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Id: biblio-1101101
Autor: Alvaia, Mateus Andrade; Maia, Heros Aureliano Antunes da Silva; Nelli, Alana de Medeiros; Guimarães, Carina Oliveira Silva; Carvalho, Evanilda Souza de Santana; Netto, José Murillo Bastos; Miranda, Eduardo de Paula; Hospital das ClínicasGomes, Cristiano Mendes; Bessa Júnior, José de.
Título: Prevalence of priapism in individuals with sickle cell disease and implications on male sexual function / Prevalência de priapismo em indivíduos com doença falciforme e suas implicações na função sexual masculina
Fonte: Einstein (Säo Paulo);18:eAO5070, 2020. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective To evaluate epidemiological aspects of priapism in patients with sickle cell disease, and these aspects impact on adult sexual function. Methods This was a cross-sectional study including individuals with sickle cell disease who were evaluated at a reference center for sickle cell. Participants completed a structured questionnaire about their sociodemographic characteristics and priapism events. Sexual function was assessed using validated two instruments, the Erection Hardness Score and one about the sex life satisfaction. Results Sixty-four individuals with median aged of 12 (7 to 28) years were interviewed. The prevalence of priapism was 35.9% (23/64). The earliest priapism episode occurred at 2 years of age and the latest at 42 years. The statistical projection was that 71.1% of individuals of the study would have at least one episode of priapism throughout life. Patients with episodes of priapism (10/23) had significantly worse erectile function Erection Hardness Score of 2 [1-3]; p=0.01 and were less satisfied with sexual life 3 [3-5]; p=0.02. Conclusion Priapism is usually present in childhood, and severe episodes are associated with cavernous damage, impairment in the quality of the erection, and lower sexual satisfaction.

RESUMO Objetivo Avaliar aspectos epidemiológicos do priapismo em pacientes com doença falciforme e o impacto desses aspectos na função sexual de adultos. Métodos Trata-se de estudo transversal, que incluiu indivíduos com doença falciforme acompanhados em um centro de referência. Os participantes responderam a um questionário estruturado acerca das características sociodemográficas e eventos de priapismo. A função sexual foi avaliada por meio de dois instrumentos validados, a Escala de Rigidez de Ereção e um sobre satisfação com a vida sexual. Resultados Foram entrevistados 64 indivíduos com média de idade de 12 (7-28) anos. A prevalência de priapismo foi de 35,9% (23/64). O episódio mais precoce ocorreu aos 2 anos de idade e o mais tardio, aos 42 anos. A projeção estatística foi de que 71,1% desses sujeitos teriam pelo menos um episódio de priapismo ao longo da vida. Pacientes adultos com episódios de priapismo (10/23) apresentaram função erétil significativamente pior Escala de Rigidez de Ereção de 2 [1-3]; p=0,01 e estavam menos satisfeitos com a vida sexual 3 [3-5]; p=0,02. Conclusão O priapismo manifesta-se desde a infância, e episódios graves estão associados a dano cavernoso, prejuízo na qualidade da ereção e menor satisfação sexual.
Descritores: Priapismo/fisiopatologia
Priapismo/epidemiologia
Disfunção Erétil/fisiopatologia
Disfunção Erétil/epidemiologia
Anemia Falciforme/fisiopatologia
Anemia Falciforme/epidemiologia
-Priapismo/etiologia
Qualidade de Vida
Ereção Peniana/fisiologia
Brasil/epidemiologia
Prevalência
Estudos Transversais
Inquéritos e Questionários
Estudos Retrospectivos
Fatores Etários
Estatísticas não Paramétricas
Intervalo Livre de Doença
Limites: Humanos
Masculino
Criança
Adolescente
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1047316
Autor: Iguma, Juliana Ishii; Machado, Sofia Santoro Si Sessa; Costa, Fernando Augusto Alves.
Título: Disfunção erétil, hipertensão arterial e uso de anti-hipertensivos - Pesquisa ativa / Erectile disfunction, arterial hypertension and anti-hypertensives - Active research
Fonte: Rev. Soc. Cardiol. Estado de Säo Paulo;29(4,Supl):383-386, out.-dez. 2019. tab.
Idioma: pt.
Resumo: Objetivo: Determinar a prevalência da disfunção erétil (DE) em pacientes com hipertensão arterial (HA) primária em tratamento medicamentoso e sua relação e análise do impacto psicossocial. Métodos: O estudo abordou homens hipertensos em tratamento medicamentoso e idade superior a 40 anos que foram avaliados segundo o Índice Internacional de Função Erétil (IIFE- 5), Escala de Ansiedade e Depressão e um questionário sobre sua opinião quanto à relação da DE com as medicações anti-hipertensivas. A dosagem da testosterona sérica foi usada para exclusão de causas orgânicas da DE. Os dados foram analisados visando identificar o coeficiente de correlação entre as varáveis. Resultados: Foi observada prevalência de DE em 74% dos pacientes e, destes, 43% referiram piora do desempenho sexual após uso crônico da medicação anti-hipertensiva. Não foi possível provar uma correlação direta entre o uso de anti-hipertensivos e a DE, entretanto observou-se aumento do coeficiente de correlação em função da progressão da idade dos pacientes. Os betabloqueadores mostraram maior coeficiente de correlação com a DE (25%), seguido dos inibidores da enzima conversora de angiotensina (19%). Dos pacientes, 43% foram classificados com provável diagnóstico de ansiedade ou depressão e 35% com possível diagnóstico. Conclusão: Foi possível inferir, mas não afirmar uma correlação entre DE, HA e o uso de anti-hipertensivos

Objective: To determine the prevalence of erectile dysfunction (ED) in patients with primary arterial hypertension (AH) undergoing drug treatment and its relationship and analysis of psychosocial impact. Methods: The study addressed hypertensive men on drug treatment and over 40 years of age who were evaluated according to the International Index of Erectile Function (IIFE-5), Anxiety and Depression Scale, and a questionnaire about their opinion regarding the relationship between ED and antihypertensive medications. Serum testosterone dosage was used to rule out the organic causes of ED. Data were analyzed to identify the correlation coefficient between variables. Results: Prevalence of ED was observed in 74% of patients and, of these, 43% reported worsened sexual performance after chronic use of antihypertensive medications. It was not possible to prove any direct correlation between the use of antihypertensive drugs and ED, however an increase in the correlation coefficient was observed as a function of patients' age progression. Beta-blockers showed higher correlation coefficient with ED (25%), followed by angiotensin-converting enzyme inhibitors (19%). 43% of patients were classified with probable diagnosis of anxiety or depression and 35% with possible diagnosis. Conclusion: It was possible to infer but not to affirm a correlation between DE, HA and the use of antihypertensive drugs
Descritores: Hipertensão/terapia
Disfunção Erétil
Anti-Hipertensivos
-Ansiedade
Doenças Cardiovasculares
Doença Crônica
Prevalência
Estudos Prospectivos
Inquéritos e Questionários
Fatores de Risco
Depressão
Tratamento Farmacológico
Responsável: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt


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Id: biblio-985551
Autor: Fonte Sevillano, Teresa; Rojas Pérez, Alberto; Hernández Pino, Yadira; Santos Hedman, Damián Jorge.
Título: Epidemiología de la disfunción sexual eréctil en ancianos de un área de salud / Epidemiology of sexual erectile dysfunction in elders of a health area
Fonte: Rev. cuba. med;57(2), abr.-jun. 2018. ilus, tab.
Idioma: es.
Resumo: Introducción: El desempeño sexual masculino en la vejez es visto, generalmente, desde sus caracteres negativos. Conocer cuál es el comportamiento y los factores de riesgo para la disfunción sexual eréctil en la población estudiada permite una mejor adaptación a los cambios fisiológicos del proceso de envejecimiento, disfrutar de una sexualidad gratificante y elevar su calidad de vida. Objetivo: Describir la presencia de disfunción eréctil en ancianos según variables sociodemográficas, epidemiológicas y clínicas e identificar los posibles factores de riesgo asociados a su aparición. Métodos: Se realizó un estudio descriptivo y transversal en ancianos de un área de salud durante el período 2013-2016. El universo estuvo conformado por 290 ancianos. Se tomó una muestra de 220 los cuales cumplieron con los criterios de inclusión y exclusión. Se les aplicó un modelo de recogida de información anónimo. Los datos fueron validados estadísticamente mediante el chi cuadrado, la prueba exacta de Fisher y la regresión logística. Resultados: Predominaron las edades de 60 a 74 años, con bajo nivel escolar y jubilados. El grado de disfunción eréctil moderada fue el más frecuente. Los factores que se asociaron a esta fueron enfermedades crónicas no transmisibles, depresión, trastornos urológicos, hábitos tóxicos y fármacos como antihipertensivos, diuréticos, digitálicos y psicofármacos. Conclusiones: La disfunción eréctil predominó en el grupo de ancianos con factores que deterioraron su salud. La sexualidad es un aspecto fundamental de esta, por lo que se incrementaron los casos de disfunción con el avance de la edad(AU)

Introduction: The sexual masculine performance in old ages is generally seen from negative points of view. Knowledge on which are the risk behaviours and factors for the sexual erectile dysfunction in the studied population allows a better adjustment of the physiological changes of the aging process, to enjoy a gratifying sexuality and to raise their life´s quality. Objective: To describe the presence of erectile dysfunction in elders according to socio-demographic, epidemiological and clinical variables and to identify possible risk factors associated with its appearance. Methods: A descriptive and cross-sectional study was conducted in elders of a health area from 2013 to 2016. The sample group consisted in 290 elders. A sample was taken in 220 of them whom met the inclusion and exclusion criteria. An anonymous model of data collection was applied to them. Data was statistically validated by means of Chi-Square, Fisher's exact test, and the logistic regression´s test. Results: Ages from 60 to 74 years, people with low educational level and pensioners were predominant. Moderate erectile dysfunction´s degree was the most frequent. The factors associated to this one were: non-chronic communicable diseases, depression, urologic disorders, toxic habits and drugs such as antihypertensive, diuretics, digitalis, and psychoactive drugs. Conclusions: Erectile dysfunction prevailed in the group of elders with factors that worsen their health. Sexuality is a fundamental aspect of health; that is why the cases of dysfunction increased at the same time as aging(AU)
Descritores: Fatores de Risco
Disfunção Erétil/epidemiologia
-Epidemiologia Descritiva
Estudos Transversais
Limites: Humanos
Masculino
Idoso
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: lil-796890
Autor: Keles, Muzaffer Oguz; Caliskan, Selahattin; Gokce, Ali Murat; Gunes, Mustafa.
Título: Assessment of sexual functions in partners of women with complaints of urinary incontinence
Fonte: Int. braz. j. urol;42(5):999-1004, Sept.-Oct. 2016. tab.
Idioma: en.
Resumo: ABSTRACT Aim: Investigation of the erectile functions in partners of women with urinary incontinence problems. Materials and Methods: Sexually active female patients over the age of 18 years with complaints of urinary incontinence (n=30) (Group-1), and without urinary incontinence (n=30) (Group-2, controls) were included this study. Evaluation of the patients were done at Erzincan Mengücek Gazi Training and Research Hospital's urology outpatient clinic between June 2012 and January 2013. Partners of group-1 and group-2 were asked to fill in the 5-item International Index of Erectile Function (IIEF-5) questionnaire, and then the scores of the two groups were compared for statistically significant differences. Results: Among the partners of the group-1 patients, 15 (50%) had mild erectile dysfunction (ED), 11 (36.6%) had moderate ED, 1 (3.4%) had severe ED, and erectile function was normal in the remaining 3 (10%). Among the partners of group-2 patients, 15 (50%) had mild ED, 7 had moderate ED, 1 (3.4%) had severe ED, and 7 (23.3%) had normal erectile function. Compared to the spouses of group-2 patients, ED was more prevalent among the spouses of group-1 patients. Conclusion: Erectile function in the partners of women with urinary incontinence may be adversely affected by the UI of their partners.
Descritores: Incontinência Urinária
Parceiros Sexuais
Disfunção Erétil/epidemiologia
-Qualidade de Vida
Índice de Gravidade de Doença
Fatores Sexuais
Inquéritos e Questionários
Estudos Retrospectivos
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: lil-794686
Autor: Kim, Kang Sup; Bae, Woong Jin; Kim, Su Jin; Kang, Kyong-Hwa; Kim, Se-Kwon; Cho, Hyuk Jin; Hong, Sung-Hoo; Lee, Ji Youl; Kim, Sae Woong.
Título: Improvement of erectile dysfunction by the active pepide from urechis unicinctus by high temperature/pressure and ultra - wave assisted lysis in streptozotocin induced diabetic rats
Fonte: Int. braz. j. urol;42(4):825-837, July-Aug. 2016. tab, graf.
Idioma: en.
Projeto: Ministry of Oceans and Fisheries.
Resumo: ABSTRACT Introduction: We investigate the effect of active peptide from Urechis unicinctus (UU) by high temperature/pressure and ultra-wave assisted lysis on erectile dysfunction in streptozotocin-induced diabetic rats. Materials and Methods: Forty 12-week-old Sprague-Dawley rats were used in this study. Diabetes was induced by a one-time intraperitoneal injection of streptozotocin (50mg/kg). One week later, the diabetic rats were randomly divided into four groups: normal control, untreated diabetes control, and groups treated with 100 or 500mg/kg/d UU peptide. Rats were fed with UU peptide by intragastric administration for 8 weeks. After 8 weeks, penile hemodynamic function was evaluated in all groups by measuring the intracavernosal pressure after electrostimulating the cavernous nerve. Nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) activities were measured and endothelial nitric oxide synthase (eNOS) and neuronal NOS (nNOS) protein expression was determined by Western blot. Results: Maximum intracavernosal pressure in diabetic control rats decreased significantly compared to normal control rats, and was increased significantly compared to untreated diabetic rats after UU peptide supplementation. Treatment with the higher dose of UU peptide significantly increased the NO and cGMP levels compared with the diabetic control group. Decreased activity and expression eNOS and nNOS were found in the diabetic rats compared with the normal control group. Decreased eNOS and nNOS in diabetic rats were improved by UU peptide administration. Conclusions: Active peptide from UU ameliorates erectile function in a streptozotocin induced diabetic rat model of erectile dysfunction.
Descritores: Peptídeos/farmacologia
Diabetes Mellitus Experimental/complicações
Disfunção Erétil/tratamento farmacológico
Anelídeos/química
-Pênis/efeitos dos fármacos
Peptídeos/análise
Peptídeos/uso terapêutico
Temperatura
Distribuição Aleatória
Células Cultivadas
Ratos Sprague-Dawley
Estreptozocina
Diabetes Mellitus Experimental/induzido quimicamente
Disfunção Erétil/etiologia
Disfunção Erétil/fisiopatologia
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-785726
Autor: Kumsar, Sukru; Kose, Osman; Aydemir, Huseyin; Halis, Fikret; Gokce, Ahmet; Adsan, Oztug; Akkaya, Zeynep Kahyaoglu.
Título: The relationship between histological prostatitis and lower urinary tract symptoms and sexual function
Fonte: Int. braz. j. urol;42(3):540-545tab, graf.
Idioma: en.
Resumo: ABSTRACT This prospective analysis assessed the effect of histological prostatitis on lower urinary tract functions and sexual function. The patients were separated into two groups as histologically observed prostatitis (Group A) and no prostatitis (Group B) according to the biopsy outcomes. International prostate symptom score, international index of erectile function-5 scores, maximal and average flow rate, and residual urine volumes were compared statistically between groups. There was no significant difference (P>0.05) in baseline age (t=0.64), body mass index value (t=0.51), prostate volume (t=0.87), prostate-specific antigen levels (t=0.43), maximal (t=0.84) and average flow rate (t=0.59), and post-void residual urine volume (t=0.71). Mean international prostate symptom score in patients with prostatitis was numerically but not significantly higher than that in those without prostatitis (t=0.794, P=0.066). Mean international index of erectile function-5 score in the prostatitis group was significantly lower than that in those without prostatitis (t=1.854, P=0.013). Histological prostatitis notably affected sexual function of patients and may serve as a major risk factor for sexual dysfunction while having little effect on lower urinary tract symptoms.
Descritores: Prostatite/fisiopatologia
Prostatite/patologia
Sintomas do Trato Urinário Inferior/fisiopatologia
Disfunção Erétil/fisiopatologia
-Tamanho do Órgão
Próstata/patologia
Hiperplasia Prostática/fisiopatologia
Hiperplasia Prostática/patologia
Biópsia por Agulha
Índice de Gravidade de Doença
Índice de Massa Corporal
Doença Crônica
Análise Multivariada
Estudos Prospectivos
Antígeno Prostático Específico/sangue
Estatísticas não Paramétricas
Progressão da Doença
Sintomas do Trato Urinário Inferior/patologia
Disfunção Erétil/patologia
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Idoso
Responsável: BR1.1 - BIREME


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Id: lil-777321
Autor: Zhou, Zhang-Yan; Zhong, Guang-Jun; Cheng, Shao-Ping; Huang, Hui; Wang, Jing; Pan, Hui; Liu, Chang-Mao; Xing, Cheng; Sun, Ya-Ling; Liu, Rong-Hua; Li, Fei.
Título: Short hairpin RNA targeting insulin-like growth factor binding protein-3 restores the bioavailability of insulin-like growth factor-1 in diabetic rats
Fonte: Int. braz. j. urol;42(1):139-145, Jan.-Feb. 2016. graf.
Idioma: en.
Projeto: National Natural Science Foundation of China.
Resumo: ABSTRACT Purpose To investigate whether intracavernosal injection of short hairpin RNA for IGFBP-3 could improve erectile function in streptozotocin-induced diabetic rats. Materials and methods After 12 weeks of IGFBP-3 short hairpin RNA injection treatment, intracavernous pressure responses to electrical stimulation of cavernous nerves were evaluated. The expression of IGFBP-3 and IGF-1 at mRNA and protein levels were detected by quantitative real-time PCR analysis and Western blot, respectively. The concentration of cavernous cyclic guanosine monophosphate was detected by enzyme-linked immunosorbent assay. Results At 12 weeks after intracavernous administration of IGFBP-3 shRNA, the cavernosal pressure was significantly increased in response to the cavernous nerves stimulation compared to the diabetic group (P<0.05). Cavernous IGFBP-3 expression at both mRNA and protein levels was significantly inhibited. At the same time, cavernous IGF-1 expression was significantly increased in the IGFBP-3 shRNA treatment group compared to the diabetic group (P<0.01). Cavernous cyclic guanosine monophosphate concentration was significantly increased in the IGFBP-3 shRNA treatment group compared to the diabetic group (P<0.01). Conclusions Gene transfer of IGFBP-3 shRNA could improve erectile function via the restoration of cavernous IGF-1 bioavailability and an increase of cavernous cGMP concentration in the pathogenesis of erectile dysfunction in streptozotocin-induced diabetic rats.
Descritores: Pênis/efeitos dos fármacos
Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina/farmacocinética
RNA Interferente Pequeno/farmacocinética
Diabetes Mellitus Experimental/fisiopatologia
Disfunção Erétil/fisiopatologia
Disfunção Erétil/tratamento farmacológico
-Fator de Crescimento Insulin-Like I/análise
Fator de Crescimento Insulin-Like I/efeitos dos fármacos
Ensaio de Imunoadsorção Enzimática
Disponibilidade Biológica
Distribuição Aleatória
Western Blotting
Reprodutibilidade dos Testes
Ratos Wistar
Estreptozocina
Diabetes Mellitus Experimental/complicações
Reação em Cadeia da Polimerase em Tempo Real
Disfunção Erétil/etiologia
Injeções
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-777334
Autor: Andrade, Weslley Santiago; Oliveira, Paulo; Laydner, Humberto; Ferreira, Eduardo Jose Pereira; Barreto Filho, Jose Augusto Soares.
Título: Severity of erectile dysfunction is highly correlated with the syntax score in patients undergoing coronariography
Fonte: Int. braz. j. urol;42(1):123-131, Jan.-Feb. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective To investigate the association between the severity of erectile dysfunction (ED) and coronary artery disease (CAD) in men undergoing coronary angiography for angina or acute myocardial infarct (AMI). Material and Methods We studied 132 males who underwent coronary angiography for first time between January and November 2010. ED severity was assessed by the international index of erectile function (IIEF-5) and CAD severity was assessed by the Syntax score. Patients with CAD (cases) and without CAD (controls) had their IIEF-5 compared. In the group with CAD, their IIEF-5 scores were compared to their Syntax score results. Results We identified 86 patients with and 46 without CAD. The IIEF-5 score of the group without CAD (22.6±0.8) was significantly higher than the group with CAD (12.5±0.5; p<0.0001). In patients without ED, the Syntax score average was 6.3±3.5, while those with moderate or severe ED had a mean Syntax score of 39.0±11.1. After adjustment, ED was independently associated to CAD, with an odds ratio of 40.6 (CI 95%, 14.3-115.3, p<0.0001). The accuracy of the logistic model to correctly identify presence or absence of CAD was 87%, with 92% sensitivity and 78% specificity. The average time that ED was present in patients with CAD was 38.8±2.3 months before coronary symptoms, about twice as high as patients without CAD (18.0±5.1 months). Conclusions ED severity is strongly and independently correlated with CAD complexity, as assessed by the Syntax score in patients undergoing coronariography for evaluation of new onset coronary symptoms.
Descritores: Índice de Gravidade de Doença
Doença da Artéria Coronariana/fisiopatologia
Doença da Artéria Coronariana/diagnóstico por imagem
Angiografia Coronária/métodos
Disfunção Erétil/fisiopatologia
-Fatores de Tempo
Doença da Artéria Coronariana/complicações
Risco
Curva ROC
Análise de Variância
Estatísticas não Paramétricas
Angina Estável/complicações
Angina Estável/fisiopatologia
Angina Estável/diagnóstico por imagem
Disfunção Erétil/etiologia
Angina Instável/complicações
Angina Instável/fisiopatologia
Angina Instável/diagnóstico por imagem
Pessoa de Meia-Idade
Infarto do Miocárdio/complicações
Infarto do Miocárdio/fisiopatologia
Infarto do Miocárdio/diagnóstico por imagem
Limites: Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME


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Id: biblio-892886
Autor: Zou, Zi-jun; Tang, Liang-you; Liu, Zhi-hong; Liang, Jia-yu; Zhang, Ruo-chen; Wang, Yu-jie; Tang, Yong-quan; Gao, Rui; Lu, Yi-ping.
Título: Short-term efficacy and safety of low-intensity extracorporeal shock wave therapy in erectile dysfunction: a systematic review and meta-analysis
Fonte: Int. braz. j. urol;43(5):805-821, Sept.-Oct. 2017. tab, graf.
Idioma: en.
Projeto: Science and Technology Foundation of the Sichuan Province; . Science and Technology Foundation of the Chengdu City.
Resumo: ABSTRACT Aim: The role of low-intensity extracorporeal shock wave therapy (LI-ESWT) in erectile dysfunction (ED) is not clearly determined. The purpose of this study is to investigate the short-term efficacy and safety of LI-ESWT for ED patients. Materials and Methods: Relevant studies were searched in Medline, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), WANFANG and VIP databases. Effective rate in terms of International Index of Erectile Function-Erectile Function Domain (IIEF-EF) and Erectile Hardness Score (EHS) at about 1XSmonth after LI-ESWT was extracted from eligible studies for meta-analysis to calculate risk ratio (RR) of effective treatment in ED patients treated by LI-ESWT compared to those receiving sham-treatment. Results: Overall fifteen studies were included in the review, of which four randomized controlled trials (RCTs) were for meta-analysis. Effective treatment was 8.31 [95°/o confidence interval (CI): 3.88-17.78] times more effective in the LI-ESWT group (n=176) than in the sham-treatment group (n= 101) at about 1 month after the intervention in terms of EHS, while it was 2.50 (95% CI: 0.74-8.45) times more in the treatment group (n= 121) than in the control group (n=89) in terms of IIEF-EF. Nine-week protocol with energy density of 0.09mJ/mm2 and 1500 pluses seemed to have better therapeutic effect than five-week protocol. No significant adverse event was reported. Conclusion: LI-ESWT, as a noninvasive treatment, has potential short-term therapeutic effect on patients with organic ED irrespective of sensitivity to PDE5is. Owing to the limited number and quality of the studies, more large-scale, well-designed and longterm follow-up time studies are needed to confirm our analysis.
Descritores: Ablação por Ultrassom Focalizado de Alta Intensidade/métodos
Disfunção Erétil/terapia
-Ensaios Clínicos Controlados Aleatórios como Assunto
Resultado do Tratamento
Ablação por Ultrassom Focalizado de Alta Intensidade/efeitos adversos
Limites: Humanos
Masculino
Tipo de Publ: Revisão
Metanálise
Revisão Sistemática
Responsável: BR1.1 - BIREME


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Id: biblio-892901
Autor: Kutlu, Omer; Karaguzel, Ersagun; Okatan, Ali Ertan; Mentese, Ahmet; Yulug, Esin; Kazaz, Ilke Onur; Kutlu, Selcuk; Dil, Eyup; Eren, Huseyin; Alver, Ahmet.
Título: Dipyridamole reduces penile apoptosis in a rat model of post-prostatectomy erectile dysfunction
Fonte: Int. braz. j. urol;43(5):966-973, Sept.-Oct. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Purpose: Despite the nerve-sparing technique, many patients suffer from erectile dysfunction after radical prostatectomy (RP) due to cavernous nerve injury. The aim of this study was to evaluate dipyridamole as a potential treatment agent of post-radical prostatectomy erectile dysfunction. Material and methods: A total of 18 male Sprague-Dawley rats were randomized into three experimental Groups (SHAM+DMSO, BCNI+DMSO and BCNI+DIP). An animal model of bilateral cavernous nerve crush injury (BCNI) was established to mimic the partial nerve damage during nerve-sparing RP. After creating of BCNI, dimethyl sulphoxide (DMSO) was administered transperitoneally as a vehicle to SHAM+DMSO and BCNI+DMSO Groups. BCNI+DIP Group received dipyiridamole (10mg/kg/day) as a solution in DMSO for 15 days. Afterwards, rats were evaluated for in vivo erectile response to cavernous nerve stimulation. Penile tissues were also analyzed biochemically for transforming growth factor-β1 (TGF-β1) level. Penile corporal apoptosis was determined by TUNEL method. Results: Erectile response was decreased in rats with BCNI and there was no significant improvement with dipyridamole treatment. TGF-β1 levels were increased in rats with BCNI and decreased with dipyridamole treatment. Dipyridamole led to reduced penile apoptosis in rats with BCNI and there was no significant difference when compared to sham operated rats. Conclusions: Although fifteen-day dipyridamole treatment has failed to improve erectile function in rats with BCNI, the decline in both TGF-β1 levels and apoptotic indices with treatment may be helpful in protecting penile morphology after cavernous nerve injury.
Descritores: Prostatectomia/efeitos adversos
Apoptose/efeitos dos fármacos
Dipiridamol/uso terapêutico
Disfunção Erétil/tratamento farmacológico
-Pênis/efeitos dos fármacos
Distribuição Aleatória
Ratos Sprague-Dawley
Modelos Animais de Doenças
Disfunção Erétil/etiologia
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME



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