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Id: biblio-1147980
Autor: Vélez, Juan Luis; López, Leidy Carlina.
Título: Trombosis porto-mesentérica aislada secundaria a trauma abdominal cerrado / Isolated porto-mesenteric thrombosis secondary to blunt abdominal trauma
Fonte: Rev. colomb. cir;35(4):675-681, 2020. fig, tab.
Idioma: es.
Resumo: En este artículo se revisan los aspectos más importantes de la epidemiología, fisiopatología, abordaje diagnóstico y terapéutico de la trombosis del sistema venoso portal y mesentérico, para finalizar discutiendo la experiencia clínica de un caso a la luz de la literatura relevante. Esta complicación es usualmente relacionada con afecciones sistémicas y hepáticas, pero rara vez se presenta aislada y relacionada con el trauma. En ausencia de tratamiento adecuado durante la etapa aguda, la trombosis puede evolucionar hacia el infarto intestinal y la muerte del paciente. En casos crónicos, se ha asociado con la degeneración del sistema venoso portal hacia cambios por hipertensión portal crónica

This article reviews the epidemiology, pathophysiology, diagnostic and therapeutic approach of the portal and mesenteric venous system thrombosis, with a clinical case discussion considering the relevant literature. This complication is usually related to systemic and hepatic conditions, but rarely occurs isolated and related to trauma. In the absence of adequate treatment during the acute stage, thrombosis can progress to intestinal infarction and death. In chronic cases, it has been associated with degeneration of the portal venous system into changes due to chronic portal hypertension
Descritores: Traumatismos Abdominais
-Sistema Porta
Trombose Venosa
Isquemia Mesentérica
Limites: Humanos
Responsável: CO113


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Id: biblio-1097699
Autor: Vanrell, Andrés Julián; Peralta, Juan; Sáez, Andrés; Ovalle Arciniegas, Hugo Mauricio.
Título: Isquemia mesentérica aguda: a propósito de un caso / Acute mesenteric ischemia: a purpose of a case
Fonte: Rev. Asoc. Méd. Argent;133(1):21-24, mar. 2020. ilus.
Idioma: es.
Resumo: La isquemia mesentérica aguda (IMA) es consecuencia de la oclusión de la arteria mesentérica superior (AMS) por trombosis o embolia, y es considerada la más letal del síndrome de abdomen agudo. Se presenta el caso de paciente femenina de 69 años con clínica difusa y confirmación diagnóstica radiológica, El objetivo de este caso clínico es proporcionar una revisión bibliográfica actual del tema y facilitar la adecuada actuación ante este problema de salud de amplio compromiso sistémico, y de aparición no tan infrecuente. (AU)

Acute mesenteric ischemia (IMA) is a consequence of occlusion of the superior mesenteric artery (AMS) by thrombosis or embolism; and it is considered the most lethal of acute abdomen syndrome. The case of a 69 years old female patient with diffuse clinic and radiological diagnostic confirmation is presented. The objective of this clinical case is to provide a current bibliographic review of the topic and facilitate adequate action in the face of this health problem with a broad systemic commitment, and with no appearance so infrequent. (AU)
Descritores: Artéria Mesentérica Superior/diagnóstico por imagem
Tomografia Computadorizada Multidetectores
Isquemia Mesentérica/etiologia
Oclusão Vascular Mesentérica/complicações
-Pelve/diagnóstico por imagem
Doença Aguda
Artéria Mesentérica Superior/cirurgia
Isquemia Mesentérica/diagnóstico
Isquemia Mesentérica/terapia
Abdome/diagnóstico por imagem
Limites: Humanos
Feminino
Idoso
Tipo de Publ: Relatos de Casos
Responsável: AR1.1 - Biblioteca Rafael Herrera Vegas


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Id: biblio-983682
Autor: Li, Qingwen; Cui, Shanshan; Jing, Guoqing; Ding, Huang; Xia, Zhongyuan; He, Xianghu.
Título: The role of PI3K/Akt signal pathway in the protective effects of propofol on intestinal and lung injury induced by intestinal ischemia/reperfusion
Fonte: Acta cir. bras;34(1):e20190010000005, 2019. graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the role of PI3k/Akt signal pathway in the protective effects of propofol on intestinal and lung injury induced by intestinal ischemia/reperfusion(I/R). Methods: Male Sprague-Dawley rats were subjected to 45 min of ischemia by occluding the superior mesenteric artery and to 2h of reperfusion to establish the model of I/R. Twenty four rats were randomly divided into four groups: Sham, intestinal I/R (II/R), propofol (P), wortmannin (W). In groups P, W, propofol was injected intravenously and continuously at the onset of reperfusion via infusion pump. PI3K inhibitor (wortmannin) was administered intravenously in group W 25 min before ischemia. Intestinal tissues and lung tissues were obtained for determination of histologic injury, wet/dry weight ratio, malondialdehyde (MDA) levels, superoxide dismutase (SOD) and myeloperoxidase (MPO) activities. Meanwhile, the expressions of caspase-3 and phosphorylated Akt (p-Akt) in intestines and lungs were detected by western blot. Results: Propofol treatment alleviated intestinal and lung morphological changes which were observed in II/R group,Moreover, wet/dry weight ratio, the MDA level, MPO activity and expression of caspase-3 were significantly decreased whereas the SOD activity and p-Akt expression were significantly increased. Notably, the protections were significantly reversed by pretreatment of wortmannin. Conclusion: PI3K/Akt pathway activation play a critical role in the protective effects of propofol on intestinal and lung injury induced by ischemia/reperfusion.
Descritores: Traumatismo por Reperfusão/tratamento farmacológico
Propofol/farmacologia
Anestésicos Intravenosos/farmacologia
Fosfatidilinositol 3-Quinases/fisiologia
Proteínas Proto-Oncogênicas c-akt/fisiologia
Lesão Pulmonar/prevenção & controle
Isquemia Mesentérica/tratamento farmacológico
-Traumatismo por Reperfusão/metabolismo
Transdução de Sinais/fisiologia
Ratos Sprague-Dawley
Modelos Animais de Doenças
Isquemia Mesentérica/metabolismo
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-973491
Autor: Taha, Murched Omar; Silva, Thaís de Melo Alexandre e; Ota, Keimy Saori; Vilela, Wander Junqueira; Simões, Ricardo Santos; Starzewski Junior, Alberto; Fagundes, Djalma José.
Título: The role of atenolol in the modulation of the expression of genes encoding pro- (caspase-1) and anti- (Bcl2L1) apoptotic proteins in endothelial cells exposed to intestinal ischemia and reperfusion in rats
Fonte: Acta cir. bras;33(12):1061-1066, Dec. 2018. tab.
Idioma: en.
Resumo: Abstract Purpose: To investigate the role of atenolol in the gene expression of caspase 1 (Casp1) and Bcl2L1 on vascular endothelium of rat intestine after ischemia and reperfusion (IR). Methods: Eighteen adult male Wistar rats were randomly divided into 3 groups (n=6): SG (Sham group): no clamping of the superior mesenteric artery; IRG: IR plus saline group: IRG+At: IR plus Atenolol group. Rats from IRG and IRG+At were subjected to 60 min of intestinal ischemia and 120 min of reperfusion. Atenolol (2mg/kg) or saline were injected in the femoral vein 5 min before ischemia, 5 min and 55 min after reperfusion. Thereafter, intestinal segments were appropriately removed and processed for Endothelial Cell Biology Rat RT2 Profiler PCR Array. Results: the anti-apoptotic Bcl2L1 gene expression was significantly down-regulated (-1.10) in the IRG and significantly up-regulated in the IRG+At (+14.15). Meanwhile, despite Casp1 gene expression was upregulated in both groups, it was significantly higher in the IRG (+35.06) than the IRG+At (+6.68). Conclusions: Atenolol presents antiapoptotic effects on rat intestine subjected to IR partly by the up-regulation of the anti-apoptotic Bcl2L1 gene expression. Moreover, atenolol can mitigate the pro-apoptotic and pro-inflammatory effects of Casp1 gene on rat intestine after IR.
Descritores: Atenolol/farmacologia
Traumatismo por Reperfusão/prevenção & controle
Expressão Gênica/efeitos dos fármacos
Substâncias Protetoras/farmacologia
Caspase 1/efeitos dos fármacos
Proteína bcl-X/efeitos dos fármacos
Intestino Delgado/irrigação sanguínea
-Fatores de Tempo
Endotélio Vascular
Distribuição Aleatória
Regulação para Baixo/efeitos dos fármacos
Regulação para Cima/efeitos dos fármacos
Reação em Cadeia da Polimerase
Reprodutibilidade dos Testes
Resultado do Tratamento
Ratos Wistar
Artéria Mesentérica Superior
Apoptose/efeitos dos fármacos
Constrição
Citoproteção/efeitos dos fármacos
Caspase 1/genética
Proteína bcl-X/genética
Isquemia Mesentérica/prevenção & controle
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-973485
Autor: Miranda, Celina Teresa Castelo Branco Couto de; Fagundes, Djalma José; Miranda, Edinaldo de; Simões, Ricardo Santos; Taha, Murched Omar.
Título: The role of ischemic preconditioning in gene expression related to inflammation in a rat model of intestinal ischemia-reperfusion injury
Fonte: Acta cir. bras;33(12):1095-1102, Dec. 2018. tab.
Idioma: en.
Resumo: Abstract Purpose: To investigate the gene expression related to inflammation on mice subjected to intestinal ischemia and reperfusion (I/R) and treated with ischemic preconditioning (IPC). Methods: Thirty rats (EPM-Wistar), distributed in five groups of six animals each, were underwent anesthesia and laparotomy. The ischemia time was standardized in 60 minutes and the reperfusion time 120 minutes. IPC was standardized in 5 minutes of ischemia followed by 10 minutes of reperfusion accomplished before I/R. The control group was submitted only to anesthesia and laparotomy. The other groups were submitted to ischemia, I/R, ischemia + IPC and I/R + IPC. It was collected a small intestine sample to analyses by Quantitative Polymerase Chain Reaction in real Time (RT-qPCR) and histological analyses. It was studied 27 genes. Results: The groups that received IPC presented downregulation of genes, observed in of genes in IPC+ischemia group and IPC+I/R group. Data analysis by clusters showed upregulation in I/R group, however in IPC groups occurred downregulation of genes related to inflammation. Conclusion: The ischemia/reperfusion promoted upregulation of genes related to inflammation, while ischemic preconditioning promoted downregulation of these genes.
Descritores: Traumatismo por Reperfusão/prevenção & controle
Expressão Gênica/fisiologia
Precondicionamento Isquêmico/métodos
Inflamação/prevenção & controle
Intestino Delgado/irrigação sanguínea
-Valores de Referência
Fatores de Tempo
Traumatismo por Reperfusão/genética
Regulação para Baixo/fisiologia
Regulação para Cima/fisiologia
Reprodutibilidade dos Testes
Resultado do Tratamento
Ratos Wistar
Reação em Cadeia da Polimerase em Tempo Real
Isquemia Mesentérica/genética
Isquemia Mesentérica/prevenção & controle
Inflamação/genética
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-1010875
Autor: Miranda, Celina Teresa Castelo Branco Couto de; Fagundes, Djalma José; Miranda, Edinaldo de; Simões, Ricardo Santos; Carbonel, Adriana Aparecida Ferraz; Florencio-Silva, Rinaldo; Taha, Murched Omar.
Título: The role of ischemic preconditioning in the expression of apoptosis-related genes in a rat model of intestinal ischemia-reperfusion injury
Fonte: Acta cir. bras;34(5):e201900501, 2019. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To analyze the effects of ischemic preconditioning (IPC) in the expression of apoptosis-related genes in rat small intestine subjected to ischemia and reperfusion. Methods: Thirty anesthetized rats underwent laparotomy and were drive into five groups: control (CG); ischemia (IG); ischemia and reperfusion (IRG); IPC and ischemia (IG+IPC); IPC and ischemia and reperfusion (I/RG+IPC). Intestinal ischemia was performed by clamping the superior mesenteric artery for 60 minutes, whereas reperfusion lasted for 120 minutes. IPC was carried out by one cycle of 5 minutes of ischemia followed by 10 minutes of reperfusion prior to the prolonged 60-minutes-ischemia and 120-minutes-reperfusion. Thereafter, the rats were euthanized and samples of small intestine were processed for histology and gene expression. Results: Histology of myenteric plexus showed a higher presence of neurons presenting pyknotic nuclei and condensed chromatin in the IG and IRG. IG+IPC and I/RG+IPC groups exhibited neurons with preserved volume and nuclei, along with significant up-regulation of the anti-apoptotic protein Bcl2l1 and down-regulation of pro-apoptotic genes. Moreover, Bax/Bcl2 ratio was lower in the groups subjected to IPC, indicating a protective effect of IPC against apoptosis. Conclusion: Ischemic preconditioning protect rat small intestine against ischemia/reperfusion injury, reducing morphologic lesions and apoptosis.
Descritores: Traumatismo por Reperfusão/prevenção & controle
Apoptose/genética
Precondicionamento Isquêmico/métodos
Proteínas Reguladoras de Apoptose/análise
Jejuno/irrigação sanguínea
Jejuno/patologia
-Valores de Referência
Distribuição Aleatória
Regulação para Baixo
Expressão Gênica
Reprodutibilidade dos Testes
Ratos Wistar
Artéria Mesentérica Superior
Constrição
Células Endoteliais/patologia
Proteínas Reguladoras de Apoptose/genética
Reação em Cadeia da Polimerase em Tempo Real
Isquemia Mesentérica/genética
Isquemia Mesentérica/patologia
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-886231
Autor: Costa, Rafael Izar Domingues da; Rasslan, Roberto; Koike, Marcia Kiyomi; Utiyama, Edivaldo Massazo; Montero, Edna Frasson de Souza.
Título: Bacterial translocation and mortality on rat model of intestinal ischemia and obstruction
Fonte: Acta cir. bras;32(8):641-647, Aug. 2017. tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: Abstract Purpose: To develop an experimental model of intestinal ischemia and obstruction followed by surgical resection of the damaged segment and reestablishment of intestinal transit, looking at bacterial translocation and survival. Methods: After anesthesia, Wistar rats was subject to laparotomy, intestinal ischemia and obstruction through an ileal ligature 1.5cm of ileum cecal valve; and the mesenteric vessels that irrigate upstream of the obstruction site to approximately 7 to 10 cm were ligated. Abdominal wall was closed. Three, six or twenty-four hours after, rats were subject to enterectomy followed by an end to end anastomosis. After 24h, mesenteric lymph nodes, liver, spleen and lung tissues were surgically removed. It was studied survival rate and bacterial translocation. GraphPadPrism statistical program was used. Results: Animals with intestinal ischemia and obstruction for 3 hours survived 24 hours after enterectomy; 6hx24h: survival was 70% at 24 hours; 24hx24h: survival was 70% and 40%, before and after enterectomy, respectively. Culture of tissues showed positivity on the 6hx24h and negativity on the 3hx24h. Conclusion: The model that best approached the clinic was the one of 6x24h of ischemia and intestinal obstruction, in which it was observed bacterial translocation and low mortality rate.
Descritores: Translocação Bacteriana/fisiologia
Modelos Animais de Doenças
Isquemia Mesentérica/microbiologia
Valva Ileocecal/irrigação sanguínea
Valva Ileocecal/microbiologia
Obstrução Intestinal/microbiologia
-Fatores de Tempo
Contagem de Colônia Microbiana
Taxa de Sobrevida
Reprodutibilidade dos Testes
Ratos Wistar
Isquemia Mesentérica/cirurgia
Isquemia Mesentérica/mortalidade
Bactérias Anaeróbias Gram-Negativas/isolamento & purificação
Bactérias Anaeróbias Gram-Negativas/fisiologia
Valva Ileocecal/cirurgia
Obstrução Intestinal/cirurgia
Obstrução Intestinal/mortalidade
Ligadura
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


  8 / 29 LILACS  
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Id: biblio-2424
Autor: Felga, Guilherme Eduardo; Forn, Cecília; Pinto, Janine; Chebli, Julio Maria; Gaburri, Pedro; Souza, Aécio Flávio; Chebli, Liliana; Nunes, Sônia Aparecida; Martins, Leonardo; Ribeiro, Simone.
Título: Trombose venosa mesentérica subaguda / Subacute mesenteric venous thrombosis
Fonte: HU rev;29(3):488-489, set.-dez.2003.
Idioma: pt.
Resumo: As tromboses venosas mesentéricas (TVM) são causas infrequentes de isquemia intestinal, respondendo por apenas 5% a 10% dos casos, mas estando relacionadas a determinadas condições clínicas em até 80% dos casos. Podem apresentar-se sob forma aguda, subaguda ou crônica. A TVM subaguda se desenvolve ao longo de semanas a meses, porém sem determinar infarto intestinal desde o início. É causa de dor abdominal de longa duração e pode evoluir para a isquemia intestinal aguda. Neste relato, apresentamos um caso de TVM subaguda com isquemia intestinal, no qual mostramos as dificuldades relativas a seu diagnóstico e manejo.
Descritores: Isquemia Mesentérica
-Trombose
Dor Abdominal
Tipo de Publ: Relatos de Casos
Responsável: BR378.1 - Biblioteca Central


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Id: biblio-946898
Autor: Carvalho, Tiago Pinheiro Vaz de; Arcoverde, Rodrigo Moraes Loyo; Nascimento, Wheverton Correia do; Paiva, Igor Henrique Rodrigues de; Aguiar Júnior, Francisco Carlos Amanajás de; Gomes, Elainne Christine de Souza; Barbosa, Constança Clara Gayoso Simões.
Título: Mesenteric ischemia as a cause of early death among mice infected by Schistosoma mansoni
Fonte: Rev. patol. trop;47(3):145-158, set. 2018. tab, graf, ilus.
Idioma: en.
Resumo: Laboratory maintenance of the Schistosoma mansoni cycle is necessary for developing studies regarding the diagnosis, treatment and control of schistosomiasis. Within this perspective, it is paramount that mice infected by the parasite should present a minimum survival of six months. However, between October 2016 and May 2017, early deaths were observed among infected animals kept in the vivarium of the Schistosomiasis Reference Service of IAMFIOCRUZ. Therefore, the purpose of the present study was to present the results obtained after investigating the main cause of death among these animals. To achieve this, animals that died or that needed to be euthanized due to clinical distress caused by parasite infection were necropsied to investigate the cause of death and clinical condition. Fragments from the intestines, mesenteric vessels and livers were removed and were subjected to histopathological studies. In addition, mouse feces were collected and analyzed using the hydrogen peroxide reaction to detect occult blood. Over an eight-month period, 70 deaths were noted. Forty two animals presented mesenteric ischemia, a vascular insufficiency syndrome that causes a reduction in the nutrient supply to the intestinal viscera. There is, therefore, a need to reduce the infective parasite load in mice to increase their survival, reduce distress caused by the infection and ensure maintenance of the S. mansoni cycle, thus enabling continuity of scientific studies on this parasitosis.
Descritores: Schistosoma mansoni
Isquemia Mesentérica
Camundongos
Limites: Animais
Camundongos
Tipo de Publ: Relatos de Casos
Responsável: BR15.1 - Biblioteca de Ciências Biomédicas


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Id: biblio-987875
Autor: Sebastián Sebastián, Cristina; Larrosa López, Raquel; Martínez Mombila, Elena; De Toledo Octavio, Sarría Luis.
Título: Hernia interna transmesentérica con signos de compromiso vascular / Transmesenteric Internal Hernia with Strangulated Obstruction
Fonte: Rev. colomb. radiol;26(4):4328-4331, 2015.
Idioma: es.
Resumo: Las hernias internas transmesentéricas (HT) son poco frecuentes en los adultos y se relacionan mayoritariamente con cirugías abdominales previas. El objetivo de este artículo es describir los principales hallazgos de las HT y de estrangulación intestinal en tomografía computarizada (TC). Se presenta un paciente sin antecedentes quirúrgicos, con una oclusión aguda en "asa cerrada" de un segmento de íleon distal, comprometido vascularmente a través de un defecto herniario transmesentérico. Las hernias internas suelen diagnosticarse cuando se produce una obstrucción en "asa cerrada" u oclusión en dos puntos del segmento intestinal herniado. La TC muestra una agrupación de asas intestinales distendidas y convergencia de vasos mesentéricos hacia el defecto herniario. Las HT suelen localizarse en posición lateral al colon transverso. Es importante descartar el compromiso vascular intestinal, frecuente en las HT. Se deben incluir las hernias internas en el diagnóstico diferencial de obstrucción intestinal, fundamentalmente en pacientes no operados previamente.

Transmesenteric internal hernias (TH) are rare in adults and are mainly related to previous abdominal surgeries. The purpose of this article is to describe the main radiological findings of TH and strangulation obstruction on computerized tomography (CT). We present a patient with no history of previous surgeries, with acute closed loop obstruction of a segment of distal ileum, vascularly compromised through a transmesenteric hernial defect. Internal hernias are usually diagnosed when a closed loop obstruction occurs, or an occlusion in two points of the herniated intestinal segment. The CT shows a group of distended intestinal loops, and convergence of the mesenteric vessels towards the hernia defect. TH are often located lateral to the transverse colon. It is important to rule out intestinal ischemia, very common in TH. We should include internal hernias in the differential diagnosis of acute small bowel obstruction, mainly in patients with no history of previous surgery.
Descritores: Hérnia Abdominal
-Tomografia Computadorizada por Raios X
Isquemia Mesentérica
Obstrução Intestinal
Limites: Humanos
Responsável: CO371.9



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