol. (Impr.);22(3):256-259, July-Sept. 2018. tab.
Idioma: en.
Resumo: Abstract Introduction There is difference of opinion about the placement of the drain in thyroid surgeries, and, to the best of our knowledge, the efficacy of drainless total thyroidectomy regarding various parameters of thyroid lesions has not been well-established. Objective To report our experience with drainless total thyroidectomy, and to define an appropriate patient population for its performance. Methods This is a retrospective case analysis of the patients who underwent total thyroidectomy for intrathyroidal lesions with or without central neck dissection in a tertiary referral hospital (number = 74). The patients, who had undergone total thyroidectomy without any drain insertion, were analyzed, and the relationships among various parameters of thyroid lesions were noted in relation to seroma and hematoma formation. Results Seroma formation was noted only in 5 out of 74 patents (6.75%). All of the seromas that occurred were observed in patients with thyroid lesions < 4 cm, and 4 out of 5 seromas were observed in patients with a malignant pathology. There was no statistically significant difference in seroma formation between patients younger or older than 50 years of age. The nature of the lesion, whether benign or malignant, did not affect the formation of seroma. Of interest is the fact that none of the 10 patients who had central neck dissection performed as part of their treatment developed seroma. Conclusions Drainless total thyroidectomy is safe across all age groups for patients harboring either benign or malignant thyroid pathologies. However, caution is to be observed in opting for drainless total thyroidectomy in patients with large lesions (> 5 cm)
Descritores: Glândula Tireoide/lesões
Tireoidectomia/métodos
-Complicações Pós-Operatórias/epidemiologia
Esvaziamento Cervical/métodos
Doenças da Glândula Tireoide/cirurgia
Neoplasias da Glândula Tireoide/cirurgia
Drenagem
Incidência
Estudos Retrospectivos
Resultado do Tratamento
Seroma/epidemiologia
Hematoma/epidemiologia
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: BR66.1 - Divisão de Biblioteca e Documentação


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Id: lil-547036
Autor: Sosa Martín, Gimel; Morales Portuondo, Kelvis; Martínez Valenzuela, Noslen.
Título: Aplicación del índice pronóstico AGES para el tratamiento del carcinoma bien diferenciado de la tiroides / Application of AGES prognostic rate for treatment of a well differentiated thyroid carcinoma
Fonte: Rev. cuba. cir;48(3), jul.-sept. 2009. tab.
Idioma: es.
Resumo: INTRODUCCIÓN. En la actualidad la selección del tratamiento quirúrgico adecuado en pacientes con carcinoma diferenciado de la tiroides en etapas tempranas es controversial. La presente investigación tuvo el objetivo de describir y evaluar los resultados del diagnóstico y tratamiento de esta enfermedad en un período de 5 años. MÉTODOS. Se realizó un estudio observacional, descriptivo con elementos analíticos incorporados, y prospectivo para la recolección de información de los pacientes atendidos por presentar nódulo de la tiroides, en el ISMM Dr. Luis Díaz Soto, entre enero del 2002 y diciembre del 2006. A estos pacientes con cánceres bien diferenciados en etapas I y II según la clasificación internacional de tumores, ganglios y metástasis, se les aplicó de forma retrospectiva el índice de pronóstico AGES. RESULTADOS. La muestra estudiada estuvo constituida por 73 pacientes, de los cuales 69 eran mujeres (94,5 por ciento). Del total de pacientes estudiados, 42 presentaron tumores benignos (57,5 por ciento) y 31, malignos (42,5 por ciento). De los 31 casos diagnosticados como carcinomas mediante parafina, 21 obtuvieron puntuación menor de 4 según el índice AGES (menor riesgo), y solo 11 de estos (67,7 por ciento) recibieron una cirugía conservadora de la tiroides. CONCLUSIONES. Existió una buena concordancia entre la biopsia por aspiración con aguja fina y la parafina, por lo que la primera se considera de valor en la exploración de un nódulo de la tiroides. El índice AGES no siempre fue tomado en cuenta para la selección del tipo de cirugía, con tendencia a la cirugía más radical. Las complicaciones mayores se asociaron con mayor frecuencia a la cirugía radical(AU)

INTRODUCTION: At the present times, the selection a suitable surgical treatment for patients presenting with an early differentiated thyroid carcinoma is a controversial question. The aim of present research was to describe and to assessment the diagnosis results and the treatment of this condition during 5 years. METHODS: Authors made an observational and descriptive study with added analytical elements, and a prospective one to retrieve information from patients presenting thyroid nodule seen in "Luís Díaz Soto" Higher Institute of Military Medicine (HIMM) from January 2002 to December 2006. AGES prognostic rate was applied in patients with well differentiated thyroid carcinoma stages I and II, according to international classification of tumors, nodules, and metastasis. RESULTS: Study sample included 73 patients of whom 69 were women (94,5 percent). From total of study patients, 42 had benign tumors (57,5 percent) and 31 had malign tumors (42,5 percent). From 31 diagnosed with carcinoma by paraffin, 21 had an score < 4 according AGES rate (lower risk), and only 11 of them (67,7 percent) has a conservative surgery of thyroid gland. CONCLUSIONS: There was a good concordance between fine-needle aspiration biopsy and [paraffin, where the first one is valuable in thyroid nodule exploration. AGE's rate not always was considered for selection of surgery but there was a trend to a more radical surgery. Major complications were associated with a great frequency for radical surgery(AU)
Descritores: Carcinoma/cirurgia
Neoplasias da Glândula Tireoide/cirurgia
Prognóstico
-Epidemiologia Descritiva
Estudos Prospectivos
Biópsia por Agulha Fina/métodos
Estudos Observacionais como Assunto
Limites: Humanos
Feminino
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-1053147
Autor: Batallés, Stella Maris; Brunas, Oscar; Novelli, José Luis.
Título: Aumento de la capacidad diagnóstica de la ecografía (informada con clasificación t-rads) cuando se agrega una punción aspirativa con aguja fina (informada con sistema bethesda) / Increase of the diagnostic yield of thyroid sonogram (reported with t-rads clasification) when a fine needle aspiration cytology (reported with bethesda system) is added
Fonte: Rev. med. Rosario;85(2):55-63, mayo-ago. 2019. ilus, tab.
Idioma: es.
Resumo: Cuando un nódulo tiroideo muestra características ecográficas sospechosas de malignidad (informada con clasificación T-RADS) casi no se discute que debe completarse el diagnóstico con una punción aspirativa con aguja fina (PAAF) (informada con sistema Bethesda). Pero cuando la ecografía sólo muestra características consideradas de benignidad, la indicación de PAAF es cuestionable y debe ser justificada. ¿Podrá la clasificación T-RADS determinar eficientemente cuáles nódulos tiroideos requieren una PAAF y cuáles no? Esta decisión está vinculada a determinar si un paciente deberá ser sometido o no a una cirugía tiroidea. Objetivo: Analizar la capacidad de la clasificación T-RADS, con y sin el agregado de sistema Bethesda para optimizar el diagnóstico de patología tiroidea. Material y métodos: se incluyeron 139 nódulos que requirieron cirugía, previamente evaluados con ecografía y con PAAF. Fueron realizadas por un mismo operador las ecografías (SMB), las punciones (OBM) y las cirugías (JLN). Se homogeneizaron las definiciones: T-RADS II-III-IVa y Bethesda II-III: Baja sospecha de malignidad; T-RADS IVb-V-VI y Bethesda IV-V-VI: Alta sospecha de malignidad. Conslusiones: se comprobó que cuando las características ecográficas de un nódulo tienen baja sospecha de malignidad (T-RADS II-III-IVa), indicar una PAAF no aporta al diagnóstico en forma estadísticamente significativa. Cuando la ecografía indica alta sospecha de malignidad (T-RADS IVb-V-VI), la realización de una PAAF incrementa significativamente la certidumbre del diagnóstico (AU)

When a thyroid nodule shows ultrasonographic characteristics of malignancy suspicion (informed with T-RADS classification), almost nobody discusses to complete diagnosis with a fine needle aspiration biopsy (FNAB) (informed with Bethesda system). But when ultrasonography only shows characteristics compatible with benignity, a FNAB indication is questionable and that must be justified. Could T-RADS classification efficiently identify which nodule requires a FNAB and which does not? That decision will linked to which patients should be undergo a thyroid surgery. Objective: to analyze T-RADS capability with and without Bethesda system to optimize the diagnosis of thyroid pathology. Material and methods: a total of 139 nodules which required surgery were included. They were previously evaluated with ultrasonography and FNAB. A same operator classified the T-RADS (SMB), the Bethesda system (OMB) and performed the surgeries (JLN). For this work, definitions were homogenized as follows: T-RADS II-III-IVa and Bethesda II-III: Low suspicion of malignancy; T-RADS IVb-V-VI and Bethesda IV-V-VI: High suspicion of malignancy. Conclusions: the evidence suggested that when a thyroid nodule shows low suspicion of malignancy by ultrasonography (T-RADS II-III-IVa), the indication of a FNAB did not add statistically significant diagnostic benefit. When a thyroid nodule shows high suspicion of malignancy (T-RADS IVb-V-VI), a FNAB added significant diagnostic accuracy (AU)
Descritores: Nódulo da Glândula Tireoide/diagnóstico por imagem
Ultrassonografia Doppler/métodos
-Doenças da Glândula Tireoide/diagnóstico por imagem
Biópsia por Agulha
Neoplasias da Glândula Tireoide/cirurgia
Neoplasias da Glândula Tireoide/diagnóstico por imagem
Diagnóstico por Imagem
Estudos Transversais
Limites: Humanos
Masculino
Feminino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: AR16.1 - Biblioteca


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Id: lil-584337
Autor: Cassola Santana, Juan; Montejo Saínz, Jesús Enrique; Delgado Alonso, Ada Irmina.
Título: Biología molecular y cáncer de tiroides / Molecular biology and thyroid cancer
Fonte: Rev. cuba. cir;49(4):109-113, oct.-dic. 2010.
Idioma: es.
Resumo: Se realiza una revisión actualizada sobre aspectos de biología molecular que servirán de base al cirujano actuante para un mejor conocimiento del cáncer tiroideo. El objetivo radica en alertar a los cirujanos sobre las nuevas evaluaciones a las que podrán someterse los tumores de la tiroides, que implicarán cambios en toda la gama de conductas actuales en estos casos. Se señalan aspectos que sin duda cambiarán los conceptos que se manejan hoy día(AU)

A updating review is carry out on the features of molecular biology as a basis for acting surgeon to a better knowledge of thyroid cancer. The objective is to alert surgeons on the new assessments for this type of cancer, implicating changes in all the range of current behaviors in these cases. The features that will change the nowadays concepts in this respect(AU)
Descritores: Biologia Molecular/tendências
Neoplasias da Glândula Tireoide/cirurgia
-Literatura de Revisão como Assunto
Limites: Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-983748
Autor: Lira, Marcia Lanzoni Alvarenga; Almeida, Mariana Abdo de; Reis-Feroldi, Michele Maria; Rocha, Jeanine Alvarenga.
Título: Follicular thyroid carcinoma metastatic to skin: a small papule and a big diagnostic change
Fonte: An. bras. dermatol;94(1):76-78, Jan.-Feb. 2019. graf.
Idioma: en.
Resumo: Abstract: Cutaneous metastases are uncommon in daily practice, although very important, since they may be the first manifestation of an undiscovered primary neoplasm or the first indication of recurrence. Cutaneous metastases from the breast are the most frequent in women and cutaneous metastases from the lung are the most frequent in men. Thyroid carcinoma, despite representing the most frequent endocrine neoplasm, is considered a rare neoplasm, corresponding to 1% of malignant neoplasms diagnosed. Cutaneous metastases from follicular carcinoma are rare and occur mainly in the head and neck area. We report a case of cutaneous metastasis in a patient with follicular thyroid carcinoma and breast carcinoma. Because of the association of these two neoplasms, the possibility of Cowden Syndrome - multiple hamartoma syndrome - was raised, but was excluded by genetic analysis of PTEN gene.
Descritores: Neoplasias Cutâneas/secundário
Neoplasias da Mama/patologia
Neoplasias da Glândula Tireoide/patologia
Adenocarcinoma Folicular/secundário
Neoplasias Primárias Múltiplas/patologia
-Neoplasias Cutâneas/diagnóstico
Biópsia
Neoplasias da Mama/diagnóstico
Neoplasias da Glândula Tireoide/diagnóstico
Imuno-Histoquímica
Adenocarcinoma Folicular/diagnóstico
Neoplasias Primárias Múltiplas/diagnóstico
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-1050822
Autor: Barros, Aline Ribeiro; Souza, Jéssica Nayane; Sobrinho, Alaor Barra; Morais, Rafael Martins de; Oliveira, Jamila R; Silva, Izabel C. Rodrigues da.
Título: Associação entre polimorfismos de citocinas inflamatórias com o carcinoma papilífero de tireóide / Association between inflammatory cytokine polymorphisms and papillary thyroid carcinoma / Asociación entre polimorfismos de citoquinas inflamatorias y carcinoma papilar de tiroides
Fonte: REVISA (Online);9(1):13-23, jan-mar.2020.
Idioma: en; pt.
Resumo: Objetivo: Analisar a associação entre os polimorfismos dos genes IFNG e IL4 com o CPT, e suas características clínicas Método: Foram coletados o sangue de 30 pacientes portadores de CPT, e de 82 controles saudáveis. A genotipagem se deu através da técnica de PCR qualitativa. Os resultados foram cruzados com os níveis de TSH e Tiroglobulina dos pacientes com CPT e analisados com o programa SPSS 25.0. O estudo teve aprovação no comitê de ética sob CAAE 57382416.6.0000. 0023. Resultados: O genótipo AA do +874 A/T IFNG apresentou frequência de 60% nos participantes com CPT, nos controles o genótipo TA apareceu em 55,6%, o valor de significância foi p=0,0038. Em relação ao IL4, o genótipo B2/B2 foi o mais comum em ambos os grupos com significância de p=0,271. As amostras estavam em equilíbrio HW. Em relação as medianas de Tiroglobulina (ng/mL) e TSH (uUI/mL), foram observados os seguintes valores de significância respectivamente: p=0,612 e p=0,419 em relação ao IFNG e p= 0,431 e p=0,655, em relação ao IL4. Conclusão: Houve associação estatística com o polimorfismo +874 A/T IFNG e o CPT, entretanto não houve associação entre os níveis de TSH e tiroglobulina em pacientes com CPT. Em relação ao gene IL4 não foram observados significância entre a frequência genotípica e o CPT e os níveis de TSH e Tiroglobulina. O presente trabalho reforça a necessidade da produção de mais estudos acerca do tema a fim de estabelecer-se se de fato é possível afirmar se tais associações (ou ausência de associação) são de fato realidade no contexto do CPT.

Objective: To assess the association between IFNG and IL4 gene polymorphisms and CPT and their clinical characteristics Method: Blood was collected from 30 patients with CPT and 82 healthy controls. Method: Blood was collected from 30 patients with TLC and 82 healthy controls. Genotyping was performed by the qualitative PCR technique. Results were crossed with TSH and Thyroglobulin levels of patients with CPT and analyzed using the SPSS 25.0 program. The study was approved by the ethics committee under CAAE 57382416.6.0000. 0023. Results: The +874 A / T IFNG AA genotype showed a frequency of 60% in participants with CPT, in controls the genotype TA appeared in 55.6%, the significance value was p = 0.0038. Regarding IL4, the B2 / B2 genotype was the most common in both groups with significance of p = 0.271. The samples were in HW equilibrium. Regarding the median Thyroglobulin (ng / mL) and TSH (uUI / mL), the following significance values were observed respectively: p = 0.612 and p = 0.419 for IFNG and p = 0.431 and p = 0.655 for IL4. Conclusion: There was a statistical association with +874 A / T IFNG polymorphism and CPT, however there was no association between TSH and thyroglobulin levels in patients with CPT. Regarding the IL4 gene, no significance was observed between genotypic frequency and CPT and TSH and Thyroglobulin levels. The present work reinforces the need to produce more studies on the subject in order to establish if it is in fact possible to affirm if such associations (or absence of association) are in fact in the context of the CPT.

Objetivo: analizar la asociación entre IFNG y polimorfismos del gen IL4 con CPT y sus características clínicas Método: Se recogió sangre de 30 pacientes con CPT y 82 controles sanos. El genotipado se realizó mediante la técnica cualitativa de PCR. Los resultados se cruzaron con niveles de TSH y tiroglobulina de pacientes con CPT y se analizaron utilizando el programa SPSS 25.0. El estudio fue aprobado por el comité de ética bajo CAAE 57382416.6.0000. 0023. Resultados: El genotipo AAA IFNG +874 A / T presentó una frecuencia del 60% en los participantes con CPT, en los controles el genotipo TA apareció en el 55,6%, el valor de significación fue p = 0,0038. Con respecto a IL4, el genotipo B2 / B2 fue el más común en ambos grupos con un significado de p = 0.271. Las muestras estaban en equilibrio HW. Con respecto a las medianas de tiroglobulina (ng / ml) y TSH (uUI / ml), se observaron los siguientes valores de significancia respectivamente: p = 0.612 y p = 0.419 para IFNG y p = 0.431 y p = 0.655 para IL4. Conclusión: hubo asociación estadística con +874 A / T IFNG polimorfismo y CPT, pero no hubo asociación entre TSH y niveles de tiroglobulina en pacientes con CPT. Sobre el gen IL4, no se observó significación entre la frecuencia genotípica y los niveles de CPT y TSH y tiroglobulina. Eso trabajo refuerza la necesidad de producir más estudios sobre el tema para establecer si de hecho es posible afirmar si tales asociaciones (o ausencia de asociación) están de hecho en el contexto del CPT
Descritores: Neoplasias da Glândula Tireoide
Responsável: BR2040.1 - Biblioteca Central


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Id: biblio-975616
Autor: Battoo, Azhar Jan; Sheikh, Zahoor Ahmad; Thankappan, Krishnakumar; Mir, Abdul Wahid; Haji, Altaf Gowhar.
Título: Level V Clearance in Neck Dissection for Papillary Thyroid Carcinoma: A Need for Homogeneous Studies
Fonte: Int. arch. otorhinolaryngol. (Impr.);22(4):449-454, Oct.-Dec. 2018.
Idioma: en.
Resumo: Abstract Introduction Papillary thyroid carcinoma has a very high rate of lateral neck node metastases, and there is almost unanimity concerning the fact that some sort of formal neck dissection must be performed to address the clinical neck disease in these cases. Although there is an agreement that levels II to IV need to be cleared in these patients, the clearance of level V is debatable. Objectives We herein have tried to analyze various papers that have documented a structured approach to neck dissection in these patients. Moreover, we have also tried to consider this issue through various aspects, like spinal accessory nerve injury and the impact of neck recurrence on survival. Data Synthesis The PubMed, Medline, Google Scholar, Surveillance, Epidemiology, and End Results (SEER), and Ovid databases were searched for studies written in English that focused on lateral neck dissection (levels II-IV or II-V) for papillary thyroid carcinoma. Case reports with 10 patients or less were excluded. Conclusions The current evidence is equivocal whether to clear level V or not, and the studies published on this issue are very heterogeneous. Level II-IV versus level II-V selective neck dissections in node-positive papillary thyroid carcinoma patients is far from categorical, with pros and cons for both approaches. Hence, we feel that there is a need for more robust homogeneous data in order to provide an answer to this question.
Descritores: Esvaziamento Cervical
Neoplasias da Glândula Tireoide/patologia
/cirurgia
AMERICAN HEART ASSOCIATIONACEDAPSONE/cirurgia
-Ombro/fisiopatologia
Nervo Acessório/cirurgia
Linfonodos/diagnóstico por imagem
Metástase Neoplásica
Recidiva Local de Neoplasia
Estadiamento de Neoplasias
Limites: Humanos
Adolescente
Adulto
Pessoa de Meia-Idade
Tipo de Publ: Revisão
Revisão Sistemática
Responsável: BR66.1 - Divisão de Biblioteca e Documentação



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