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Id: biblio-1001084
Autor: Li, Ou; Yi, Weimin; Yang, Pingzhou; Guo, Chao; Peng, Chuang.
Título: Relationship between serum MMP-9 level and prognosis after radical resection for Hilar cholangiocarcinoma patients
Fonte: Acta cir. bras;34(4):e201900409, 2019. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To analyze the preoperative serum matrix metalloproteinase-9 (MMP-9) levels and prognosis of patients with hilar cholangiocarcinoma (HC) undergoing radical resection. Methods: Preoperative serum MMP-9 levels in patients with HC undergoing radical resection were detected by enzyme-linked immunosorbent assay (ELISA). The ROC curve assay was used to analyze the preoperative serum MMP-9 level to determine the most valuable cut-off point. The relationship between MMP-9 and clinicopathological features of HC patients was analyzed. Kaplan-Meier method was used to analyze the prognostic factors, and COX regression model was used to analyze the independent risk factors affecting prognosis. Results: Preoperative serum MMP-9 levels were significantly elevated in the death patients compared with the survival patients. The most valuable cut-off point for preoperative serum MMP-9 for prognosis was 201.93 ng/mL. Preoperative serum MMP-9 was associated with Bismuth-Corlette classification) and lymph node metastasis. Kaplan-Meier analysis showed that MMP-9, Bismuth-Corlette classification, Lymph node metastasis, Portal vein invasion, Hepatic artery invasion, Liver invasion, Incised margin, and Preoperative biliary drainage were related to prognosis. Cox regression model confirmed that hepatic artery invasion, liver invasion, incised margin, and MMP-9 have the potential to independence predicate prognosis in HC patients. Conclusion: Preoperative serum MMP-9 has high predictive value for prognosis and is an independent influencing factor for the prognosis of patients with hilar cholangiocarcinoma.
Descritores: Neoplasias dos Ductos Biliares/cirurgia
Neoplasias dos Ductos Biliares/sangue
Tumor de Klatskin/cirurgia
Tumor de Klatskin/sangue
Metaloproteinase 9 da Matriz/sangue
-Período Pós-Operatório
Prognóstico
Valores de Referência
Fatores de Tempo
Neoplasias dos Ductos Biliares/mortalidade
Neoplasias dos Ductos Biliares/patologia
Ensaio de Imunoadsorção Enzimática
Análise Multivariada
Fatores de Risco
Curva ROC
Tumor de Klatskin/mortalidade
Tumor de Klatskin/patologia
Estimativa de Kaplan-Meier
Período Pré-Operatório
Invasividade Neoplásica
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-949874
Autor: Ocanha-Xavier, Juliana Polizel; Xavier-Junior, José Cândido Caldeira; Marques, Mariângela Esther Alencar.
Título: Melanoma: clinical, evolutive and histopathological characteristics of a series of 136 cases
Fonte: An. bras. dermatol;93(3):373-376, May-June 2018. tab, graf.
Idioma: en.
Resumo: Abstract: BACKGROUND: The incidence of melanoma has been increasing in Brazil and all over the world. Despite improvements in diagnosis and treatment, mortality remains unchanged. OBJECTIVE: To associate clinical and histopathological aspects with the evolution of 136 cases of cutaneous melanoma. METHODS: Retrospective cohort study that analyzed all patients diagnosed with melanoma during the period from 2003 to 2011, with at least 4 years follow up. Archived slides were analyzed to study histopathological variables (Breslow, ulceration, mitoses and histological regression). Medical records were used to retrieve clinical variables (age, sex, localization, time of appearance, diameter) and progression (metastases or death). Association measures were assessed by statistical analysis. RESULTS: There was no statistically significant difference between groups according to age. Superficial spreading subtype showed lower Breslow (0.5mm) than acral lentiginous and nodular subtypes (2 and 4.6mm respectively), less ulceration and metastases (9.4% against 50 and 70.6%). Nodular subtype had higher mitoses' median (5.0/mm2) than superficial spreading and lentigo maligna (0.0/mm2, for both). Regression was more frequent in superficial spreading and lentigo maligna subtypes. There were only deaths by melanoma in the acral group, however, there were deaths for other reasons in groups superficial spreading one, acral lentiginous one and lentigo maligna two. STUDY LIMITATIONS: Use of medical records as a source of data to the study. CONCLUSIONS: Superficial spreading subtype presents better prognosis indicators. Histological subtype should be considered in follow-up and treatment protocols of patients with cutaneous melanoma.
Descritores: Neoplasias Cutâneas/patologia
Sarda Melanótica de Hutchinson/patologia
Melanoma/patologia
-Prognóstico
Neoplasias Cutâneas/mortalidade
Brasil/epidemiologia
Taxa de Sobrevida
Estudos Retrospectivos
Seguimentos
Sarda Melanótica de Hutchinson/mortalidade
Melanoma/mortalidade
Invasividade Neoplásica/patologia
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


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Texto completo SciELO Cuba
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Id: lil-584335
Autor: García Rodríguez, Miguel Emilio.
Título: Estadificación y valoración mediastínica del cáncer del pulmón / Staging and mediastinal assessment of lung cancer
Fonte: Rev. cuba. cir;49(4):82-93, oct.-dic. 2010.
Idioma: es.
Resumo: El cáncer de pulmón se considera la más letal de las neoplasias, tanto en los hombres como en las mujeres, y supera la suma de todas las muertes por cáncer de colon, próstata y mama. En el momento del diagnóstico más del 40 por ciento de los pacientes tienen una enfermedad localmente avanzada, en la que las posibilidades de curación son escasas y la supervivencia a los 5 años es de apenas un 15 por ciento. La estadificación de la enfermedad, así como la valoración mediastínica es crucial para realizar un tratamiento correcto, establecer pronósticos y realizar investigaciones que conlleven a una conducta adecuada ante estos pacientes. Con el objetivo de actualizar el tema se realizó una revisión en varias bases de datos en inglés: Pubmed, Medline y Ebsco, utilizando las palabras clave: lung cancer staging, mediastinal lymphonode excision y lung carcinoma(AU)

The lung cancer is considered the most lethal of neoplasias both in men and women and it is the highest figure of all death by colon, prostate and breast deaths. At diagnosis more than the 40 percent of patients have a locally advanced disease with scarce possibilities of cure and the 5-years survival is hardly of a 15 percent. Disease's staging as well as the mediastinal assessment is crucial to a proper diagnosis, to establish prognoses and the carry out researches leading to a appropriate behavior in these cases. The objective of present paper was to update on this subject authors made search in some databases in English language: Pubmed, Medline and Ebsco, using lung cancer staging, mediastinal lymphonode excision and lung carcinoma as key words(AU)
Descritores: Estadiamento de Neoplasias/métodos
Neoplasias Pulmonares/patologia
Neoplasias do Mediastino/secundário
-Invasividade Neoplásica
Limites: Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: lil-621516
Autor: Gullo, Caio Eduardo; Dami, Anna Luiza Tannús; Barbosa, Amanda Pires; Marques, Aline Maria de Vita; Palmejani, Marianna Angelo; Lima, Luiz Guilherme Cernaglia Aureliano de; Bonilha, Jane Lopes.
Título: Results of a control quality strategy in cervical cytology / Resultados de uma estratégia de controle de qualidade em colpocitologia
Fonte: Einstein (Säo Paulo);10(1):86-91, jan.-mar. 2012. ilus, tab.
Idioma: en; pt.
Resumo: Objective: To determine the efficacy of a quality control strategy in cervical cytology in the detection of high-grade squamous intraepithelial lesions. Methods: Forty-two patients were selected who underwent a Pap smear and cervical uterine biopsy between April 2008 and December 2009, with evidence of a high-grade squamous intraepithelial lesion in one or both tests. The statistical parameters of the smear test were calculated before and after systematic meetings for review of the archived test results (6 years), in which the following was done: interobserver diagnostic consensus; cytohistological correlation, with the latter as gold standard; and evaluation of the therapeutic status of each patient. Results: Once these controls were applied, it was noted that sensitivity and positive likelihood ratio of the test for high-grade squamous intraepithelial lesion increased 9.5% (34.5 to 44%) and 0.45% (1.64 to 2.09%), respectively, while specificity remained at 79%. Reduction in interference of false-negative results associated with errors in the analytical phase of the cytological productive process gave an estimate of failures in collection of the specimens (pre-analytical phase). Conclusion: In addition to improving the performance of the cytological diagnosis of the high-grade squamous intraepithelial lesion, the proposed quality control strategy allows a reflection on the causes of incorrect or conflicting scrutiny.

Objetivo: Determinar a eficácia de uma estratégia de controle de qualidade em colpocitologia na detecção da lesão intraepitelial escamosa de alto grau. Métodos: Foram selecionadas 42 pacientes que realizaram Papanicolaou e biópsia cervicouterina entre abril de 2008 e dezembro de 2009, com evidência de lesão intraepitelial escamosa de alto grau em um ou em ambos os exames. Os parâmetros estatísticos do esfregaço foram calculados antes e após reuniões sistematizadas de revisão dos exames arquivados (6 anos), nas quais se procedeu a: consensualização diagnóstica interobservadores; correlação cito-histológica, sendo a última padrão-ouro; e avaliação do status terapêutico de cada paciente. Resultados: Aplicados tais controles, observou-se que a sensibilidade e a likelihood ratio positiva do teste para lesão intraepitelial escamosa de alto grau aumentaram 9,5% (34,5 para 44%) e 0,45% (1,64 para 2,09%), respectivamente, enquanto sua especificidade se manteve em 79%. A redução da interferência dos falso-negativos associados a erros na fase analítica do processo produtivo citológico traz estimativa das falhas de coleta do material (fase pré-analítica). Conclusão: Além de melhorar o desempenho do diagnóstico colpocitológico de lesão intraepitelial escamosa de alto grau, a estratégia de controle de qualidade proposta permite refletir sobre as causas de escrutínio incorreto ou discordante.
Descritores: Biópsia
Carcinoma de Células Escamosas/patologia
Neoplasia Intraepitelial Cervical/patologia
Colo do Útero/patologia
Garantia da Qualidade dos Cuidados de Saúde
Neoplasias do Colo do Útero/patologia
Esfregaço Vaginal
-Algoritmos
Biópsia/normas
Biópsia/estatística & dados numéricos
Carcinoma de Células Escamosas/diagnóstico
Neoplasia Intraepitelial Cervical/diagnóstico
Estudos Transversais
Reações Falso-Negativas
Reações Falso-Positivas
Invasividade Neoplásica
Valor Preditivo dos Testes
Controle de Qualidade
Sensibilidade e Especificidade
Neoplasias do Colo do Útero/diagnóstico
Esfregaço Vaginal/normas
Esfregaço Vaginal/estatística & dados numéricos
Limites: Humanos
Feminino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Saúde Pública
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Id: lil-423257
Autor: Tirado-Gómez, Laura Leticia; Mohar-Betancourt, Alejandro; López-Cervantes, Malaquías; García-Carrancá, Alejandro; Franco-Marina, Francisco; Borges, Guilherme.
Título: Factores de riesgo de cáncer cervicouterino invasor en mujeres mexicanas / Risk factors in invasive cervical cancer among Mexican women
Fonte: Salud pública Méx;47(5):342-350, sept.-oct. 2005. tab.
Idioma: es.
Projeto: CONACyT. 26198-M.
Resumo: OBJETIVOS: Evaluar la asociación entre cáncer cervicouterino (CaCu) invasor y el virus del papiloma humano de alto riesgo (VPH-AR) (carga viral/tipo 16), así como con factores ginecológicos y socioeconómicos. MATERIAL Y MÉTODOS: Estudio de casos y controles pareado individualmente (215 casos con CaCu invasor y 420 controles). La población de estudio se reclutó entre los años 2000 y 2001. Se evaluaron variables tradicionalmente asociadas con CaCu (ginecológicas y socioeconómicas) y dos variables asociadas con la presencia de VPH (carga viral y el tipo 16). La presencia de VPH-AR se determinó mediante Captura de Híbridos II. La carga viral se midió a través de unidades relativas de luz y picogramos por ml (1 RLU=1 pg/ml), divididas en cuatro categorías: negativa (<1 pg/ml), baja carga viral (1-49 pg/ml), carga viral intermedia (50-499 pg/ml) y alta carga viral (>499 pg/ml). El análisis estimó razones de momios (RM) ajustadas a través de modelos de regresión logística condicionada. RESULTADOS: La presencia de VPH-AR incrementa en 78 veces la probabilidad de presentar CaCu invasor; cuando el VPH es tipo 16, el incremento es mayor (RM= 429.7) comparado con otros tipos (RM=64.1). Se observó una tendencia importante en la RM al elevarse la carga viral (RM=46.6 carga baja; RM=250.7 intermedia y RM=612.9 alta). Finalmente, los factores demográficos y obstétricos conocidos, incrementaron la probabilidad de CaCu invasor. No se observó asociación entre CaCu invasor y tabaquismo en la población de estudio. CONCLUSIONES: Este estudio contribuye a la identificación de las mujeres con alto riesgo de desarrollar CaCu invasor, entre las pacientes infectadas con VPH-AR. Por otra parte, confirma la importancia de la infección de VPH-AR y refleja la carga viral del VPH-AR como cofactor y posible promotor en el desarrollo de la enfermedad. Por último, este biomarcador puede contribuir a mejorar la prevención y la detección temprana de esta enfermedad.
Descritores: Papillomaviridae/isolamento & purificação
Infecções por Papillomavirus/complicações
Neoplasias do Colo do Útero/complicações
Neoplasias do Colo do Útero/virologia
Carga Viral
-Estudos de Casos e Controles
México
Invasividade Neoplásica
Fatores de Risco
Neoplasias do Colo do Útero/patologia
Limites: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Humanos
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-728291
Autor: Díaz-Peña, Roberto; Castro-Santos, Patricia.
Título: Histological changes implicated in metastasis / Cambios histológicos implicados en metástasis
Fonte: Int. j. morphol;32(3):935-941, Sept. 2014. ilus.
Idioma: en.
Projeto: Universidad Autónoma de Chile.
Resumo: The process of malignancy emergence is associated with the acquisition of the capacity to invade other tissues. Several different biological processes have been described as involved in this process. Specifically, epithelial mesenchymal transition (EMT), a mechanism associated with embryogenesis and wound repair but also with mobility acquisition, is one of the concerned processes. In EMT an epithelial cell loses its epithelial characteristics, its junctions with neighbor cells and with the basal lamina and acquires mobility and mesenchymal characteristics. Also, factors of the tumor microenvironment have been described as involved. Tumor presence triggers a response in the surrounding tissue known as reactive stromal. It shows particular characteristics similar to those found in wound healing stroma: an increase of the fibroblast number and enhancing of the capillary density. The notable difference is the chronicity in the tumoral process. Of a high relevance seems to be the role of activated macrophages with a characteristic phenotype. Finally, cancer associated fibroblasts (CAF) are a type of cells found in tumors, developed from local tissue or possibly from bone marrow. CAF characteristically show a distinct morphology and secrete a high number of metalloproteases allowing tumoral cells advance through the tissue. Additionally, CAF have a direct effect on the survival of the epithelial cells. The three processes are interrelated and metastasis is probably caused by the effect of all of them and probably by other additional factors.

El desarrollo de malignidad está asociado con la adquisición de la capacidad de invadir otros tejidos. Varios procesos diferentes han sido asociados con la aparición de metástasis. Concretamente, la transición epitelio mesénquima (TEM), un mecanismo asociado con embriogénesis y reparación de heridas pero también con adquisición de movilidad, es uno de ellos. En la TEM, una célula epitelial pierde sus características epiteliales, sus uniones con las células vecinas y con la lámina basal y adquiere movilidad y características mesenquemáticas. También han sido asociados factores del microambiente del tumor. La presencia del tumor produce una respuesta en el tejido que lo rodea descrito como estroma reactivo. Sus características son similares a las del estroma de las heridas en proceso de curación: un incremento del número de fibroblastos y un aumento de la densidad de capilares. La gran diferencia es la cronicidad del proceso tumoral. De gran relevancia es el papel de los macrófagos activados que muestran un fenotipo característico. Finalmente, los fibroblastos asociados a cáncer (FAC) son un tipo de células encontradas en tumores, que se desarrollan a partir del tejido local o quizá de la médula ósea. Los FAC, de modo característico muestran una morfología diferente y secretan una gran cantidad de metaloproteasas permitiendo a la célula tumoral avanzar a través del tejido. Además, los FAC ejercen un efecto directo sobre la supervivencia de las células epiteliales. Los tres procesos están interrelacionados y la metástasis es causada probablemente por el efecto de todos ellos y probablemente por otros factores adicionales.
Descritores: Células Epiteliais/patologia
Fibroblastos Associados a Câncer/patologia
Metástase Neoplásica/patologia
-Transição Epitelial-Mesenquimal
Invasividade Neoplásica
Neoplasias/patologia
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
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Id: biblio-889068
Autor: Jiao, Yang; Wu, Yan; Du, Dong.
Título: Polydatin inhibits cell proliferation, invasion and migration, and induces cell apoptosis in hepatocellular carcinoma
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(4):e6867, 2018. graf.
Idioma: en.
Projeto: Innovative Research Program; . Science and Technology Program.
Resumo: Polydatin, a small molecule from Polygonum cuspidatum, has many biological functions, particularly anti-cancer effects. However, the anti-cancer effects of polydatin in hepatocellular carcinoma (HCC) have not been examined yet. In the present study, MTT assay, BrdU assay, transwell invasion assay, and wound healing assay were performed to determine cell proliferation, invasion and migration. Flow cytometry and TUNEL assay were used to measure cell apoptosis. Quantitative real-time PCR and western blotting assays were used to determine mRNA and protein expression levels. Xenograft experiment was performed to determine the in vivo anti-tumor effect of polydatin. Immunostaining was performed to analyze the expression of caspase-3 and Ki-67. Our results showed that polydatin inhibited cell proliferation in a concentration-dependent and time-dependent manner in the HCC cell lines. Polydatin also induced cell apoptosis in a concentration-dependent manner possibly via increasing the caspase-3 activity, and up-regulating the protein expression of caspase-3, caspase-9, Bax, and down-regulating the protein expression of Bcl-2. In addition, polydatin treatment had an inhibitory effect on cell proliferation, invasion and migration in HCC cell lines. Polydatin treatment also suppressed the Wnt/beta-catenin signaling activities in HCC cells. Polydatin treatment significantly reduced tumor growth in nude mice inoculated with HepG2 cells, suppressed the expression of Ki-67, and increased caspase-3 expression and TUNEL activity. Our data indicated the important role of polydatin for the suppression of HCC progression.
Descritores: Estilbenos/farmacologia
Movimento Celular/efeitos dos fármacos
Apoptose/efeitos dos fármacos
Carcinoma Hepatocelular/tratamento farmacológico
Proliferação de Células/efeitos dos fármacos
Glucosídeos/farmacologia
Neoplasias Hepáticas Experimentais/tratamento farmacológico
-Medicamentos de Ervas Chinesas
Western Blotting
Carcinoma Hepatocelular/patologia
Linhagem Celular Tumoral
Reação em Cadeia da Polimerase em Tempo Real
Citometria de Fluxo
Neoplasias Hepáticas Experimentais/patologia
Camundongos Endogâmicos BALB C
Camundongos Nus
Invasividade Neoplásica
Limites: Animais
Masculino
Camundongos
Responsável: BR1.1 - BIREME


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Id: biblio-1022495
Autor: Zhao, Hu; Zhang, Xueqin.
Título: Enhanced apoptosis and inhibition of gastric cancer cell invasion following treatment with LDH@Au loaded Doxorubicin
Fonte: Electron. j. biotechnol;32:13-18, Mar. 2018. ilus, graf.
Idioma: en.
Resumo: Background: The suppression of cancer cell growth and invasion has become a challenging clinical issue. In this study, we used nanotechnology to create a new drug delivery system to enhance the efficacy of existing drugs. We developed layered double hydroxide by combing Au nanosol (LDH@Au) and characterized the compound to prove its function as a drug delivery agent. The anti-cancer drug Doxorubicin was loaded into the new drug carrier to assess its quality. We used a combination of apoptosis assays, cell cycle assays, tissue distribution studies, cell endocytosis, transwell invasion assays, and immunoblotting to evaluate the characteristics of LDH@Au as a drug delivery system. Results: Our results show that the LDH@Au-Dox treatment significantly increased cancer cell apoptosis and inhibited cell invasion compared to the control Dox group. Additionally, our data indicate that LDH@Au-Dox has a better target efficiency at the tumor site and improved the following: cellular uptake, anti-angiogenesis action, changes in the cell cycle, and increased caspase pathway activation. Conclusions: Our findings suggest the nano drug is a promising anti-cancer agent and has potential clinical applications.
Descritores: Neoplasias Gástricas/tratamento farmacológico
Doxorrubicina/administração & dosagem
Apoptose/efeitos dos fármacos
Nanopartículas/administração & dosagem
Antibióticos Antineoplásicos/administração & dosagem
-Doxorrubicina/farmacologia
Ciclo Celular/efeitos dos fármacos
Western Blotting
Sistemas de Liberação de Medicamentos
Nanotecnologia
Linhagem Celular Tumoral
Microscopia Eletrônica de Transmissão
Proliferação de Células/efeitos dos fármacos
Endocitose/efeitos dos fármacos
Hidróxidos
Antibióticos Antineoplásicos/farmacologia
Invasividade Neoplásica/prevenção & controle
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-987907
Autor: Samaniego, Aldo; Bartomeu, Enzo; Fernández, Enrique; Villalba, Luis; Ávila, Pedro.
Título: Caracterización de pacientes tratados por cáncer de pene, con invasión de ganglios locorregionales en el Servicio de Urología del HCIPS de Asunción del Paraguay / Characterization of Patients treated for Penile Cancer with Locoregional Nodes Invasion in HCIPS Urology Unit, Asunción del Paraguay
Fonte: Rev. argent. urol. (1990);83(4):138-144, 2018. graf.
Idioma: es.
Resumo: Introducción: El cáncer de pene tiene una alta incidencia en Latinoamérica, siendo el carcinoma epidermoide el tipo histológico más frecuente. También es sabido que el cáncer de pene suele presentar diseminación a los ganglios linfáticos inguinales, antes de la progresión a la enfermedad metastásica. Objetivo: Caracterizar a los pacientes tratados por cáncer de pene con invasión locorregional en el Servicio de Urología del Hospital Central del Instituto de Previsión Social (HCIPS) de Asunción del Paraguay. Materiales y métodos: Se realizó un estudio retrospectivo, de pacientes tratados con cáncer de pene con invasión locorregional entre los años 2014 y 2017. Se analizaron las siguientes variables: estadificación, tratamientos empleados según la clasificación y complicaciones. Resultados: Los 18 pacientes tratados por cáncer de pene con invasión locorregional fueron adultos mayores, con una edad media de 78,5 años. El tipo de intervención más frecuente fue la linfadenectomía inguinal bilateral (44%). Solo cuatro pacientes fueron sometidos simultáneamente a penectomía y linfadenectomía. Las complicaciones posoperatorias se presentaron en 8 casos (44%), siendo el linfedema la más frecuente. Conclusiones: Los factores pronósticos adversos más importantes son la presencia de adenopatías, el estadío clínico al diagnóstico y el grado de diferenciación celular. El tratamiento más eficaz del cáncer de pene es quirúrgico, reservando la quimioterapia y la radioterapia para adyuvancia o terapia de rescate, siendo las complicaciones más graves, mientras más radical sea la cirugía.(AU)

Introduction: Penile cancer has a high incidence in Latin America, with squamous cell carcinoma being the most frequent histological type. It is also known that penile cancer has a spread to the inguinal lymph nodes, before the progression to metastatic disease. Objective: Characterize the patients treated for penile cancer with locoregional invasion in the Urology Service of the Hospital Central del Instituto de Previsión Social (HCIPS), Asunción of Paraguay. Materials and methods: A retrospective study was conducted of patients treated with penile cancer with locoregional invasion between 2014 and 2017. The following variables were analyzed: staging, treatments used according to the classification and complications. Results: The 18 patients treated for penile cancer with locoregional invasion were older adults, with an average age of 78.5 years. The most frequent type of intervention was the bilateral ilioinguinal (44%). Only four patients were subjected simultaneously to penectomy and lymphadenectomy. Postoperative complications occurred in 8 cases (44%), lymphedema being the most frequent. Conclusions: The most important adverse prognostic factors are the presence of adenopathies, the clinical stage at diagnosis and the degree of cell differentiation. The most effective treatment of penile cancer is surgical, reserving chemotherapy and radiotherapy for adjuvance or rescue therapy, being the complications more serious, the more radical the surgery is.(AU)
Descritores: Neoplasias Penianas/cirurgia
Neoplasias Penianas/complicações
Neoplasias Penianas/diagnóstico
Neoplasias Penianas/epidemiologia
Excisão de Linfonodo
Linfonodos/cirurgia
-Estudos Transversais
Estudos Retrospectivos
Estudo Observacional
Canal Inguinal
Linfonodos/patologia
Invasividade Neoplásica
Estadiamento de Neoplasias
Limites: Humanos
Masculino
Pessoa de Meia-Idade
Idoso
Tipo de Publ: Estudo Observacional
Responsável: AR305.1 - SID - Servicio de Información y Documentación


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Id: biblio-878015
Autor: Chilatra Fonseca, José Mauricio; Morales Camacho, William Javier; Plata Ortiz, Jessica Estefanía; Gómez Mancilla, Yisela Patricia; Villabona Rosales, Sergio Alberto.
Título: Derrame pericárdico maligno secundario a adenocarcinoma de pulmón: Reporte de caso / Malignant Pericardial Effusion Secondary to Lung Adenocarcinoma: Case Report
Fonte: MedUNAB;20(1):63-69, 2017. tab, graf.
Idioma: en.
Resumo: Introduction: Malignant pericardial effusion is the accumulation of liquid in the pericardial space secondary to advanced stage neoplasia, becoming in an indicator of bad prognosis. Malignant tumors that are most often related to this entity are the ones from pulmonary, mammary, and hematolymphoid origin. Clinically, it may present imminent signs of cardiac tamponade and hemodynamic instability, so that it merits an early diagnosis and management with emerging decompression maneuvers. Objective: This article presents a malignant pericardial effusion case, since this clinical condition implies a diagnostic challenge. Case presentation and Conclusions: A case of a 63 year old male patient is presented. He has one month of clinical evolution characterized by cervical adenopathies, also in the past fifteen days has been presenting precocious satiety, nocturnal sweating, sensation of distended abdomen, and functional class deterioration to having dyspnea during small physical efforts. This was the reason why he went to the emergency room. During the medical observation, the patient quickly deteriorates to hemodynamic instability, refractory to treatment. Some imaging studies were performed, which show severe pericardial effusion so a decompressive pericardiocentesis and a multidisciplinary integral management were performed...(AU)

Introducción: El derrame pericárdico maligno es la acumulación de líquido en el espacio pericárdico secundario a neoplasias en estadios avanzados, siendo así, un indicador de mal pronóstico. Los tumores malignos que con mayor frecuencia se relacionan con esta entidad son los de origen pulmonar, mamario y hematolinfoides. Clínicamente puede cursar con signos inminentes de taponamiento cardiaco e inestabilidad hemodinámica, por lo que amerita un diagnóstico temprano y manejo urgente con maniobras de descompresión. Objetivo: Este articulo busca presentar un caso de derrame pericárdico maligno, debido a que esta condición clínica implica un reto diagnóstico. Presentación del caso y conclusiones: Presentamos el caso de un paciente masculino de 63 años de edad, con cuadro clínico de 1 mes de evolución, caracterizado por presencia de adenopatías cervicales, quien en los últimos 15 días presenta saciedad precoz, sudoración nocturna, sensación de distensión abdominal y deterioro de la clase funcional hasta disnea de pequeños esfuerzos, motivo por el cual consulta al servicio de urgencias. Durante la observación médica rápidamente progresa a inestabilidad hemodinámica, refractaria a manejo; se realizan estudios imagenológicos, en donde se evidencia derrame pericárdico severo, por lo que se procede a realizar pericardiocentesis descompresiva emergente y manejo integral multidisciplinario...(AU)

Introdução: o derrame pericárdico maligno é o acúmulo de líquido no espaço pericárdico secundário a neoplasias em estádios avançados, sendo, portanto, um indicador de mau prognóstico. Os tumores malignos, frequentemente associados a esta categoría, são aqueles de origem pulmonar, mamária e hematolinfóides. Clinicamente, podem apresentar sinais iminentes de tamponamento cardíaco e instabilidade hemodinâmica, o que justifica um diagnóstico precoce e tratamento urgente com manejo de descompressão. Objetivo: Este artigo tem como objetivo apresentar um caso de derrame pericárdico maligno, pois esta condição clínica implica um desafio diagnóstico. Apresentação e conclusões do caso: apresentamos o caso de um paciente do sexo masculino de 63 anos, com o quadro clínico de 1 mês de evolução, caracterizado pela presença de linfadenopatia cervical, que nos últimos 15 dias apresenta saciedade precoce, sudação noturna, distensão abdominal e deterioração da classe funcional até a dispnéia de pequenos esforços, motivo pelo qual consulta o serviço de emergência. Durante a observação médica, ele progride rapidamente para a instabilidade hemodinâmica, refratária ao manejo; Estudos de imagem são realizados, nos quais o derrame pericárdico grave é evidente, por isso é necessário realizar pericardiocentese descompressiva emergente e gerenciamento integral multidisciplinar...(AU)
Descritores: Derrame Pericárdico
Tamponamento Cardíaco
Neoplasias Pulmonares
-Pericardiocentese
Invasividade Neoplásica
Limites: Humanos
Tipo de Publ: Relatos de Casos
Responsável: CO179.9 - Facultad de Medicina



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