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Texto completo SciELO Chile
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Id: biblio-978139
Autor: Muftoz, Paula; Bustos, Roberto; Manfredi, Jocelyn.
Título: Hamartoma fibroso de la infancia umbilical: reporte de un caso / Umbilical fibrous hamartoma of infancy: a case report
Fonte: Rev. chil. pediatr;89(5):655-659, oct. 2018. graf.
Idioma: es.
Resumo: Resumen: Introducción: el hamartoma fibroso de la infancia (HFI) es un tumor benigno de partes blandas que se presenta generalmente en población infantil y que posee una morfología histológica característica. Objetivo: describir un caso de HFI congénito de características clínicas e histológicas atípicas. Caso Clínico: recién nacido de término, sexo masculino, sin antecedentes mórbidos perinatales, es deriva do a dermatología por placa eritematosa congénita en región umbilical. Estudio histológico evidenció proliferación fusocelular en dermis e hipodermis, de morfología bifásica, con un patrón arremolina do infiltrante y otro de bandas de células fusadas con hábitos fibroblásticos y miofibroblásticos, aso ciada en profundidad a un componente de tejido adiposo maduro. El estudio inmunohistoquímico mostró positividad difusa a CD34 y focalmente para FXIIIa, con ausencia de inmunoreactividad a ac- tina, desmina, MyoD1, S100, HMB45, Melan A y EMA. Fluorescent in situ hybridization (FISH) para platelet-derived growth factor beta (PDGF beta) y para el gen ETV6 negativos, presentes en el dermatofibrosarcoma protuberans congénito y fibrosarcoma infantil, respectivamente. Estos antecedentes, sumado a los hallazgos histológicos previos, apoyaron el diagnóstico de HFI. Se realizó extirpación quirúrgica, sin signos de recidiva durante el seguimiento clínico. Conclusión: es importante consi derar el HFI dentro del diagnóstico diferencial de tumores subcutáneos infantiles, principalmente en población menor de 2 años. Si bien su comportamiento es benigno, presenta similitud con múltiples lesiones benignas y malignas, lo que hace imperativo realizar un estudio histológico exhaustivo ante lesiones clínicas sospechosas.

Abstract: Introduction: Fibrous hamartoma of infancy (FHI) is a benign, soft tissue tumor that usually oc curs in children and has a characteristic histological morphology. Objective: To describe a case of congenital FHI with atypical histological and clinical characteristics. Clinical case: Full-term male newborn, with no perinatal morbid history was referred to dermatology due to a congenital erythe matous plaque in the umbilical region. The histological study showed a fusocelullar proliferation in dermis and hypodermis of biphasic distribution, with an infiltrative, swirling pattern and bundles of spindle fibroblast-like and myofibroblast-like cells, associated in depth with a mature adipose tissue component. The immunohistochemical study revealed diffuse positivity for CD34, and focal posi tivity for FXIIIa, without immunoreactivity for actin, desmin, MyoD1, S100, HMB45, Melan-A, or EMA. Fluorescent in situ hybridization (FISH) was negative for platelet-derived growth factor recep tor beta (PDGFR-beta) and for ETV6 gene. PDGFR-beta and ETV6 gene are present in congenital dermatofibrosarcoma protuberans and infantile fibrosarcoma, respectively. This history, in addition to previous histological findings, supported the diagnosis of FHI. Surgical resection was performed, without signs of recurrence during clinical follow-up. Conclusion: It is important to consider the FHI within the differential diagnosis of subcutaneous tumors in children, especially in those under two years of age. Although its behavior is benign, it is similar to multiple benign and malignant le sions, which makes it imperative to perform a histological study in front of suspicious clinical lesions.
Descritores: Neoplasias de Tecidos Moles/diagnóstico
Umbigo/patologia
Hamartoma/diagnóstico
-Neoplasias de Tecidos Moles/congênito
Neoplasias de Tecidos Moles/patologia
Hamartoma/congênito
Hamartoma/patologia
Limites: Humanos
Masculino
Recém-Nascido
Tipo de Publ: Relatos de Casos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1045697
Autor: Yazicioglu, A; Altinok, T; Agackiran, Y; Karaoglanoglu, N.
Título: Intrathoracic hibernoma: an uncommon tumour / Hibernoma intratorácico: un tumor poco frecuente
Fonte: West Indian med. j;62(6):554-556, July 2013. ilus.
Idioma: en.
Resumo: Hibernomas are uncommon benign tumours that arise from the remnants of fetal brown adipose tissue. They are usually asymptomatic and have a slow growth pattern. Intrathoracic and pleural locations are exceptional for localization of hibernoma. A review of the English language medical literature revealed more than 110 cases, 20 of which were intrathoracic. In the article below, we discuss a 40-year old male patient who had pleural involvement and was treated by surgical resection. Following resection, the patient has remained problem-free for nine years.

Los hibernomas son tumores benignos poco frecuentes que surgen de restos del tejido adiposo marrón fetal. Son generalmente asintomáticos y tienen un patrón de crecimiento lento. Las localizaciones intratorácicas y pleurales son excepcionales para la localización del hibernoma. Una revisión de la literatura médica en lengua inglesa reveló más de 110 casos, 20 de los cuales se trataban de hibernomas intratorácicos. En el siguiente artículo, discutimos el caso de un paciente de 40 años de edad, que tenía una afección pleural y fue tratado con una resección quirúrgica. Después de la resección, el paciente ha permanecido sin problemas durante nueve años.
Descritores: Neoplasias de Tecidos Moles/diagnóstico
Neoplasias Torácicas/diagnóstico
Lipoma/diagnóstico
-Toracotomia
Tomografia Computadorizada por Raios X
Limites: Humanos
Adulto
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-1222729
Autor: Ortega Cedeño, John; Solórzano Pérez, Evelyn.
Título: Condrosarcoma mesenquimal en región pectoral, reporte de caso / Mesenchymal chondrosarcoma in the pectoral re-gion, case report
Fonte: Oncol. (Guayaquil) = Oncol. (Guayaquil);31(1):86-92, Abril 30, 2021.
Idioma: es.
Resumo: Introducción: El condrosarcoma mesenquimal extraesquelético (CME), corresponde al 1% de todos los tumores malignos de los tejidos blandos. Se localizan principalmente en la región de la cabeza y cuello, sobre todo en la órbita, y en la duramadre del cráneo, seguida de las extremidades inferiores particularmente a nivel del muslo. La ubicación pectoral es rara, motivo de reporte. Reporte de caso: Paciente hombre de 38 años quien desarrolla un nódulo de aproximadamente 2 cm de diámetro localizado en región pectoral derecha con dolor mínimo a la palpación y crecimiento rápido. Dos meses después, al momento la de resección, el nódulo mide 7.5x 6.5 x 3.5 cm, y pesa 106g. Presenta aspecto lobulado, color café grisáceo, al corte es de consistencia cauchosa y superficie blanquecina nodular con áreas centrales de aspecto mineralizado/calcificado. Se procesa 6 cortes de parafina y se diagnostica como condrosarcoma mesenquimal (CM). Evolución: El paciente fue egresado y está en control por consulta externa no ha desarrollado recidivas hasta el momento. Conclusiones: El crecimiento acelerado de una masa de consistencia cartilaginosa se correlacionó en este paciente con la presencia de un condrosarcoma mesenquimal extraesquelético.

Introduction: The extraskeletal mesenchymal chondrosarcoma (ESC) corresponds to 1% of all malignant soft tissue tumors. They are located mainly in the head and neck region, especially in the orbit, and in the dura mater of the skull, followed by the lower extremities, particularly at the level of the thigh. Pectoral location is rare, reason for report. Case report: 38-year-old male patient who developed a nodule approximately 2 cm in diameter located in the right pectoral region with minimal pain on palpation and rapid growth. Two months later, at the time of resection, the nodule measures 7.5 x 6.5 x 3.5 cm, and weighs 106g. It has a lobulated appearance, greyish brown color, when cut it is of a rubbery consistency and a nodular whitish surface with central areas of mineralized / calcified appearance. 6 paraffin sections are processed and diagnosed as mesenchymal chondrosarcoma (CM). Evolution: The patient was discharged and is being monitored by an outpatient clinic. He has not developed recurrences to date. Conclusions: The accelerated growth of a mass of cartilaginous consistency was correlated in this patient with the presence of an extraskeletal mesenchymal chondrosarcoma.
Descritores: Relatos de Casos
Condrossarcoma Mesenquimal
-Neoplasias de Tecidos Moles
Responsável: EC104.1 - Biblioteca


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Texto completo SciELO Brasil
Lopes, Márcio Ajudarte
Almeida, Oslei Paes de
Vargas, Pablo Agustin
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Id: biblio-1142395
Autor: Pérez-de-Oliveira, Maria Eduarda; Morais, Thayná Melo de Lima; Lopes, Márcio Ajudarte; Almeida, Oslei Paes de; van Heerden, Willie F P; Vargas, Pablo Agustin.
Título: Ossifying fibromyxoid tumor of the oral cavity: rare case report and long-term follow-up
Fonte: Autops. Case Rep;11:e2020216, 2021. tab, graf.
Idioma: en.
Projeto: CAPES.
Resumo: Ossifying fibromyxoid tumor (OFMT) is a rare mesenchymal soft tissue benign neoplasm with an uncertain line of differentiation, which arises most frequently in extremities. The head and neck region involvement is uncommon, with only ten intraoral cases published in the English-language literature. One additional case of OFMT is reported here, including a literature review of intraoral reported cases. A 45-year-old female patient presented a painless nodule involving the buccal mucosa of approximately two years duration, measuring nearly 1.3 cm in maximum diameter. The main histopathological features include ovoid to round cells embedded in a fibromyxoid matrix with a perpheral shell of lamellar bone. Immunohistochemically, the tumor showed immunoreactivity for vimentin and S100. No recurrence has been detected after 7 years of follow-up.
Descritores: Neoplasias de Tecidos Moles/patologia
Neoplasias de Cabeça e Pescoço/patologia
Boca
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Revisão
Responsável: BR26.7 - Serviço de Biblioteca e Documentação Científica


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Id: biblio-974348
Autor: Ozmen, Omer Afsin; Alpay, Melih; Saraydaroglu, Ozlem; Demir, Uygar Levent; Kasapoglu, Fikret; Coskun, Hamdi Hakan; Basut, Oguz Ibrahim.
Título: Prognostic significance of soft tissue deposits in laryngeal carcinoma / Importância prognóstica de depósitos de tecido mole no carcinoma laríngeo
Fonte: Braz. j. otorhinolaryngol. (Impr.);84(5):566-573, Sept.-Oct. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Introduction: Soft tissue deposits is tumorous islands apart from lymph nodes and occasionally diagnosed in neck dissection specimens. Their importance has begun to be recognized, however, their value has not been investigated in laryngeal cancer as a single tumor site. Objective: To investigate the prognostic value of soft tissue deposits in patients with laryngeal carcinoma. Methods: Medical records of 194 patients with laryngeal carcinoma who were treated primarily by surgery and neck dissection were reviewed. Prognostic significance of soft tissue deposits was assessed along with other clinical and pathological findings. Recurrence rates, overall and disease-specific survival rates were examined. Results: The incidence of soft tissue deposits was found to be 7.2% in laryngeal carcinoma. N stage was more advanced in patients who had soft tissue deposits. Regional recurrence rate was higher and disease specific and overall survivals rates were significantly lower in patients with soft tissue deposits in univariate analysis. However, in multivariate analysis, soft tissue deposits were not found as an independent risk factor. Conclusion: In laryngeal carcinoma, soft tissue deposits was diagnosed in patients with more advanced neck disease and their significance was lesser than other factors including extranodal extension.

Resumo Introdução: Depósitos de tecido mole são ilhas tumorais diferente dos linfonodos e ocasionalmente diagnosticados em amostras de esvaziamento cervical. Sua importância começou a ser reconhecida, mas seu valor não foi investigado no câncer de laringe como um único local de tumor. Objetivo: Investigar o valor prognóstico do depósito de tecido mole em pacientes com carcinoma laríngeo. Método: Os prontuários de 194 pacientes com carcinoma laríngeo tratados principalmente por cirurgia e esvaziamento cervical foram analisados. O significado prognóstico dos depósitos de tecido mole foi avaliado juntamente com outros achados clínicos e histopatológicos. As taxas de recidiva, as taxas de sobrevida geral e específicas da doença foram avaliadas. Resultados: Observou-se uma incidência de depósitos de tecido mole de 7,2% no carcinoma laríngeo. O estágio N foi mais avançado em pacientes com depósitos de tecido mole. A taxa de recorrência regional foi maior e as taxas de sobrevida geral e específica da doença foram significativamente menores nesses pacientes na análise univariada. No entanto, na análise multivariada, o depósito de tecido mole não foi observado como um fator de risco independente. Conclusão: No carcinoma laríngeo, o depósito de tecido mole foi diagnosticado em pacientes com doença cervical mais avançada, mas sua significância foi menor do que outros fatores, inclusive a extensão extranodal.
Descritores: Neoplasias de Tecidos Moles/secundário
Neoplasias Laríngeas/patologia
-Prognóstico
Esvaziamento Cervical
Brasil/epidemiologia
Carcinoma de Células Escamosas/cirurgia
Carcinoma de Células Escamosas/patologia
Neoplasias Laríngeas/cirurgia
Neoplasias Laríngeas/mortalidade
Taxa de Sobrevida
Fatores de Risco
Metástase Linfática/patologia
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: biblio-1135623
Autor: Loures, Fabricia H; Conceição, Lissandro G; Amorim, Renee L; Nobrega, Juliano; T. Neto, Rafael; Costa, Eduardo P; Silva, Fabyano Fonseca e.
Título: Progesterone and estrogen receptor expression by canine cutaneous soft tissue sarcomas / Expressão de receptores para progesterona e estrógeno em sarcomas de tecidos moles cutâneos em cães
Fonte: Pesqui. vet. bras = Braz. j. vet. res;40(4):284-288, Apr. 2020. ilus.
Idioma: en.
Resumo: Canine soft tissue sarcomas (STS) comprise a heterogeneous group of malignancies that share similar histopathological features, a low to moderate recurrence rate and low metastatic potential. In human medicine, the expression of estrogen receptors (ER) and progesterone receptors (PR) in sarcomas has been studied to search for prognostic factors and new treatment targets. Similar studies have yet to be conducted in veterinary medicine. The objective of this study was therefore to investigate by immunohistochemistry (IHC) the ER and PR expression in a series of 80 cutaneous and subcutaneous sarcomas in dogs with histopathological features of peripheral nerve sheath tumor (PNST) and perivascular wall tumor (PWT). All cases were positive for PR and negative for ER. Tumors of high malignancy grade (grade III) exhibited higher PR expression than low-grade tumors (grade I). Tumors with mitotic activity greater than 9 mitotic figures/10 high power fields also exhibited higher PR expression. In addition, there was a positive correlation between cell proliferation (Ki67) and PR expression. Therefore, it is possible that progesterone plays a greater role than estrogen in the pathogenesis of these tumors. Future studies should explore the potential for selective progesterone receptor modulators as therapeutic agents in canine STS, as well as evaluating PR expression as a predictor of prognosis.(AU)

Sarcomas de tecidos moles (STM) caninos compreendem um grupo heterogêneo de neoplasias malignas, que apresentam alterações histopatológicas similares, baixa a moderada taxa de recorrência e baixo potencial metastático. Em medicina humana, a expressão de receptor para estrógeno (RE) e receptor para progesterona (RP) nos sarcomas tem sido estudada, visando a busca por fatores prognósticos e novos alvos para tratamentos. Na medicina veterinária, ainda não foram realizados estudos similares. O objetivo deste trabalho foi investigar por imuno-histoquímica a expressão de RE e RP em uma série de 80 sarcomas cutâneos e subcutâneos de cães, com características histopatológicas de tumor de bainha de nervo periférico e tumor de parede perivascular. Todos os casos foram positivos para RP e negativos para RE. Tumores de alto grau de malignidade (grau III) exibiram maior expressão deste receptor que os tumores de baixo grau (grau I). Tumores com atividade mitótica maior que 9 figuras mitóticas/10 campos de grande aumento também exibiram maior expressão do RP. Em adição, houve correlação positiva entre o índice de proliferação celular (Ki67) e a expressão de RP. Assim, é possível que a progesterona desempenhe maior papel que o estrógeno na patogênese desses tumores. Futuros trabalhos poderão explorar o potencial dos moduladores seletivos de RP como agente terapêutico em STM caninos, bem como avaliar a expressão de RP como preditiva de prognóstico.(AU)
Descritores: Sarcoma
Neoplasias de Tecidos Moles/veterinária
Receptores de Progesterona
Receptores de Estrogênio
Limites: Animais
Masculino
Feminino
Cães
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-1131847
Autor: Priya, Madhu; Singh, Parvendra; Malhotra, Manu; Angral, Sumeet; Varshney, Saurabh; Bhardwaj, Abhishek; Tyagi, Amit Kumar; Kumar, Amit; Gupta, Manish Kumar.
Título: Cervical Infantile Fibrosarcoma: a rare cause of paediatric parapharyngeal neck mass
Fonte: Autops. Case Rep;10(4):e2020189, 2020. graf.
Idioma: en.
Resumo: Soft tissue tumors are not uncommon in childhood and comprise entities that range from common to very rare malignancies. Infantile fibrosarcoma (IFS) is a rare pediatric malignancy mainly seen in the first two years of life. The data about the incidence of infantile fibrosarcoma occurring in the neck in the Indian subcontinent is scarce. To the best of our knowledge, only one case of infant cervical IFS has been reported previously in the Indian subcontinent. We present another case of an eight-year-old male patient with a rapidly growing mass on the left side of the neck. He was successfully treated with a combined modality of surgery and chemotherapy with a good outcome. Among the soft tissue tumors of childhood, IFS is a rare entity. It has a good prognosis and lesser chance of distant metastasis as compared to adult fibrosarcoma. Though surgical excision is the mainstay of treatment, chemotherapy also has a significant role in the treatment of primary tumor and metastasis. We discuss the stated case to bring to the notice this uncommon cause, which can be considered as a differential diagnosis of upper cervical swellings. A better understanding of this entity would help in early diagnosis and aggressive treatment, reducing the overall morbidity and mortality.
Descritores: Rabdomiossarcoma
Fibrossarcoma/patologia
Neoplasias de Cabeça e Pescoço
-Neoplasias de Tecidos Moles/patologia
Diagnóstico Diferencial
Limites: Humanos
Masculino
Criança
Tipo de Publ: Relatos de Casos
Responsável: BR26.7 - Serviço de Biblioteca e Documentação Científica


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Cardoso, Divina das Dores de Paula
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Id: biblio-1039195
Autor: Sousa, Teresinha Teixeira de; Almeida, Tâmera Nunes Vieira; Fiaccadori, Fabíola Souza; Souza, Menira; Badr, Kareem Rady; Cardoso, Divina das Dôres de Paula.
Título: Identification of Human Bocavirus type 4 in a child asymptomatic for respiratory tract infection and acute gastroenteritis - Goiânia, Goiás, Brazil
Fonte: Braz. j. infect. dis;21(4):472-476, July-Aug. 2017. graf.
Idioma: en.
Resumo: Abstract Human Bocavirus (HBoV) has been identified from feces and respiratory samples from cases of both acute gastroenteritis and respiratory illness as well as in asymptomatic individuals. The aim of this study was to detect and characterize HBoV from fecal samples collected from hospitalized children aged less than five years old with no symptoms of respiratory tract infection (RTI) or acute gastroenteritis (AGE). The study involved 119 children and one fecal sample was collected from each participant between 2014 and 2015. HBoV was detected using Nested-PCR, and the viral type identified by genomic sequencing. HBoV-4 was identified from one sample obtained from a hospitalized child with soft tissue tumor of the submandibular region. This is the first report of HBoV-4 identification in Brazil, but we consider that this type may be circulating in the country similar to the other types and new investigations are necessary.
Descritores: Infecções Respiratórias/virologia
Infecções por Parvoviridae/virologia
Bocavirus Humano/isolamento & purificação
Gastroenterite/virologia
-Infecções Respiratórias/complicações
Infecções Respiratórias/epidemiologia
Neoplasias de Tecidos Moles/complicações
Brasil/epidemiologia
Neoplasias Mandibulares/complicações
Doença Aguda
Infecções por Parvoviridae/complicações
Infecções por Parvoviridae/epidemiologia
Bocavirus Humano/classificação
Gastroenterite/complicações
Gastroenterite/epidemiologia
Limites: Humanos
Masculino
Feminino
Lactente
Pré-Escolar
Criança
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-835460
Autor: Ghisi, Juan Pablo; Distilo, Leandro.
Título: Instruccion ortopedica de posgrado - IOP - imagenes / Post-graduate orthopedic instruction - images elastofibroma dorsi
Fonte: Rev. Asoc. Argent. Ortop. Traumatol;81(4):321-323, 2016. ilus.
Idioma: es.
Descritores: Fibroma
Neoplasias de Tecidos Moles
Limites: Humanos
Feminino
Idoso
Responsável: AR337.1 - Biblioteca A.A.O.T.


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Id: biblio-1118220
Autor: Rivarola Etcheto, Horacio; Collazo, Cristian; Meninato, Marcos; Cosini, Facundo; Carraro, Juan Martin.
Título: Presentación inusual de hemangioma arteriovenoso trombosado de rodilla: reporte de caso / Unusual thrombosed arteriovenous hemangioma of the knee. Case report
Fonte: Artrosc. (B. Aires);27(2):69-72, 2020.
Idioma: es.
Resumo: Se presenta un caso de presentación inusual de hemangioma arteriovenoso trombosado de rodilla, en un paciente de sexo masculino de 54 años de edad quien consulta por dolor en cara anterior e interlínea interna de rodilla izquierda, y episodios de pseudobloqueos. Sin antecedente traumático previo. Debido a la lesión meniscal interna y la sospecha diagnóstica de tumor de partes blandas de rodilla, se indicó el tratamiento quirúrgico combinado, artroscopía para la resolución de la lesión meniscal interna y, por otro abordaje, biopsia escicional con remoción del tumor de partes blandas.El estudio anatomopatológico confirmó el diagnóstico de hemangioma arteriovenoso trombosado. Tipo de estudio: Reporte de caso. Nivel de evidencia: V

We present an unusual case of thrombosed arteriovenous hemangioma of the knee. A 54-year-old male patient, with pain about de left knee, with previous blocking episodes, without prior traumatic history.Due to the internal meniscus lesion and diagnostic suspicion of soft tissue tumor of the knee. Surgical treatment was considered, both, arthroscopy and mini open surgery.Surgical treatment was performed, arthroscopy and biopsy with removal of the soft tissue tumor. Histopathological findings confirmed the diagnosis of thrombosed arteriovenous hemangioma. Type of study: Case report. Level of evidence: V
Descritores: Neoplasias de Tecidos Moles
Hemangioma Cavernoso/cirurgia
Hemangioma Cavernoso/diagnóstico
Articulação do Joelho/cirurgia
Articulação do Joelho/patologia
Limites: Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: AR337.1 - Biblioteca A.A.O.T.



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