Base de dados : LILACS
Pesquisa : C10.228.140.300.150.477.200.450 [Categoria DeCS]
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Id: biblio-889118
Autor: Wanchao, Shi; Chen, Ma; Zhiguo, Su; Futang, Xie; Mengmeng, Shi.
Título: Protective effect and mechanism of Lactobacillus on cerebral ischemia reperfusion injury in rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(7):e7172, 2018. graf.
Idioma: en.
Resumo: The present study was designed to investigate the protective effects and mechanism of inactivated lactobacillus (ILA) on cerebral ischemia reperfusion injury (CIRI) in rats. In this experiment, 30 male Sprague Dawley rats were randomly divided into control group, IRI groups, and ILA group. A middle cerebral artery occlusion and reperfusion model was prepared. The rats were killed after 24 hours of recovery of blood flow of cerebral ischemia resulting from 60-min occlusion. The cerebral infarction volume and neurological scores were assayed by staining and behavioral observation. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were assayed by biochemical kits. Cell apoptosis was assayed by Tunnel and the Toll-like receptor (TLR)-4, IkB, and A20 were assayed by western blot. The neurobehavioral scores in IRI rats were significantly lower compared to the control group while ILA improved the neurobehavioral scores of the ILA groups. The cerebral infarction volume and neural cell apoptosis of rats in the ILA groups decreased significantly compared with those in the IRI group. In addition, MDA level in the ILA groups decreased whereas SOD activity increased compared to the IRI group. Moreover, ILA also inhibited the expression of TLR-4 and promoted the expression of IkB and A20. ILA inhibited the apoptosis of neural cells, decreased cerebral infarction volume, and reduced oxidative stress through inhibition of TLR-4/NF-kappa B signaling, improving neurobehavioral scores. Thus from the present study it was concluded that ILA has protective effect on CIRI.
Descritores: Apoptose
Isquemia Encefálica/prevenção & controle
Infarto da Artéria Cerebral Média/complicações
Lactobacillus paracasei
Fármacos Neuroprotetores/administração & dosagem
Traumatismo por Reperfusão/prevenção & controle
-Isquemia Encefálica/etiologia
Modelos Animais de Doenças
Regulação para Baixo
NF-kappa B/sangue
Distribuição Aleatória
Ratos Sprague-Dawley
Traumatismo por Reperfusão/etiologia
Receptor 4 Toll-Like/sangue
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-839280
Autor: Li, Y; Gao, X; Wang, Q; Yang, Y; Liu, H; Zhang, B; Li, L.
Título: Retinoic acid protects from experimental cerebral infarction by upregulating GAP-43 expression
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(4):e5561, 2017. graf.
Idioma: en.
Projeto: National Natural Science Foundation; . Science and Technology Planning Project.
Resumo: The aim of this study was to investigate whether exogenous retinoic acid (RA) can upregulate the mRNA and protein expression of growth-associated protein 43 (GAP-43), thereby promoting brain functional recovery in a rat distal middle cerebral artery occlusion (MCAO) model of ischemia. A total of 216 male Sprague Dawley rats weighing 300–320 g were divided into 3 groups: sham-operated group, MCAO+vehicle group and MCAO+RA group. Focal cortical infarction was induced with a distal MCAO model. The expression of GAP-43 mRNA and protein in the ipsilateral perifocal region was assessed using qPCR and immunocytochemistry at 1, 3, 7, 14, 21, and 28 days after distal MCAO. In addition, an intraperitoneal injection of RA was given 12 h before MCAO and continued every day until the animal was sacrificed. Following ischemia, the expression of GAP-43 first increased considerably and then decreased. Administration of RA reduced infarction volume, promoted neurological functional recovery and upregulated expression of GAP-43. Administration of RA can ameliorate neuronal damage and promote nerve regeneration by upregulating the expression of GAP-43 in the perifocal region after distal MCAO.
Descritores: Proteína GAP-43/metabolismo
Expressão Gênica/efeitos dos fármacos
Infarto da Artéria Cerebral Média/prevenção & controle
Fármacos Neuroprotetores/farmacologia
Tretinoína/farmacologia
Regulação para Cima/efeitos dos fármacos
-Isquemia Encefálica/prevenção & controle
Proteína GAP-43/genética
Imuno-Histoquímica
Infarto da Artéria Cerebral Média/metabolismo
Infarto da Artéria Cerebral Média/patologia
Distribuição Aleatória
Ratos Sprague-Dawley
Reação em Cadeia da Polimerase em Tempo Real
Reprodutibilidade dos Testes
Fatores de Tempo
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-791521
Autor: González Díaz, María Elena; Morales Aguiar, Diana Rosa.
Título: La enfermedad periodontal, ¿un factor de riesgo más para el infarto cerebral isquémico aterotrombótico? / Periodontal disease, is it one more risk factor for atherothrombotic ischemic stroke?
Fonte: Rev. cuba. med. gen. integr;32(1):0-0, mar. 2016.
Idioma: es.
Resumo: De forma compactada se explica la relación biológicamente plausible que existe entre la aparición de accidentes cerebrovasculares, particularmente de infarto cerebral isquémico aterotrombótico y la precedencia de enfermedad periodontal inmuno-inflamatoria crónica. Se sugiere la necesidad de estudios que vinculen ambas entidades para conciliar los resultados de las investigaciones internacionales con las realizadas en nuestro medio. Se propone el análisis del estado periodontal en los pacientes pertenecientes a grupos de riesgo o víctimas de enfermedades cerebrovasculares. La consideración de la enfermedad periodontal inmuno-inflamatoria crónica como un factor de riesgo más para el infarto cerebral isquémico aterotrombótico, debe pasar de una interrogante a una estrategia(AU)

The biologically plausible relation existing between the occurrence of cerebrovascular accidents, particularly of atherothrombotic ischemic stroke, and the presence of chronic immunoinflammatory periodontal disease is explained in a compacted way. The need for studies linking both entities is suggested for conciliating the results of the international researches with those carried out in our environment. The analysis of the periodontal state in patients from risk groups of victims on cerebrovascular disease is proposed. Considering the chronic immunoinflammatory periodontal disease as a risk factor for atherothrombotic ischemic stroke should pass from a question to a strategy(AU)
Descritores: Infarto da Artéria Cerebral Média/etiologia
Infarto da Artéria Cerebral Média/prevenção & controle
Doenças Periodontais/complicações
-Fatores de Risco
Limites: Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: lil-790601
Autor: Carvallo, P; Carvallo, E; Rivas, R; Carvallo, L; Sol, M. del.
Título: Oclusión de la arteria cerebral media en ataque cerebrovascular isquémico agudo / Middle cerebral artery occlusion in acute ischaemic cerebrovascular attack
Fonte: Int. j. med. surg. sci. (Print);3(1):747-751, 2016. ilus, tab.
Idioma: es.
Resumo: El ataque cerebrovascular isquémico (ACV) es una de las principales causas de morbimortalidad a nivel mundial y nacional. Se estudiaron 35 pacientes identificándose que las arterias que presentaron mayor frecuencia de oclusión en el ACV isquémico agudo fueron la arteria cerebral media y la arteria cerebral posterior. Consideramos necesario que los especialistas puedan localizar anatómicamente los ACV para la aplicación de terapias neuroprotectoras mejorando las opciones de tratamiento y previniendo obstrucciones secundarias...

Ischaemic stroke (CVA) is one of the leading causes of morbidity and mortality at a global and national level. We studied 35 patients, determined the arteries that presented a higher frequency of occlusion in acute ischemic stroke and identified the middle cerebral artery and the posterior cerebral artery. We consider it necessary that specialists can locate anatomically strokes in order to apply neuroprotective therapies to improve treatment options and preventing secondary obstructions...
Descritores: Infarto da Artéria Cerebral Média/epidemiologia
Infarto da Artéria Cerebral Posterior/epidemiologia
Isquemia Encefálica/complicações
-Doença Aguda
Acidente Vascular Cerebral/complicações
Infarto da Artéria Cerebral Média/patologia
Infarto da Artéria Cerebral Posterior/patologia
Imagem por Ressonância Magnética
Índice de Gravidade de Doença
Limites: Humanos
Masculino
Adulto
Feminino
Pessoa de Meia-Idade
Idoso de 80 Anos ou mais
Responsável: CL1.1 - Biblioteca Central


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Id: lil-788941
Autor: Fang, T; Zhou, D; Lu, L; Tong, X; Wu, J; Yi, L.
Título: LXW7 ameliorates focal cerebral ischemia injury and attenuates inflammatory responses in activated microglia in rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;49(9):e5287, 2016. graf.
Idioma: en.
Projeto: Scientific and Technological Innovation Committee.
Resumo: Inflammation plays a pivotal role in ischemic stroke, when activated microglia release excessive pro-inflammatory mediators. The inhibition of integrin αvβ3 improves outcomes in rat focal cerebral ischemia models. However, the mechanisms by which microglia are neuroprotective remain unclear. This study evaluated whether post-ischemic treatment with another integrin αvβ3 inhibitor, the cyclic arginine-glycine-aspartic acid (RGD) peptide-cGRGDdvc (LXW7), alleviates cerebral ischemic injury. The anti-inflammatory effect of LXW7 in activated microglia within rat focal cerebral ischemia models was examined. A total of 108 Sprague-Dawley rats (250–280 g) were subjected to middle cerebral artery occlusion (MCAO). After 2 h, the rats were given an intravenous injection of LXW7 (100 μg/kg) or phosphate-buffered saline (PBS). Neurological scores, infarct volumes, brain water content (BWC) and histology alterations were determined. The expressions of pro-inflammatory cytokines [tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β)], and Iba1-positive activated microglia, within peri-ischemic brain tissue, were assessed with ELISA, western blot and immunofluorescence staining. Infarct volumes and BWC were significantly lower in LXW7-treated rats compared to those in the MCAO + PBS (control) group. The LXW7 treatment lowered the expression of pro-inflammatory cytokines. There was a reduction of Iba1-positive activated microglia, and the TNF-α and IL-1β expressions were attenuated. However, there was no difference in the Zea Longa scores between the ischemia and LXW7 groups. The results suggest that LXW7 protected against focal cerebral ischemia and attenuated inflammation in activated microglia. LXW7 may be neuroprotective during acute MCAO-induced brain damage and microglia-related neurodegenerative diseases.
Descritores: Anti-Inflamatórios/uso terapêutico
Isquemia Encefálica/tratamento farmacológico
Infarto da Artéria Cerebral Média/complicações
Inflamação/tratamento farmacológico
Fármacos Neuroprotetores/uso terapêutico
Peptídeos Cíclicos/uso terapêutico
-Isquemia Encefálica/etiologia
Modelos Animais de Doenças
Interleucina-1beta/metabolismo
Microglia/efeitos dos fármacos
Ratos Sprague-Dawley
Fator de Necrose Tumoral alfa/metabolismo
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-753042
Autor: Ducci, Renata Dal-Prá; Lange, Marcos Christiano; Moro, Carla Heloísa; Harger, Rodrigo; Longo, Alexandre Luiz; Cabral, Norberto Luiz; Germiniani, Francisco Manoel Branco; Nóvak, Edison Matos; Zétola, Viviane de Hiroki Flumignan.
Título: Does the side of middle cerebral artery compromise matters in the mortality after thrombolysis in ischemic stroke? / O lado acometido da artéria cerebral média interfere na mortalidade do acidente vascular isquêmico pós trombólise?
Fonte: Arq. neuropsiquiatr;73(8):644-647, 08/2015. tab.
Idioma: en.
Resumo: The impact of the side in middle cerebral artery (MCA) ischemic stroke is not well established. Our aim was to analyze the differences between right (RMCA) and left middle cerebral artery (LMCA) stroke in patients submitted to intravenous thrombolysis and the influence of the affected side in the patient’s mortality after 3 months. Method Patients with MCA ischemic stroke submitted to intravenous thrombolysis from March 2010 to December 2011 at two Brazilian Stroke Centers were included. Differences between patients with RMCA and LMCA stroke were identified by univariate analysis. Results Forty-five patients with RMCA stroke and 67 with LMCA stroke were analyzed. Patients with LMCA had a higher incidence of atrial fibrillation (p = 0.031), although patients with RMCA more often had a previous ischemic stroke (p = 0.034). The mortality over 3 months was similar for either side (OR = 1.20 ;0.37 - 4.29, p = 0.772). Conclusion The side of the MCA ischemic stroke did not influence the patients mortality. .

O impacto do lado de acometimento da artéria cerebral média (ACM) não é bem estabelecido. Nosso objetivo é analisar as diferenças entre pacientes com acidente vascular isquêmico (AVCi) de ACM direita (ACMD) e esquerda (ACME) submetidos à trombólise endovenosa e a influência do lado acometido na mortalidade em 3 meses. Método Pacientes com AVCi ACMD e ACME submetidos à trombólise endovenosa entre Março de 2010 a Dezembro de 2012 em duas Unidades de AVC brasileiras foram incluídos. Diferenças entre AVCi ACMD e ACME foram identificadas pela análise univariada. Resultados Quarenta e cinco pacientes com AVCi de ACMD e 67 de ACME foram analisados. Pacientes com AVCi de ACME tiveram maior incidência de fibrilação atrial (p = 0,031), enquanto de ACMD maior de AVCi prévio (p = 0,034). A mortalidade em 3 meses foi similar em ambos os grupos (OR = 1,20; 0,37 -4,29, p = 0,772). Conclusão O lado de acometimento da ACM no AVCi não influencia na mortalidade. .
Descritores: Infarto da Artéria Cerebral Média/tratamento farmacológico
Infarto da Artéria Cerebral Média/mortalidade
Infarto da Artéria Cerebral Média/patologia
Terapia Trombolítica/mortalidade
-Administração Intravenosa
Estudos Transversais
Hemorragia Cerebral/mortalidade
Prognóstico
Estudos Retrospectivos
Índice de Gravidade de Doença
Estatísticas não Paramétricas
Fatores de Tempo
Limites: Idoso
Idoso de 80 Anos ou mais
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: lil-753041
Autor: Gagliardi, Rubens José.
Título: Could side of middle cerebral artery obstruction be a prognostic factor for mortality in thrombolysed patients? / Poderia o lado da obstrução da artéria cerebral média ser um fator para o prognóstico de mortalidade nos doentes trombolizados?
Fonte: Arq. neuropsiquiatr;73(8):639-640, 08/2015.
Idioma: en.
Descritores: Infarto da Artéria Cerebral Média/tratamento farmacológico
Infarto da Artéria Cerebral Média/mortalidade
Infarto da Artéria Cerebral Média/patologia
Terapia Trombolítica/mortalidade
Limites: Feminino
Humanos
Masculino
Tipo de Publ: Comentário
Editorial
Responsável: BR1.1 - BIREME


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Id: lil-726796
Autor: Ochoa, John Fredy; Ascencio, José Luis; Suárez, Juan Camilo.
Título: Aplicación de técnicas avanzadas de neuroimágenes en rehabilitación motora / Application of advanced neuroimaging in motor rehabilitation
Fonte: Biomédica (Bogotá);34(3):330-339, July-Sept. 2014. ilus.
Idioma: es.
Resumo: Introducción. La resonancia magnética funcional es una técnica no invasiva que permite el mapeo cerebral y la visualización de redes de conectividad. La hemiparesia posterior a un accidente cerebrovascular constituye un buen modelo biológico para estudiar los cambios en la conectividad cerebral. El uso de este modelo se puede expandir si se obtiene información antes y después de la rehabilitación neurológica. Objetivo. Presentar los hallazgos por neuroimágenes funcionales de un paciente con accidente cerebrovascular antes y después del tratamiento de rehabilitación neurológica. Materiales y métodos. Como parte del protocolo de rehabilitación neurológica se tomaron imágenes de resonancia antes y después del tratamiento con un equipo que operaba a 1,5 T. Se obtuvieron imágenes volumétricas potenciadas en T1, imágenes de difusión para tractografía, imágenes de resonancia funcional con el paciente en reposo y haciendo movimientos de pinza con la mano derecha. Resultados. Se obtuvieron mapas funcionales antes y después de la terapia, los cuales se presentan conjuntamente con las imágenes de conectividad estructural obtenidas mediante tractografía. Se observó que los cambios clínicos estaban acompañados de cambios en los patrones de activación obtenidos por resonancia magnética funcional. Conclusión. La versatilidad que ofrece la resonancia magnética permite conocer el estado funcional y estructural del cerebro, generando así nuevas posibilidades de diagnóstico y pronóstico en pacientes que reciben rehabilitación neurológica, con lo que se pueden cuantificar y develar ciertos procesos dinámicos de plasticidad neuronal posteriores a una lesión, que son propios del sistema nervioso central.

Introduction: Functional magnetic resonance imaging is a noninvasive technique that allows mapping and visualizing of brain connectivity networks. The hemiparesis after a stroke is a good biological model to study changes in brain connectivity. This model can be expanded if information is obtained before and after neurorehabilitation therapy. Objective: To present the functional neuroimaging findings in a patient with stroke before and after performing neurorehabilitation therapy. Materials and methods: As part of the neurorehabilitation protocol, resonance imaging was performed before and after treatment with an equipment operating at 1.5 T. Volumetric T1-weighted images, diffusion images for tractography, functional resonance images with the patient at rest and with the patient performing pincer movement with the right hand were obtained. Results: Functional maps before and after therapy were obtained, which are presented together with structural connectivity images obtained by tractography. Clinical changes can be seen accompanied by changes in activation patterns obtained by functional magnetic resonance imaging. Conclusion: The versatility of magnetic resonance imaging allows further knowledge of the structural and functional state of the brain generating new possibilities for diagnosis and prognosis in patients undergoing neurorehabilitation therapy. Neurological rehabilitation processes can be quantified and they can reveal certain postlesional neuroplasticity dynamic processes that the central nervous system possesses.
Descritores: Mapeamento Encefálico/métodos
Imagem de Tensor de Difusão/métodos
Infarto da Artéria Cerebral Média/complicações
Imagem por Ressonância Magnética/métodos
Paresia/reabilitação
Tratos Piramidais/patologia
-Dominância Cerebral
Mãos/fisiopatologia
Atividade Motora/fisiologia
Modalidades de Fisioterapia
Paresia/etiologia
Reflexo Anormal
Sepse/complicações
Limites: Criança
Humanos
Masculino
Tipo de Publ: Relatos de Casos
Responsável: CO332 - Facultad de Medicina


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Id: lil-722171
Autor: Chen, C.C.; Chang, M.W.; Chang, C.P.; Chan, S.C.; Chang, W.Y.; Yang, C.L.; Lin, M.T..
Título: A forced running wheel system with a microcontroller that provides high-intensity exercise training in an animal ischemic stroke model
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;47(10):858-868, 10/2014. tab, graf.
Idioma: en.
Resumo: We developed a forced non-electric-shock running wheel (FNESRW) system that provides rats with high-intensity exercise training using automatic exercise training patterns that are controlled by a microcontroller. The proposed system successfully makes a breakthrough in the traditional motorized running wheel to allow rats to perform high-intensity training and to enable comparisons with the treadmill at the same exercise intensity without any electric shock. A polyvinyl chloride runway with a rough rubber surface was coated on the periphery of the wheel so as to permit automatic acceleration training, and which allowed the rats to run consistently at high speeds (30 m/min for 1 h). An animal ischemic stroke model was used to validate the proposed system. FNESRW, treadmill, control, and sham groups were studied. The FNESRW and treadmill groups underwent 3 weeks of endurance running training. After 3 weeks, the experiments of middle cerebral artery occlusion, the modified neurological severity score (mNSS), an inclined plane test, and triphenyltetrazolium chloride were performed to evaluate the effectiveness of the proposed platform. The proposed platform showed that enhancement of motor function, mNSS, and infarct volumes was significantly stronger in the FNESRW group than the control group (P<0.05) and similar to the treadmill group. The experimental data demonstrated that the proposed platform can be applied to test the benefit of exercise-preconditioning-induced neuroprotection using the animal stroke model. Additional advantages of the FNESRW system include stand-alone capability, independence of subjective human adjustment, and ease of use.
Descritores: Teste de Esforço/métodos
Terapia por Exercício/métodos
Infarto da Artéria Cerebral Média/prevenção & controle
Esforço Físico
Condicionamento Físico Animal/instrumentação
-Calibragem
Infarto Cerebral/patologia
Infarto Cerebral/prevenção & controle
Modelos Animais de Doenças
Desenho de Equipamento
Invenções
Infarto da Artéria Cerebral Média/patologia
Resistência Física
Distribuição Aleatória
Ratos Wistar
Índice de Gravidade de Doença
Software
Fatores de Tempo
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: lil-712403
Autor: Sabogal, Angélica María; Arango, César Augusto; Cardona, Gloria Patricia; Céspedes, Ángel Enrique.
Título: Atorvastatin protects GABAergic and dopaminergic neurons in the nigrostriatal system in an experimental rat model of transient focal cerebral ischemia / La atorvastatina protege las neuronas gabérgicas y dopaminérgicas del sistema nigroestriatal en un modelo experimental de isquemia cerebral focal transitoria en ratas
Fonte: Biomédica (Bogotá);34(2):207-217, abr.-jun. 2014. ilus, graf.
Idioma: en.
Resumo: Introduction: Cerebral ischemia is the third leading cause of death and the primary cause of permanent disability worldwide. Atorvastatin is a promising drug with neuroprotective effects that may be useful for the treatment of stroke. However, the effects of atorvastatin on specific neuronal populations within the nigrostriatal system following cerebral ischemia are unknown. Objective: To evaluate the effects of atorvastatin on dopaminergic and GABAergic neuronal populations in exofocal brain regions in a model of transient occlusion of the middle cerebral artery. Materials and methods: Twenty-eight male eight-week-old Wistar rats were used in this study. Both sham and ischemic rats were treated with atorvastatin (10 mg/kg) or carboxymethylcellulose (placebo) by gavage at 6, 24, 48 and 72 hours post-reperfusion. We analyzed the immunoreactivity of glutamic acid decarboxylase and tyrosine hydroxylase in the globus pallidus, caudate putamen and substantia nigra. Results: We observed neurological damage and cell loss in the caudate putamen following ischemia. We also found an increase in tyrosine hydroxylase immunoreactivity in the medial globus pallidus and substantia nigra reticulata, as well as a decrease in glutamic acid decarboxylase immunoreactivity in the lateral globus pallidus in ischemic animals treated with a placebo. However, atorvastatin treatment was able to reverse these effects, significantly decreasing tyrosine hydroxylase levels in the medial globus pallidus and substantia nigra reticulata and significantly increasing glutamic acid decarboxylase levels in the lateral globus pallidus. Conclusion: Our data suggest that post-ischemia treatment with atorvastatin can have neuro-protective effects in exofocal regions far from the ischemic core by modulating the GABAergic and dopaminergic neuronal populations in the nigrostriatal system, which could be useful for preventing neurological disorders.

Introducción. La isquemia cerebral es la tercera causa de muerte y la primera de discapacidad permanente en el mundo. La atorvastatina es un fármaco neuroprotector prometedor para el tratamiento de la apoplejía; sin embargo, su acción sobre las poblaciones neuronales del sistema nigroestriatal después de la isquemia aún se desconoce. Objetivo. Evaluar el efecto de la atorvastatina sobre poblaciones gabérgicas y dopaminérgicas en regiones exofocales en un modelo de oclusión transitoria de la arteria cerebral media. Materiales y métodos. Se utilizaron 28 ratas Wistar macho de ocho semanas de edad. Los ejemplares con isquemia simulada y los ejemplares sometidos a isquemia fueron tratados con atorvastatina (10 mg/kg) y carboximetilcelulosa (placebo) administrados por medio de sonda a las 6, 24, 48 y 72 horas después de la reperfusión. Se analizó la inmunorreacción de la descarboxilasa del ácido glutámico y de la tirosina hidroxilasa en el globo pálido, el putamen caudado y la sustancia negra. Resultados. Los datos confirmaron el daño neurológico y la pérdida celular en el putamen caudado. Se incrementó la inmunorreacción de la tirosina hidroxilasa en el globo pálido medial y la sustancia negra pars reticulata , disminuyendo la inmunorreacción de la descarboxilasa del ácido glutámico en el globo pálido lateral de los animales isquémicos tratados con placebo; sin embargo, el tratamiento con atorvastatina pudo revertirla, lo que logró una disminución significativa de la tirosina hidroxilasa en el globo pálido medial y la sustancia negra pars reticulata y aumentando los niveles de descarboxilasa del ácido glutámico en el globo pálido lateral. Conclusión. Nuestros datos sugieren que la atorvastatina en el tratamiento posterior a la isquemia ejerce neuroprotección en las zonas exofocales, modulando las poblaciones neuronales gabérgicas y dopaminérgicas del sistema nigroestriatal, lo que podría prevenir trastornos neurológicos.
Descritores: Corpo Estriado/efeitos dos fármacos
Neurônios Dopaminérgicos/efeitos dos fármacos
Neurônios GABAérgicos/efeitos dos fármacos
Ácidos Heptanoicos/uso terapêutico
Infarto da Artéria Cerebral Média/tratamento farmacológico
Ataque Isquêmico Transitório/tratamento farmacológico
Fármacos Neuroprotetores/uso terapêutico
Pirróis/uso terapêutico
Substância Negra/efeitos dos fármacos
-Comportamento Animal
Corpo Estriado/irrigação sanguínea
Corpo Estriado/patologia
Avaliação Pré-Clínica de Medicamentos
Neurônios Dopaminérgicos/enzimologia
Neurônios Dopaminérgicos/patologia
Indução Enzimática/efeitos dos fármacos
Neurônios GABAérgicos/enzimologia
Neurônios GABAérgicos/patologia
Glutamato Descarboxilase/biossíntese
Glutamato Descarboxilase/genética
Ácidos Heptanoicos/farmacologia
Infarto da Artéria Cerebral Média/patologia
Ataque Isquêmico Transitório/patologia
Transtornos dos Movimentos/etiologia
Transtornos dos Movimentos/prevenção & controle
Proteínas do Tecido Nervoso/biossíntese
Proteínas do Tecido Nervoso/genética
Fármacos Neuroprotetores/farmacologia
Pirróis/farmacologia
Ratos Wistar
Recuperação de Função Fisiológica
Organismos Livres de Patógenos Específicos
Transtornos das Sensações/etiologia
Transtornos das Sensações/prevenção & controle
Substância Negra/irrigação sanguínea
Substância Negra/patologia
/biossíntese
TYROSINE ABATTOIRS-MONOOXYGENASE/biossíntese
/genética
TYROSINE ABATTOIRS-MONOOXYGENASE/genética
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CO332 - Facultad de Medicina



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