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Id: biblio-975640
Autor: Manuel Ochoa-López, Juan; Gabilondo-Pliego, Bernardo; Collura-Merlier, Sylvain; Herrera-Cáceres, Jaime O; Sotomayor de Zavaleta, Mariano; Rodríguez-Covarrubias, Francisco Tomás; Feria-Bernal, Guillermo; Gabilondo-Navarro, Fernando; Castillejos-Molina, Ricardo Alonso.
Título: Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients
Fonte: Int. braz. j. urol;44(5):874-881, Sept.-Oct. 2018. tab.
Idioma: en.
Resumo: ABSTRACT Purpose: To provide data of the incidence and management of common urological malignancies in renal transplant recipients. Materials and Methods: We conducted a retrospective analysis of a prospective database from August 1967 to August 2015. A descriptive analysis of the sample was performed. Results: Among 1256 consecutive RTR a total of 88 patients developed malignancies (7%). There were 18 genitourinary tumors in the 16 patients (20.45 % of all malignant neoplasms), incidence of 1.27%. The most common neoplasm encounter was renal cancer (38.8%), followed by urothelial carcinoma (33.3%). Median follow-up of transplantation was 197 months (R, 36-336). Mean time from RT to cancer diagnosis 89±70 months (R, 12-276). CsA and AZA was the most common immunosuppression regimen in 68.75%. Mean follow-up after diagnosis was 103±72 months (R 10-215). Recurrence free survival rate of 100%. Overall survival of 89.5% of the sample; there were two non-related cancer deaths during follow-up. Conclusions: The incidence of neoplasms in RTR was lower than in other series, with favorable functional and oncologic results after treatment. This suggests that actions to reduce the risk of these malignancies as well as a strict follow-up are mandatory for an early detection and treatment.
Descritores: Transplante de Rim/efeitos adversos
Neoplasias Urogenitais/terapia
Neoplasias Urogenitais/epidemiologia
-Incidência
Estudos Prospectivos
Estudos Retrospectivos
Transplante de Rim/estatística & dados numéricos
México/epidemiologia
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1134284
Autor: Rodríguez-Covarrubias, Francisco; Castillejos-Molina, Ricardo A; Autrán-Gómez, Ana María.
Título: Summary and considerations in genitourinary cancer patient care during the COVID-19 pandemic
Fonte: Int. braz. j. urol;46(supl.1):98-103, July 2020.
Idioma: en.
Resumo: ABSTRACT Purpose: To provide a summary and recommendations for the set-up of strategies for cancer patients care in genitourinary oncology clinics during the pandemic and in the recovery period. Material and Methods: A non-systematic review of available literature on the management of urological malignancies during the COVID-19 pandemic was performed to summarize recommendations to improve the diagnosis and treatment of urological cancers during and after the contingence, including clinical and research aspects. Results: Urological cancer diagnosis and management should be tailored according to the severity of the COVID-19 crisis in each region and the aggressiveness of each tumor. Clinicians should adhere to strict protocols in order to prioritize the attention of patients with high-risk malignancies while optimizing resources to avoid the saturation of critical care services. Conclusions: During the COVID-19 pandemic urological cancer care has been severely impaired. For proper patient management, multidisciplinary approach is encouraged tailoring therapy according to COVID-19 regional behavior and local institutional resources. Patients with high-risk malignancies should be prioritized.
Descritores: Pneumonia Viral/embriologia
Neoplasias Urogenitais/terapia
Infecções por Coronavirus/epidemiologia
-Pandemias
Betacoronavirus
Assistência ao Paciente
SARS-CoV-2
COVID-19
Oncologia/métodos
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-1131829
Autor: Chand, Momal Tara; Edens, Jacob; Lin, Tayson; Anderson, Ian; Berri, Richard.
Título: Benign multicystic peritoneal mesothelioma: literature review and update
Fonte: Autops. Case Rep;10(3):e2020159, 2020. graf.
Idioma: en.
Resumo: Benign multicystic peritoneal mesothelioma (BMPM) is a rare peritoneal tumor diagnosed predominantly in pre-menopausal women. Associated risk factors include endometriosis and pelvic inflammatory disease in women, and prior abdominal surgery in both genders. To date, the pathogenesis of this disease remains controversial with possible etiologies, including a neoplastic versus a reactive process. Given the risk factors, some authors believe that this disease is secondary to a reactive process. However, because some studies describe cases where there is no prior surgical history or inflammatory milieu present, and because of this entity's predilection for recurrence, some authors believe the origin to be neoplastic. Some genetic and familial associations have also been reported. Malignant transformation is extremely rare, with only two cases reported in the literature, despite the recurrence potential. Like the etiology, the name of this entity is also controversial. Some authors prefer the term "peritoneal inclusion cyst (PCM)" instead of "benign cystic mesothelioma" and argue that the term mesothelioma should only be used when there is evidence of atypia. Most cases of BMPM are discovered incidentally. Others reflect sequela of tumor mass effect. It appears intra-operatively as large, multi-focal, cystic lesions in the peritoneal and pelvic cavity. Diagnosis is achieved through surgical sampling with histopathological examination. Immunobiologically, BMPM exhibits multiple small cystic spaces with flattened lining containing calretinin positive cells without atypical features, mitotic figures, or tissue invasion. Treatment includes cytoreductive surgery. Here we present a case of BMPM in a 60-year-old male - a rare disease in an uncommon patient population.
Descritores: Neoplasias Urogenitais/patologia
Mesotelioma Cístico/patologia
Linfangioma Cístico/patologia
-Asbestos
Fatores de Risco
Limites: Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR26.7 - Serviço de Biblioteca e Documentação Científica


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Id: biblio-1119383
Autor: Daza, Marcial; Betancourt, Carlos; Vásquez, Juan; Lugo, Carlos; Llaque, Guillermo.
Título: Carcinoma urotelial del tracto urinario superior: a propósito de un caso y revisión de la literatura / Upper urinary tract urothelial carcinoma: case report and review of the literature
Fonte: Bol. méd. postgrado;36(1):56-59, jul.2020. ilus.
Idioma: es.
Resumo: El carcinoma urotelial (CU) del tracto urinario superior es infrecuente y representa solo del 5%-10% de todos los CU. Estas neoplasias crecen a partir del urotelio de los cálices renales hasta el tercio distal del uréter. Se reporta el caso de un paciente masculino de 68 años de edad quien presenta enfermedad actual de 3 meses de evolución caracterizada por dolor lumbar izquierdo, tipo cólico, de leve a moderada intensidad, el cual atenúa parcialmente con el uso de AINES, asociado a hematuria visible total de predominio nocturno. El uroanálisis mostró hematuria macroscópica y la citología urinaria evidenció atipias sugerentes de carcinoma. La TAC abdomino-pélvica contrastada evidenció un defecto de llenado en relación al cáliz inferior de riñón izquierdo y plastrón ganglionar paraaórtico izquierdo. Se practicó nefroureterectomía radical izquierda evidenciando tumor de 3 x 3 x 1 cm en relación a pelvis renal extensiva a cáliz inferior invadiendo parénquima renal. El estudio histopatológico mostró un carcinoma urotelial papilar infiltrativo de alto grado con márgenes sin lesiones y ganglios linfáticos con metástasis. El paciente evoluciona satisfactoriamente durante el período postoperatorio y actualmente recibe terapia adyuvante. A pesar de ser una patología poco frecuente, puede presentarse y el urólogo debe estar en capacidad para poder enfrentarla(AU)

Upper urinary tract urothelial carcinoma (UC) is infrequent and represents only 5%-10% of all UCs. These neoplasms grow from the urothelium of renal calyces to the distal third of the ureter. A case of UC of the upper urinary tract is reported in a 68-year-old male patient with a 3-month history of left lumbar mild to moderate pain, which partially mitigates with the use of NSAIDs associated with visible total predominantly nocturnal hematuria. Macroscopic hematuria was evident and urinary cytology reported carcinoma suggestive atypias. Contrasted CT of abdomen and pelvis showed filling defect in relation to lower calyx of the left kidney and left para-aortic ganglion plastron. Radical left nephroureterectomy was performed showing a 3 x 3 x 1 cm tumor in relation to the renal pelvis extending to the lower cavity and invading renal parenchyma. Histopathology showed high grade infiltrative papillary CU with margins without lesions and lymph nodes with metastasis. Patient evolves satisfactorily in the postoperative period and is currently in adjuvant therapy. Although this pathology is rare, it can occur and the urologist must be able to face it(AU)
Descritores: Neoplasias da Bexiga Urinária
Neoplasias Urogenitais
Técnicas de Diagnóstico Urológico
-Tabagismo
Carcinógenos
Urotélio/fisiopatologia
Limites: Humanos
Masculino
Idoso
Tipo de Publ: Relatos de Casos
Responsável: VE1.1 - Biblioteca Humberto Garcia Arocha


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Id: biblio-910951
Autor: Athanazio, DA; Trpkov, K.
Título: What is new in Genitourinary Pathology? Recent developments and highlights of the new 2016 World Health Organization classification of tumors of the urinary system and male genital organs
Fonte: Appl. cancer res;36:1-11, 2016. ilus.
Idioma: en.
Resumo: The recently published 2016 World Health Organization (WHO) Classification of Tumors of the Urinary System and Male Genital Organs stems from the accumulated knowledge and data collected during the last 12 years, since the previous edition of the WHO "blue book" 2004. The major changes in prostate pathology include the introduction of a novel grading system for prostate cancer (Grade Groups/International Society of Urological Pathology (ISUP) grades 1­5), the recognition of intraductal carcinoma as a new entity, and the terminological changes regarding the neuroendocrine prostatic neoplasms. In bladder and urothelial tract, within the spectrum of flat and non-invasive lesions, a newly introduced term "urothelial proliferation of uncertain malignant potential" replaced the term "urothelial hyperplasia", and the term "urothelial dysplasia" was better defined. A category of "invasive urothelial carcinoma with divergent differentiation" was introduced for tumors showing a component of "usual type" urothelial carcinoma combined with other morphologies. A new WHO/ISUP renal tumor grading system was recommended (Grade 1­4). The definition of renal papillary adenoma was modified and expanded to include papillary neoplasms measuring up to 1.5 cm. Several new epithelial renal tumors were recognized as new entities including: hereditary leiomyomatosis and renal cell carcinoma (RCC) syndrome­associated RCC, succinate dehydrogenase­deficient RCC, tubulocystic RCC, acquired cystic disease­associated RCC, and clear cell papillary RCC. In testis pathology, intratubular proliferations of testicular germ cell tumors were renamed as "germ cell neoplasia in-situ" (GCNIS), and the testicular neoplasms were divided into two main groups: derived from or unrelated to GCNIS. A major change in penile pathology was the introduction of a new classification of penile squamous cell carcinoma, based on the presence of human papillomavirus (HPV), which characterizes penile tumor subtypes as HPV-related or non-HPV-related. A similar distinction was introduced for the preneoplastic penile intraepithelial precursor lesion (PeIN) into non-HPV related (differentiated PeIN) and HPV-related types (undifferentiated PeIN). In this review, we provide a summary and highlight the changes in the genitourinary pathology introduced by the 2016 WHO blue book, and we also discuss some recent developments that may impact the practice of genitourinary pathology in the near future (AU)
Descritores: Neoplasias Penianas/classificação
Neoplasias da Próstata/classificação
Neoplasias Testiculares/classificação
Neoplasias da Bexiga Urinária/classificação
Classificações em Saúde
Neoplasias Urogenitais/patologia
Neoplasias Urológicas/classificação
Neoplasias dos Genitais Masculinos/classificação
Neoplasias Renais/classificação
Limites: Humanos
Masculino
Tipo de Publ: Revisão
Responsável: BR30.1 - Biblioteca


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Id: lil-770687
Autor: Arnesi, Nora; Hachuel, Leticia; Prunello, Marcos.
Título: Uso del enfoque bayesiano para la estimación y proyección de tasas / Use of a bayesian approach to rate estimation and projection
Fonte: Rev. panam. salud pública = Pan am. j. public health;38(4):286-291, oct. 2015. ilus.
Idioma: es.
Resumo: OBJETIVO: Aplicar y valorar el enfoque bayesiano para realizar proyecciones de tasas de mortalidad por cáncer a través del ajuste de modelos edad-período-cohorte (EPC). MÉTODOS: El método de estimación bayesiano se aplica a datos de mortalidad por cáncer de vejiga en Argentina. Se adopta un esquema autorregresivo de segundo orden para la especificación a priori de los coeficientes del modelo EPC. Se comparan las estimaciones obtenidas con toda la información disponible y excluyendo los grupos de edad con tasas de mortalidad bajas, a fin de valorar el comportamiento del enfoque ante datos esparcidos. Se proyectan las tasas de mortalidad a dos períodos sucesivos a los observados. RESULTADOS: Se comprueba la robustez del método, lo cual evita excluir los grupos de edad con tasas de mortalidad nulas o bajas. Las tasas observadas caen todas dentro de las bandas de credibilidad y confirman la bondad del ajuste del modelo. Se observa una tendencia general decreciente de las tasas de mortalidad por cáncer de vejiga. Las estimaciones y proyecciones de estas tasas resultan más precisas en los grupos etarios que presentan mayor incidencia de mortalidad. CONCLUSIONES: La formulación bayesiana utilizada permite reducir la variación aleatoria entre estimaciones adyacentes al especificar que los efectos de cada escala dependan de los inmediatos anteriores. Se demuestra la capacidad del enfoque para manejar frecuencias bajas y obtener estimaciones confiables de las tasas de mortalidad, como así también proyecciones precisas sin necesidad de realizar supuestos adicionales como sucede en el ajuste clásico de un modelo EPC.

OBJECTIVE: Apply and assess a Bayesian approach to projecting cancer mortality rates by fitting age-period-cohort (APC) models. METHODS: The Bayesian estimation method was applied to bladder cancer mortality data in Argentina. A second-order autoregressive model was adopted for a priori specification of APC model coefficients. The estimates obtained were compared with all available information and excluding age groups with low mortality, to assess behavior of the approach in light of scattered data. Mortality was projected for two successive periods following the ones observed. RESULTS: Robustness of the method was verified, which avoids excluding age groups with null or low mortality. Observed rates all fall within the credibility bands and confirm the model's goodness of fit. An overall downward trend in bladder cancer mortality was observed. Estimates and projections of these rates are more precise in age groups that have greater incidence of mortality. CONCLUSIONS: The Bayesian formulation used herein makes it possible to reduce random variation between adjacent estimates by specifying that the effects of each scale depend on the immediately preceding ones. It was demonstrated that the approach has the capacity to handle low frequencies and obtain reliable mortality estimates, as well as precise projections, without the need for making additional assumptions, as happens in classical APC model fitting.
Descritores: Métodos Epidemiológicos
Teorema de Bayes
Neoplasias Urogenitais/prevenção & controle
-Argentina
Estatística como Assunto
Responsável: BR1.1 - BIREME


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Id: biblio-987068
Autor: Pàez Coello, Guillermo; Pino Bedón, Marco Antonio; Pérez Pazmiño, Francisco.
Título: Mujeres inmigrantes y tamizaje de cáncer cervical en un centro ginecológico privado de Quito - Ecuador / Immigrant women and cervical cancer screening in a private gynecology center in Quito - Ecuador
Fonte: Metro cienc;25(2):7-18, 2017.
Idioma: es.
Resumo: Objetivo: las mujeres inmigrantes enfrentan problemas para acceder a programas de salud, en relación al tamizaje del cáncer cervical y su prevención. Estudios demuestran que mientras más reciente es la migración (<10 años), es menos probable la realización de exámenes para detectar cáncer cervical. Se plantea la hipótesis de que las mujeres inmigrantes tendrán índices menores de tamizaje de lesiones cervicales causadas por el virus del papiloma humano (HPV) comparadas con las mujeres ecuatorianas. Métodos: se realizó un estudio observacional en 113 mujeres de 17 a 55 años de edad: 56 mujeres inmigrantes/refugiadas y 57 mujeres ecuatorianas Se usó citología cérvico-vaginal y una prueba de detección de ADN del HPV basada en Captura Híbrida II. Las participantes fueron reclutadas mediante selección no probabilística (desde mayo 2014 hasta junio 2015). Las mujeres ecuatorianas fueron incluidas por solicitud voluntaria una vez que recibieron toda la información del proceso; mientras que las mujeres inmigrantes se incluyeron mediante información gráfica y entrevistas, lográndose alianzas entre organizaciones comunitarias dedicadas a ayudarlas y proveedores médicos privados. Resultados: tanto las ecuatorianas (14.15%, n=16) como las inmigrantes (5.3%, n=6) que nunca se realizaron un examen de citología, presentan resultados positivos en el examen de ADN-HPV (alto o bajo riesgo). Las ecuatorianas acceden a la citología cérvico-vaginal, independientemente de su edad, mientas que las mujeres inmigrantes menores de 30 años no han conseguido, hasta el momento del estudio, acceder a este servicio (p < 0.05). Conclusiones: existe una diferencia significativa en los índices de tamizaje de cáncer cervical entre los grupos de inmigrantes /refugiadas y residentes, de acuerdo al lugar de nacimiento y la duración de su estadía en Ecuador.

Objective: immigrant women face health problems and challenges to access health care, no matter what destination country they choose. Regarding cervical cancer screening and prevention, migrant women access to a health care programme is an important issue. Some studies have shown that while migration is recent (under 10 years), is less likely to get cervical cancer examination services comparing with non-immigrant women. The hypothesis stated that immigrant women would have lower rates of screening and a higher prevalence of HPV related lesions, compared to those women from Ecuador. Methods: a 12 months period study was performed including 113 women age 17 to 55, split into two groups: 56 migrant/refugee and 57 Ecuadorian residents, using cervical cytology and a DNA for HPV test based on hybrid capture II. Agreements between community organizations and private providers were reached to help the groups. Results: both groups, Ecuadorian women (14.15%, n=16) and immigrant women (5.3%, n=6) that never had a Papanicolaou test, have HPV-DNA test positive for high and low risk types. Ecuadorian residents have access to cervical cytology regardless their age, while immigrant/refugee women under 30 years have not access to the test, the difference is statistically significant. Conclusions: there is a significant difference in screening levels for cervical cancer between immigrant/refugee women according to place of origin and duration of stay in Ecuador.
Descritores: Neoplasias do Colo do Útero
Colo do Útero
Neoplasias Urogenitais
-Migrantes
Peneiramento de Líquidos
Limites: Humanos
Feminino
Tipo de Publ: Artigo Histórico
Responsável: EC110.1 - Biblioteca


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Id: biblio-948826
Autor: Torres, Bárbara; Pieressa, Nicolás; Reyes, Javiera; Oporto, Sebastián; Coz, Fernando.
Título: Egresos hospitalarios por cáncer urogenital en Chile: cuarta parte / Hospital discharges because of genitourinary cancer in Chile: fourth part
Fonte: Rev. chil. urol;83(3):31-35, 2018. graf.
Idioma: es.
Resumo: RESUMEN El objetivo del presente trabajo es actualizar el análisis de los egresos hospitalarios (EH) por cáncer genitourinario (CGU), específicamente cáncer de próstata, testículo, vejiga y riñón en nuestro país. Para estos efectos se obtuvieron os datos del Boletín de Egresos Hospitalarios del Ministerio de Salud (MINSAL) del año 2010 y 2015, utilizándose los códigos de la clasificación internacional de enfermedades de la Organización Mundial de la Salud (OMS CIE-10). Los distintos diagnósticos fueron caracterizados según su composición geográfica y demográfica, comparándose con la información publicada en los reportes anteriores.(AU)

ABSTRACT The aim of the study is to update the analysis of hospital discharges for genitourinary cancer, specifically prostatic, testicular, bladder and renal cancers in our country. For this purpose, data was obtained from the registers of the Chilean Ministry of Health (MINSAL) for the years 2010 and 2015, using the international classification codes of diseases from the World Health Organization (WHO ICD-10). The different diagnoses were characterized according to their geographic and demographic distribution, comparing them to the information published in the previous reports.(AU)
Descritores: Alta do Paciente
Neoplasias Urogenitais
-Chile
Tipo de Publ: Artigo Clássico
Responsável: CL10.1 - Biblioteca Biomédica


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Id: biblio-836206
Autor: Symington, Banu.
Título: La epidemia silenciosa de cancer asociado a HPV y como prevenirla: Mensajes para los profesionales, pacientes y padres de mi comunidad / The silent epidemic of cancer associated with HPV and how to prevent it: messages for professionals, patients and parents in my community
Fonte: Rev. med. Rosario;82(2):55-57, may.-ago. 2016.
Idioma: es.
Descritores: Infecções por Papillomavirus/prevenção & controle
PAPILLOMAVIRUS HUMANO 1ABDOMINAL NEOPLASMS
PAPILLOMAVIRUS HUMANO ABNORMALITIES, MULTIPLE
-Alphapapillomavirus
Neoplasias do Ânus
Doenças Virais Sexualmente Transmissíveis/prevenção & controle
Doenças Sexualmente Transmissíveis/prevenção & controle
Estados Unidos/epidemiologia
Neoplasias dos Genitais Femininos
Neoplasias dos Genitais Masculinos
Neoplasias Bucais
Vacinas contra Papillomavirus
Neoplasias da Língua
Neoplasias Tonsilares
Neoplasias Urogenitais
Limites: Humanos
Masculino
Feminino
Criança
Responsável: AR16.1 - Biblioteca


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Id: biblio-832357
Autor: Mildner, Natália Machado; Penno, Gilnei Kruger; Frizon, André; Gonzatti, Adriana Gomes da Rocha.
Título: Hemangiopericitoma de Bexiga: relato de uma patologia rara / Hemangiopericytoma of the bladder: report of a rare disease
Fonte: Rev. AMRIGS;60(3):234-236, jul.-set. 2016. ilus.
Idioma: pt.
Resumo: A maioria dos tumores da bexiga é formada por células transicionais. Hemangiopericitoma é um tumor de tecidos moles e apresenta grande variabilidade histológica e ocorrência extremamente rara na bexiga. Neste trabalho é relatado um caso de hemangiopericitoma de bexiga em um paciente de 23 anos. Os achados clínicos e anatomopatológicos deste tumor são discutidos no presente relato, com revisão da literatura(AU)

Most bladder tumors are formed by transitional cells. Hemangiopericytoma is a soft tissue tumor which presents great histologic variability and extremely rare occurrence in the bladder. Here the authors report a case of hemangiopericytoma of the bladder in a 23-year-old patient. The clinical and pathological features of this tumor are discussed in this report with a literature review(AU)
Descritores: Hemangiopericitoma
Bexiga Urinária
Neoplasias Urogenitais
Limites: Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: BR18.1 - Biblioteca FAMED/HCPA



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