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Texto completo SciELO Brasil
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Id: lil-706980
Autor: Santos, Guida; Sousa, Lourdes.
Título: Syndrome in Question
Fonte: An. bras. dermatol;89(2):361-362, Mar-Apr/2014. graf.
Idioma: en.
Resumo: Multiple autoimmune syndrome is a rare condition, described by Humbert and Dupond in 1988. It is defined by the association of at least 3 autoimmune diseases in the same patient. Vitiligo is the most common skin condition in this syndrome. This article presents the case of a 31-year-old male with vitiligo, alopecia areata, Crohn's disease, psoriasis vulgaris and oral lichen planus. The rarity of this case is highlighted by the coexistence of four autoimmune skin diseases in association with Crohn's disease, never described in the literature.
Descritores: Psoríase/patologia
Doenças Autoimunes/patologia
Vitiligo/patologia
Doença de Crohn/patologia
Líquen Plano Bucal/patologia
Alopecia em Áreas/patologia
-Psoríase/complicações
Doenças Autoimunes/complicações
Síndrome
Vitiligo/complicações
Doença de Crohn/complicações
Líquen Plano Bucal/complicações
Alopecia em Áreas/complicações
Limites: Seres Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-1001200
Autor: Félez Moliner, Inés; García Romero, Ruth; Ros Arnal, Ignacio; Clavero Adell, Marcos; Ubalde Sainz, Eduardo; Medrano San Ildefonso, Marta.
Título: Artritis como debut de enfermedad inflamatoria intestinal en pediatría / Arthritis as clinical presentation of inflammatory bowel disease in children
Fonte: Arch. argent. pediatr;117(3):270-273, jun. 2019. ilus.
Idioma: es.
Resumo: La incidencia de enfermedad inflamatoria intestinal en la edad pediátrica se ha incrementado mundialmente en las últimas décadas. La forma de presentación puede ser diversa y, hasta en un 6-35 %, las manifestaciones extraintestinales pueden ser el debut; la artritis periférica es la más frecuente de estas. Una presentación atípica implica un retraso diagnóstico y, asociado a que el fenotipo de enfermedad inflamatoria intestinal es más grave en los niños, conlleva un incremento de las complicaciones intestinales y secuelas asociadas. Se presentan dos casos clínicos de enfermedad de Crohn cuya clínica inicial fue la claudicación de la marcha por una artritis periférica y una entesitis, respectivamente.

Inflammatory bowel disease in children has increased worldwide during the last decades. Clinical presentations are diverse and extraintestinal manifestations are the presenting sign in 6-35 % of patients, the most common of them being peripheral arthritis. An atypical clinical presentation results in diagnosis delay and, added to the greater seriousness of inflammatory bowel disease phenotypes in children, it entails more intestinal complications and sequelae. We describe two cases of inflammatory bowel disease with an initial symptom of lameness due to peripheral arthritis and enthesitis, respectively.
Descritores: Artrite
Doenças Inflamatórias Intestinais
Doença de Crohn
Tendinopatia
Limites: Seres Humanos
Criança
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


  3 / 581 LILACS  
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Id: lil-792437
Autor: Gontijo, João Renato Vianna; Leidenz, Franciele Antonieta Bianchi; Sousa, Maria Silvia Laborne Alves de.
Título: Case for diagnosis. Metastatic Crohn's disease
Fonte: An. bras. dermatol;91(4):531-533, July-Aug. 2016. graf.
Idioma: en.
Resumo: Abstract: Metastatic Crohn's disease is a rare skin manifestation, defined by granulomatous skin lesions that are discontinuous to the affected gastrointestinal tract and histopathologically resembling inflammatory bowel lesions. Up to 44% of patients with Crohn's disease have cutaneous manifestations, of which metastatic lesions are the least common. We present a case of an adolescent with refractory Crohn's disease and persistent papules and plaques on the skin.
Descritores: Doença de Crohn/complicações
Doença de Crohn/patologia
Eritema/etiologia
Eritema/patologia
-Pele/patologia
Biópsia
Limites: Seres Humanos
Feminino
Adolescente
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: lil-787309
Autor: Antonio, João Roberto; Sanmiguel, Jessica; Cagnon, Giovana Viotto; Augusto, Marília Silveira Faeda; Godoy, Moacir Fernandes de; Pozetti, Eurides Maria Oliveira.
Título: Infliximab in patients with psoriasis and other inflammatory diseases: evaluation of adverse events in the treatment of 168 patients
Fonte: An. bras. dermatol;91(3):306-310tab, graf.
Idioma: en.
Resumo: Abstract: Background: Psoriasis is immune-mediated chronic inflammatory disease with preference for skin and joints. The skin involvement occurs by hyperproliferation and abnormal differentiation of keratinocytes. It is associated with comorbidities, mainly related to the clinical manifestations of the metabolic syndrome. Increased TNF-alpha expression (TNF-α) is related to its pathophysiology. Infliximab is an intravenous drug that acts neutralizing the biological activity of TNF-α and prevents the binding of the molecule to the target cell receptor, inhibiting cell proliferation of psoriasis and other diseases mediated by TNF-α. A lot of infusion reactions have been described in the literature. Objective: To evaluate the adverse effects of intravenous treatment with infliximab, analyzing patients with psoriasis compared to those with other chronic inflammatory diseases (rheumatoid arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis). Method: Analysis of medical records and adverse events of 168 patients undergoing infliximab infusion for psoriasis and chronic inflammatory diseases treatment. Results: 168 patients who have used infliximab were evaluated, 24 had psoriasis and 144 had chronic inflammatory diseases. Only 2 (8.3%) patients with psoriasis showed adverse events requiring treatment discontinuation, and just 6 (4.2%) female patients with chronic inflammatory diseases experienced adverse events. Conclusion: Infliximab is a safe drug, with a low percentage of adverse events and there were more adverse events in women with chronic inflammatory diseases and in patients who received more infliximab infusions.
Descritores: Psoríase/tratamento farmacológico
Antirreumáticos/efeitos adversos
Infliximab/efeitos adversos
-Artrite Reumatoide/tratamento farmacológico
Espondilite Anquilosante/tratamento farmacológico
Doença de Crohn/tratamento farmacológico
Fatores Sexuais
Estudos Transversais
Estudos Retrospectivos
Fator de Necrose Tumoral alfa/antagonistas & inibidores
Fator de Necrose Tumoral alfa/metabolismo
Infliximab/uso terapêutico
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-243688
Autor: Aquino Espinola, Salmi Aleli; Aranda Ferreira, Cinthia Leticia; Báez Torres, Laura Patricia; Insfrán Cáceres, Wilson Nicolás; Vera Salerno, Carlos Marcelo.
Título: Enfermedad de crohn.
Fonte: Asunción; Universidad Nacional de Asunción; 1998. 22 p.
Idioma: es.
Descritores: Doença de Crohn
-Paraguai
Responsável: PY2.1 - Centro de Documentación
610/75


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Texto completo SciELO Brasil
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Id: biblio-838065
Autor: Lima, Caren dos Santos; Pinto, Roberta Duarte Bezerra; Góes, Heliana Freitas de Oliveira; Salles, Simone de Abreu Neves; Vilar, Enoi Aparecida Guedes; Lima, Carla dos Santos.
Título: Sweet's syndrome associated with Crohn's disease
Fonte: An. bras. dermatol;92(2):263-265, Mar.-Apr. 2017. graf.
Idioma: en.
Resumo: Abstract: Sweet's syndrome is an uncommon benign skin disorder, whose pathogenesis remains unknown. Its classic form is more common in women and presents itself as papular-nodular, painful and erythematous or violaceous lesions. It mainly affects the face, neck, and upper limbs. Fever and neutrophilic leukocytosis are also common features. Although it is considered a systemic disease marker in more than half of patients, the association of this condition with Crohn's disease is rare, with few cases reported in the literature, of which, none in Brazil. We report the case of a patient with Crohn's disease who developed the classical features of Sweet's syndrome.
Descritores: Doença de Crohn/complicações
Síndrome de Sweet/complicações
-Dermatopatias/patologia
Doença de Crohn/patologia
Síndrome de Sweet/patologia
Limites: Seres Humanos
Feminino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


  7 / 581 LILACS  
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Rocha, José Joaquim Ribeiro da
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Id: lil-779764
Autor: Feitosa, Marley Ribeiro; Féres Filho, Omar; Tamaki, Camila Mussolin; Perazzoli, Camila; Bernardes, Mário Vinícius Angelete Alvarez; Parra, Rogério Serafim; Rocha, José Joaquim Ribeiro da; Féres, Omar.
Título: Adjunctive Hyperbaric Oxygen Therapy promotes successful healing in patients with refractory Crohn's disease
Fonte: Acta cir. bras;31(supl.1):19-23, 2016. tab, graf.
Idioma: en.
Resumo: PURPOSE: To investigate de adjunctive effect of Hyperbaric Oxygen Therapy in a group of patients with refractory Crohn's disease. METHODS: A total of 29 subjects with refractory Crohn's disease were submitted to daily sessions of Hyperbaric Oxygen Therapy, in a 2800 Sechrist Monoplace Hyperbaric Chamber (Sechrist, USA) pressurized to 2.4 ATA. Each session lasted 2 hours. The endpoint was closure of enterocutaneous fistulas and complete healing of Pyoderma Gangrenosum and perineal Crohn's disease. RESULTS: A total of 829 HBOT sessions were performed and no complications were noted. Overall success rate was 76% (22 cases). Pyoderma Gangrenosum and enterocutaneous fistulas had the highest successful healing rates (100% and 91%, respectively). Perineal Crohn's disease healing rate was 65%. CONCLUSION: Adjunctive Hyperbaric Oxygen Therapy promoted satisfactory healing in a group of patients with refractory Crohn's disease.
Descritores: Cicatrização
Doença de Crohn/terapia
Fístula Intestinal/terapia
Pioderma Gangrenoso/terapia
Oxigenação Hiperbárica/métodos
-Fatores de Tempo
Estudos Prospectivos
Reprodutibilidade dos Testes
Resultado do Tratamento
Terapia Combinada
Oxigenação Hiperbárica/estatística & dados numéricos
Limites: Seres Humanos
Masculino
Criança
Adulto
Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


  8 / 581 LILACS  
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Id: biblio-1016364
Autor: Berkowitz, Loni; Álvarez-Lobos, Manuel.
Título: Impacto del cigarrillo en el tracto gastrointestinal: efecto diferencial en enfermedad de Crohn y colitis ulcerosa / Impact of the cigarette on the gastrointestinal tract: differential effect in Crohn's disease and ulcerative colitis
Fonte: ARS med. (Santiago, En línea);42(1):34-40, 2017.
Idioma: es.
Resumo: El impacto del consumo de cigarrillo a nivel respiratorio y cardiovascular ha sido extensamente investigado, sin embargo, aún queda mucho por estudiar sobre su impacto en el tracto gastrointestinal. Está demostrado que el tabaquismo es un importante factor de riesgo para desórdenes gastrointestinales, incluyendo úlceras pépticas, Enfermedad de Crohn y distintos tipos de cáncer. Los mecanismos propuestos incluyen daños a nivel de la mucosa, alteraciones en la irrigación del tejido y cambios en la respuesta inmune. Paradojalmente, el consumo de cigarrillo constituye un factor protector para el desarrollo y la progresión de la Colitis Ulcerosa. Esta patología, junto a la Enfermedad de Crohn, conforman las dos entidades más importantes dentro de las Enfermedades Inflamatorias Intestinales y comparten diversas características. El impacto diferencial del consumo de cigarrillo entre ambas ha sido un tema de gran interés en los últimos treinta años, y aún no ha logrado ser esclarecido. En esta revisión describiremos los efectos conocidos del tabaquismo sobre el tracto gastrointestinal, y particularmente que intentan explicar el efecto opuesto del cigarrillo en la Enfermedad de Crohn y la Colitis Ulcerosa.(AU)

The impact of cigarette smoking on respiratory and cardiovascular diseases has been extensively researched, although further investigation is required to elucidate its impact on the gastrointestinal tract. It has been demonstrated that smoking is a major risk factor for gastrointestinal disorders, including peptic ulcers, Crohn's disease and various cancers. Proposed mechanisms include mucosal damage, changes in gut irrigation and changes in the mucosal immune response. Paradoxically, cigarette smoking is a protective factor for the development and progression of Ulcerative Colitis. Both Ulcerative colitis and Crohn's disease represent the two most important entities in Inflammatory Bowel Diseases and share several characteristics. The differential impact of smoking between these two disorders has been a topic of great interest in the last thirty years, and has yet to be clarified. In this review we describe the known effects of smoking on the gastrointestinal tract, and particularly in the intestinal inflammation, delving into the available studies that attempt to explain the opposite effect of smoking in Crohn's disease and Ulcerative colitis.(AU)
Descritores: Produtos do Tabaco
Gastroenteropatias
-Doenças Inflamatórias Intestinais
Colite Ulcerativa
Doença de Crohn
Inflamação
Limites: Seres Humanos
Masculino
Feminino
Tipo de Publ: Revisão
Responsável: CL10.1 - Biblioteca Biomédica


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Chebli, Júlio Maria Fonseca
Souza, Aécio Flávio Meirelles de
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Id: lil-530878 LILACS-Express
Autor: Chebli, Júlio Maria Fonseca; Gaburri, Pedro Duarte; Souza, Aécio Flávio Meirelles de; Oliveira, Lívia dos Remédios Pamplona de; Silva, Fernanda Santos; Vianna, Luciana de Paula.
Título: Azatioprina na doença inflamatória intestinal seria um fator de risco para Strongyloides stercoralis? / Would azathioprine in inflammatory bowel disease be a risk factor for Strongyloides stercoralis infection?
Fonte: HU rev;32(2):33-35, abr.-jun. 2006. tab.
Idioma: pt.
Resumo: A azatioprina é um dos mais comuns imunomoduladores utilizados no tratamento de Doença de Crohn e Retocolite Ulcerativa Idiopática, sendo que alguns pacientes desenvolvem imunossupressão. Por outro lado, o Strongyloides stercoralis está relacionado à infecção em pacientes imunocomprometidos. No presente estudo, pesquisa-se a prevalência do parasita nos pacientes portadores de Doença Inflamatória Intestinal em uso de azatioprina, através de exames parasitológicos de fezes. Analisa-se também a relação entre eosinofilia e a referida parasitose. No grupo tratado com azatioprina, 5,8% (4/69) dos pacientes estavam infectadospor Strongyloides stercoralis e apresentavam eosinofilia. Naquele tratado com outras drogas, somente 1,8% (1/55) apresentou a infecção e o número de eosinófilos dentro do referencial. Concluiu-se que a infecção pelo parasita é mais freqüente em pacientes da zona rural e que a eosnofilia pode ser um marcador indireto desta infecção.

Although azathioprine is one of the most common immunomodulatory drugs used in the treatment of Crohn's disease and ulcerative colitis, some patients can develop imunnosuppression. Strongyloides stercoralis infection may be associated with immunocompromised patients. In this study, our aim was to evaluate the prevalence of this infection in patients with Inflammatory bowel disease being treated with azathioprine, through parasitologic stool examination. The association between peripheral blood eosinophil counts and the infection was also studied. In the group treated with azathioprine, 5.8% (4/69) patients were infected by Strongyloides stercoralis and showed high level of eosinophil. In the other group, treated with different drug, only one patient (1.8%) revealed the infection and the number of eosinophil was normal. These observations demonstrated that the infection caused by this parasite was more frequent in patients from rural area. Besides, the high level of eosinophil could be an indirect marker for this infection.
-Proctocolite
Azatioprina
Doença de Crohn
Imunossupressão
Strongyloides stercoralis
Limites: Seres Humanos
Masculino
Feminino
Adolescente
Adulto
Meia-Idade
Idoso
Tipo de Publ: Relatos de Casos
Responsável: BR378.1 - Biblioteca Central


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Id: biblio-887392
Autor: Vicentín, Rosalía; Wagener, Marta; Pais, Alejandro B; Contreras, Mónica; Orsi, Marina.
Título: Registro prospectivo durante un año de enfermedad inflamatoria intestinal en población pediátrica argentina / One-year prospective registry of inflammatory bowel disease in the Argentine pediatric population
Fonte: Arch. argent. pediatr;115(6):533-540, dic. 2017. ilus, tab.
Idioma: en; es.
Resumo: Introducción. La enfermedad inflamatoria intestinal (EII) comprende la colitis ulcerosa (CU) y la enfermedad de Crohn (EC). Su diagnóstico es cada vez más frecuente en pediatría y la incidencia es desconocida en Argentina. El objetivo de este trabajo fue determinar la incidencia anual de EII en menores de 18 años de nuestro país, los aspectos epidemiológicos y las formas clínicas de presentación. Población y métodos. Estudio prospectivo, multicéntrico y observacional que abarcó todo el territorio nacional. Se incluyeron menores de 18 años con diagnóstico de EII de centros públicos y privados entre el 1/6/2012 y el 31/5/2013, a través de protocolo en la web. Resultados. Participaron 17 centros, y se registraron 50 pacientes en 10 centros. La incidencia fue 0, 4/100 000 < 18 años; EC, 20; CU, 25; y EII no clasificable, 5. Distribución según sexo: 26 varones y 24 mujeres. La edad media al momento del diagnóstico fue de 9, 7 años y la demora diagnóstica, de 16, 5 meses. Los síntomas y signos más frecuentes fueron diarrea crónica con sangre y/o moco, dolor abdominal y adelgazamiento. El retraso del crecimiento fue menor de lo esperado. Las manifestaciones extraintestinales se presentaron en el 24% en CU y en el 25% en EC. La localización más frecuente en EC fue ileocolónica, y, en CU, pancolónica. No se observó CU con formas graves. Conclusiones. La incidencia fue menor que la reportada por otros registros. Se considera conveniente la creación de un registro permanente, que no solo permita conocer la incidencia, sino también servir de apoyo a los centros referentes que diagnostican y tratan esta patología.

Introduction. Inflammatory bowel disease (IBD) includes ulcerative colitis (UC) and Crohn's disease (CD). IBD diagnosis has become increasingly common in pediatrics but its incidence is unknown in Argentina. The objective of this study was to determine the annual incidence of IBD in children and adolescents younger than 18 years in Argentina, its epidemiological aspects, and clinical presentations. Population and methods. Prospective, observational, multicenter study conducted in Argentina. Children and adolescents younger than 18 years from public and private facilities, diagnosed with IBD between June 1st, 2012 and May 31st, 2013 were included via a web protocol. Results. Seventeen sites participated in the study; 50 patients were recruited from 10 sites. IBD incidence was 0.4/100 000 among individuals <18 years; CD, 20; UC, 25; and idiopathic IBD, 5. Distribution by sex: 26 boys and 24 girls. Patients' mean age at diagnosis was 9.7 years, and delay in the diagnosis was 16.5 months. The most common symptoms and signs were chronic diarrhea with blood and/or mucus, abdominal pain, and weight loss. Growth retardation was less common than expected. Extraintestinal manifestations were observed in 24% of UC cases and in 25% of CD cases. The most common location of CD was the ileum and colon, and of UC was the entire colon (pancolonic). There were no cases with severe UC. Conclusions. The incidence was lower than that reported in other registries. We recommend the development of an ongoing registry, to establish the incidence of IBD, but also to serve as backup for referring facilities where this disease is diagnosed and treated.
Descritores: Doenças Inflamatórias Intestinais/epidemiologia
-Argentina/epidemiologia
Colite Ulcerativa/epidemiologia
Doença de Crohn/epidemiologia
Sistema de Registros
Incidência
Estudos Prospectivos
Limites: Seres Humanos
Lactente
Pré-Escolar
Criança
Adolescente
Tipo de Publ: Estudo Multicêntrico
Estudo Observacional
Responsável: AR94.1 - Centro de Información Pediatrica



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