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Id: biblio-1224035
Autor: Melara Fernández, Yazmin del Carmen; Quintanilla Soriano, Zorayda Floricel; Quintanilla Velasco, Verónica de Los Ángeles; Romero Morales, Erik Stanley.
Título: Efectividad de dos medicamentos utilizados como antisépticos y desinfectantes en diferentes especies del género cándida en pacientes con estomatitis sub-protésica / Effectiveness of two drugs used as antiseptics and disinfectants in different species of the genus Candida in patients with sub-prosthetic stomatitis.
Fonte: San Salvador; s.n; 2011. 53 p. Tab, Ilus.
Idioma: es.
Tese: Apresentada a Universidad de El Salvador para obtenção do grau de Doctor.
Resumo: Objetivo: Determinar la efectividad del Gluconato de Clorhexidina al 0.12% y del Bicarbonato de Sodio al 0.12% como desinfectantes de prótesis dentales y antiséptico de la mucosa bucal sobre las diferentes especies del género Cándida presentes en los pacientes con Estomatitis Sub-Protésica. Metodología: La investigación fue desarrollada en el periodo comprendido del 19 de julio al 2 de septiembre de 2011, en las clínicas de la Facultad de Odontología y el Laboratorio Microbiológico del Centro de Investigaciones Científicas y Desarrollo en Salud (CENSALUD) de la Universidad de El Salvador con un total de 30 pacientes portadores de prótesis dentales removibles totales o parciales, con diagnostico de Estomatitis Sub-Protésica tipo I, II, III de Newton. Para la identificación de las diferentes especies de Cándida se utilizo el medio de cultivo selectivo CHROMagar Cándida. Se tomaron muestras de la mucosa bucal de soporte y del aparato protésico antes y después de la aplicación de los fármacos para efectuar los recuentos de Unidades Formadoras de Colonias (U.F.C.) y evaluar la efectividad del tratamiento administrado en un periodo de 14 días. Resultados: Los resultados de este estudio demostraron que los porcentajes de colonización de las especies del genero Cándida en mucosa bucal fueron: C. albicans 52.01% C. krusei 46.93% C. Tropicalis 1.06%; en prótesis dental fueron: C. albicans 47.8% C. krusei 51.56% C. Tropicalis 0.64% utilizando el método estadístico de Dunn se obtuvo que en ambas superficies C. albicans y C. krusei colonizan de forma similar. Conclusión: Ambos fármacos resultaron tener similar efectividad como antiséptico sobre las diferentes especies del género Cándida presentes en mucosa bucal y desinfectante en prótesis dental en el tratamiento de Estomatitis Sub-Protésica.

Objective: To determine the effectiveness of 0.12% Chlorhexidine Gluconate and 0.12% Sodium Bicarbonate as disinfectants for dental prostheses and antiseptic for the oral mucosa on the different species of the genus Candida present in patients with Sub-Prosthetic Stomatitis. Methodology: The research was developed in the period from July 19 to September 2, 2011, in the clinics of the Faculty of Dentistry and the Microbiological Laboratory of the Center for Scientific Research and Development in Health (CENSALUD) of the University of El Salvador with a total of 30 patients with partial or total removable dental prostheses, with a diagnosis of Newton's Sub-Prosthetic Stomatitis type I, II, III. For the identification of the different Candida species, the selective culture medium CHROMagar Candida was used. Samples of the supporting buccal mucosa and the prosthetic apparatus were taken before and after the application of the drugs to carry out the counts of Colony Forming Units (CFU) and evaluate the effectiveness of the treatment administered in a period of 14 days. Results: The results of this study showed that the colonization percentages of the species of the genus Candida in the buccal mucosa were: C. albicans 52.01% C. krusei 46.93% C. Tropicalis 1.06%; in dental prostheses they were: C. albicans 47.8% C. krusei 51.56% C. Tropicalis 0.64% using Dunn's statistical method, it was obtained that C. albicans and C. krusei colonize in a similar way on both surfaces. Conclusion: Both drugs were found to have similar effectiveness as antiseptic on the different species of the genus Candida present in oral mucosa and disinfectant in dental prostheses in the treatment of Sub-Prosthetic Stomatitis.
Descritores: Anti-Infecciosos Locais
-Estomatite sob Prótese
Candida
Desinfetantes de Equipamento Odontológico
Responsável: SV2 - Departamento de Gobernanza y Gestión del Conocimiento


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Id: biblio-1151489
Autor: Huerta, Elisa; Gorup, Daisy; Manríquez, Manuel; Cruz Choappa, Rodrigo; Vieille, Peggy; González-Arriagada, Wilfredo.
Título: Efficacy of copper sulphate on candida albicans on heat-polymerized acrylic resin / Eficacia del sulfato de cobre sobre candida albicans en resinas acrílicas de termocurado
Fonte: J. oral res. (Impresa);9(1):57-62, feb. 28, 2020. graf, tab.
Idioma: en.
Resumo: The ageing of population is increasing, and a great percentage of these patients wear removable prostheses, and can suffer denture stomatitis, a condition that has been associated with candidiasis. Aims: To evaluate in vitro the effectiveness of Copper Sulfate against Candida albicans in samples of heat-polymerized acrylic resin, compared to nystatin, sodium hypochlorite and chlorhexidine. Materials and Methods: Initially, the minimum inhibitory concentration (MIC) of copper sulfate for Candida albicans was determined by microdilution. Then, 54 resin samples were divided into 6 treatment groups corresponding to Nystatin 100.000 UI, Sodium Hypochlorite 0.5%, chlorhexidine 0.12%, Copper Sulfate 4.7µg/ml, Copper Sulfate 9.4µg/ml and physiological saline solution, in which samples were submerged for 6 hours. Resin samples were then washed and cultured on solid media at 37°C for 72 hours. The number of colony-forming units was determined using a Quebec colony counter. The statistical analysis was performed using the Kruskal-Wallis test and the Mann-Whitney U test. Results: Copper sulfate at a concentration of 9.4µg/ml presented a similar effectiveness as the other control products regarding the reduction in the number of colonies of Candida albicans post-treatment. Conclusion: The effectiveness of copper sulfate against Candida albicans on acrylic resin was similar to that of nystatin, sodium hypochlorite and chlorhexidine.

En las últimas décadas se ha observado un aumento de la población de adultos mayores, de los cuales un gran porcentaje es portador de prótesis removible, y dos tercios pueden sufrir estomatitis subprotésica, enfermedad que es asociada a infecciones como candidiasis. Objetivo: Evaluar la efectividad antimicótica in vitro del sulfato de cobre en placas de resinas acrílicas de termocurado inoculadas con Candida albicans, frente a Nistatina, Hipoclorito de Sodio y Clorhexidina. Material y Métodos: Inicialmente, y mediante microdilución del sulfato de cobre, se determinó la concentración mínima inhibitoria (CMI) para Candida albicans. En la fase experimental, 54 muestras de resina se dividieron en 6 grupos correspondientes a Nistatina 100.000 UI, Hipoclorito 0.5%, Clorhexidina 0.12%, Sulfato de Cu 4.7µg/ml, Sufato de Cu 9.4 µg/ml y suero fisiológico. Las muestras fueron sumergidas en estos agentes por 6 horas, para posteriormente ser lavadas y cultivada en medios solidos a 37°C por 72 horas. Luego se realizó el conteo de unidades formadoras de colonias mediante contador tipo Quebec. El análisis estadístico se realizó mediante la prueba de Kruskal-Wallis y la prueba U de Mann-Whitney. Resultado: El sulfato de cobre a una concentración de 9.4µg/ ml presentó una efectividad similar a los otros productos, en la reducción de colonias de Candida albicans. Conclusión: La efectividad del sulfato de cobre contra Candida albicans fue semejante a la de Nistatina, Hipoclorito y Clorhexidina.
Descritores: Resinas Acrílicas
Candida albicans/efeitos dos fármacos
Sulfato de Cobre/farmacologia
-Hipoclorito de Sódio
Estomatite sob Prótese
Técnicas In Vitro
Candidíase/tratamento farmacológico
Clorexidina
Meios de Cultura
Limites: Humanos
Responsável: CL30.1 - Biblioteca


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Id: biblio-1126926
Autor: Barreiro-Mendoza, Nataly; Díaz-Pérez, Carlos Alberto; Martin-Moya, Luz Amarilis; Martínez-Rodríguez, Milagros; Santos-Zambrano, Thainah Bruna.
Título: Caracterización de la estomatitis subprotésica en portadores de prótesis removible en clínicas de la Universidad San Gregorio de Portoviejo, Ecuador / Characterization of subprosthetic stomatitis in patients with removable prosthesis. San Gregorio de Portoviejo University
Fonte: Rev. inf. cient;99(2):107-114, mar.-abr. 2020. tab.
Idioma: es.
Resumo: RESUMEN Introducción: La estomatitis subprotésica es un proceso inflamatorio de la mucosa bucal que se encuentra cubierta por una prótesis removible, de causa multifactorial y alta prevalencia. Objetivo: Caracterizar la estomatitis subprotésica en pacientes portadores de prótesis removible atendidos en las clínicas odontológicas de la Universidad San Gregorio de Portoviejo en el período marzo-noviembre de 2019. Método: Se realizó un estudio descriptivo transversal, con los criterios de inclusión siguientes: mayores de 18 años, ambos sexos, buen estado de salud general, no practicar hábitos tóxicos, usar prótesis removible, total o parcial, confeccionada de acrílico o metales. Todos los sujetos de la investigación firmaron el consentimiento informado antes de realizarles la historia clínica de odontología del Ministerio de Salud Pública del Ecuador de donde se extrajeron los datos sociodemográficos, signos clínicos y características de la prótesis. Resultados: Fueron evaluados 100 pacientes. El 45 %, presentaba signos clínicos de estomatitis subprotésica; predominó el sexo femenino con el 33 % y el grupo de edad de 40 a 59 años con un 26 %. La mayoría de las prótesis no se ajustan ni adaptan de manera correcta, y tienen un mal estado físico, en el 80, 82,2 y el 91 %, respectivamente. El 84,4 % de los pacientes utilizaba prótesis parcial removible, confeccionadas con acrílico, por un periodo de 1 a 6 años en el 60 % de los casos. Conclusiones: El diagnóstico de estomatitis subprotésica se asocia con el mal estado físico, desajuste e inadecuada adaptación de las prótesis removibles, lo que indica la necesidad de la institución para el establecimiento de estrategias docentes hacia la comunidad para su prevención y diagnóstico temprano.

ABSTRACT Introduction: Subprosthetic stomatitis is an inflammatory process of the mucosa in the oral cavity covered by a removable prosthesis, with a multifactorial cause and high prevalence. Objective: To characterize subprosthetic stomatitis in patients with removable prosthesis treated at the dental clinics of San Gregorio University in Portoviejo in the period March-November 2019. Method: A cross-sectional descriptive study was conducted, with the following inclusion criteria: patients over 18 years old, both sexes, good general health, no toxic habits, use of removable prosthesis, total or partial, made of acrylic or metals. All the patients involved in the research signed their consent, information given to them before taking their dental records taken by the Ministry of Public Health of Ecuador, from which socio-demographic data, clinical signs and characteristics of the prosthesis were extracted. Results: 100 patients were evaluated. Forty-five per cent showed clinical signs of subprosthetic stomatitis; the female sex (33%) predominated and the age group 40-59 years with (26%). Most of the prosthesis did not fit or adapt correctly and were in poor physical condition in 80%, 82.2% and 91% respectively. 84.4% of the patients used removable partial prosthesis, made of acrylic, for a period of 1 to 6 years, (60%) of the cases. Conclusions: The diagnosis of subprosthetic stomatitis is associated with poor physical condition, maladjustment and inadequate adaptation of removable prostheses, which indicates the need for the institution to establish educational strategies towards the community for prevention and early diagnosis.
Descritores: Estomatite sob Prótese/diagnóstico
Estomatite sob Prótese/etiologia
Estomatite sob Prótese/prevenção & controle
Prótese Parcial Removível/efeitos adversos
-Estudos Transversais
Responsável: CU419.1 - Centro Provincial de Información de Ciencias Médicas de Guantánamo


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Id: biblio-1040232
Autor: Fouda, Shaimaa M; Gad, Mohammed M; Ellakany, Passent; Al-Thobity, Ahmad M; Al-Harbi, Fahad A; Virtanen, Jorma I; Raustia, Aune.
Título: The effect of nanodiamonds on candida albicans adhesion and surface characteristics of PMMA denture base material - an in vitro study
Fonte: J. appl. oral sci;27:e20180779, 2019. tab, graf.
Idioma: en.
Resumo: Abstract Candida albicans is the main causative pathogen of denture stomatitis, which affects many complete denture patients. Objective: To evaluate the effect of different concentrations of nanodiamonds (NDs) added to polymethyl methacrylate (PMMA) denture base material on Candida albicans adhesion as well as on surface roughness and contact angle. Methodology: Acrylic resin specimens sized 10×10×3 mm3 were prepared and divided into four groups (n=30) according to ND concentration (0%, 0.5%, 1%, 1.5% by wt). Surface roughness was measured with a profilometer, and the contact angle with a goniometer. The effect of NDs on Candida albicans adhesion was evaluated using two methods: 1) slide count and 2) direct culture test. Analysis of variance (ANOVA) and Tukey's post hoc test were used in the statistical analyses. Results: Addition of NDs decreased the Candida albicans count significantly more than in the control group (p<0.05), with a lowest of 1% NDs. Addition of NDs also significantly decreased the surface roughness (p<0.05), but the contact angle remained the same. Incorporation of NDs into the PMMA denture base material effectively reduced Candida albicans adhesion and decreased surface roughness. Conclusion: PMMA/NDs composites could be valuable in the prevention of denture stomatitis, which is considered one of the most common clinical problems among removable denture wearers.
Descritores: Resinas Acrílicas/química
Candida albicans/efeitos dos fármacos
Polimetil Metacrilato/química
Bases de Dentadura/microbiologia
Nanodiamantes/microbiologia
Nanodiamantes/química
-Valores de Referência
Estomatite sob Prótese/microbiologia
Estomatite sob Prótese/prevenção & controle
Propriedades de Superfície
Teste de Materiais
Microscopia Eletrônica de Varredura
Reprodutibilidade dos Testes
Análise de Variância
Limites: Humanos
Tipo de Publ: Estudo de Avaliação
Responsável: BR28.1 - Serviço de Biblioteca e Documentação Professor Doutor Antônio Gabriel Atta


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Id: biblio-1102370
Autor: Silva, Amanda de Macedo; Silva, Gabriel Gomes da; França, Glória Maria de; Morais, Everton Freitas de; Leite, Rafaella Bastos; Pinheiro, Juliana Campos.
Título: Estomatite protética associada a candidíase pseudomembranosa em paciente geriátrico: relato de caso / Prosthetic stomatitis associated with pseudomembranus candidiasis in geriatric patient: case report
Fonte: Rev. Odontol. Araçatuba (Impr.);41(1):30-33, jan.-abr. 2020. ilus.
Idioma: pt.
Resumo: As próteses removíveis são consideradas facilitadoras em potencial da estomatite protética, caracterizada por aspectos hiperplásicos e eritematosos na mucosa de suporte. Este trabalho tem como objetivo relatar as principais manifestações orais da estomatite protética em um paciente geriátrico associada a candidíase oral pseudomembranosa. Paciente do gênero masculino, setenta e quatro anos, apresentava uma lesão exofítica, na região de palato com dois centímetros de extensão, além da presença de candidíase pseudomembranosa, fazia o uso de uma prótese parcial superior removível há aproximadamente dez anos. Foi levantada a hipótese diagnóstica de estomatite protética associada a candidíase pseudomembranosa. A terapêutica instituída consistiu no uso de antifúngico por um período de quinze dias e biópsia incisional. O exame histopatológico confirmou o diagnóstico de hiperplasia fibrosa inflamatória. Foi recomendado a confecção de uma nova prótese para que fosse evitado a recorrência da lesão, e o paciente também foi instruído quanto a sua higiene oral evitando-se desta forma a recorrência da candidíase. O cirurgião-dentista deve ser capaz de reconhecer e diagnosticar a estomatite protética em sua prática diária e tratar o paciente de acordo com a sua etiologia, oferecendo desta forma para o paciente um maior conforto e melhores condições de vida(AU)

Removable total dentures are considered potential facilitators of prosthetic stomatitis, characterized by hyperplastic and erythematous aspects in the supporting mucosa. This paper aims to report the main oral manifestations of prosthetic stomatitis in an elderly patient associated with pseudomembranous oral candidiasis. A seventyseven-year-old male patient presented with an exophytic lesion in the palate region of two centimeters in length, in addition to the presence of pseudomembranous candidiasis, and had been using a removable upper partial denture for approximately ten years. The diagnostic hypothesis of prosthetic stomatitis associated with pseudomembranous candidiasis was raised. The therapy instituted consisted of the use of antifungal for a period of fifteen days and incisional biopsy. Histopathological examination confirmed the diagnosis of inflammatory fibrous hyperplasia. It was recommended to make a new prosthesis to avoid recurrence of the lesion, and the patient was also instructed as to its oral hygiene, thus avoiding the recurrence of candidiasis. The dentist should be able to recognize and diagnose prosthetic stomatitis in his daily practice and treat the patient according to its etiology, thus offering the patient greater comfort and better living conditions(AU)
Descritores: Estomatite sob Prótese
Prótese Dentária
-Estomatite
Estomatite sob Prótese/diagnóstico
Estomatite sob Prótese/terapia
Candidíase Bucal
Limites: Humanos
Masculino
Idoso
Responsável: BR186.1 - Biblioteca Honório Monteiro


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Id: lil-462834
Autor: Nápoles González, Isidro; Hidalgo Hidalgo, Siomara; Milanés Santana, Rafael; Fernández Franch, Neyda; Echemendía Guzmán, Olga.
Título: Aplicación de un colutorio de aloe en el tratamiento de la estomatitis subprótesis / Aplication of an aloe gargle in the treatment of subprosthetic stomatitis
Fonte: Arch. méd. Camaguey;7(5):560-567, sept.-oct. 2003. tab.
Idioma: es.
Resumo: Se realizó un ensayo clínico fase II abierto en la clínica Estomatológica Docente La Vigía, de la ciudad de Camagüey, en el período de enero de 2000 a julio de 2001. La muestra se conformó con 30 pacientes mayores de 20 años de ambos sexos (10 en cada grado clínico de la lesión) Para esta selección se tuvieron en cuenta los criterios de diagnóstico, inclusión y exclusión.. Para el tratamiento de la estomatitis subprótesis se utilizó un colutorio de Aloe fabricado en el Laboratorio de Producción de Medicamentos de Camagüey, el cual fue aplicado por el paciente tres veces al día. Se consideraron curados todos los que eliminaron los signos y síntomas por los cuales fueron incluidos en el estudio. Se concluyó que los pacientes de los grados I y II necesitaron menor tiempo para curar que los del grado III. No se presentaron reacciones adversas durante la investigación
Descritores: Preparações de Plantas
Aloe
Fitoterapia
Antissépticos Bucais/uso terapêutico
Estomatite sob Prótese/tratamento farmacológico
Limites: Humanos
Masculino
Feminino
Responsável: CU1.3 - CPICM - Centro Provincial de Información de Ciencias Médicas


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Id: biblio-1087487
Autor: Morel, Laura Lourenço; Possebon, Anna Paula da Rosa; Faot, Fernanda; Pinto, Luciana de Rezende.
Título: Prevalence of risk factors for denture stomatitis in complete denture wearers
Fonte: Braz. j. oral sci;18:e191414, jan.-dez. 2019. tab.
Idioma: en.
Resumo: Aim: The prevalence of denture stomatitis and the relationship with its risk factors was evaluated via secondary data from 62 complete denture (CD) wearers, between 2015 and 2017. Methods: The data was stored in an Excel database and was analyzed using the statistics software STATA/SE 12.0. A descriptive analysis was performed taking into account a categorization of the clinical variables according to risk factor in 4 domains: CD usage, systemic health, hygiene habits, and usage habits. The association amongst the denture stomatitis and risk factors variables was tested by the Chi-square test and the results were statistically significant at p-values <0.05. Results: The CD wearers participants were composed by a majority of elderly (80.64%) and women (72.78%); with 45.16% having been using the current denture for more than 10 years and another 74.19% related a continuous usage. Diabetes and hypertension were related by 83.87% and 67.74%, respectively, with 87.10% using medication. Although 75.80% reported cleaning their dentures 3 times per day or more, and 59.68% considered their oral hygiene very good, 50% of the complete dentures showed dirtiness and clinical signs of Denture Stomatitis were present in 30.64% of the patients. Despite of the evaluated sample shows many risk factors for the development of the disease, an association between the variables was not observed. Conclusion: Considering the high prevalence of the disease in the studied sample, preventive and educational measures on denture usage and hygiene must be reinforced in order to maintain the oral health of the edentulous patients
Descritores: Estomatite sob Prótese/epidemiologia
Fatores de Risco
Prótese Total
Limites: Humanos
Masculino
Feminino
Responsável: BR218.1 - Biblioteca Carlos Henrique Robertson Liberalli


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Id: lil-746939
Autor: Lee Muñoz, Ximena; Cajas Cajas, Nataly; Gómez Carranza, Leyla; Vergara Núñez, Cristian; Ivankovic Silva, Mariana; Astorga Bustamante, Elizabeth.
Título: Ocurrencia de levaduras del género Candida y estomatitis protésica antes y después del tratamiento rehabilitador basado en prótesis removible / Occurrence of genus Candida yeast and prosthetic stomatitis before and after rehabilitation treatment based on removable prosthesis
Fonte: Rev. clín. periodoncia implantol. rehabil. oral (Impr.);8(1):31-37, 2015. ilus, tab.
Idioma: es.
Projeto: Universidad de Chile. Facultad de Odontología.
Resumo: El 63,2% de la población chilena mayor de 65 años utiliza prótesis removible. Cuando estas pierden funcionalidad pueden producirse lesiones en la mucosa oral, siendo la más prevalente la estomatitis protésica, proceso inflamatorio de la mucosa de soporte de diversa extensión y severidad, cuyo principal factor etiológico es la infección por Candida spp. El objetivo de esta investigación fue determinar la cantidad y las especies de levaduras del género Candida y su asociación con estomatitis protésica en portadores de prótesis removible antes y después del tratamiento rehabilitador. Se realizó un estudio descriptivo cuantitativo, n = 34, en ambos géneros, edad promedio de 69 años, portadores de prótesis removible no funcionales, con y sin estomatitis protésica. Para el recuento e identificación de levaduras del género Candida se tomaron muestras de saliva antes y después del tratamiento. Las variables fueron analizadas estadísticamente. Los resultados indicaron el diagnóstico de estomatitis protésica en el 55,9% de los sujetos, de los cuales tipo I = 29,4% y tipo II = 26,5%. Los recuentos de Candida spp. fueron mayores en aquellos con estomatitis protésica, tanto antes como después del tratamiento. Al instalar prótesis funcionales el recuento disminuyó significativamente, sin embargo permaneció alto en aquellos con estomatitis protésica diagnosticada previa al tratamiento rehabilitador. La especie identificada más frecuentemente fue Candida albicans.

Almost two-thirds (63.2%) of the Chilean population aged 65 and above use removable prosthesis. When they cease to be functional, injuries may occur in the oral mucosa, with denture stomatitis being the most prevalent. This is an inflammatory process of the supportive mucosa of varying extension and severity, with its main etiologic factor being infection by Candida spp. The aim of this investigation was to determine the quantity and species of yeast of the genus Candida and their association with denture stomatitis in carriers of removable prosthesis, before and after the rehabilitation treatment. A descriptive quantitative study was conducted on 34 patients, with a mean age of 69 years, and carriers of a non-functional removable prosthesis, with and without prosthetic stomatitis. Saliva samples were taken before and after the treatment for the counting and identification of genus Candida yeast. The variables were statistically analyzed. The results showed a diagnosis of prosthetic stomatitis in 55.9% of the subjects, of which 29.4% were Type I and 26.5% were Type II. The Candida sppcount was higher in the subjects with prosthetic stomatitis both before and after the treatment. The count decreased significantly after installing a functional prosthesis. However, it remained high in those with prosthetic stomatitis. The most frequently identified species was Candida albicans.
Descritores: Estomatite sob Prótese/microbiologia
Candida/isolamento & purificação
Prótese Parcial Removível/efeitos adversos
Prótese Parcial Removível/microbiologia
-Saliva/microbiologia
Epidemiologia Descritiva
Reabilitação Bucal/efeitos adversos
Limites: Humanos
Masculino
Adulto
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-893620
Autor: GARDIZANI, Taiane Priscila; PINKE, Karen Henriette; LIMA, Heliton Gustavo de; LARA, Vanessa Soares.
Título: Phagocytosis and nitric oxide production by peritoneal adherent cells in response to Candida albicans in aging: a collaboration to elucidate the pathogenesis of denture stomatitis
Fonte: J. appl. oral sci;25(3):265-273, May-June 2017. tab, graf.
Idioma: en.
Projeto: São Paulo Research Foundation.
Resumo: Abstract Elderly denture wearers are commonly affected by Candida-associated denture stomatitis (DS), an inflammatory process of the oral mucosa strongly associated with Candida spp and other microorganisms, as well as local and systemic factors. The impaired immune response against pathogens is among the inherent host factors that have been also associated with the pathogenesis of DS. Mononuclear phagocytes respond to the pathogens through phagocytosis followed by the production of several substances inside the phagosomes, among them are the reactive nitrogen species (RNS). A failure in these mechanisms may contribute to the DS development. Objective The aim of this study was to investigate the influence of aging on the internalization and the production of nitric oxide (NO) by peritoneal adherent cells (PAC), in response to Candida albicans (C. albicans). Material and methods PAC obtained from young and aged mice were challenged with dead or viable C. albicans by using predetermined proportions (cells:yeast) for 30 and 120 minutes. Phagocytosis was analyzed by acridine orange dye, and NO production by the Griess reaction. Results C. albicans phagocytosis by PAC from aged mice was similar to that of young mice, although the cells from older mice cells present more internalized fungi compared with matched control. In addition, a tendency towards impaired NO production by peritoneal mononuclear phagocytes from aged mice was observed. Conclusions PAC from aged mice may capture and store many fungi, which in turn may mean that these cells are effectively unable to eliminate fungi, probably due to impaired NO production. Therefore, considering the important role of C. albicans overgrowth in the pathogenesis of DS and the aspects observed in this study, aging may favor the onset and severity of local candidosis such as DS and its systemic forms.
Descritores: Fagocitose/fisiologia
Estomatite sob Prótese/metabolismo
Estomatite sob Prótese/microbiologia
Candida albicans/patogenicidade
Envelhecimento/fisiologia
Adesão Celular/fisiologia
Óxido Nítrico/biossíntese
-Peritônio/citologia
Valores de Referência
Fatores de Tempo
Candida albicans/isolamento & purificação
Candidíase/microbiologia
Fatores Etários
Camundongos Endogâmicos C57BL
Óxido Nítrico/análise
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: lil-787208
Autor: Bermúdez Alemán, Reina; Pérez Ordóñez, Ivonne; Martínez Bermúdez, Gustavo; Monteagudo de la Guardia, Vivian; Hernández Rodríguez, Juana Maritza; Rodríguez Santos, Caridad.
Título: Efectividad del bórax y la crema de áloe al 25 % en la estomatitis subprotésica / Effectiveness of borax and 25 % aloe cream in treating subprosthesis stomatitis
Fonte: Medicentro (Villa Clara);20(3):193-201, jul.-set. 2016.
Idioma: es.
Descritores: Estomatite
Estomatite sob Prótese
Responsável: CU425.1 - Centro Provincial de Información de Ciencias Médicas de Villa Clara



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