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Id: biblio-1091457
Autor: Boza Oreamuno, Yadira V; Guillén Colombari, Diego.
Título: Queilitis actínica: Reporte de tres casos y revisión de literatura / Actinic Cheilitis: Report of Three Cases and Review of Literature
Fonte: Odovtos (En línea);20(3):33-42, Sep.-Dec. 2018. graf.
Idioma: es.
Resumo: RESUMEN La queilitis actínica (QA) es un desorden potencialmente maligno del labio inducido por la exposición crónica a la luz ultravioleta, que afecta principalmente al bermellón del labio inferior de personas adultas y de piel clara. Si no es tratada en forma oportuna puede transformarse en un carcinoma de células escamosas del labio. Histológicamente la QA presenta una serie de alteraciones a nivel epitelial que van desde hiperplasia a displasia; en el tejido conectivo se presentan distintos grados de elastosis actínica acompañada por infiltrado inflamatorio. El objetivo de este trabajo es presentar tres casos de pacientes con QA y analizar sus características clínicas e histopatológicas.

ABSTRACT Actinic cheilitis (AC) is a potentially malignant lip disorder induced by chronic exposure to ultraviolet light, which mainly affects the vermilion of the lower lip of adults and fair skin. If it is not treated in a timely manner it can become a squamous cell carcinoma of the lip. Histologically, AC presents a series of alterations at the epithelial level ranging from hyperplasia to dysplasia; Connective tissue presents different degrees of actinic elastosis accompanied by inflammatory infiltrate. The objective of this work is to present three cases of patients with AC and analyze their clinical and histopathological characteristics.
Descritores: Carcinoma de Células Escamosas
Queilite/diagnóstico
-Ceratose Actínica/tratamento farmacológico
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: CR1.1 - BINASSS - Biblioteca Nacional de Salud y Seguridad Social


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Id: lil-694378
Autor: Álvarez Martínez, Efraín; Duque F, Carlos Simón.
Título: Lesiones bucales potencialmente malignas / Potentially malignant oral lesions
Fonte: Acta otorrinolaringol. cir. cabeza cuello;41(1):51-56, ene.-mar. 2013. ilus.
Idioma: es.
Resumo: Existen muchas lesiones que pueden afectar no solo la lengua sino también el resto de la mucosa de la cavidad oral. Además de la descripción de las entidades más comunes, se presentan fotos ilustrativas. Pretendemos mostrar varias lesiones, que eventualmente pueden tornarse en una verdadera enfermedad maligna; de igual modo, se describen signos de alerta para sospechar cuándo una lesión de la cavidad oral se ha transformado en carcinoma…

There are many lesions that can affect not only the tongue but also the entire oral cavity mucosa. Along with a description of the most common entities, an illustrative picture is shown. We intend to show a wide number of lesions that eventually might become a true malignant disease; giving at the same time, hints as to when to suspect that one of these oral cavity lesions has turned into a carcinoma…
Descritores: Eritroplasia
Leucoplasia Oral
Neoplasias
Ceratose
Ceratose Actínica
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CO361.9


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Id: biblio-1052316
Autor: Silva, Widban Altobelli Resplandes; Araújo, Henrique da Silva Oliveira; Neto, Maurício Gomes da Silva; Noronha, Márcia Pessoa de Sousa; García-Zapata, Marco Tulio Antonio; Pereira, Ângela Lima.
Título: PREVALÊNCIA DE CERATOSE ACTÍNICA EM IDOSOS DE UMA REGIÃO NEOTROPICAL / PREVALENCE OF ACTINIC KERATOSIS IN THE ELDERLY OF A NEOTROPICAL REGION / PREVALENCIA DE QUERATOSIS ACTÍNICA EN LOS ADULTOS MAYORES DE UNA REGIÓN NEOTROPICAL
Fonte: J. Health NPEPS;1(2):208-217, Julho-Dezembro. 2016.
Idioma: pt.
Resumo: Objetivo: identificar a prevalência de ceratose actínica (CA) em idosos residentes no município de Palmas, TO, Brasil. Método: estudo epidemiológico, observacional, transversal realizado no município de Palmas, no período de janeiro a junho de 2016, com pessoas, de ambos os sexos, com idade acima de 60 anos. Resultados: fizeram parte do estudo 259 idosos, com predomínio na faixa etária entre 60 e 69 anos, média de idade de 72 anos. A prevalência de CA foi de 2,3%, com predomínio no sexo feminino (66,7%), na faixa etária entre 68 e 91, e que se declararam brancos (66,7%). Conclusão: estudos alertam quanto ao risco de desenvolvimento de CA por pessoas idosas, relacionando a exposição solar ao longo da vida. Embora esse estudo não tenha investigado os hábitos de vida quanto ao histórico de exposição solar, os resultados confirmam o risco para idosos. Evidencia a importância de cuidados preventivos com a pele, especialmente quanto a exposição solar, visando a prevenção da CA.

Objective: Identify the prevalence of Actinic Keratosis (CA) in elderly residents in the city of Palmas, TO, Brazil. Method: it is an observational, cross-sectional epidemiologic study, conducted in the city of Palmas from January to June of 2016, with subjects of both sexes, aged above 60 years. Results: two hundred sixty-nine elders were part of this study, most of them aged between 60 and 69 years, with an average age of 72 years. The CA prevalence was 2.3%, mostly women (66.7%), aged between 68 and 91, and who declared themselves white (66.7%). Conclusion: Studies warn about the risk of elderly people developing CA related to solar exposure throughout the life. Although this study did not investigate the life habits related to sun exposure, the results confirm this risk for seniors. This study highlights the importance of preventive skin care, especially related to sun exposure, aiming the CA prevention.

Objetivo: identificar la prevalencia de queratosis actínica (CA) en los adultos mayores residentes en la ciudad de Palmas, Tocantins, Brasil. Método: estudio epidemiológico, observacional, transversal, realizado en la ciudad de Palmas, en el período de enero a junio de 2016, con las personas de ambos sexos, mayores de 60 años. Resultados: los sujetos fueron 259 ancianos, predominantemente con edades comprendidas entre 60 y 69 años, con una edad media de 72 años. La prevalencia de la CA fue de 2,3%, con predominio en mujeres (66,7%), con edades comprendidas entre los 68 y 91, y que se declararon raza blanca (66,7%). Conclusión: estudios advierten sobre el riesgo de desarrollo de CA para las personas ancianas que une la exposición al sol durante toda la vida. Aunque este no estudio ha investigado los hábitos de vida como la historia de la exposición al sol, los resultados confirman el riesgo para ancianos. Destaca la importancia de la atención preventiva de la piel, sobre todo por exposición al sol, con el objetivo de la prevención del CA.
Descritores: Idoso
Ceratose Actínica
Responsável: BR1972.9 - DE - Departamento de Enfermagem


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Id: lil-786612
Autor: Méndez Matthey, Vanessa E.
Título: Queratosis actínica / Actinic keratosis
Fonte: Rev. méd. hered;27(1):67-67, ene.-jun. 2016. ilus.
Idioma: es.
Descritores: Ilustração Médica
Ceratose Actínica
Limites: Humanos
Feminino
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: biblio-1054877
Autor: Miola, Anna Carolina; Castilho, Mariana Anteghini; Schmitt, Juliano Vilaverde; Marques, Mariangela Esther Alencar; Miot, Helio Amante.
Título: Contribution to characterization of skin field cancerization activity: morphometric, chromatin texture, proliferation, and apoptosis aspects,
Fonte: An. bras. dermatol;94(6):698-703, Nov.-Dec. 2019. tab, graf.
Idioma: en.
Resumo: Abstract Background: A skin field cancerization is a cutaneous area with subclinical changes resultant from chronic sun exposure, with a higher predisposition to development of pre-neoplastic and neoplastic lesions. So far, there are no well-defined objective parameters that can indicate their degree of activity. Objectives: To describe and compare morphometric aspects and expression of factors related to apoptosis and cell proliferation in actinic keratosis (AK), in both photoexposed and photoprotected epidermis. Methods: A cross-sectional study of patients with actinic keratosis in the forearms, biopsied at two points: the actinic keratosis and the axillary region. The biopsies of the actinic keratosis, perilesional area, and axilla were evaluated through keratinocyte intraepithelial neoplasia (KIN), and immunohistochemistry of p53, survivin, and Ki67. Nuclear morphometry of basal layer cells was performed through digital image analysis: entropy, area, perimeter, Ra, fractal dimension, circularity, color intensity, and largest diameter. Results: There were 13 patients included and 38 actinic keratosis biopsied. In morphometry, 1039 nuclei were analyzed, of which 228 represented axillary skin, 396 demonstrated actinic keratosis, and 415 represented the perilesional area to the actinic keratosis. There was a significant difference (p < 0.05) in all variables tested for the topographies evaluated. A significant correlation was identified between nucellar morphometric elements, KIN, proliferation markers, and apoptosis. Joint patterns of p53, Ki67, and KIN discriminated the topographies sampled. Study limitations: This was a cross-sectional study with a small number of patients. Conclusions: There are patterns of proliferation, resistance to apoptosis, and different cellular morphometrics between photoprotected skin and photoexposed skin. The joint expression of p53, Ki67, and KIN can characterize skin field cancerization activity.
Descritores: Neoplasias Cutâneas/patologia
Carcinoma de Células Escamosas/patologia
Ceratose Actínica/patologia
-Pele/anatomia & histologia
Neoplasias Cutâneas/diagnóstico
Limites: Humanos
Adulto
Responsável: BR191.1 - Biblioteca e Centro de Documentação Luiza Keffer


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Id: lil-588898
Autor: Cabral, Luciana Sanches; Festa Neto, Cyro; Sanches Júnior, José A; Ruiz, Itamar R. G.
Título: Genomic instability in human actinic keratosis and squamous cell carcinoma
Fonte: Clinics;66(4):523-528, 2011. ilus, tab.
Idioma: en.
Resumo: OBJECTIVE: To compare the repetitive DNA patterns of human actinic keratoses and squamous cell carcinomas to determine the genetic alterations that are associated with malignant transformation. INTRODUCTION: Cancer cells are prone to genomic instability, which is often due to DNA polymerase slippage during the replication of repetitive DNA and to mutations in the DNA repair genes. The progression of benign actinic keratoses to malignant squamous cell carcinomas has been proposed by several authors. MATERIAL AND METHODS: Eight actinic keratoses and 24 squamous cell carcinomas (SCC), which were pair-matched to adjacent skin tissues and/or leucocytes, were studied. The presence of microsatellite instability (MSI) and the loss of heterozygosity (LOH) in chromosomes 6 and 9 were investigated using nine PCR primer pairs. Random Amplified Polymorphic DNA patterns were also evaluated using eight primers. RESULTS: MSI was detected in two (D6S251, D9S50) of the eight actinic keratosis patients. Among the 8 patients who had squamous cell carcinoma-I and provided informative results, a single patient exhibited two LOH (D6S251, D9S287) and two instances of MSI (D9S180, D9S280). Two LOH and one example of MSI (D6S251) were detected in three out of the 10 patients with squamous cell carcinoma-II. Among the four patients with squamous cell carcinoma-III, one patient displayed three MSIs (D6S251, D6S252, and D9S180) and another patient exhibited an MSI (D9S280). The altered random amplified polymorphic DNA ranged from 70 percent actinic keratoses, 76 percent squamous cell carcinoma-I, and 90 percent squamous cell carcinoma-II, to 100 percent squamous cell carcinoma-III. DISCUSSION: The increased levels of alterations in the microsatellites, particularly in D6S251, and the random amplified polymorphic DNA fingerprints were statistically significant in squamous cell carcinomas, compared with actinic keratoses. CONCLUSION: The overall alterations that were observed in the repetitive DNA of actinic keratoses and squamous cell carcinomas indicate the presence of a spectrum of malignant progression.
Descritores: Carcinoma de Células Escamosas/genética
Primers do DNA/genética
Ceratose Actínica/genética
Perda de Heterozigosidade/genética
Instabilidade de Microssatélites
Neoplasias Cutâneas/genética
-Transformação Celular Neoplásica/genética
Transformação Celular Neoplásica/patologia
CHROMOSOMES, HUMAN, PAIR ABDOMEN, ACUTE
Cromossomos Humanos Par 9
Impressões Digitais de DNA
Progressão da Doença
Ceratose Actínica/patologia
Técnica de Amplificação ao Acaso de DNA Polimórfico/métodos
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: biblio-1054862
Autor: Marçon, Carolina Reato; Maia, Marcus.
Título: Albinism: epidemiology, genetics, cutaneous characterization, psychosocial factors
Fonte: An. bras. dermatol;94(5):503-520, Sept.-Oct. 2019. tab, graf.
Idioma: en.
Resumo: Abstract Oculocutaneous albinism is an autosomal recessive disease caused by the complete absence or decrease of melanin biosynthesis in melanocytes. Due to the reduction or absence of melanin, albinos are highly susceptible to the harmful effects of ultraviolet radiation and are at increased risk of actinic damage and skin cancer. In Brazil, as in other parts of the world, albinism remains a little known disorder, both in relation to epidemiological data and to phenotypic and genotypic variation. In several regions of the country, individuals with albinism have no access to resources or specialized medical care, and are often neglected and deprived of social inclusion. Brazil is a tropical country, with a high incidence of solar radiation during the year nationwide. Consequently, actinic damage and skin cancer occur early and have a high incidence in this population, often leading to premature death. Skin monitoring of these patients and immediate therapeutic interventions have a positive impact in reducing the morbidity and mortality associated with this condition. Health education is important to inform albinos and their families, the general population, educators, medical professionals, and public agencies about the particularities of this genetic condition. The aim of this article is to present a review of the epidemiological, clinical, genetic, and psychosocial characteristics of albinism, with a focus in skin changes caused by this rare pigmentation disorder.
Descritores: Albinismo/genética
Albinismo/patologia
-Neoplasias Cutâneas/etiologia
Neoplasias Cutâneas/fisiopatologia
Raios Ultravioleta/efeitos adversos
Brasil/epidemiologia
Carcinoma Basocelular/etiologia
Carcinoma Basocelular/patologia
Carcinoma de Células Escamosas/etiologia
Carcinoma de Células Escamosas/patologia
Albinismo/complicações
Albinismo/epidemiologia
Prevalência
Fatores de Risco
Ceratose Actínica/etiologia
Ceratose Actínica/patologia
Melaninas/deficiência
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-1054878
Autor: Reinehr, Clarissa Prieto Herman; Bakos, Renato Marchiori.
Título: Actinic keratoses: review of clinical, dermoscopic, and therapeutic aspects
Fonte: An. bras. dermatol;94(6):637-657, Nov.-Dec. 2019. tab, graf.
Idioma: en.
Resumo: Abstract Actinic keratoses are dysplastic proliferations of keratinocytes with potential for malignant transformation. Clinically, actinic keratoses present as macules, papules, or hyperkeratotic plaques with an erythematous background that occur on photoexposed areas. At initial stages, they may be better identified by palpation rather than by visual inspection. They may also be pigmented and show variable degrees of infiltration; when multiple they then constitute the so-called field cancerization. Their prevalence ranges from 11% to 60% in Caucasian individuals above 40 years. Ultraviolet radiation is the main factor involved in pathogenesis, but individual factors also play a role in the predisposing to lesions appearance. Diagnosis of lesions is based on clinical and dermoscopic examination, but in some situations histopathological analysis may be necessary. The risk of transformation into squamous cell carcinoma is the major concern regarding actinic keratoses. Therapeutic modalities for actinic keratoses include topical medications, and ablative and surgical methods; the best treatment option should always be individualized according to the patient.
Descritores: Dermoscopia/métodos
Ceratose Actínica/terapia
Ceratose Actínica/diagnóstico por imagem
-Neoplasias Cutâneas/patologia
Neoplasias Cutâneas/diagnóstico por imagem
Índice de Gravidade de Doença
Carcinoma de Células Escamosas/patologia
Carcinoma de Células Escamosas/diagnóstico por imagem
Fatores de Risco
Ceratose Actínica/patologia
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-949909
Autor: Saraiva, Maria Isabel Ramos; Portocarrero, Larissa Karine Leite; Vieira, Marcella Amaral Horta Barbosa; Swiczar, Bethania Cabral Cavalli; Westin, Andrezza Telles.
Título: Ingenol mebutate in the treatment of actinic keratoses: clearance rate and adverse effects
Fonte: An. bras. dermatol;93(4):529-534, July-Aug. 2018. tab, graf.
Idioma: en.
Resumo: Abstract: Background: Actinic keratoses are benign intraepithelial skin neoplasms that develop in photoexposed areas and can progress to invasive carcinoma. They are seen frequently in dermatological practice, occurring in 5.1% of consultations. Ingenol mebutate (IM) was recently approved in Brazil as a topical therapy for field cancerization in actinic keratosis. Objective: To evaluate the clearance rate and adverse events in the treatment of actinic keratoses with ingenol mebutate. Methods: A longitudinal, prospective, non-randomized, interventional, open, single-center study was conducted. Patients with actinic keratoses applied ingenol mebutate on a 25cm2 area of the face and/or scalp for three consecutive days (0.015%) or on the forearm for two days (0.05%). Results: 27 patients completed the protocol, of whom 13 on the face and/or scalp and 14 on the forearm. Complete clearance occurred in 53.8% in the first group and 42.8% in the second. Partial response was observed in 15.4% and 35.7%, respectively. The most common side effects were erythema, edema, desquamation, pruritus, and local erosion. Study limitations: The study had a small sample and was not randomized, double-blind, placebo-controlled, or vehicle-controlled. Conclusion: Ingenol mebutate is well-tolerated for the treatment of actinic keratosis, with good patient adherence thanks to the short treatment period.
Descritores: Diterpenos/uso terapêutico
Ceratose Actínica/tratamento farmacológico
-Método Duplo-Cego
Estudos Prospectivos
Estudos Longitudinais
Resultado do Tratamento
Diterpenos/efeitos adversos
Diterpenos/farmacocinética
Ceratose Actínica/metabolismo
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Ensaio Clínico Controlado
Responsável: BR1.1 - BIREME


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Id: biblio-949908
Autor: Çerman, Aslı Aksu; Karabay, Ezgi Aktaş; Altunay, Ilknur Kivanc; Cesur, Seher Küçükoğlu.
Título: Vitamin D levels in actinic keratosis: a preliminary study
Fonte: An. bras. dermatol;93(4):535-538, July-Aug. 2018. tab.
Idioma: en.
Resumo: Abstract: Background: Recent studies that investigated the effect of vitamin D on skin cancer risk have exhibited inconsistent results. Objective: The aim of the study was to evaluate vitamin D status in patients with actinic keratosis. Methods: A cross-sectional study was conducted on 31 patients with actinic keratosis and 29 healthy controls. Serum vitamin D levels in the study group were determined by liquid chromatography/tandem mass spectrometry. Results: Serum 25(OH)D levels in patients with actinic keratosis were significantly higher than those of the healthy controls (P=0.04). Prevalence of 25(OH)D deficiency was significantly higher in the healthy controls (75.9%) compared to the patients with actinic keratosis (54.8%), but the difference was not statistically significant (P= 0.09). Study limitations: The cross-sectional design of the study, data on smoking based on patient self-report, and subjects' different dietary habits, which can influence 25(OH)D levels, are the study's limitations. Conclusion: Serum vitamin D level can be used as a marker for ultraviolet B radiation from sun exposure; therefore, it can be used in individuals at risk of actinic keratosis. Oral intake of vitamin D through diet or supplements is proposed instead of prolonged ultraviolet exposure to maintain adequate vitamin D serum levels. Further research is needed to elucidate the role of vitamin D in skin carcinogenesis.
Descritores: Vitamina D/sangue
Ceratose Actínica/sangue
-Biomarcadores/sangue
Estudos de Casos e Controles
Estudos Transversais
Cromatografia Líquida de Alta Pressão
Espectrometria de Massas em Tandem
Limites: Humanos
Masculino
Feminino
Idoso
Responsável: BR1.1 - BIREME



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