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Pesquisa : C05.116.099.343.347 [Categoria DeCS]
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Id: lil-794560
Autor: Yousefzadeh, Nasibeh; Jeddi, Sajad; Alipour, Mohammad Reza.
Título: Effect of Fetal Hypothyroidism on Cardiac Myosin Heavy Chain Expression in Male Rats / O Efeito de Hipotireoidismo Fetal na Expressão da Miosina Cardíaca de Cadeia Pesada em Ratos Macho
Fonte: Arq. bras. cardiol;107(2):147-153, Aug. 2016. tab, graf.
Idioma: en.
Resumo: Abstract Background: Thyroid hormone deficiency during fetal life could affect the cardiac function in later life. The mechanism underlying this action in fetal hypothyroidism (FH) in rats has not been elucidated thus far. Objective: The aim of this study is to evaluation the effect of FH on cardiac function in male rats and to determine the contribution of α-myosin heavy chain (MHC) and β-MHC isoforms. Methods: Six pregnant female rats were randomly divided into two groups: The hypothyroid group received water containing 6-propyl-2-thiouracil during gestation and the controls consumed tap water. The offspring of the rats were tested in adulthood. Hearts from the FH and control rats were isolated and perfused with langendroff setup for measuring hemodynamic parameters; also, the heart mRNA expressions of α- MHC and β-MHC were measured by qPCR. Results: Baseline LVDP (74.0 ± 3.1 vs. 92.5 ± 3.2 mmHg, p < 0.05) and heart rate (217 ± 11 vs. 273 ± 6 beat/min, p < 0.05) were lower in the FH rats than controls. Also, these results showed the same significance in ±dp/dt. In the FH rats, β-MHC expression was higher (201%) and α- MHC expression was lower (47%) than control. Conclusion: Thyroid hormone deficiency during fetal life could attenuate normal cardiac functions in adult rats, an effect at least in part due to the increased expression of β-MHC to α- MHC ratio in the heart.

Resumo Fundamento: Deficiência de hormônio da tireoide durante vida fetal pode afetar a função cardíaca no futuro. O mecanismo subjacente dessa ação em hipotireoidismo fetal (HF) em ratos ainda não tem explicação. Objetivo: O objetivo desse estudo é avaliar o efeito de HF na função cardíaca em ratos macho e determinar a contribuição da α-miosina de cadeia pesada (α-MCP) e de isoformas β-MCP. Métodos: Seis ratos fêmea gestantes foram aleatoriamente divididas em dois grupos. O grupo do hipotireoidismo recebeu água contendo 6-propil-2-tiouracil durante a gestação, e os ratos no grupo de controle receberam água de torneira. Os filhotes dos ratos foram testados quando atingiram idade adulta. O coração dos ratos HF e controle foram isolados e submetidos a perfusão pelo método de Langendorff para medição de parâmetros hemodinâmicos. Também foram medidas as expressões de mRNA do coração de α-MCP e β-MCP por qPCR. Resultados: PVED de base (74,0 ± 3,1 vs. 92,5 ± 3,2 mmHg, p < 0,05) e pressão arterial (217 ± 11 vs. 273 ± 6 batidas/min, p < 0,05) mostraram-se mais baixas em ratos HF do que em ratos controle. Além disso, esses resultados mostraram a mesma significância em ±dp/dt. Em ratos HF, a expressão de β-MCP foi mais alta (201%) e a de α-MCP foi mais baixa (47%) do que em ratos controle. Conclusão: Deficiência de hormônio da tireoide durante a vida fetal pode enfraquecer funções cardíacas normais em ratos adultos, efeito devido em parte à expressão aumentada de β-MCP em relação a α-MCP no coração.
Descritores: Peso Corporal/efeitos dos fármacos
Cadeias Pesadas de Miosina/metabolismo
Hipotireoidismo Congênito/metabolismo
Miocárdio/metabolismo
-Propiltiouracila
Antitireóideos
Tiroxina/sangue
Tri-Iodotironina/sangue
RNA Mensageiro/metabolismo
Distribuição Aleatória
Ratos Wistar
Pressão Ventricular
DNA Complementar/metabolismo
Hipotireoidismo Congênito/induzido quimicamente
Hipotireoidismo Congênito/sangue
Modelos Animais de Doenças
Frequência Cardíaca
Limites: Animais
Masculino
Feminino
Gravidez
Responsável: BR1.1 - BIREME


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Id: lil-798184
Autor: Matos, Diana M; Ramalho, Roberto J R; Carvalho, Bruno M; Almeida, Maria Augusta C T; Passos, Luciana F D; Vasconcelos, Talmay T S; Melo, Enaldo V; Oliveira, Carla R P; Santos, Elenilde G; Resende, Karla F; Aguiar-Oliveira, Manuel H.
Título: Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil
Fonte: Arch. endocrinol. metab. (Online);60(5):450-456, Oct. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objectives To assess the evolution to permanent or transient conditions in children with positive neonatal TSH tests in Sergipe, Brazil, from 2004 to 2010. Subjects and methods Out of 193,794 screened newborns, 713 presented a neonatal TSH level higher than the local cutoff (5.2 µU/mL). From the confirmatory serum TSH values, the children were diagnosed with initial congenital hypothyroidism (CH) or suspect CH. From the evolution, they were classified as permanent CH, hyperthyrotropinemia, or transient TSH elevation. The mean incidence of each final condition was calculated for the total period of time. Results The initial diagnosis included 37 CH (18.1%) and 167 suspect CH (81.9%) cases. The final diagnosis included 46 cases of permanent CH (22.5%), 56 of hyperthyrotropinemia (27.5%), and 102 of transient TSH elevation (50.0%). Out of the 37 cases of initial CH, 23 (62.2%) had permanent CH, nine (24.3%) had hyperthyrotropinemia, and five (13.5%) had transient TSH elevation. Out of the 167 suspect CH cases, 23 (13.8%) had permanent CH, 47 (28.1%) had hyperthyrotropinemia and 97 (58.1%) had transient TSH elevation. The mean incidence after the follow up was 1:4,166 for permanent CH, 1:3,448 for hyperthyrotropinemia, and 1:1,887 for transient TSH elevation. Eighty-six percent of the children with an initial diagnosis of CH and 41.9% with suspect CH had a permanent condition (CH or hyperthyrotropinemia). Conclusions The follow-up of children with an initial diagnosis of CH or suspect CH is necessary to determine whether the disorder is permanent because predicting the evolution of the condition is difficult.
Descritores: Tireotropina/sangue
Triagem Neonatal/métodos
Hipotireoidismo Congênito/diagnóstico
Hipotireoidismo Congênito/sangue
-Padrões de Referência
Valores de Referência
Tiroxina/sangue
Fatores de Tempo
Brasil/epidemiologia
Incidência
Valor Preditivo dos Testes
Estudos Retrospectivos
Seguimentos
Progressão da Doença
Hipotireoidismo Congênito/fisiopatologia
Hipotireoidismo Congênito/epidemiologia
Limites: Humanos
Masculino
Feminino
Recém-Nascido
Responsável: BR1.1 - BIREME


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Id: biblio-827794
Autor: Guo, Man-Li; Zheng, Xiao; Yang, Liu-Xue; Qiu, Ya-Li; Cheng, Liang; Ma, Shao-Gang.
Título: Coexistence of resistance to thyroid hormone and ectopic thyroid: ten-year follow-up
Fonte: Arch. endocrinol. metab. (Online);60(6):601-604, Nov.-Dec. 2016. tab, graf.
Idioma: en.
Projeto: Social Development Project of Huai’an City; . Maternal and Child Health Research Project; . Guangxi University.
Resumo: SUMMARY Resistance to thyroid hormone (RTH) coexisting with ectopic thyroid is rare. Here we report a case of RTH with ectopic thyroid. A ten-year-old girl had been misdiagnosed as congenital hypothyroidism and treated with levothyroxine since she was born. Ten-year follow-up showed that the elevated thyrotropin was never suppressed by levothyroxine and no signs indicating hyperthyroidism or hypothyroidism despite elevated FT3 and FT4 levels. Therefore the girl developed no defects in physical and cognitive development. Pituitary adenoma was excluded by magnetic resonance imaging. Ultrasonography did not find the thyroid gland in the normal place, while the thyroid scan found a large lingual thyroid gland. The octreotide inhibition test showed a reduction in thyrotropin by 41.98%. No mutation was detected in the thyroid hormone receptor (THR) β, THRα, thyrotropin receptor (TSHR), and GNAS1 genes. To our knowledge, it is an interesting RTH case coexisting with lingual thyroid.
Descritores: Receptores dos Hormônios Tireóideos/genética
Síndrome da Resistência aos Hormônios Tireóideos/complicações
Disgenesia da Tireoide/complicações
-Tiroxina/uso terapêutico
Fatores de Tempo
Doenças da Língua/diagnóstico por imagem
DNA/isolamento & purificação
Tireotropina/análise
Análise Mutacional de DNA
Seguimentos
Síndrome da Resistência aos Hormônios Tireóideos/genética
Hipotireoidismo Congênito/diagnóstico
Erros de Diagnóstico
Disgenesia da Tireoide/genética
Disgenesia da Tireoide/diagnóstico por imagem
Limites: Humanos
Feminino
Criança
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: lil-790747
Autor: Huerta-Sáenz, Lina; Del Águila, Carlos; Espinoza, Oscar; Falen-Boggio, Juan; Mitre, Naim.
Título: Tamizaje nacional unificado de hipotiroidismo congénito en el Perú: un programa inexistente / National congenital hypothyroidism screening in Peru: a broken program
Fonte: Rev. peru. med. exp. salud publica;32(3):579-585, jul.-sep. 2015.
Idioma: es.
Resumo: El hipotiroidismo congénito (HC) es la principal causa prevenible de retardo mental. La prevalencia de HC varía de acuerdo con la región geográfica y la población racial. En el hemisferio norte, la incidencia es 1:4000 recién nacidos vivos. En Latinoamérica, la incidencia varía debido a la heterogeneidad racial/étnica y al nivel de desarrollo. En el Perú, un estudio realizado en 1984 describió esta prevalencia como 1:1250. En el 2007, esta prevalencia fue reportada como 1:1638 por el Instituto Nacional Materno Perinatal. Un reciente estudio del Instituto Nacional de Salud del Niño durante 1995û2005, describió la edad promedio de diagnóstico de HC como 5,9 meses +/- 5,28. Esta tardía edad de diagnóstico sugiere la poca eficiencia de los actuales programas de tamizaje. Todo niño peruano tiene derecho a recibir diagnóstico oportuno y tratamiento de HC y es el Estado Peruano, el responsable principal de asegurar que esta meta se cumpla...

Congenital hypothyroidism (CH) is the most important cause of preventable mental retardation. The prevalence of CH varies by geographic region, race and ethnicity. In the countries of the Northern hemisphere, the prevalence has been reported as 1:4,000 live newborns. The prevalence is remarkably different among the countries of Latin America not only because of their different races and ethnicities but also because of the heterogeneous social-economic development. The prevalence of CH in 1984 in Peru was reported as 1:1250. In 2007, the reported incidence by the Instituto Nacional Materno Perinatal was 1:1638. A recent retrospective study performed by the Instituto Nacional de Salud del Niño in Lima, Peru described the average age of diagnosis of CH as 5,9 months +/- 5,28. This late age of CH diagnosis certainly suggests the poor efficiency of the current neonatal CH screening programs in Peru. Every Peruvian infant deserves a timely newborn screening and treatment for CH. The Peruvian government is responsible for ensuring this mandatory goal is achieved promptly...
Descritores: Hipotireoidismo Congênito
Hipotireoidismo Congênito/diagnóstico
Triagem Neonatal
-Peru
Limites: Humanos
Responsável: PE14.1 - Biblioteca de la Sede Central


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Borges, Maria de Fátima
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Id: biblio-887585
Autor: Borges, Maria de Fátima; Sedassari, Nathalie de Almeida; Sedassari, Anelise de Almeida; Souza, Luis Ronan Marquez Ferreira de; Ferreira, Beatriz Pires; Lara, Beatriz Hallal Jorge; Palhares, Heloísa Marcelina Cunha.
Título: Timing of thyroid ultrasonography in the etiological investigation of congenital hypothyroidism
Fonte: Arch. endocrinol. metab. (Online);61(5):432-437, Sept.-Oct. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objectives To describe the findings of thyroid ultrasonography (T-US), its contribution to diagnose congenital hypothyroidism (CH) and the best time to perform it. Subjects and methods Forty-four patients with CH were invited to undergo T-US and 41 accepted. Age ranged from 2 months to 45 years; 23 patients were females. All were treated with L-thyroxine; 16 had previously undergone scintigraphy and 30 had previous T-US, which were compared to current ones. Results At the current T-US, the thyroid gland was not visualized in its normal topography in 10 patients (24.5%); 31 T-US showed topic thyroid, 17 with normal or increased volume due to probable dyshormonogenesis, 13 cases of hypoplasia and one case of left-lobe hemiagenesis. One patient had decreased volume due to central hypothyroidism. Scintigraphy scans performed 3-4 years earlier showed 100% agreement with current results. Comparisons with previous T-US showed concordant results regarding thyroid location, but a decrease in current volume was observed in eight due to the use of L-thyroxine, calling the diagnosis of hypoplasia into question. Conclusions The role of T-US goes beyond complementing scintigraphy results. It allows inferring the etiology of CH, but it must be performed in the first months of life. An accurate diagnosis of CH will be attained with molecular study and the T-US can guide this early assessment, without therapy withdrawal.
Descritores: Glândula Tireoide/diagnóstico por imagem
Hipotireoidismo Congênito/diagnóstico por imagem
-Tiroxina/uso terapêutico
Fatores de Tempo
Ultrassonografia
Sensibilidade e Especificidade
Hipotireoidismo Congênito/etiologia
Hipotireoidismo Congênito/tratamento farmacológico
Limites: Humanos
Masculino
Feminino
Lactente
Pré-Escolar
Criança
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-887595
Autor: Andrade, Caio Leônidas Oliveira de; Machado, Gabriela Carvalho; Fernandes, Luciene da Cruz; Albuquerque, Jamile Morais de; Casais-e-Silva, Luciana Lyra; Ramos, Helton Estrela; Alves, Crésio de Aragão Dantas.
Título: Mechanisms involved in hearing disorders of thyroid ontogeny: a literature review
Fonte: Arch. endocrinol. metab. (Online);61(5):501-505, Sept.-Oct. 2017. graf.
Idioma: en.
Resumo: ABSTRACT Endocochlear, retrocochlear and/or central origin hearing damage may be related to the absence of appropriate levels of thyroid hormone during morphogenesis and/or auditory system development. Hearing disorders related to the thyroid are not well studied, despite speculation on the pathophysiological mechanisms. The objective of this review was to characterize the main pathophysiological mechanisms of congenital hypothyroidism and to evaluate the relationship with central and peripheral hearing disorders. We conducted a literature review using the databases MedLine, LILACS, Cochrane Library, SciELO, Institute for Scientific Information (ISI), Embase, and Science Direct between July and September on 2016. We identified the studies that address hearing disorder mechanisms on the congenital hypothyroidism. Congenital hypothyroidism may have clinical and subclinical manifestations that affect the auditory system and may be a potential risk factor for hearing impairment. Hearing impairment can severely impact quality-of-life, which emphasizes the importance of monitoring and evaluating hearing during the clinical routine of these patients.
Descritores: Hipotireoidismo Congênito/complicações
Perda Auditiva/etiologia
-Modelos Animais de Doenças
Perda Auditiva/embriologia
Limites: Humanos
Animais
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Amorim, Tatiana
Acosta, Angelina Xavier
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Id: biblio-950085
Autor: Cerqueira, Taíse Lima de Oliveira; Ramos, Yanne Rocha; Strappa, Giorgia Bruna; Jesus, Mariana Souza de; Santos, Jailciele Gonzaga; Sousa, Camila; Carvalho, Gildásio; Fernandes, Vladimir; Boa-Sorte, Ney; Amorim, Tatiana; Silva, Thiago Magalhães; Ladeia, Ana Marice Teixeira; Acosta, Angelina Xavier; Ramos, Helton Estrela.
Título: Mutation screening in the genes PAX-8, NKX2-5, TSH-R, HES-1 in cohort of 63 Brazilian children with thyroid dysgenesis
Fonte: Arch. endocrinol. metab. (Online);62(4):466-471, July-Aug. 2018. tab, graf.
Idioma: en.
Projeto: FAPESB; . CNPq.
Resumo: ABSTRACT Objective: To evaluate the candidate genes PAX-8, NKX2-5, TSH-R and HES-1 in 63 confirmed cases of thyroid dysgenesis. Subjects and methods: Characterization of patients with congenital hypothyroidism into specific subtypes of thyroid dysgenesis with hormone levels (TT4 and TSH), thyroid ultrasound and scintigraphy. DNA was extracted from peripheral blood leukocytes and the genetic analysis was realized by investigating the presence of mutations in the transcription factor genes involved in thyroid development. Results: No mutations were detected in any of the candidate genes. In situ thyroid gland represented 71.1% of all cases of permanent primary congenital hypothyroidism, followed by hypoplasia (9.6%), ectopia (78%), hemiagenesis (6.0%) and agenesis (5.5%). The highest neonatal screening TSH levels were in the agenesis group (p < 0.001). Conclusions: Thyroid dysgenesis is possibly a polygenic disorder and epigenetic factors could to be implicated in these pathogeneses.
Descritores: Receptores da Tireotropina/genética
Proteína Homeobox Nkx-2.5/genética
Fator de Transcrição PAX8/genética
Mutação/genética
-Brasil
Análise Mutacional de DNA
Testes Genéticos
Estudos de Coortes
Ultrassonografia
Hipotireoidismo Congênito/etiologia
Hipotireoidismo Congênito/genética
Hipotireoidismo Congênito/diagnóstico por imagem
Disgenesia da Tireoide/genética
Limites: Humanos
Masculino
Feminino
Recém-Nascido
Lactente
Pré-Escolar
Responsável: BR1.1 - BIREME


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Id: biblio-983806
Autor: Aminzadeh, Majid.
Título: Higher prevalence of permanent congenital hypothyroidism in the Southwest of Iran mostly caused by dyshormonogenesis: a five-year follow-up study
Fonte: Arch. endocrinol. metab. (Online);62(6):602-608, Dec. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective: The incidence of congenital hypothyroidism (CH) varies globally. This 5-year study aimed to determine the prevalence of permanent CH in the southwest of Iran. Materials and methods: Between January 2007 and December 2009, all newborns in Ahvaz, the biggest city in the southwest of Iran, were screened for CH using a heel-prick sample for thyrotropin (TSH) levels. Subjects with TSH ≥ 5 mU/L were evaluated for T4-TSH. Infants with T4 < 6.5 µg/dL, TSH > 10 mU/L, and normal T4 but persistent (> 60 days) high TSH were considered to have CH. After the third birthday, treatment was discontinued, and T4-TSH was reevaluated; subjects with TSH ≥ 10 mU/L were investigated using thyroid Tc99 scintigraphy (TS). Based on TS, they were classified as normal, dysgenetic, or athyretic (agenesis). Results: Screening was performed for 86,567 neonates, and 194 were confirmed to have CH (100 males; F/M = 0.94; overall incidence 1:446). After the third birthday, reevaluation was performed in all (except 18 that were not accessible). From 176 patients, 81 (46%) were diagnosed with permanent CH, and 95 were discharged as transient. Considering the same percentage in the lost cases, the prevalence of permanent CH was found to be 1:970. TS performed for 53 of the permanent subjects found agenesis/dysgenesis in 25 (F:M = 15:10) and a normal result in 28 (F:M = 11:17), indicating dyshormonogenesis as the cause in more than 50% of subjects. Conclusions: The incidence of CH in this area was found to be higher than that in other countries but less than the incidence rate reported in central Iran. The large number of transient cases of CH suggests environmental or maternal causes for the incidence rather than a genetic basis.
Descritores: Glândula Tireoide/anormalidades
Hipotireoidismo Congênito/epidemiologia
-Valores de Referência
Tiroxina/sangue
Ensaio de Imunoadsorção Enzimática
Tireotropina/sangue
Modelos Logísticos
Incidência
Prevalência
Fatores de Risco
Seguimentos
Triagem Neonatal
Irã (Geográfico)/epidemiologia
Limites: Humanos
Masculino
Feminino
Recém-Nascido
Responsável: BR1.1 - BIREME


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Id: biblio-1011160
Autor: Tapia-Martínez, Jorge; Franco-Colín, Margarita; Ortiz-Butron, Rocio; Pineda-Reynoso, Marisol; Cano-Europa, Edgar.
Título: Hypothyroid offspring replacement with euthyroid wet nurses during lactation improves thyroid programming without modifying metabolic programming
Fonte: Arch. endocrinol. metab. (Online);63(3):199-207, May-June 2019. tab, graf.
Idioma: en.
Projeto: CONACyT; . CONACyT; . CONACyT.
Resumo: ABSTRACT Objective Determine the milk quality effect during lactation on the metabolic and thyroid programming of hypothyroid offspring. Materials and methods Ten-week-old female Wistar rats were divided into two groups: euthyroid and thyroidectomy-caused hypothyroidism. The rats were matted and, one day after birth, the pups were divided into three groups: euthyroid offspring (EO), hypothyroid offspring (HO) and hypothyroid with a euthyroid replacement wet nurse (HRO). During lactation, the milk quality and offspring body length were evaluated. The body weight and energy intake were determined on a weekly basis, as well as the metabolic profile at the prepubertal (P35-36) and postpubertal (P55-56) ages. At P56, the animals were sacrificed, the adipose tissues were weighed and the thyroid glands were dissected for histological processing. Results The milk of the hypothyroid wet nurse decreases proteins (16-26%), lipids (22-29%) and lactate (22-37%) with respect to euthyroid. The HO has a lower body weight gain (23-33%), length (11-13%) and energy intake (15-21%). In addition, HO presents impaired fasting glucose and dyslipidemia, as well as a reduction in seric thyroid hormone (18-34%), adipose reserves (26-68%) and thyroid gland weight (25-34%). The HO present thyroid gland cytoarchitecture alteration. The HRO develop the same metabolic alterations as the HO. However, the thyroid gland dysfunction was partially prevented because the HRO improved under about 10% of the serum thyroid hormone concentration, the thyroid gland weight although histological glandular changes presented. Conclusions The replacement of hypothyroid offspring with a euthyroid wet nurse during lactation can improve the thyroid programming without modifying metabolic programming.
Descritores: Hormônios Tireóideos/metabolismo
Lactação/metabolismo
Hipotireoidismo Congênito/metabolismo
Fenômenos Fisiológicos da Nutrição Materna
-Glândula Tireoide/patologia
Ratos Wistar
Modelos Animais de Doenças
Limites: Animais
Feminino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-786468
Autor: Marín G, Marta Elena; Villa Perea, Julián A; Vera Polanía, Felipe; Urbano Garzón, Sivia Fernanda.
Título: Hashitoxicosis: a propósito de un caso / Hashitoxicosis: a case report
Fonte: Rev. med. Risaralda;22(1):61-63, ene.-jun. 2016.
Idioma: es.
Resumo: Se conoce como Hashitoxicosis a la Tiroiditis de Hashimoto que coexiste conepisodios de hipertiroidismo; se debe a la liberación excesiva de hormonatiroidea en un paciente con diagnóstico previo de enfermedad de Hashimoto.Puede ser más común de lo que se pensaba, debido al aparente aumento depacientes con Tiroiditis de Hashimoto y/o avances en su diagnóstico.Se presenta el caso de un paciente femenino de 12 años de edad, que porhallazgos clínicos se le diagnostica un hipertiroidismo por enfermedad deGraves Basedow. Sin embargo, los estudios iniciales y la evolución posterior de la paciente, orientan el diagnóstico hacia una etiología diferente...
Descritores: Hipertireoidismo
Hipotireoidismo Congênito
Limites: Humanos
Tipo de Publ: Relatos de Casos
Responsável: CO64.3 - Biblioteca Jorge Roa Martinez



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