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Id: biblio-1059096
Autor: Güven, Esref Oguz; Selvi, Ismail; Karaismailoglu, Eda.
Título: Association between benign prostate enlargement-related storage and voiding symptoms and systolic blood pressure: a single-center cross-sectional study
Fonte: Säo Paulo med. j;137(5):446-453, Sept.-Oct. 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT BACKGROUND: Lower urinary tract symptoms significantly worsen quality of life. The hypothesis that they might lead to serious systolic blood pressure alterations through inducing sympathetic nervous activity has not been studied so far. OBJECTIVES: To investigate the relationship between benign prostate enlargement-related storage and voiding symptoms and systolic blood pressure. DESIGN AND SETTING: Cross-sectional single-center study on data from a hospital patient record system. METHODS: We evaluated the medical records of all consecutive patients with benign prostate enlargement-related lower urinary tract symptoms admitted between January 2012 and December 2017. Storage and voiding symptoms were assessed separately. International Prostate Symptom Score, uroflowmetry, postvoiding residual urine volume and systolic blood pressure were recorded. Pearson correlation and linear regression analysis were used. RESULTS: Positive correlations were found between systolic blood pressure and all of the storage symptoms. Among these, urgency had the most significant effect. There were 166 patients (41.4%) with urgency for urination, which increased mean systolic blood pressure from 124.88 mmHg (average value in elevated blood pressure group) to 132.28 mmHg (average value in stage-1 hypertension group). Hesitancy in urinating and feeling of incomplete bladder emptying had weak positive correlations with systolic blood pressure. There was a negative correlation between systolic blood pressure and intermittency of urination. CONCLUSIONS: With increasing numbers of urine storage symptoms, systolic blood pressure also increases, while the opposite occurs for voiding symptoms in patients with benign prostate enlargement. We conjecture that storage symptoms may lead to this increase through inducing sympathetic hyperactivity. Further prospective studies with larger groups are needed to confirm these findings.
Descritores: Hiperplasia Prostática/complicações
Micção/fisiologia
Pressão Sanguínea/fisiologia
Sintomas do Trato Urinário Inferior/complicações
Hipertensão/complicações
-Tamanho do Órgão
Próstata/fisiopatologia
Índice de Gravidade de Doença
Estudos Transversais
Sintomas do Trato Urinário Inferior/fisiopatologia
Hipertensão/fisiopatologia
Limites: Masculino
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-985534
Autor: Alonso-Mariño, Olga Lidia; Alonso-Mariño, Ana Luisa.
Título: Hemofilia A adquirida. A propósito de un caso / Acquired hemophilia A. A case report
Fonte: Rev. cuba. hematol. inmunol. hemoter;34(3):1-5, jul.-set. 2018. ilus.
Idioma: es.
Resumo: La hemofilia A adquirida es un trastorno hemorrágico poco frecuente caracterizado por la presencia de autoanticuerpos contra el factor VIII (FVIII) circulante. Se ha observado en un grupo heterogéneo de entidades que incluyen, entre otros, enfermedades malignas; de ellas el 32 por ciento asociada a procesos urológicos, donde el cáncer de próstata tiene la mayor prevalencia. Se presenta un paciente que fue atendido en el servicio de Oncología del Hospital Universitario Celestino Hernández Robau con el diagnóstico de hemofilia A adquirida en la evolución de un adenocarcinoma prostático. Se realizó estudio de coagulación en el Instituto de Hematología e Inmunología donde se comprobó la presencia de inhibidor del factor VIII, lo que confirmó el diagnóstico. Se puso tratamiento inmunosupresor con prednisona 1 mg/kg de peso, con una evolución favorable(AU)

Acquired hemophilia A is a rare bleeding disorder characterized by the presence of autoantibodies against circulating factor VIII (FVIII). It has been observed in a heterogeneous group of entities that include, among others, malignant diseases; 32 percent associated with urological processes, where prostate cancer has the highest prevalence. We present a patient who was treated at the Oncology Service of the Celestino Hernández Robau University Hospital with the diagnosis of acquired hemophilia A in the course of a prostatic adenocarcinoma. A coagulation study was carried out at the Institute of Hematology and Immunology where the presence of factor VIII inhibitor was confirmed, confirming the diagnosis. Immunosuppressive treatment was given with prednisone 1 mg/kg of weight, with a favorable evolution(AU)
Descritores: Prednisona/uso terapêutico
Hemofilia A/complicações
Hemofilia A/tratamento farmacológico
-Hiperplasia Prostática/complicações
Hemofilia A/diagnóstico
Transtornos Hemorrágicos/complicações
Limites: Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: lil-794678
Autor: Wei, Yong; Xu, Ning; Chen, Shao-Hao; Li, Xiao-Dong; Zheng, Qing-Shui; Lin, Yun-Zhi; Xue, Xue-Yi.
Título: Bipolar transurethral enucleation and resection of the prostate versus bipolar resection of the prostate for prostates larger than 60gr: A retrospective study at a single academic tertiary care center
Fonte: Int. braz. j. urol;42(4):747-756, July-Aug. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective: To evaluate the efficacy and safety of bipolar transurethral enucleation and resection of the prostate (B-TUERP) versus bipolar transurethral resection of the prostate (B-TURP) in the treatment of prostates larger than 60g. Material and Methods: Clinical data for 270 BPH patients who underwent B-TUERP and 204 patients who underwent B-TURP for BPH from May 2007 to May 2013 at our center were retrospectively analyzed. Outcome measures included operative time, decreased hemoglobin level, total prostate specific antigen (TPSA), International Prostate Symptom Score (IPSS), maximal urinary flow rate (Qmax), quality of life (QoL) score, post void residual urine volume (RUV), bladder irrigation duration, hospital stay, and the weight of resected prostatic tissue. Other measures included perioperative complications including transurethral resection syndrome (TURS), hyponatremia, blood transfusion, bleeding requiring surgery, postoperative acute urinary retention, urine incontinence and urinary sepsis. Patients in both groups were followed for two years. Results: Compared with the B-TURP group, the B-TUERP group had shorter operative time, postoperative bladder irrigation duration and hospital stay, a greater amount of resected prostatic tissue, less postoperative hemoglobin decrease, better postoperative IPSS and Qmax, as well as lower incidences of hyponatremia, urinary sepsis, blood transfusion requirement, urine incontinence and reoperation (P<0.05 for all). Conclusions: B-TUERP is superior to B-TURP in the management of large volume BPH in terms of efficacy and safety, but this finding needs to be validated in further prospective, randomized, controlled studies.
Descritores: Próstata/cirurgia
Hiperplasia Prostática/cirurgia
Ressecção Transuretral da Próstata/métodos
-Período Pós-Operatório
Qualidade de Vida
Micção
Estudos Retrospectivos
Seguimentos
Retenção Urinária/etiologia
Resultado do Tratamento
Antígeno Prostático Específico/sangue
Ressecção Transuretral da Próstata/efeitos adversos
Duração da Cirurgia
Centros de Atenção Terciária
Irrigação Terapêutica
Tempo de Internação
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Idoso
Responsável: BR1.1 - BIREME


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Id: lil-794683
Autor: Kobayashi, Shuichiro; Yano, Masataka; Nakayama, Takayuki; Kitahara, Satoshi.
Título: Predictive risk factors of postoperative urinary incontinence following holmium laser enucleation of the prostate during the initial learning period
Fonte: Int. braz. j. urol;42(4):740-746, July-Aug. 2016. tab.
Idioma: en.
Resumo: ABSTRACT Purpose: To determine the predictive factors for postoperative urinary incontinence (UI) following holmium laser enucleation of the prostate (HoLEP) during the initial learning period. Patients and Methods: We evaluated 127 patients with benign prostatic hyperplasia who underwent HoLEP between January 2011 and December 2013. We recorded clinical variables, including blood loss, serum prostate-specific antigen levels, and the presence or absence of UI. Blood loss was estimated as a decline in postoperative hemoglobin levels. The predictive factors for postoperative UI were determined using a multivariable logistic regression analysis. Results: Postoperative UI occurred in 31 patients (24.4%), but it cured in 29 patients (93.5%) after a mean duration of 12 weeks. Enucleation time >100 min (p=0.043) and blood loss >2.5g/dL (p=0.032) were identified as significant and independent risk factors for postoperative UI. Conclusions: Longer enucleation time and increased blood loss were independent predictors of postoperative UI in patients who underwent HoLEP during the initial learning period. Surgeons in training should take care to perform speedy enucleation maneuver with hemostasis.
Descritores: Próstata/cirurgia
Hiperplasia Prostática/cirurgia
Incontinência Urinária/etiologia
Ressecção Transuretral da Próstata/efeitos adversos
Lasers de Estado Sólido/uso terapêutico
-Período Pós-Operatório
Índice de Massa Corporal
Modelos Logísticos
Análise Multivariada
Fatores de Risco
Antígeno Prostático Específico/sangue
Curva de Aprendizado
Hólmio
Limites: Humanos
Masculino
Idoso
Responsável: BR1.1 - BIREME


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Id: lil-794689
Autor: Pearce, Shane M; Pariser, Joseph J; Malik, Rena D; Famakinwa, Olufenwa J; Chung, Doreen E.
Título: Outcomes following Thulium vapoenucleation of large prostates
Fonte: Int. braz. j. urol;42(4):757-765, July-Aug. 2016. tab.
Idioma: en.
Resumo: ABSTRACT Introduction: Thulium laser VapoEnucleation of the prostate (ThuVEP) is an evolving surgical technique for BPH. Most studies have focused on outcomes in small to medium sized prostates and have originated from Europe and Asia. We sought to describe our experience with ThuVEP for very large prostates in a North American cohort. Materials and Methods: From December 2010 to October 2014, 25 men underwent ThuVEP using the CyberTM® (Quantastem, Italy) thulium laser, all with prostate volume >75mL. Data collected included patient demographics, comorbidities, intraoperative parameters, complications, and post-operative outcomes including maximum flow rate (Qmax), post-void residual (PVR), International Prostate Symptom Score (IPSS), and quality of life score (QoL) in one year of follow-up. Statistical analysis was done using Wilcoxon signed-rank test. Results: At baseline, mean age was 70±9 years and prostate size was 163±62g. Most patients (84%) were in retention and 10 (40%) patients were on anticoagulation. Seven (28%) patients went home the day of surgery (mean hospital stay: 1.2±1.2d). There were 2 intraoperative complications (8%), both cystotomies related to morcellation. Nine patients (36%) experienced a complication, all within 30 days. There were no Clavien ≥III complications. Significant improvements were seen in Qmax, PVR, IPSS, and QoL score at each time interval to 12-months following surgery (all p<0.05). Of 21 patients initially in retention, all were voiding at last follow-up. Conclusions: Our findings suggest that ThuVEP is an effective treatment for BPH in patients with large prostates with sustained results for one year.
Descritores: Prostatectomia/métodos
Hiperplasia Prostática/cirurgia
Túlio/uso terapêutico
Terapia a Laser
Lasers de Estado Sólido/uso terapêutico
-Tamanho do Órgão
Estudos Prospectivos
Resultado do Tratamento
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: lil-785726
Autor: Kumsar, Sukru; Kose, Osman; Aydemir, Huseyin; Halis, Fikret; Gokce, Ahmet; Adsan, Oztug; Akkaya, Zeynep Kahyaoglu.
Título: The relationship between histological prostatitis and lower urinary tract symptoms and sexual function
Fonte: Int. braz. j. urol;42(3):540-545tab, graf.
Idioma: en.
Resumo: ABSTRACT This prospective analysis assessed the effect of histological prostatitis on lower urinary tract functions and sexual function. The patients were separated into two groups as histologically observed prostatitis (Group A) and no prostatitis (Group B) according to the biopsy outcomes. International prostate symptom score, international index of erectile function-5 scores, maximal and average flow rate, and residual urine volumes were compared statistically between groups. There was no significant difference (P>0.05) in baseline age (t=0.64), body mass index value (t=0.51), prostate volume (t=0.87), prostate-specific antigen levels (t=0.43), maximal (t=0.84) and average flow rate (t=0.59), and post-void residual urine volume (t=0.71). Mean international prostate symptom score in patients with prostatitis was numerically but not significantly higher than that in those without prostatitis (t=0.794, P=0.066). Mean international index of erectile function-5 score in the prostatitis group was significantly lower than that in those without prostatitis (t=1.854, P=0.013). Histological prostatitis notably affected sexual function of patients and may serve as a major risk factor for sexual dysfunction while having little effect on lower urinary tract symptoms.
Descritores: Prostatite/fisiopatologia
Prostatite/patologia
Sintomas do Trato Urinário Inferior/fisiopatologia
Disfunção Erétil/fisiopatologia
-Tamanho do Órgão
Próstata/patologia
Hiperplasia Prostática/fisiopatologia
Hiperplasia Prostática/patologia
Biópsia por Agulha
Índice de Gravidade de Doença
Índice de Massa Corporal
Doença Crônica
Análise Multivariada
Estudos Prospectivos
Antígeno Prostático Específico/sangue
Estatísticas não Paramétricas
Progressão da Doença
Sintomas do Trato Urinário Inferior/patologia
Disfunção Erétil/patologia
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Idoso
Responsável: BR1.1 - BIREME


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Id: lil-785733
Autor: Castelli, Tommaso; Russo, Giorgio Ivan; Reale, Giulio; Privitera, Salvatore; Chisari, Mario; Fragalà, Eugenia; Favilla, Vincenzo; Cimino, Sebastiano; Morgia, Giuseppe.
Título: Metabolic syndrome and prostatic disease: potentially role of polyphenols in preventive strategies. A review
Fonte: Int. braz. j. urol;42(3):422-430tab, graf.
Idioma: en.
Resumo: ABSTRACT Benign prostatic hyperplasia and prostate cancer are two common urological diseases of the elderly. Scientific community has always looked for a link that could explain the correlation between the two diseases and the role of chronic inflammation in the pathogenesis of BPH and PCa. As shown by the reports of the two diseases relationship with oxidative stress and metabolic syndrome, the use of compounds with antioxidant action could therefore affect both the symptoms and their onset. Polyphenols appear to act not only against oxidative stress but also at different levels. The aim of this review is to evaluate the role of the most important polyphenols on these two urological diseases. As antioxidants these compounds seems to have a direct action on the cell cycle and hormone function, important for both prostate cancer and BPH. Despite a large number of articles about the relationship of the polyphenols with prostate cancer, very little evidence exists for BPH. Additional clinical trials or meta-analysis are necessary on this topic.
Descritores: Hiperplasia Prostática/prevenção & controle
Neoplasias da Próstata/prevenção & controle
Síndrome Metabólica/prevenção & controle
Polifenóis/uso terapêutico
Antioxidantes/uso terapêutico
-Hiperplasia Prostática/metabolismo
Hiperplasia Prostática/tratamento farmacológico
Neoplasias da Próstata/metabolismo
Neoplasias da Próstata/tratamento farmacológico
Resultado do Tratamento
Estresse Oxidativo/efeitos dos fármacos
Síndrome Metabólica/tratamento farmacológico
Limites: Humanos
Masculino
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: lil-785723
Autor: Shim, Sung Ryul; Kim, Jae Heon; Won, Jong Ho; Song, Eun Seop; Song, Yun Seob.
Título: Association between ambient temperature and lower urinary tract symptoms: a community-based survey
Fonte: Int. braz. j. urol;42(3):521-530tab, graf.
Idioma: en.
Projeto: MSIP.
Resumo: ABSTRACT Purpose The aim of this study was to evaluate the individual change of International prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS) in each patient by temperature conditions. Materials and Methods The severity of lower urinary tract symptoms (LUTS) was explored using the IPSS and OABSS questionnaires that were completed by 2.486 subjects (923 males and 1.563 females) aged 60 years and older. Korea Meteorological Administration data was used to determine daily average temperature and daily temperature difference on the interview dates at each site. Results The mean IPSS and mean age for males was 13.45±8.24 and 75.03±6.20 years, respectively. The mean OABSS and mean age for females was 4.41±3.10 and 73.74±6.03years, respectively. Daily average temperature and daily temperature difference ranged from-3.4-28.3oC and 2.2-16.9oC, respectively. Age was a significantly risk factor for IPSS, OABSS, and QoL (P<0.001, <0.001, and 0.005, respectively). After multiple regression analysis, daily average temperatures did not show a statistically significant change in IPSS and OABSS. Only daily temperature differences were associated with male LUTS. Conclusions While LUTS could be worsened in low temperatures generally, IPSS and OABSS were not affected by daily average temperature conditions. Daily temperature differences may be more influential than daily average temperatures.
Descritores: Hiperplasia Prostática/fisiopatologia
Temperatura Baixa
Clima Frio
Sintomas do Trato Urinário Inferior/fisiopatologia
-Qualidade de Vida
Estações do Ano
Fatores de Tempo
Índice de Gravidade de Doença
Fatores Sexuais
Métodos Epidemiológicos
Fatores de Risco
Fatores Etários
Exposição Ambiental
República da Coreia
Limites: Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME


  9 / 460 LILACS  
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Pompeo, Antônio Carlos Lima
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Id: lil-782847
Autor: Carneiro, Arie; Sakuramoto, Paulo; Wroclawski, Marcelo Langer; Forseto, Pedro Herminio; Julio, Alexandre Den; Bautzer, Carlos Ricardo Doi; Lins, Leonardo Monte Marques; Kataguiri, Andre; Yamada, Fernanda Batistini; Teixeira, Gabriel Kushiyama; Tobias-Machado, Marcos; Pompeo, Antonio Carlos Lima.
Título: Open suprapubic versus retropubic prostatectomy in the treatment of benign prostatic hyperplasia during resident's learning curve: a randomized controlled trial
Fonte: Int. braz. j. urol;42(2):284-292, Mar.-Apr. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Purpose: This study compared the suprapubic (SP) versus retropubic (RP) prostatectomy for the treatment of large prostates and evaluated perioperative surgical morbidity and improvement of urinary symptoms. Materials and Methods: In this single centre, prospective, randomised study, 65 consecutive patients with LUTS and surgical indication with prostate volume greater than 75g underwent open prostatectomy to compare the RP (32 patients) versus SP (33 patients) technique. Results: The SP group exhibited a higher incidence of complications (p=0.002). Regarding voiding pattern analysis (IPSS and flowmetry), both were significantly effective compared to pre-treatment baseline. The RP group parameters were significantly better, with higher peak urinary flow (SP: 16.77 versus RP: 23.03mL/s, p=0.008) and a trend of lower IPSS score (SP: 6.67 versus RP 4.14, p=0.06). In a subgroup evaluation of patients with prostate volumes larger than 100g, blood loss was lower in those undergoing SP prostatectomy (p=0.003). Patients with prostates smaller than 100g in the SP group exhibited a higher incidence of low grade late complications (p=0.004). Conclusions: The SP technique was related to a higher incidence of minor complications in the late postoperative period. High volume prostates were associated with increased bleeding when the RP technique was utilized. The RP prostatectomy was associated with higher peak urinary flow and a trend of a lower IPSS Score.
Descritores: Prostatectomia/métodos
Hiperplasia Prostática/cirurgia
Curva de Aprendizado
-Complicações Pós-Operatórias
Próstata/cirurgia
Prostatectomia/educação
Prostatectomia/efeitos adversos
Fatores de Tempo
Estudos Prospectivos
Resultado do Tratamento
Estatísticas não Paramétricas
Sintomas do Trato Urinário Inferior/cirurgia
Duração da Cirurgia
Complicações Intraoperatórias
Corpo Clínico Hospitalar/educação
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: lil-782863
Autor: Arista-Nasr, Julian; Martinez-Benitez, Braulio; Bornstein-Quevedo, Leticia; Aguilar-Ayala, Elizmara; Aleman-Sanchez, Claudia Natalia; Ortiz-Bautista, Raul.
Título: Low grade urothelial carcinoma mimicking basal cell hyperplasia and transitional metaplasia in needle prostate biopsy
Fonte: Int. braz. j. urol;42(2):247-252, Mar.-Apr. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Purpose The vast majority of urothelial carcinomas infiltrating the bladder are consistent with high-grade tumors that can be easily recognized as malignant in needle prostatic biopsies. In contrast, the histological changes of low-grade urothelial carcinomas in this kind of biopsy have not been studied. Materials and Methods We describe the clinicopathologic features of two patients with low-grade bladder carcinomas infiltrating the prostate. They reported dysuria and hematuria. Both had a slight elevation of the prostate specific antigen and induration of the prostatic lobes. Needle biopsies were performed. At endoscopy bladder tumors were found in both cases. Results Both biopsies showed nests of basophilic cells and cells with perinuclear clearing and slight atypia infiltrating acini and small prostatic ducts. The stroma exhibited extensive desmoplasia and chronic inflammation. The original diagnosis was basal cell hyperplasia and transitional metaplasia. The bladder tumors also showed low-grade urothelial carcinoma. In one case, the neoplasm infiltrated the lamina propria, and in another, the muscle layer. In both, a transurethral resection was performed for obstructive urinary symptoms. The neoplasms were positive for high molecular weight keratin (34BetaE12) and thrombomodulin. No metastases were found in either of the patients, and one of them has survived for five years. Conclusions The diagnosis of low-grade urothelial carcinoma in prostate needle biopsies is difficult and may simulate benign prostate lesions including basal cell hyperplasia and urothelial metaplasia. It is crucial to recognize low-grade urothelial carcinoma in needle biopsies because only an early diagnosis and aggressive treatment can improve the prognosis for these patients.
Descritores: Hiperplasia Prostática/patologia
Neoplasias da Próstata/patologia
Neoplasias da Próstata/secundário
Neoplasias da Bexiga Urinária/patologia
Carcinoma de Células de Transição/patologia
Urotélio/patologia
-Próstata/patologia
Biópsia por Agulha
Antígeno Prostático Específico/sangue
Diagnóstico Diferencial
Gradação de Tumores
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Idoso
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME



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