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Id: biblio-998236
Autor: Ganji, Kiran Kumar; Tantry, Bilal Ahmad.
Título: Prevalence and Molecular Analysis of Novel Newly Identified Periodontal Pathogens in Subgingival Plaque Samples of Saudi Patients with Chronic Periodontitis
Fonte: Pesqui. bras. odontopediatria clín. integr;19(1):4679, 01 Fevereiro 2019. tab.
Idioma: en.
Resumo: Objective: To evaluate the prevalence of novel newly identified periodontal pathogenic strains in subgingival plaque samples and relate it with bleeding on probing, probing pocket depth and age. Material and Methods: 268 chronic periodontitis patients with a mean age of 46.0 ± 6.0 years were included. The following microorganisms were evaluated: Campylobacter gracilis (Cg), Fusobacterium nucleatum (Fn), Porphyromonas gingivalis (Pg), and Tannerella forsythia (Tf). Full mouth examination was registered; the probing pocket depth and clinical attachment level were assessed at six sites per tooth. Dental subgingival plaque samples were taken in the deepest pocket per arch in the maxilla and mandible. DNA analysis was performed using DNA-strip technology. Pearson's correlation coefficient was used for statistical analysis. Results: Porphyromonas gingivalis and Tannerella forsythia were detected at high level of 80% and 82% respectively. F nucleatum revealed a rate of 94%. Bacterial load significantly increased by increasing mean probing depth of the examined sites. Pearson's coefficient was the highest for Pg (r=0.62, p=0.0001) and the lowest for Cg (r=0.08, p=0.04). The bacterial load significantly increased by increasing the number of bleeding sites; Pearson's coefficient varied from r= 0.14 for Pg (p=0.01) to r=0.39 for Tf (p=0.001). Conclusion: It was confirmed the presence of main putative periodontal pathogens detectable in Saudi periodontal subjects, also providing a comprehensive view for correlation of these putative periodontal pathogens with the increase in probing pocket depth to the presence and load of all the bacterial species.
Descritores: Doenças Periodontais
Bolsa Periodontal
Porphyromonas gingivalis
Periodontite Crônica
-Arábia Saudita
Modelos Logísticos
Estatísticas não Paramétricas
Limites: Seres Humanos
Masculino
Feminino
Meia-Idade
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos


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Id: biblio-998214
Autor: Eslami, Hosein; Faramarzi, Masoumeh; Majidi, Jafar; Bohlouli, Sepideh; Khani, Anahita Javad; Aghebati-Maleki, Leili; Motahari, Paria.
Título: Comparing the Levels of Gingival Crevicular Fluid Prostaglandin E2 in Generalized Chronic Periodontitis Between Healthy and Type 2 Diabetes Patients: A Case-Control Study
Fonte: Pesqui. bras. odontopediatria clín. integr;19(1):4523, 01 Fevereiro 2019. tab, graf.
Idioma: en.
Resumo: Objective: To compare the prostaglandin E2 (PGE2) levels of gingival crevicular fluid in generalized chronic periodontitis between healthy and type 2 diabetic patients. Material and Methods: 56 diabetic and non-diabetic participants with generalized chronic periodontitis were selected randomly. They were divided into two groups (G1: generalized chronic periodontitis patients with normal blood sugar; and G2: generalized chronic periodontitis patients with diabetes). Gingival crevicular fluid samples were obtained from both groups. The average of 2 samples per day were centrifuged in a laboratory at 2500 rpm and temperature of 4°C for 5 minutes and placed in a refrigerator at -20°C. The level of PGE2 was measured using ELISA and Abcam kit. Data were analyzed by Kolmogorov-Smirnov, Mann-Whitney U Test, Pearson and independent T tests. The significant amount was considered 0.05 in this test (α<0.05). Results: The mean level of PGE2 was significantly different in the two groups and the mean level of PGE2 in the control group was lower than the case group. There was no statistically significant relationship between PGE2 with pocket depth, fasting blood sugar (FBS) and HBA1C (p>0.05). Conclusion: PGE2 level of diabetic patient group with chronic generalized periodontitis was significantly more than non-diabetic group with generalized chronic periodontitis.
Descritores: Higiene Bucal
Doenças Periodontais
Estudos de Casos e Controles
Diabetes Mellitus
Periodontite Crônica/diagnóstico
-Estatísticas não Paramétricas
Irã (Geográfico)
Limites: Seres Humanos
Tipo de Publ: Estudo Comparativo
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos


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Id: biblio-1007045
Autor: Andrea, Badanian; Bueno, Luis; Papone, Virginia.
Título: Análisis bacteriano comparativo de cuadros de Periodontitis Crónica y Agresiva en una población muestra de Uruguay / Comparative bacterial analysis of chronic and aggressive periodontitis in a sample population from Uruguay
Fonte: Odontoestomatol;21(33):5-13, ene.-jun. 2019.
Idioma: es.
Resumo: Objetivos: analizar comparativamente la prevalencia de ciertos patógenos periodontales en cuadros de periodontitis agresiva y crónica según la clasificación vigente al momento de los estudios, en 101 pacientes uruguayos. Métodos: Este análisis se basa en los trabajos de detección de patógenos periodontales en pacientes con periodontitis crónica y agresiva en Uruguay mediante metodología convencional y molecular 1,2. Ambos trabajos analizaron los mismos microorganismos y utilizaron las mismas técnicas de recuperación y análisis. Se estudiaron Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia y Fusobacterium nucleatum. Resultados: En los cuadros crónicos destacó F. nucleatum, T. forsythia y P.gingivalis. En los agresivos F. nucleatum y P. intermedia, y dentro de éstos en los generalizados una mayor proporción de P. gingivalis y T. forsythia y de A. actinomycetemcomitans en los localizados. Conclusiones: Se pudo constatar que se mantienen los patrones documentados en la bibliografía en Uruguay.3,4

Objectives: To compare the prevalence of certain periodontal pathogens in aggressive and chronic periodontitis in 101 Uruguayan patients according to the valid classification at the time the studies were conducted. Methods: This analysis is based on studies conducted to detect periodontal pathogens in patients with chronic and aggressive periodontitis in Uruguay using conventional and molecular methods. Both studies analyzed the same microorganisms and used the same recovery and analysis techniques. Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia and Fusobacterium nucleatum were studied. Results: A higher prevalence of F. nucleatum, T. forsythia and P. gingivalis was detected in chronic cases, whereas higher rates of F. nucleatum and P. intermedia were observed in aggressive ones. Within the last one, a higher proportion of P. gingivalis and T. forsythia was detected in the generalized cases and A. actinomycetemcomitans in the localized ones. Conclusions: The patterns detected are in line with those included in the literature for our country
Descritores: Periodontite
Periodontite Agressiva
Periodontite Crônica
-Uruguai
Limites: Seres Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: UY20.1 - Departamento de Documentación y Biblioteca


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Id: biblio-991327
Autor: Loredo Sandoval, Yenit; Cruz Morales, Rosario; Cazamayor Laime, Zuleica; Montero Arguelles, Mayra.
Título: Comportamiento de la enfermedad periodontal inmunoinflamatoria crónica. Jovellanos. Matanzas / Behavior of the chronic immunoinflammatory periodontal disease. Jovellanos. Matanzas
Fonte: Rev. medica electron;41(1):78-89, ene.-feb. 2019. tab.
Idioma: es.
Resumo: RESUMEN Introducción: Para la Organización Mundial de la Salud, la enfermedad periodontal representa un problema de salud pública en países industrializados y en los que están en vías de desarrollo. Afecta la calidad de vida de quienes las sufren. Este término agrupa una serie de entidades que afectan los tejidos de protección e inserción del diente, dentro de las cuales se encuentra la periodontitis, proceso inmunoinflamatoria crónico. Objetivo: estimar la prevalencia de la enfermedad periodontal inmunoinflamatoria crónica en el municipio de Jovellanos, provincia de Matanzas. Materiales y métodos: con el objetivo de estimar la prevalencia de la enfermedad periodontal inmunoinflamatoria crónica, en el municipio de Jovellanos, provincia de Matanzas se realizó un estudio observacional, descriptivo transversal, en el período comprendido entre el mes junio del 2009 a junio del 2010. Resultados: el 54,5 % de la población no presentó la enfermedad estudiada. El grupo de 5 a 11 años fue el que más aportó a este resultado. La enfermedad fue diagnosticada en el 45,5 % de la población examinada, la cual comenzó a manifestarse a partir del grupo de edad de 15 a 18 años. El 92,9 % de los individuos de 60 a 74 años fueron los más afectados. Conclusiones: en cuanto a la enfermedad periodontal inmuno inflamatoria la cantidad de pacientes sanos, desde el punto de vista periodontal, estuvo entre un 49,4 % y un 59,6 % del total de la población. La incidencia de la enfermedad aumenta con la edad. La presencia de bolsas resultó mayor a partir de los 35 años y causó gran afectación en los individuos de 60 a 74 años.

ABSTRACT Introduction: According to the World Health Organization, periodontal disease represents a public health problem in the developed countries and in the developing ones. It affects the life quality of people suffering it. This term groups together several entities affecting the tooth´s insertion and protection tissues; periodontitis, a chronic immunoinflammatory process, is found among them. Objective: estimate the prevalence of periodontal disease inmunoinflamatoria chronic in the municipality of Jovellanos, province of Matanzas. Materials and methods: a cross-sectional descriptive, observational study was carried out in the municipality of Jovellanos, province of Matanzas from June 2009 to June 2010 for the sake of estimating the prevalence of the chronic immunoinflammatory periodontal disease. Results: 54.5 % of the population did not present the studied disease. The 5-11-years-old group was the one contributing more to these results. The disease was diagnosed in 45.5 % of the studied population, and started to manifest beginning from the 15-18-years-old age group. 92.9 % of the individuals aged 60 to 74 years were the most affected ones. Conclusions: from the periodontal point of view, the quantity of healthy patients oscillated between 49.4 % and 59.6 % of the total population. The disease incidence increases with age. The presence of pockets was higher from the age of 35 years on, and caused great affectation in individuals aged 60-74 years.
Descritores: Fatores de Risco
Periodontite Crônica/imunologia
Periodontite Crônica/epidemiologia
Gengivite/imunologia
Gengivite/epidemiologia
-Doenças Periodontais/imunologia
Doenças Periodontais/epidemiologia
Epidemiologia Descritiva
Estudos Transversais
Estudo Observacional
Limites: Seres Humanos
Tipo de Publ: Artigo Clássico
Responsável: CU424.1 - Centro Provincial de Información de Ciencias Médicas


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Id: biblio-900295
Autor: Rojas, Miguel A; Jacques, Jaime; Molinett, Sebastian; Botelho, Juliana N; Padilla, Carlos.
Título: Distribución gen fimA de Porphyromonas gingivalis en pacientes chilenos con periodontitis crónica / Distribution of fimA genotypes of Porphyromonas gingivalis in Chilean patients with chronic periodontitis
Fonte: Rev. clín. periodoncia implantol. rehabil. oral (Impr.);10(3):141-144, dic. 2017. tab, graf.
Idioma: es.
Resumo: RESUMEN: Antecedentes: Gen fimA de Porphyromonas gingivalis es un importante factor de virulencia asociado al desarrollo y la progresión de periodontitis. Objetivo: Cuantificar los niveles de P. gingivalis y la prevalencia de genotipos fimA en pacientes chilenos con diferentes grados de severidad de periodontitis crónica. Metodología: Se analizaron 135 muestras subgingivales de 45 adultos (15 con leve, 15 con moderada y 15 con periodontitis severa) mediante qPCR para P. gingivalis y genotipos fimA (I-V and Ib). Resultados: Se detectó P. gingivalis en el 73,3% de los pacientes con periodontitis crónica (46,6%, 73,3% y 100% para las formas leve, moderada y severa, respectivamente). El gen fimA se detectó en el 66% de los sujetos positivos para P. gingivalis, siendo el fimA IV y I los genotipos más prevalentes. Además, se detectó fimA IV en el 75% y fimA I en el 62,5% de los casos severos y moderados de periodontitis, respectivamente. Los niveles aumentados de fimA IV se asociaron con periodontitis crónica severa. Conclusiones: Los resultados sugieren una alta prevalencia de P. gingivalis y de sus genotipos fimA IV y I en pacientes con periodontitis crónica. Además fimA IV fue asociado con formas más severas de periodontitis crónica en esta población chilena.

ABSTRACT: Background: Porphyromonas gingivalis fimA gene is a key virulence factor and has been associated with development and progression of periodontal diseases. Aim: To quantify the levels of P. gingivalis and the prevalence of fimA genotypes in Chilean patients with different severity of chronic periodontitis. Methodology: One hundred and thirty five subgingival samples from 45 adults (15 with slight, 15 with moderate and 15 with severe chronic periodontitis, respectively) were analyzed by qPCR for P. gingivalis and fimA genotypes (I-V and Ib). Results: P. gingivalis was detected in 73.3% of patients (46.6%, 73.3% and 100% of patients with slight, moderate and severe chronic periodontitis, respectively). The genotype fimA was detected in 66% of positive subjects for P. gingivalis, whereas fimA IV and I were the most prevalent genotypes. In addition, fimA IV was detected in 75% and fimA I in 62.5% of severe and moderate cases, respectively. Increased levels of fimA IV were associated with severe chronic periodontitis. Conclusions: These findings suggest that there is a high prevalence of P. gingivalis and its fimA IV and I genotypes in chronic periodontitis patients. Furthermore, fimA IV was associated with severe chronic periodontitis in this Chilean population.
Descritores: Porphyromonas gingivalis/genética
Periodontite Crônica/microbiologia
-Distribuição de Qui-Quadrado
Chile/epidemiologia
Prevalência
Estudos Transversais
Porphyromonas gingivalis/isolamento & purificação
Proteínas de Fímbrias/genética
Placa Dentária/microbiologia
Reação em Cadeia da Polimerase em Tempo Real
Genótipo
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Idoso
Adulto Jovem
Responsável: CL58.1 - Biblioteca


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Id: biblio-1010178
Autor: Rodríguez Godoy, Mauricio; Vesga, Jasmín; Corzo, Leyder; Serrano Méndez, Carlos A; Cuevas, Adriana Marcela; Sanabria, Mauricio.
Título: Prevalence of periodontitis in a population of patients on dialysis in Colombia
Fonte: Acta odontol. latinoam;32(1):17-21, 2019. tab.
Idioma: en.
Resumo: The aim of this study is to establish the prevalence of Chronic Periodontitis (CP) in patients with Chronic Kidney Disease (CKD) and to ascertain its relationship with several factors or indicators of micro inflammation. One hundred and thirtyfive CKD patients on dialysis treatment were included. Biochemical parameters, clinical attachment level and pocket depth were recorded according of the American Academy of Periodontology and the CDC (CDCAAP). Gingivitis and CP were recorded based on the biofilmgingival interface (BGI) periodontal diseases classification. The rate of nonresponse to the survey was 10 percent. A total 2,636 teeth in 135 patients were examined, of whom 52.5% were males. Average age was 55.7 years (SD ± 1.32); 41.4% had a smoking history; 78/135 patients were on hemodialysis and 57/135 on peritoneal dialysis; 55.5% had been on dialysis for more than three years. Prevalence of gingivitis and periodontitis was 14.8%, 95% CI (9.721.9) and 82.2%, 95% CI (74.7 ­ 87.8), respectively; according to the BGI Index. Severity of CP was: No periodontitis, 14.0% 95% CI (9.1 21.1) ; mild, 11.1% 95% CI (6.7 17.7) ; moderate, 28.8% 95% CI (21.7 37.1) ; and severe, 45.9% 95% CI (31.654.47). Peritoneal dialysis and time on dialysis > 3 years increase the chance of having periodontitis, OR 11.0 95% CI (2.253.8) and OR 7.6 95% CI (1.150.2), respectively. In view of the high prevalence of CP in this population, programs designed to ensure better periodontal and gingival care in the population on dialysis need to be established (AU)

El objetivo de este estudio fue establecer la prevalencia de Periodontitis Crónica (PC) en pacientes con enfermedad renal crónica (ERC) en diálisis y determinar la relación de su presencia con algunos indicadores de micro inflamación. Un total de 135 pacientes con ERC en terapia dialítica fueron incluidos en este estudio. Se evaluaron parámetros bioquímicos, nivel de inserción clínica (NIC) y profundidad de sondaje (PS), de acuerdo con la Asociación Americana de Periodoncia y el CDC de Atlanta (CDCAAP). También fue evaluada, la gingivitis y la PC de acuerdo con la clasificación interface biopeliculaencia (BGI). La tasa de no respuesta a la encuesta fue del 10%. Un total de 2636 dientes en 135 pacientes fueron evaluados, (52.5% hombres, edad promedio 55.7 ± 1.32), 56% con antecedente de tabaquismo. 78/135 en hemodiálisis y 57/135 en diálisis peritoneal, el 55.5 % con un tiempo en diálisis mayor a tres años. La prevalencia de gingivitis por la clasificación BGI fue del 14.8% IC 95% (9.7 21.9) y de periodontitis 82.2% IC 95% (74.7 ­ 87.8). La severidad de la PC fue: sin periodontitis 14.0% 95% IC (9.1 21.1) ; leve 11.1% 95% IC (6.7 17.7) ; moderada 28.8% 95% IC (21.7 37.1) y severa 45.9% 95% IC (31.654.47) La diálisis peritoneal y el tiempo en diálisis aumentaron la chance de tener PC: OR 11.0 95% IC (2.253.8) y OR 7.6 95% CI (1.150.2) respectiva mente. Por la alta prevalencia de PC en esta población, es necesario establecer programas para asegurar el cuidado de la salud periodontal en esta población en diálisis (AU)
Descritores: Diálise Peritoneal
Insuficiência Renal Crônica
Periodontite Crônica/epidemiologia
-Estudos Transversais
Análise Estatística
Colômbia
Gengivite/epidemiologia
Limites: Seres Humanos
Masculino
Feminino
Adolescente
Adulto
Meia-Idade
Responsável: AR29.1 - Biblioteca


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Id: biblio-1009980
Autor: Mourão, Leila Cristina dos Santos.
Título: Efeitos da homeopatia no tratamento da Periodontite Crônica Generalizada em pacientes diabéticos tipo II: ensaio clínico randomizado, duplo-cego, placebo-controlado, com um ano de acompanhamento / Effect of homeopathy in the treatment of generalized chronic periodontitis in type 2 diabetic patients: randomized, double-blind, placebo-controlled, with a year of acompanhamentthe.
Fonte: Rio de janeiro; s.n; 2015. 60 p. ilus.
Idioma: pt.
Tese: Apresentada a Universidade do Estado do Rio de Janeiro. Faculdade de Odontologia para obtenção do grau de Doutor.
Resumo: Introdução e objetivo: a periodontite crônica (PC) é uma doença inflamatória crônica resultante do rompimento da homeostase entre microbiota subgengival e as defesas do hospedeiro. Como a homeopatia (H) visa restabelecer o equilíbrio da energia vital do paciente permitindo o movimento de cura do organismo. O objetivo do presente estudo foi avaliar os efeitos longitudinais (um ano) da terapia homeopática como coadjuvante no tratamento da periodontite crônica generalizada (PC) em pacientes diabéticos tipo II, sobre os parâmetros clínicos e laboratoriais, e seu impacto na qualidade de vida do paciente. Materiais e métodos: Oitenta pacientes com PC e DM II, de ambos os sexos e com idades entre 32 e 70 anos de idade, participaram desse ensaio clínico randomizado, duplo-cego, placebo-controlado. Os pacientes foram divididos em dois grupos: grupo controle (GC) e o Grupo teste (GT). Ambos os grupos receberam a Terapia periodontal básica (TPB). G-T recebeu adicionalmente a Terapia homeopática (TH): Berberis, Mercurius solubilis/ Belladona/ Hepar sulphur e Pyrogenium, enquanto GC recebeu placebo. As avaliações foram feitas no baseline e após 30 dias, 6 e 12 meses de tratamento. As respostas locais e sistêmicas foram avaliadas por parâmetros clínicos e laboratoriais respectivamente. Também, foi utilizado um questionário de qualidade de vida, Oral Health Impact Profile-14 (OHIP-14). Os dados foram analisados pelos testes paramétricos e não paramétricos. O nível de significância foi de 5%. Resultados: A avaliação intragrupos mostrou melhoras significativas em ambos os grupos, ao longo do estudo, para os parâmetros clínicos periodontais estudados. Na análise laboratorial, G-T mostrou níveis estatisticamente menores de LDL, Colesterol Total, Glicemia, Hemoglobina glicada e ácido úrico após 1ano de acompanhamento. Em relação ao impacto na qualidade de vida, G-T apresentou valores significativamente menores nos domínios limitação funcional, aos seis meses e dor física, aos seis meses. Conclusão: ambos os grupos apresentaram melhoras clínicas periodontais significativas durante o acompanhamento de um ano, No entanto, os resultados sugerem que os medicamentos homeopáticos, como coadjuvante para TPB, podem proporcionar melhoras em parâmetros laboratoriais e qualidade de vida para o tratamento convencional da PC.

Introduction and objective: the chronic periodontitis (CP) is a chronic inflammatory disease that results from the disruption of homeostasis between Subgingival microbiota and host defenses. As Homeopathy (H) aims to restore the balance of the vital energy of the patient allowing the healing movement of the body, the aim of this study was to evaluate the effects of H as a supporting role for basic periodontal therapy (BTP) in individuals with Diabetes mellitus type 2 (DMII).Materials and methods: After the calculation of sample size, 80 individuals with CP and DM II, of both sexes and aged between 32 and 70 years of age, participated in this randomized, double-blind, placebo-controlled. The patients were divided into two groups: control group (GC) and the test group (GT) both groups received the TPB. G-T received Additionally the homeopathic Therapy (TH): Berberis, Mercurius solubilis/Belladonna/Hepar sulphur and Pyrogenium, while GC received placebo. The evaluations were made at baseline and after 30 days, six and 12 months of treatment. The local and systemic responses were evaluated by clinical and laboratory parameters respectively. Also, it was used a questionnaire of quality of life, Oral Health Impact Profile-14 (OHIP-14). Data were analyzed by parametric and nonparametric tests. The significance level was 5%. Results: Intra-group evaluation showed significant improvement in both groups, throughout the study, for most of the parameters studied. G-T and G-C, in three evaluation periods (1, 6 and 12 months), most biofilm (BTI) and lower values of PBS were verified in G-C above the G-T, although similar levels of bleeding have been observed in the same periods; It was observed a value significantly lower NIC in G-T only to 30 days; in laboratory testing, G-T showed statistically lower levels of various parameters, namely: LDL, Total cholesterol and Glucose, glycated Hemoglobin and uric acid after 12 months. In relation to the impact on quality of life, G-T presented significantly lower values in functional domains and physical pain, to six months after BPT Conclusion: both groups showed significant improvement during the follow-up of one year However, the results of the present study suggest that homeopathy as supplement of BTP may improve some laboratory parameters and the quality of life of PC.
Descritores: Ação Farmacodinâmica do Medicamento Homeopático
Periodontite Crônica/terapia
Tratamento Conservador
-Ensaio Clínico Controlado Aleatório
Perfil de Impacto da Doença
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Idoso
Responsável: BR1366.1 - Biblioteca Biomédica B - CB/B (Odontologia e Enfermagem)
BR1366.1; 616.314, M929, TO832


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Id: biblio-910611
Autor: Escobar Arregoces, Francina María; Latorre Uriza, Catalina; Velosa Porras, Juliana; Roa Molina, Nelly; Ruiz, Alvaro J; Silva, Jaime; Arias, Estefania; Echeverri, Juliana.
Título: Inflammatory response in pregnant women with high risk of preterm delivery and its relationship with periodontal disease: a pilot study / Respuesta inflamatoria en pacientes embarazadas con alto riesgo de parto pretérmino y su relación con la enfermedad periodontal. Estudio piloto
Fonte: Acta odontol. latinoam;31(1):53-57, 2018. ilus, tab.
Idioma: en.
Resumo: Periodontal disease and its inflammatory response have been related to adverse outcomes in pregnancy such as preterm birth, preeclampsia and low birth weight. This study analyzed systemic inflammatory response in patients with high risk of preterm delivery and its relationship to periodontal disease. A pilot study was conducted for a case and control study, on 23 patients at risk of preterm delivery and 23 patients without risk of preterm delivery as controls. Exclusion criteria were patients who had received periodontal treatment, antibiotic or antimicrobial agents within the past three months, or with infections or baseline diseases such as diabetes or hypercholesterolemia. All patients underwent periodontal assessment, laboratory tests (complete blood count, lipid profile, baseline glycemia) and quantification of cytokines (IL2, IL4, IL6, IL10, TNFα and INFγ). Higher levels of proinflammatory cytokines (IL2, IL4, IL6, IL10, TNFα and INFγ) were found in patients with chronic periodontitis than in patients with gingivitis or periodontal health. These cytokines, in particular IL2, IL10 and TNFα, were higher in patients at high risk of preterm delivery. Patients with high risk of preterm delivery had higher severity of periodontal disease as well as higher levels of the proinflammatory markers IL2, IL4, IL6, IL10, TNFα and INFγ (AU)

La enfermedad periodontal y su repuesta inflamatoria ha sido relacionada con desenlaces adversos del embarazo como el parto pretérmino, preeclampsia y bajo peso al nacer. La presente investigación analizó la respuesta inflamatoria sistémica en pacientes embarazadas con alto riesgo de parto pretérmino y su relación con la enfermedad periodontal. Se realizó un estudio piloto de casos y controles, en el cual se contó con 23 pacientes que presentaban riesgo de parto pretérmino como casos y 23 pacientes sin riesgo de parto pretérmino como controles. Fueron excluidas las pacientes que hubieran recibido tratamiento periodontal, antibióticos o antimicrobianos en los últimos tres meses, que tuvieran infecciones, o enfermedades de base como diabetes o hipercolesterolemia. A todas las pacientes se les hicieron valoración periodontal, exámenes de laboratorio (cuadro hemático, perfil lipídico, glucemia basal) y cuanti ficación de citocinas (IL2, IL4, IL6, IL10, TNFα e INFγ). En las pacientes con periodontitis crónica se encontraron niveles más elevados en las citocinas proinflamatorias (IL2, IL4, IL6, IL10, TNFα e INFγ) en comparación con las pacientes con gingivitis o sanas periodontales. Estas citocinas se encontraron más elevadas en las pacientes con alto riesgo de parto pretérmino, en especial la IL2, IL10 y TNFα. Las pacientes con alto riesgo de parto pretérmino presentaron mayor severidad de la enfermedad periodontal y adicional mente niveles aumentados de los marcadores pro inflamatorios IL2, IL4, IL6, IL10, TNFα e INFγ (AU)
Descritores: Fatores de Risco
Nascimento Prematuro
Periodontite Crônica
Trabalho de Parto Prematuro
-Projetos Piloto
Citocinas
Limites: Seres Humanos
Feminino
Gravidez
Adulto
Responsável: AR29.1 - Biblioteca


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Id: biblio-999058
Autor: Santos, Caroline de Moura Martins Lobo dos.
Título: Função endotelial e tratamento periodontal não cirúrgico de pacientes diabéticos com periodontite / Endothelial function and non-surgical periodontal treatment in diabetic patients with periodontitis.
Fonte: Rio de Janeiro; s.n; 2016. 122 p.
Idioma: pt.
Tese: Apresentada a Universidade do Estado do Rio de Janeiro. Faculdade de Odontologia para obtenção do grau de Doutor.
Resumo: O objetivo desse estudo foi investigar alterações na função endotelial, além de realizar meta-análises sobre o uso de antibióticos adjuvantes ao tratamento periodontal não cirúrgico em relação aos possíveis benefícios em termos de parâmetros clínicos periodontais e controle glicêmico nos pacientes diabéticos com periodontite. Quarenta e oito pacientes foram avaliados quanto aos parâmetros periodontais e função endotelial. Desses 48, 11 não tinham doença periodontal e não eram diabéticos (grupo A), 17 tinham periodontite crônica e não eram diabéticos (grupo B), e 20 tinham periodontite crônica e diabetes mellitus tipo 2 (grupo C). Dois revisores independentes examinaram ensaios clínicos controlados em 6 bases de dados eletrônicas, registros de ensaios clínicos, resumos de reuniões e 4 principais revistas odontológicas. A vasodilatação dependente do endotélio (fluxo de hiperemia) foi significantemente menor no grupo C quando comparado com os grupos A e B, assim como foi significantemente menor no grupo B quando comparado com o grupo A (p<0,05). As meta-análises mostraram um efeito significativo favorecendo tratamento periodontal associado a antibióticos para reduções na média de profundiade de sondagem (-0,22 mm [-0,34, -0,11]) e na média de porcentagem de sangramento a sondagem (4% [-7, -1]). Não houve efeito significativo no ganho de nível de inserção clínica e redução do índice de placa. Além disso, a associação de antibióticos e tratamento periodontal não reduziu os valores de hemoglobina glicada média (-0,11% [-0,35, 0,13]), e um intervalo de previsão estimado variando de -0,45 a 0,23. Também não houve efeito significativo favorecendo o uso adjuvante de doxiciclina sub-antimicrobiana na redução média da hemoglobina glicada (-0,19% [-1,07, 0,68]). Sendo assim, pode-se concluir que a periodontite crônica está associada a diminuição da vasodilatação dependente do endotélio do indivíduo, assim como diminui ainda mais quando associada ao diabetes mellitus. O antibiótico sistêmico adjuvante ao tratamento periodontal proporciona benefícios estatisticamente significantes em termos de reduções de média de profundidade de bolsa a sondagem e o percentual de sangramento a sondagem, porém não proporciona um benefício significativo em termos de melhoria de nível de inserção clínico, índice de placa e hemoglobina glicada.

The aim of this study was to investigate alterations in endothelial function, besides performing meta-analyzes on the use of adjuvant antibiotics to non-surgical periodontal treatment in relation to the possible benefits in terms of periodontal clinical parameters and glycemic control in diabetic patients with periodontitis. Forty-eight patients were evaluated for periodontal parameters and endothelial function. Of these, 11 h ad no periodontal disease and were not diabetic (group A), 17 had chronic periodontitis and were not diabetic (group B), and 20 had chronic periodontitis and type 2 diabetes mellitus (group C). Two independent reviewers examined controlled clinical trials in 6 electronic databases, clinical trial records, meeting summaries, and 4 major dental journals. Endothelium-dependent vasodilation (hyperemia flow) was significantly lower in group C when compared to groups A and B, as well as significantly lower in group B when compared to group A (p <0.05). The meta-analyzes showed a significant effect favoring antibiotic-associated periodontal treatment for reductions in the mean probing pocket depth (-0,22 mm [-0,34; -0,11]) and the mean percentage of bleeding probing ( 4% [-7, -1]). There was no significant effect on gain of clinical attachment level and reduction of plaque index. In addition, the association of antibiotics and periodontal treatment did not reduce mean glycated hemoglobin values (-0,11% [-0,35, 0,13]), and an estimated prediction interval ranging from -0,45 to 0,23. There was also no significant effect favoring the adjuvant use of sub-antimicrobial doxycycline in the mean reduction of glycated hemoglobin (-0,19% [-1,07, 0,68]). Thus, it may be concluded that chronic periodontitis is associated with decreased vasodilatation dependent on the endothelium of the individual, as well as decreases even more when associated with diabetes mellitus. The systemic antibiotic adjuvant to periodontal treatment provides statistically significant benefits in terms of reductions of mean probing pocket depth and % of bleeding on probing, but does not provide a significant benefit in terms of improvement of clinical attachment level, plaque index and glycated hemoglobin.
Descritores: Periodontite/terapia
Vasodilatação/fisiologia
Diabetes Mellitus Tipo 2/complicações
Endotélio/fisiologia
Periodontite Crônica/complicações
-Hemoglobina A Glicada/efeitos dos fármacos
Índice Periodontal
Análise de Variância
Estatísticas não Paramétricas
Periodontite Crônica/tratamento farmacológico
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Responsável: BR1366.1 - Biblioteca Biomédica B - CB/B (Odontologia e Enfermagem)
BR1366.1; 616.314, S237, TO822


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Id: lil-794519
Autor: Duque, Andrés.
Título: Prevalencia de periodontitis crónica en Iberoamérica / Chronic periodontitis in Latin America
Fonte: Rev. clín. periodoncia implantol. rehabil. oral (Impr.);9(2):208-215, ago. 2016. tab.
Idioma: es.
Resumo: La prevalencia de las enfermedades periodontales es alta y está relacionada con la biopelícula oral y otros factores de riesgo como la edad, el hábito de fumar, diabetes, factores hereditarios, etc. Objetivo El objetivo de esta revisión fue explorar la evidencia publicada sobre la prevalencia de periodontitis crónica en Iberoamérica. Métodos Se llevó a cabo una búsqueda de los estudios de corte trasversal y cohortes con el fin de comparar la prevalencia de periodontitis crónica en Iberoamérica. Se identificaron las características clínicas de las enfermedades periodontales usadas en cada estudio, como: profundidad clínica de sondaje, nivel clínico de inserción y sangrado al sondaje. También se analizaron los índices clínicos utilizados. Resultados Aunque se han realizado consensos para unificar la definición de caso de la periodontitis, no siempre son utilizados en estudios de prevalencia de la enfermedad. Por tal razón la comparación entre los diferentes estudios es difícil. La evidencia sobre la prevalencia de periodontitis en Iberoamérica encontrada en Pubmed y otros buscadores es limitada. Solo en Argentina, Brasil, Chile, Colombia, España, República Dominicana y Guatemala fue posible encontrar información. Existen pocos estudios poblacionales y los criterios diagnósticos utilizados son heterogéneos. No fue posible hacer un metaanálisis. Estas dificultades no permiten una comparación exacta entre los países. Igualmente algunos estudios utilizan índices actualmente no reconocidos en consensos periodontales para determinar la verdadera prevalencia de enfermedades periodontales (Índice Periodontal Comunitario). Conclusiones La mayoría de los estudios en Iberoamérica demuestran que la prevalencia de la periodontitis crónica es alta y que existe un incremento en la extensión y la severidad de la pérdida de inserción y la profundidad de sondaje relacionado con la edad.

The prevalence of periodontal diseases is high, and is related to oral biofilm and other risk factors such as age, smoking, diabetes, hereditary factors, etc. Objective The objective of this review was to examine studies on the prevalence of chronic periodontitis in Latin America. Methods A search was conducted for cross sectional and cohort studies to determine the prevalence of chronic periodontitis in Latin America. The clinical features of the periodontal diseases used for diagnosis in epidemiologic studies were identified, such as clinical probing depth, clinical attachment level, and bleeding on probing. An analysis was also performed on the periodontal indices used. Results Although consensus criteria have been formed to unify the case definition of periodontitis, they are not always used in studies of periodontal disease prevalence. For this reason the comparison between different studies is difficult. The evidence on the prevalence of periodontitis in Latin America found in PubMed and other Scientific data bases is limited. Only in Argentina, Brazil, Chile, Colombia, Spain, Dominican Republic and Guatemala was it possible to find information. There are few population studies in Latin America, and the diagnostic criteria used are heterogeneous. It was not possible to perform a meta-analysis. All this makes it difficult to make an accurate comparison between countries. Also, some studies use indices that are not currently recognised in periodontal consensus in order to determine the true prevalence of periodontal diseases (Community Periodontal Index). Conclusion Most studies show that the prevalence of chronic periodontitis in Latin America is high, and the extent and severity of insertion loss and increased probing depth increases with age.
Descritores: Periodontite Crônica/epidemiologia
-Doenças Periodontais/epidemiologia
Prevalência
América Latina/epidemiologia
Limites: Seres Humanos
Tipo de Publ: Revisão
Responsável: CL58.1 - Biblioteca



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