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Id: biblio-1054689
Autor: Ossick, Marina Vian; Ferrari, Karen Linares; Nunes-Silva, Igor; Denardi, Fernandes; Reis, Leonardo Oliveira.
Título: Chorioallantoic urothelial tumor avatar. A clinical tool for phenotype-based therapy
Fonte: Acta cir. bras;34(12):e201901207, 2019. graf.
Idioma: en.
Projeto: CNPq; . CAPES.
Resumo: Abstract In the muscle invasive bladder cancer (MIBC) standard of care treatment only patients presenting a major pathological tumor response are more likely to show the established modest 5% absolute survival benefit at 5 years after cisplatin-based neoadjuvant chemotherapy (NAC). To overcome the drawbacks of a blind NAC (i.e. late cystectomy with unnecessary NAC adverse events) with potential to survival improvements, preclinical models of urothelial carcinoma have arisen in this generation as a way to pre-determine drug resistance even before therapy is targeted. The implantation of tumor specimens in the chorioallantoic membrane (MCA) of the chicken embryo results in a high-efficiency graft, thus allowing large-scale studies of patient-derived "tumor avatar". This article discusses a novel approach that exploits cancer multidrug resistance to provide personalized phenotype-based therapy utilizing the MIBC NAC dilemma.
Descritores: Neoplasias da Bexiga Urinária/tratamento farmacológico
Carcinoma/tratamento farmacológico
Urotélio/patologia
Membrana Corioalantoide/patologia
Neoplasias Experimentais/tratamento farmacológico
-Fenótipo
Neoplasias da Bexiga Urinária/patologia
Carcinoma/patologia
Terapia Neoadjuvante
Ilustração Médica
Inoculação de Neoplasia
Neoplasias Experimentais/patologia
Limites: Humanos
Animais
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: lil-575488
Autor: García García, Adolfo; Sala Riveroll, Julio Cesar; Matos Lobaina, Eivis; Pedro Silva, Isis Emérita; Infante Leyva, Reynaldo; Cedeño Yera, Ernesto D.
Título: Resultados de la ileocistoplastia ortotópica en pacientes con tumor vesical / Orthotopic ileocystoplasty results in patient presenting vesical tumor
Fonte: Rev. cuba. cir;49(1), ene.-mar. 2010. tab.
Idioma: es.
Resumo: INTRODUCCIÓN. El cáncer de la vejiga es considerado un problema de salud tanto en Cuba como en el mundo. La cistectomía radical y sus variantes terapéuticas tienen la finalidad de curar o controlar la enfermedad, y conllevan la creación de un reservorio lo más semejante posible a la vejiga, por lo que se trabaja en la creación y perfeccionamiento de neovejigas a partir de un segmentointestinal. El objetivo de esta investigación fue evaluar los resultados de la ileocistoplastia ortotópica como procedimiento derivativo de la orina, después de la cistectomía total. MÉTODOS. Se realizó un estudio descriptivo, retrospectivo y prospectivo de 40 pacientes tratados en el Hospital Hermanos Ameijeiras, en La Habana, entre los años 2000 y 2008. La fuente de información fueron los expedientes clínicos de los pacientes, y los datos se procesaron por medios automatizados. RESULTADOS. La mayor incidencia se encontró en los pacientes con 65 años de edad. La enuresis fue la forma de incontinencia urinaria que predominó y la mayoría de los pacientes tenían micciones voluntarias. Siete pacientes presentaron hidronefrosis y las fístulas del reservorio se relacionaron con la radioterapia. La mortalidad fue del 7,5 por ciento. CONCLUSIONES. La ileocistoplastia ortotópica es un sustituto vesical aceptable en los pacientes con tumores vesicales(AU)

INTRODUCTION: The bladder cancer is considered a health problem in Cuba and worldwide. The aim of radical cystectomy and its therapeutical variants is to cure or control the disease and it is necessary the creation of a reservoir very similar to bladder and nowadays it is working in creation and improvement of the neo-bladders from an intestinal segment. The aim of present research was to assess the orthotopic ileocystoplasty results as urine derivative procedure after total cystectomy. METHODS: A prospective, retrospective and descriptive study was conducted in 40 patients seen in Hermanos Ameijeiras Clinical Surgical Hospital of Ciudad de La Habana between 2000 and 2008. The information's source was the patient clinical expedients and data were processed by automated means. RESULTS: The higher incidence was found inpatients aged 65. Enuresis was the predominant urinary incontinence and most of patients had voluntary urination. Seven patients had hydronephrosis and reservoir fistulae were related to radiotherapy. Mortality rate was of 7,5 percent. CONCLUSIONS: Orthotopic ileocystoplasty is a acceptable vesical substitute in patients presenting with vesical tumors(AU)
Descritores: Cistectomia/métodos
Neoplasias da Bexiga Urinária/cirurgia
-Epidemiologia Descritiva
Estudos Prospectivos
Estudos Retrospectivos
Limites: Humanos
Masculino
Feminino
Idoso
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-837657
Autor: Santos, Alessandra Marques dos; Coelho, Joao Paulo Ferreira; Juanes, Camila de Carvalho; Azevedo, Rafael Barbosa de; Melo, Nayanna de Oliveira Ramos; Jamacaru, Francisco Vagnaldo Fechine; Dornelas, Conceição Aparecida.
Título: Carcinogenesis in rats subjected to a new model ureterosigmoidostomy and treated with L-lysine
Fonte: Acta cir. bras;31(12):793-800, Dec. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To evaluate the effects of L-lysine on the intestinal and urothelial epithelium of rats subjected to ureterosigmoidostomy (new model for surgical carcinogenesis). METHODS: Forty-two rats, 9 weeks of age, were divided into 6 groups. Animals in groups A, B, C were subjected to ureterosigmoidostomy (US) and treated with L-lysine, celecoxib and H2O, respectively. Groups D, E and F (non-operated controls) received L-lysine, celecoxib and H2O, respectively. The L-lysine dose was 150 mg/kg and that of celecoxib was 20 mg/kg. The colon was analyzed for the presence of aberrant crypt foci (ACF) under a stereomicroscope.The tissue was stained with hematoxylin and eosin and PAS alcian blue. RESULTS: There were rare ACF, and there was no statistically significant difference between the groups. Histopathologic study of the ureteral epithelium identified moderate to severe urothelial hyperplasia in rats with ureterosigmoidostomy. Transitional hyperplasia in the ureters of animals receiving L-lysine (A) showed an apparent difference compared to the control (C) (P=0.2424). There was no dysplasia or atypia CONCLUSION: L-lysine does not promote carcinogenesis of the intestinal and urethelial epithelium of rats subjected to ureterosigmoidostomy at the doses and times studied.
Descritores: Colo Sigmoide/cirurgia
Estomas Cirúrgicos
Focos de Criptas Aberrantes/patologia
Carcinogênese
Neoplasias Intestinais/etiologia
Lisina/farmacologia
-Neoplasias da Bexiga Urinária/etiologia
Ureterostomia/métodos
Ratos Wistar
Modelos Animais de Doenças
Estomas Cirúrgicos/efeitos adversos
Mucosa Intestinal/patologia
Limites: Animais
Feminino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-745887
Autor: Calado, Bruno Nagel; Maron, Paulo Eduardo Goulart; Vedovato, Bruno César; Barrese, Tomas Zecchini; Fernandes, Roni de Carvalho; Perez, Marjo Deninson Cardenuto.
Título: Small cell carcinoma of the bladder / Carcinoma de células pequenas de bexiga
Fonte: Einstein (Säo Paulo);13(1):114-116, Jan-Mar/2015. graf.
Idioma: en.
Resumo: Small cell carcinoma of the urinary bladder is an extremely aggressive and rare tumor. Even though small cell carcinoma most commonly arises from the lungs there are several reports of small cell carcinoma in extrapulmonary sites. Due to its low frequency there is no well-established management for this disease. We report the case of a 61 year-old man with small cell carcinoma of the bladder who underwent radical cystectomy following neoadjuvant chemotherapy. We also reviewed the literature for the optimal treatment strategy.

O carcinoma de células pequenas da bexiga urinária é um tumor extremamente agressivo e raro. Apesar desses tumores terem como sítio principal o pulmão, existem diversos relatos de carcinoma de pequenas células extrapulmonares. Pela baixa frequência, ainda não existe um tratamento bem estabelecido para essa neoplasia. Relatamos o caso de um homem de 61 anos de idade com carcinoma de células pequenas da bexiga urinária que foi submetido à quimioterapia neoadjuvante seguida de cistectomia radical. Fazemos ainda revisão na literatura em busca dos métodos de maior sucesso para o tratamento.
Descritores: Neoplasias da Bexiga Urinária/patologia
Carcinoma de Células Pequenas/patologia
-Neoplasias da Bexiga Urinária/cirurgia
Evolução Fatal
Carcinoma de Células Pequenas/cirurgia
Progressão da Doença
Limites: Humanos
Masculino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-1026170
Autor: Azevedo, Marcel Arcanjo Silva; Oliveira, Eduardo Vargas de; Trivilin, Leonardo Oliveira; Nunes, Louisiane de Carvalho.
Título: Lavado vesical de bovinos com hematúria enzoótica: padronização de técnica de colheita, obtenção de amostras e avaliação citopatológica / Bovine urinary bladder washing with enzootic hematuria: standardization of harvesting technique, sample collection and cytopathological evaluation
Fonte: Arq. Inst. Biol;82:1-8, 2015. ilus, tab.
Idioma: pt.
Projeto: Fundação de Amparo à Pesquisa do Estado do Espírito Santo.
Resumo: A hematúria enzoótica bovina é uma doença crônica que causa neoplasias na bexiga, e o exame citopatológico poderia auxiliar no diagnóstico precoce. Objetivou-se padronizar a técnica de colheita, obtenção de amostras e avaliação citopatológica do lavado vesical de bovinos com hematúria enzoótica bovina. Foram utilizadas 10 vacas, adultas, distribuídas em dois grupos. No grupo A foi recuperado todo o líquido vesical infundido, no grupo B foi recuperado apenas o último lavado. Os lavados foram submetidos à avaliação citopatológica. Apesar do volume final de líquido vesical ter sido maior no grupo A, em relação ao número de células, não houve diferença significativa (p > 0,05) entre os grupos. A quantidade de células inflamatórias e células epiteliais obtidas por amostra revelou que nos dois grupos todos os animais apresentavam mais células inflamatórias do que epiteliais, entretanto, não houve diferença entre o tipo de colheita realizada. As células epiteliais foram encontradas em 60% dos casos e as alterações morfológicas observadas foram discretas, não sendo possível classificar nenhuma amostra como hiperplásica ou neoplásica. Os dados deste estudo permitiram concluir que o exame citopatológico do lavado vesical de bovinos pode auxiliar no diagnóstico da hematúria enzoótica bovina e que os dois métodos de colheita empregados mostraram-se adequados para obtenção de amostras viáveis. A avaliação citopatológica permitiu a identificação de lesões não neoplásicas predominantemente inflamatórias. Acredita-se que a utilização de técnicas moleculares com biomarcadores em amostras citológicas seria importante para detectar precocemente lesões pré-neoplásicas ou neoplásicas nesses animais.(AU)

The bovine enzootic hematuria is a chronic disease that causes tumors in the bladder, and the cytophatologic test could assist in the early diagnosis. Aimed to standardize the technique of harvesting, obtaining samples and cytophatologic evaluation of bovine urinary bladder washing with bovine enzootic hematuria, 10 adult cows were divided into two groups: A (all the liquid infused in the bladder was recovered) and B (only the latter liquid was recovered). Liquids recovered were subjected to cytophatological evaluation. It was observed that the final volume of bladder liquid was higher in group A, however, in relation to the number of cells, no significant difference (p > 0.05) was observed between groups. The amount of inflammatory cells and epithelial cells obtained per sample revealed that in both groups all animals had more inflammatory cells than epithelial cells, however, there was no difference between the type of washing done. The epithelial cells were found in 60% of cases, the alterations observed were discretes and it was not possible to classify any sample as hyperplastic or neoplastic. Data from this study showed that the cytophatological examination of bovine urinary bladder washing may aid in the diagnosis of bovine enzootic hematuria and the two harvesting methods employed were adequate for obtaining viable samples. Cytopathological evaluation allowed the identification of non-neoplastic lesions predominantly inflammatory. It is believed that the use of molecular markers in cytological samples is important for early detection of pre-neoplastic or neoplastic lesions in these animals.(AU)
Descritores: Neoplasias da Bexiga Urinária/veterinária
Coleta de Tecidos e Órgãos/veterinária
Hematúria/diagnóstico
-Coleta de Tecidos e Órgãos/métodos
Limites: Animais
Bovinos
Responsável: BR1942.1 - NID - Biblioteca - Núcleo de Informação e Documentação


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Id: biblio-1015726
Autor: Zang, Chongsen; Liu, Zixuan; Yang, Kunmeng; Li, Rui; Wang, Xinxin; Zhang, Jizhou; Xiao, Yechen.
Título: Expression, purification and biological effect of a novel single chain Fv antibody and protamine fusion protein for the targeted delivery of siRNAs to FGFR3 positive cancer cells
Fonte: Electron. j. biotechnol;28:14-19, July. 2017. ilus, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Bio-pharmaceutical grant from Jilin Provincial Science & Technology Department.
Resumo: Background: Gain-of-function of fibroblast growth factor receptor 3 (FGFR3) is involved in the pathogenesis of many tumors. More and more studies have focused on the potential usage of therapeutic single-chain Fv (ScFv) antibodies against FGFR3. RNA interference (RNAi) has been considered as a promising therapeutic method against cancer. A tool which can deliver small interference RNAs (siRNAs) into FGFR3 positive cancer cells is very promising for anti-tumor therapy. Results: In this study, a novel fusion protein R3P, which consists of FGFR3-ScFv and protamine, was generated in Escherichia coli by inclusion body expression strategy and Ni-NTA chromatography. Its yield reached 10 mg per liter of bacterial culture and its purity was shown to be higher than 95%. 1 µg of R3P could efficiently bind to about 2.5 pmol siRNAs and deliver siRNAs into FGFR3 positive RT112 and K562 cells. Annexin V staining results showed that R3P can deliver the amplified breast cancer 1 (AIB1) siRNAs to induce RT112 cell apoptosis. Conclusion: These results indicated that R3P was a promising carrier tool to deliver siRNAs into FGFR3 positive cancer cells and to exert anti-tumor effect.
Descritores: Neoplasias da Bexiga Urinária/metabolismo
Proteínas Recombinantes de Fusão/metabolismo
Anticorpos de Cadeia Única/metabolismo
-Proteínas Recombinantes de Fusão/genética
Protaminas/metabolismo
Corpos de Inclusão
Clonagem Molecular
Apoptose
RNA Interferente Pequeno
Escherichia coli/metabolismo
Receptor Tipo 3 de Fator de Crescimento de Fibroblastos
Anticorpos de Cadeia Única/isolamento & purificação
Anticorpos de Cadeia Única/genética
Citometria de Fluxo
Responsável: CL1.1 - Biblioteca Central


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Lucón, Antonio Marmo
Id: lil-28698
Autor: Lucón, Antonio Marmo; Wroclawski, Eric Roger; Góes, Gilberto Menezes de.
Título: Tabagismo e câncer de bexiga / Smoking and bladder cancer
Fonte: In: Gama Rodrigues, Joaquim; Cordeiro, Anói Castro; Habr Gama, Angelita; Szego, Thomas; Bechara, Milton Jacob; Sousa Júnior, Afonso Henrique da Silva e. Fumo ou saúde. s.l, BRADEPCA, 1985. p.256-256, tab.
Idioma: pt.
Descritores: Tabaco
Neoplasias da Bexiga Urinária/etiologia
-Triptofano/metabolismo
Neoplasias da Bexiga Urinária/metabolismo
Limites: Humanos
Responsável: BR1.1 - BIREME
BR1.1/1162.15; BR67.1; 614.58*54; BR440.1; 616994865*F976


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Id: biblio-987929
Autor: Favre, Gabriel; González, Matías; Zubieta, Ercilia; Jaunarena, Jorge; Tejerizo, Juan.
Título: Resultados oncológicos en pacientes con cáncer de vejiga pT0 posterior a cistectomía radical / Oncological outcomes of Patients with pT0 Bladder Cancer after Radical Cystectomy
Fonte: Rev. argent. urol. (1990);83(4):145-149, 2018. tab, ilus.
Idioma: es.
Resumo: Introducción: El estadío pT0 del cáncer de vejiga implica la ausencia de enfermedad en la pieza de cistectomía radical (CR). El objetivo de este estudio es describir los resultados oncológicos de los pacientes con estadío pT0 posterior a CR por carcinoma urotelial de vejiga. Materiales y métodos: Estudio retrospectivo de pacientes sometidos a CR por cáncer de vejiga, en una sola institución, sin neoadyuvancia, entre junio de 2005 y julio de 2013. Se incluyeron aquellos pacientes con diagnóstico histológico de estadío pT0 pN0. Se estimó la sobrevida global, sobrevida cáncer-específica y sobrevida libre de recidiva con el método de Kaplan-Meier. Resultados: De 254 pacientes cistectomizados, 17 presentaron estadío pT0 pN0 (6,7%). La mediana de edad fue 67 años (rango 49-85), 15 pacientes fueron hombres (88%). Los resultados patológicos posterior a resección transuretral de vejiga (RTUv) fueron 17% pT1 (n=3) y 83% pT2 (n=14). La mediana de tiempo entre RTUv y CR fue 60 días (rango 30- 95). Al 41% se le realizó derivación urinaria tipo Bricker y al 59%, una neovejiga. La mediana de estadía hospitalaria fue 8 días (rango 6-44). Se evidenció adenocarcinoma de próstata en 4 pacientes. La mediana de ganglios resecados fue 6 (rango 2-17). Ningún paciente recibió adyuvancia. La mediana de seguimiento fue 69 meses (rango 5-120). Un paciente presentó recidiva uretral a los 72 meses de la CR. La sobrevida cáncer-específica fue 100%, la sobrevida libre de recaída a 5 años fue 83,3% (intervalo de confianza [IC] de 95%: 53,5-100) y la sobrevida global a 5 años fue 82,4% (IC 95%: 64,7-100). Conclusión: El estadío pT0 del cáncer de vejiga presenta resultados oncológicos más favorables que los estadíos más avanzados. Sin embargo, la posibilidad de recurrencia existe, por lo que no se debe discontinuar el seguimiento de estos pacientes (AU)

Introduction: There are cases in which there is no evidence of disease in the radical cystectomy (RC) specimen (pT0 stage). The purpose of this study is to evaluate oncological outcomes of patients with pT0 bladder cancer after RC, in a single institution, without neo-adjuvant therapy. Materials and methods: Patients who underwent radical cystectomy from June 2005 to July 2013 were reviewed retrospectively. All patients had history of bladder urothelial carcinoma, treated with transurethral resection of the bladder (TURB) and confirmed with pathological analysis. Study variables included TURB pathology, time to RC, and pathologic features. Overall survival (OS), cancer-specific survival (CSS) and recurrence-free survival (RFS) were estimated. Results: RC was performed on 254 patients; 17 patients (6.7%) had pT0N0 stage. Median age was 67 years (range 49-85 years); 15 patients were male (88%). TURB pathology specimens were 17% pT1 (n=3), and 83% pT2 (n=14). Median time between TURB and RC was 60 days (range 30-95). Seven patients (41%) received an ileal conduit, and ten patients (59%) received a neobladder. Median hospital stay was eight days (range 6-44). Prostate adenocarcinoma was found in four (23%) patients. Median resected lymph nodes were six (range 2-17). No patients received adjuvant chemotherapy. Median follow-up was 69 months (range 5-120 months). One patient had a urethral relapse 72 months after RC. There was no cancer-specific mortality. RFS at 5 years was 83.3% (confidence interval [CI] 95%: 53.5-100); OS at 5 years was 82.4% (CI 95%: 64.7-100). Conclusion: pT0 stage after radical cystectomy shows more favorable oncologic outcomes than higher stages. However, cancer recurrence was found in a low number of patients, thus, patient follow-up should be maintained (AU)
Descritores: Neoplasias da Bexiga Urinária/cirurgia
Carcinoma de Células de Transição/cirurgia
Cistectomia
Taxa de Sobrevida
Resultado do Tratamento
-Neoplasias da Bexiga Urinária/patologia
Estudos Retrospectivos
Limites: Humanos
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: AR305.1 - SID - Servicio de Información y Documentación


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Lopes, Ademar
Id: lil-180308
Autor: Fonseca, Francisco Paulo da; Lopes, Ademar.
Título: Câncer invasico da bexiga / Invasive bladder neoplasms
Fonte: In: Fundaçäo Antonio Prudente. Hospital A. C. Camargo. Manual de condutas diagnósticas e terapêuticas em oncologia. Säo Paulo, Ambito Editores, 1996. p.446-446.
Idioma: pt.
Descritores: Neoplasias da Bexiga Urinária/cirurgia
Neoplasias da Bexiga Urinária/diagnóstico
-Cistectomia
Limites: Humanos
Responsável: BR1.1 - BIREME
BR1.1/2734.63; BR75.1; 616-006, M319. 3053


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Lopes, Ademar
Id: lil-180307
Autor: Fonseca, Francisco Paulo da; Melarato Junior, Walter Antonio; Lopes, Ademar.
Título: Câncer da bexiga superficial / Surface bladder neoplasms
Fonte: In: Fundaçäo Antonio Prudente. Hospital A. C. Camargo. Manual de condutas diagnósticas e terapêuticas em oncologia. Säo Paulo, Ambito Editores, 1996. p.441-441.
Idioma: pt.
Descritores: Neoplasias da Bexiga Urinária/cirurgia
Neoplasias da Bexiga Urinária/diagnóstico
-Recidiva
Prognóstico
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME
BR1.1/2734.62; BR75.1; 616-006, M319. 3053



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