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Id: lil-798081
Autor: Vasconcelos-Moreno, Mirela P; Bücker, Joana; Bürke, Kelen P; Czepielewski, Leticia; Santos, Barbara T; Fijtman, Adam; Passos, Ives C; Kunz, Mauricio; Bonnín, Caterina del Mar; Vieta, Eduard; Kapczinski, Flavio; Rosa, Adriane R; Kauer-Sant’Anna, Marcia.
Título: Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls
Fonte: Rev. bras. psiquiatr;38(4):275-280, Oct.-Dec. 2016. tab.
Idioma: en.
Resumo: Objective: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was accessed using the Functioning Assessment Short Test (FAST). A sub-group of patients with BD (n=21), unaffected siblings (n=14), and healthy controls (n=22) also underwent a battery of neuropsychological tests: California Verbal Learning Test (CVLT), Stroop Color and Word Test, and Wisconsin Card Sorting Test (WCST). Clinical and sociodemographic characteristics were analyzed using one-way analysis of variance or the chi-square test; multivariate analysis of covariance was used to examine differences in neuropsychological variables. Results: Patients with BD showed higher FAST total scores (23.90±11.35) than healthy controls (5.86±5.47; p < 0.001) and siblings (12.60±11.83; p 0.001). Siblings and healthy controls also showed statistically significant differences in FAST total scores (p = 0.008). Patients performed worse than healthy controls on all CVLT sub-tests (p < 0.030) and in the number of correctly completed categories on WCST (p = 0.030). Siblings did not differ from healthy controls in cognitive tests. Conclusion: Unaffected siblings of patients with BD may show poorer functional performance compared to healthy controls. FAST scores may contribute to the development of markers of vulnerability and endophenotypic traits in at-risk populations.
Descritores: Transtorno Bipolar/psicologia
Cognição/fisiologia
Transtornos Cognitivos/psicologia
Irmãos/psicologia
-Aprendizagem Verbal
Estudos de Casos e Controles
Estudos Transversais
Análise Multivariada
Transtornos Cognitivos/fisiopatologia
Endofenótipos
Deficiências da Aprendizagem/diagnóstico
Transtornos da Memória/diagnóstico
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-792746
Autor: Coutinho, Gabriel; Drummond, Cláudia; Teldeschi, Alina; Mattos, Paulo.
Título: Awareness of memory deficits is useful to distinguish between depression and mild cognitive impairment in the elderly
Fonte: Rev. bras. psiquiatr;38(3):231-234, July-Sept. 2016. tab.
Idioma: en.
Resumo: Objective: To investigate whether the level of awareness of memory deficits is useful for discriminating between major depressive disorder (MDD) and mild cognitive impairment (MCI) in the elderly. Methods: Sixty-three consecutively referred patients (38 women and 25 men) with memory concerns comprising three groups (clinical control, MDD and MCI) underwent a memory test (Rey Auditory Verbal Learning Test [RAVLT]) and completed the Memory Assessment Complaints-Questionnaire (MAC-Q). Level of awareness was estimated by the difference between the MAC-Q score and the score on the fifth presentation of the RAVLT. Memory performance, Mini-Mental State Examination (MMSE) and depressive symptoms (Geriatric Depression Scale [GDS]) were also assessed. Results: The control (n=25), MDD (n=16), and MCI (n=22) groups were similar in age, educational level, and MMSE (p > 0.05). Among the groups, the MDD group had the most memory complaints, whereas the MCI group had the worst objective memory performance. Level of awareness was capable of discriminating between MDD and MCI (p < 0.05), but not between MDD and clinical controls (p > 0.05). MDD subjects tended to underestimate their memory functioning as compared to controls (p < 0.05). Conclusion: Level of awareness of memory deficits was significantly useful to discriminate between MCI and MDD, which is a common difficulty faced by clinicians. Future studies with larger samples are needed to confirm these findings.
Descritores: Conscientização
Transtorno Depressivo Maior/diagnóstico
Disfunção Cognitiva/diagnóstico
Transtornos da Memória/diagnóstico
-Estudos de Casos e Controles
Valor Preditivo dos Testes
Inquéritos e Questionários
Análise de Variância
Estatísticas não Paramétricas
Transtorno Depressivo Maior/fisiopatologia
Diagnóstico Diferencial
Disfunção Cognitiva/fisiopatologia
Transtornos da Memória/fisiopatologia
Pessoa de Meia-Idade
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: biblio-844184
Autor: Azeredo, Lucas A de; De Nardi, Tatiana; Levandowski, Mateus L; Tractenberg, Saulo G; Kommers-Molina, Julia; Wieck, Andrea; Irigaray, Tatiana Q; Silva Filho, Irênio G da; Grassi-Oliveira, Rodrigo.
Título: The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults
Fonte: Rev. bras. psiquiatr;39(2):90-94, Apr.-June 2017. tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Methods: Eighty-seven subjects aged > 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. Results: BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). Conclusion: These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults.
Descritores: Valina/genética
Fator Neurotrófico Derivado do Encéfalo/genética
Polimorfismo de Nucleotídeo Único
Transtornos da Memória/genética
Metionina/genética
-Análise e Desempenho de Tarefas
Escalas de Wechsler
Análise Multivariada
Fatores de Risco
Fatores Etários
Estatísticas não Paramétricas
Predisposição Genética para Doença
Alelos
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: biblio-985348
Autor: Berberian, Arthur A; Gadelha, Ary; Dias, Natália M; Mecca, Tatiana P; Comfort, William E; Bressan, Rodrigo A; Lacerda, Acioly T.
Título: Component mechanisms of executive function in schizophrenia and their contribution to functional outcomes
Fonte: Rev. bras. psiquiatr;41(1):22-30, Jan.-Mar. 2019. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Objective: In schizophrenia, scores reflecting deficits in different cognitive processes are strongly correlated, making it difficult to establish a solid relationship between different cognitive mechanisms and other features of this disorder. The objective of this study was to explore whether three frequently postulated executive functions (updating, shifting, and inhibition) could be compared between groups and considered independently in terms of their respective roles in functional outcome. Methods: This study relied on confirmatory factor analysis of schizophrenia patients (n=141) and healthy controls (n=119). The main analyses examined the degree to which three executive functions (updating, set-shifting, and inhibition) could be separated in schizophrenia and compared this model among groups. Structural equation modeling analysis was also performed to examine the extent to which executive function components contribute to functional outcome in schizophrenia. Results: Multiple-group confirmatory factor analysis with unconstrained model parameters indicated that the full three-factor model may fit the data in both groups (χ2 = 61.48, degrees of freedom = 34, p < 0.001, comparative fit index = 0.95; standardized root mean square residual = 0.037; root mean square error of approximation = 0.04; Akaike's information criteria = 169.49; normed fit index = 0.90), although there was also a good data fit for the patient group with a two-factor model. In the patient group, structural equation modeling suggested that shifting and (principally) updating were associated with the general measure of functional outcome (regression path coefficients: 0.34, p < 0.005; 0.39, p < 0.005, respectively), although when combined the mechanisms fail to contribute. Conclusion: This data suggests that the factor structure may be similar but not identical between groups, and both updating and shifting may play an important role in functional outcome in schizophrenia.
Descritores: Esquizofrenia/fisiopatologia
Função Executiva/fisiologia
Inibição Psicológica
Transtornos da Memória/fisiopatologia
-Estudos de Casos e Controles
Escolaridade
Pessoa de Meia-Idade
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: BR1.1 - BIREME


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Aldrighi, José Mendes
Aldrighi, José Mendes
Id: biblio-1069347
Autor: Aldrighi, José Mendes; Calvoso Jr, Roberto; Faludi, André Arpadi; Mansur, Antonio de Pádua.
Título: Climatério e menopausa / Climacteric and menopause
Fonte: In: Aldrighi, José Mendes; Faludi, André Arpad; Mansur, Antonio de Pádua. Doença cardiovascular no climatério. São Paulo, Atheneu, 2005. p.23-29, ilus.
Idioma: pt.
Descritores: Climatério/fisiologia
Depressão
Fogachos
Infertilidade
Menopausa/fisiologia
Transtornos da Memória
Transtornos do Sono-Vigília
-Endocrinologia
Ganho de Peso
Limites: Feminino
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Humanos
Responsável: BR79.1 - CIC - Centro de Informação Cardiovascular Mendonça de Barros
BR79.1


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Id: lil-623964
Autor: Zhu, Xing-Zu.
Título: Development of natural products as drugs acting on central nervous system
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):173-175, 1991.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: We have recenty studied several natural product constituents which have effects on the CNS. (1) Tetrahydropalmatine (THP) and its analogues were isolated from Corydalis ambigua and various species of Stephania. (+)-THP and (-)-THP posses not only analgesic activity, but also exert sedative-tranquillizing and hypnotic actions. Results of receptor binding assay and their pre-and post-synaptic effects on dopaminergic system indicate that (-)-THP and (-)-stepholidine are dopamine receptor antagonists while (+)-THP is a selective dopamine depletor. (2) 3-Acetylaconitine (AAC) is an alkaloid isolated from Aconitum flavum. The relative potency of analgesic action of AAC was 5.1-35.6 and 1250-3912 times that of morphine and aspirin, respectively. The analgesic effect of AAC was antagonized by naloxone, but was eliminated by reserpine. In monkeys, after AAC was injected for 92 days, no abstinence syndrome was seen after sudden AAC withdrawal or when challenged with nalorphine. (3) Huperzine A (Hup-A) is an alkaloid isolated from Huperzia serrata which was found to be a selective ChE inhibitor and could improve learning and retrieval process. Preliminary clinical studies showed that Hup-A improve short-and long-term memory in patients of cerebral arteriosclerosis with memory impairment. (4) Ranamargarin is a new tetradecapeptide isolated from the skin of the Chines frog Rana margaratae. This peptide may mainly act on NK-1 receptor.
Descritores: Medicamentos de Ervas Chinesas/farmacologia
Depressores do Sistema Nervoso Central/farmacologia
Fármacos do Sistema Nervoso Central/farmacologia
Transtornos da Memória/tratamento farmacológico
-Dados de Sequência Molecular
Sequência de Aminoácidos
Avaliação de Medicamentos
Avaliação Pré-Clínica de Medicamentos
Limites: Humanos
Animais
Responsável: BR1.1 - BIREME


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Id: lil-795289
Autor: Roman, Fabian; Iturry, Mónica; Rojas, Galeno; Barceló, Ernesto; Buschke, Herman; Allegri, Ricardo F.
Título: Validation of the Argentine version of the Memory Binding Test (MBT) for Early Detection of Mild Cognitive Impairment / Validação da versão argentina do Memory Binding Test (MBT) para a detecção precoce do transtorno cognitivo leve
Fonte: Dement. neuropsychol;10(3):217-226, July-Sept. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT. Background: "Forgetfulness" is frequent in normal aging and characteristic of the early stages of dementia syndromes. The episodic memory test is central for detecting amnestic mild cognitive impairment (MCI). The Memory Binding Test (MBT) is a simple, easy and brief memory test to detect the early stage of episodic memory impairment. Objective: To validate the Argentine version of the MBT in a Latin American population and to estimate the diagnostic accuracy as a tool for early detection of MCI. Methods: 88 subjects (46 healthy controls and 42 patients with amnestic MCI) matched for age and educational level were evaluated by an extensive neuropsychological battery and the memory binding test. Results: A significantly better performance was detected in the control group; all MBT scales were predictive of MCI diagnosis (p<.01). The MBT showed high sensitivity (69%) and high specificity (88%), with a PPV of 93% and a NPV of 55% for associative paired recall. A statistically significant difference (c2=14,164, p<.001) was obtained when comparing the area under the curve (AUC) of the MBT (0.88) and the MMSE (0.70). Conclusion: The Argentine version of the MBT correlated significantly with the MMSE and the memory battery and is a useful tool in the detection of MCI. The operating characteristics of the MBT are well suited, surpassing other tests commonly used for detecting MCI.

RESUMO. "Esquecimento" é queixa frequente no envelhecimento normal e também ocorre nos primeiros estágios de síndromes demenciais. Testes de memória episódica são fundamentais para detectar comprometimento cognitivo amnéstico (CCL). O teste de Memória Associativa (Memory Binding Test-MBT) é um teste fácil e breve para detectar a fase inicial de perda de memória episódica. Objetivo: Validar a versão argentina do MBT e estimar a sua acurácia como instrumento diagnóstico para a detecção precoce do CCL. Métodos: 88 indivíduos (46 controles saudáveis ​​e 42 pacientes com CCL amnéstico), emparelhados por idade e nível educacional, foram avaliados com extensa bateria neuropsicológica e o MBT. Resultados: Um desempenho significativamente melhor foi detectada no grupo controle; todas as escalas do MBT foram preditivas do diagnóstico de CCL (p<0,01). O MBT apresentou alta sensibilidade (69%) e alta especificidade (88%), com valor preditivo (VP) positivo de 93% e e VP negativo de 55% para a recordação dos itens associados (associative paired recall). Diferença estatisticamente significativa (c2=14,164, p<0,001) foi obtida quando foram comparadas as áreas sob as curvas (AUC) do MBT (0,88) e o Mini-Exame do Estado Mental (MEEM) (0,70). Conclusão: A versão argentina do MBT correlacionou-se significativamente com o MEEM e com a bateria de memória e é uma ferramenta útil na detecção de CCL. As características operacionais do MBT são bem adequadas, superando outros testes usualmente utilizados para a detecção de CCL.
Descritores: Determinação
Doença de Alzheimer
Memória Episódica
Testes de Estado Mental e Demência
Transtornos da Memória
Limites: Humanos
Tipo de Publ: Artigo Clássico
Responsável: BR15.3 - Biblioteca Emília Bustamante


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Id: lil-542653
Autor: Aguiar, Ana Cristina Procópio de Oliveira(org); Ribeiro, Miriam Ikeda(org); Jacinto, Alessandro Ferrari(coord).
Título: Subjective memory complaint in the elderly may be related to factors other than cognitive deficit / Queixas subjetivas de memória no idoso podem ser relacionadas a outros fatores além de déficit cognitivo
Fonte: Dement. neuropsychol;4(1), mar. 2010.
Idioma: pt.
Resumo: Prevalence of subjective memory complaints (SMC) in elderly community dwellers (ECD) ranges from 25 to 50%. Some controversy exists over the association between SMC and cognitive status. Objective: We investigated whether a correlation in cognitive performance existed between two different groups according to SMC. Methods: The Mini Mental State Examination (MMSE) and Dementia Rating Scale-Mattis (DRS-Mattis) were applied to two groups: ECD (n=14) with SMC and residents (n=14) of a long-term care facility (LTCF) without SMC. Results: The median age in the ECD group was 81.0 years, and in the LTCF group was 75.0 years. There was a statistically significant difference (p=0.048) between these groups regarding age. Concerning schooling (1-8 or ?9 years), there was no statistically significant difference between the groups (p=0.638). No statistically significant difference between the two groups was found for scores on the cognitive tests. Conclusion: SMC might be related to extrinsic factors other than insipient cognitive decline.

A prevalência de queixa subjetiva de memória (QSM) em idosos da comunidade (IRC) varia de 25-50%. Controvérsias existem a respeito da associação entre QSM e cognição. Objetivos: Foi investigado se há correlação entre QSM e declínio cognitivo em dois diferentes grupos. Método: Foi aplicado o Mini Exame do Estado Mental (MEEM) e a Escala de Avaliação de Demência Mattis (DRS-Mattis) em dois grupos de idosos: IRC (n=14) que apresentaram QSM e residentes (n=14) de uma instituição de longa permanência (ILP) sem QSM. Resultados: A mediana de idade do grupo ?IRC? foi de 81,0 anos e a do grupo ?ILP? foi de 75,0. Houve diferença estatisticamente significante (p=0,048) entre eles, considerando a idade. Não houve esta diferença (p=0,638) na distribuição dos indivíduos quando analisada a escolaridade (1-8 ou ?9 anos). Considerando-se os escores dos instrumentos cognitivos, não houve diferença estatisticamente significante entre grupos. Conclusões: QSM pode estar relacionada a outros fatores em idosos, e não somente à presença de declínio cognitivo.
Descritores: Idoso
Disfunção Cognitiva
Transtornos da Memória
Limites: Humanos
Tipo de Publ: Artigo Clássico
Responsável: BR15.3 - Biblioteca Emília Bustamante


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Id: biblio-1047184
Autor: Alurralde, Micaela Belén.
Título: Asociación entre dolor crónico, deterioro cognitivo y demencia en una cohorte longitudinal de adultos mayores / Association Between Persistent Pain and Memory Decline and Dementia in a Longitudinal Cohort of Elders
Fonte: Evid. actual. práct. ambul;22(3):e001080., nov. 2019.
Idioma: es.
Descritores: Envelhecimento/fisiologia
Cognição/fisiologia
Demência/diagnóstico
Dor Crônica/diagnóstico
Transtornos da Memória/diagnóstico
-Fatores Socioeconômicos
Estados Unidos/epidemiologia
Medição da Dor
Atividades Cotidianas
Envelhecimento/psicologia
Estatística como Assunto
Estudos Longitudinais
Competência Mental
Demência/fisiopatologia
Demência/epidemiologia
Dor Crônica/psicologia
Dor Crônica/epidemiologia
Transtornos da Memória/fisiopatologia
Transtornos da Memória/epidemiologia
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Comentário
Responsável: AR2.1 - Biblioteca Central


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Id: biblio-1017077
Autor: Joffily, Sylvia Beatriz; Joffily, Lucia; Andraus, Nathália Monteiro.
Título: O estado de sono no processo de aprendizagem / The sleep state in the learning process
Fonte: Ciênc. cogn;19(3):531-543, fev. 2014.
Idioma: pt.
Resumo: Para melhor conhecer a influência do estado de sono nas dificuldades escolares que afetam a população brasileira, analisa-se uma série de teorias e pesquisas de campo versando sobre o estado de sono, aprendizagem, memória, reserva cognitiva, atenção, motivação, automação, plasticidade neural, alfabetização, letramento, leitura, escrita e seus respectivos substratos neurais. A análise revelou que a qualidade e a quantidade de sono afetam principalmente a atenção e a memória de trabalho, funções cognitivas que estão no cerne da aprendizagem, da leitura e da escrita. Desta forma, espera-se resgatar o aspecto neuroeducacional do conceito de sono, descrevendo-o como um dos grandes responsáveis pelo desempenho escolar da população brasileira

In order to get better knowledge about the influence of the state of sleep on the school difficulties met with by the Brazilian population, a series of theories and field research projects are analyzed concerning the state of sleep,learning, memory, cognitive reserve, attention, motivation, automaticity, neural plasticity, (basic, intermediate and advanced) literacy, reading, writing and their respective neural substrates. This analysis showed that the quality and amount of sleep mainly aff ct attention and working memory, cognitive functions that are at the core of learning, reading and writing. Thus, we hope to have contributed to rescue the neuroeducational aspect of the concept of sleep, describing it as one of the major factors responsible for the school performance of the Brazilian population
Descritores: Privação do Sono
Baixo Rendimento Escolar
Plasticidade Neuronal
Neuropsicologia
-Memória
Transtornos da Memória
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR2474.1 - Biblioteca



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