Base de dados : LILACS
Pesquisa : C10.597.305 [Categoria DeCS]
Referências encontradas : 4 [refinar]
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Id: lil-565558
Autor: Sánchez-López, Araceli; Centurión, David; Lozano-Cuenca, Jair; Muñoz-Islas, Enriqueta; Cobos-Puc, Luis E; M. Villalón, Carlos.
Título: Receptores de la serotonina que inhiben el tono simpático vasopresor en la rata descerebrada y desmedulada / Role of serotonin receptors in vascular tone in the pithed rat
Fonte: Arch. cardiol. Méx;79(supl.2):83-94, dic. 2009. tab.
Idioma: es.
Resumo: Serotonin (5-hydroxytryptamine; 5-HT) has been shown to produce vascular sympatho-inhibition in a wide variety of isolated blood vessels by activation of prejunctional 5-HT1 receptors. After considering the mechanisms involved in modulating neuroeffector transmission, the present review analyzes the experimental findings identifying the pharmacological profile of the 5-HT receptors that inhibit the sympathetically-induced vasopressor responses in pithed rats. Thus, 5-HT-induced sympatho-inhibition has been shown to be: (i) unaffected by physiological saline or by the selective antagonists ritanserin (5-HT2), MDL72222 (5-HT3) or tropisetron (5-HT3/4); (ii) blocked by methysergide, a non-selective 5-HT1/2 receptor antagonist; and (iii) potently mimicked by 5-carboxamidotryptamine (5-CT), a non-selective 5-HT1 receptor agonist, as well as by the selective agonists 8-OH-DPAT (5-HT1A), indorenate (5-HT1A), CP93,129 (5-HT1B), and sumatriptan (5-HT1B/1D). These findings show the involvement of prejunctional 5-HT1 receptors. With the use of selective antagonists, it has been shown subsequently that the sympatho-inhibition induced by indorenate, CP93, 129, and sumatriptan was selectively antagonized by WAY100635 (5-HT1A), cyanopindolol (5-HT1A/1B), and GR127935 (5-HT1B/1D), respectively. These results demonstrate that the 5-HT1 receptors mediating sympatho-inhibition on the systemic vasculature of pithed rats resemble the pharmacological profile of the 5-HT1A, 5-HT1B, and 5-HT1D subtypes.
Descritores: Vasos Sanguíneos/fisiologia
Receptores de Serotonina/fisiologia
-Estado de Descerebração
Receptores de Serotonina
Sistema Nervoso Simpático/fisiologia
Limites: Animais
Ratos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


  2 / 4 LILACS  
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Fotocópia
Id: lil-207692
Autor: Riarte, José Enrique.
Título: Alteración de la conciencia en el paciente crítico en coma: protocolo de seguimiento razonado / Conscience alteration at critical patients in coma: records of a reasoned follow - up
Fonte: Rev. med. Tucumán;1(4):175-98, jul.-ago. 1994. ilus, tab, graf.
Idioma: es.
Descritores: Coma/diagnóstico
Coma/etiologia
Consciência
Estado Vegetativo Persistente
Protocolos Clínicos/normas
Anormalidades do Sistema Respiratório
-Afasia Acinética
Descorticação Cerebral
Respiração de Cheyne-Stokes
Fossa Craniana Posterior/lesões
Estado de Descerebração
Movimentos Oculares
Escala de Coma de Glasgow
Hipotálamo Posterior/lesões
Hiperventilação
Miose
Limites: Masculino
Feminino
Seres Humanos
Responsável: AR1.1 - Biblioteca Rafael Herrera Vegas


  3 / 4 LILACS  
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Fotocópia
Lopes, O. U
Id: lil-154708
Autor: Cravo, S. l; Lopes, O. U; Fraga, C. A. B; Iaria, C. Timo.
Título: Cardiovascular adjustments in limb retraction provoked by noxious stimulation in decerebrate and spinal cats: evidence for a somatotopic organization
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;28(3):385-96, Mar. 1995. tab, graf.
Idioma: en.
Resumo: Arterial blood pressure, heart rate and iliac blood flow were continuously recorded in 61 adult cats and their alteration induced by noxious stimulation of the interdigital spaces of the four limbs was studied in intact (anesthetized) and in decerebrate and spinal preparations. Noxious stimulation of any limb in the decerebrate animals provoked retraction 61 percent of the times and an increase of blood pressure and heart rate in approximately 80 percent of the stimulations. Stimulations of a hindlimb provoked an increase of blood flow in the same limb in about 80 percent of the stimulations, due to active vasodilation. Contralateral stimulation provoked as smaller increase of blood flow but with an increase in vascular resistance, indicating some degree of vasoconstriction. Stimulation of the forelimbs induced small increases of blood flow in the hindlimbs but the calculated vascular resistance was higher than the basal values, also indicating vasoconstriction. Neuromuscular blockade with gallamine did not affect the increase of hindlimb blood flow, suggesting a central regulation of the intricate distribution of blood to the limbs...
Descritores: Estado de Descerebração/fisiopatologia
Extremidades/fisiologia
Fluxo Sanguíneo Regional/fisiologia
Frequência Cardíaca/fisiologia
Pressão Arterial/fisiologia
-Análise de Variância
Estimulação Elétrica
Resistência Vascular
Limites: Animais
Gatos
Responsável: BR1.1 - BIREME


  4 / 4 LILACS  
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Fotocópia
Vasquez, Elisardo Corral
Id: lil-86913
Autor: Futuro Neto, Henrique de Azevedo; Dantas, Mario Armando; Santos, Marcia Gabriel; Vasquez, Elisardo Corral.
Título: Cardiovascular regulation in the acute decerebrate rat
Fonte: Acta physiol. pharmacol. latinoam;37(4):445-53, 1987. ilus.
Idioma: en.
Resumo: Male Wistar rats were decerebrated at precollicular level, by aspiration under ether anaesthesia. The experiments employed rats instrumented for chronic electrocardiogram (ECG) recordings or mean blood pressure (MBP) and heart rate (Hr) determination. Immediately after surgery, decerebrate (D) and sham operated (SO) animals presented a small and ismilar increase in their HR. Three and a half hours after surgery, SO group presented a normal HR, whilst D animals continued to show an increas ein their HR up to 4.5 h, when it stabilized. Twenty four hours after surgery both groups presented similar MBP (D:110ñ6; SO:108ñ11; SO:335ñ5 beats/min). The blockade of parasympathetic tonus induced significant increases in the HR of both groups, withou major changes in their MBP. Beta-adrenergic blockade reduced HR of both groups, bringin HR of D almost to control level. Simultaneously there was a reduction in MBP of D but not of SO animals. When parasympathetic blockade was superimposed to beta-adrenergic blockade, there was a significant increase in HR of SO, but not of D or in MBP of both groups. Thus we conclude that the decerebrate rat presents normal MBP with simultaneous tachycardia mainly caused by increased sympathetic outflow to the heart
Descritores: Sistema Cardiovascular/fisiologia
Estado de Descerebração/fisiopatologia
Frequência Cardíaca/fisiologia
Pressão Sanguínea/fisiologia
-Atropina/farmacologia
Teto do Mesencéfalo/cirurgia
Frequência Cardíaca/efeitos dos fármacos
Pressão Sanguínea/efeitos dos fármacos
Propranolol/farmacologia
Ratos Endogâmicos
Limites: Ratos
Animais
Masculino
Responsável: BR1.1 - BIREME



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