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Pesquisa : C12.294.936 [Categoria DeCS]
Referências encontradas : 204 [refinar]
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Id: lil-782851
Autor: Yamaçake, K. G. R; Cocuzza, M; Torricelli, F. C. M; Tiseo, B. C; Frati, R; Freire, G. C; Antunes, A. A; Srougi, M.
Título: Impact of body mass index, age and varicocele on reproductive hormone profile from elderly men
Fonte: Int. braz. j. urol;42(2):365-372, Mar.-Apr. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objectives: To study the impact of obesity, age and varicocele on sexual hormones fof adult and elderly men. Materials and Methods: 875 men who were screened for prostate cancer were enrolled in this study. Data recorded comprised age, body mass index (BMI), serum levels of total testosterone (TT), free testosterone (FT), sex hormone-binding globulin (SHBG), luteinizing hormone (LH) and follicular stimulating hormone (FSH). Patients were divided in groups according to their BMI in underweight, normal weight, overweight and obese grades 1, 2 or 3. First, it was studied the association between age, BMI, and hormone profile. Then, clinical varicocele was evaluated in 298 patients to assess its correlation to the others parameters. Results: Obese patients had lower levels of TT, FT and SHBG (p<0.001) compared to underweight or normal weight patients. There were no differences in age (p=0.113), FSH serum levels (p=0.863) and LH serum levels (p=0.218) between obese and non-obese patients. Obese grade 3 had lower levels of TT and FT compared to obese grade 1 and 2 (p<0.05). There was no difference in the SHBG levels (p=0.120) among obese patients. There was no association between varicocele and BMI; and varicocele did not impact on testosterone or SHBG levels. Conclusions: Men with higher BMI have a lower serum level of TT, FT and SHBG. The presence of clinical varicocele as well as its grade has no impact on hormone profile in elderly men.
Descritores: Testosterona/sangue
Varicocele/sangue
Globulina de Ligação a Hormônio Sexual/análise
Hormônio Luteinizante/sangue
Hormônio Foliculoestimulante/sangue
Obesidade/sangue
-Valores de Referência
Varicocele/fisiopatologia
Índice de Gravidade de Doença
Índice de Massa Corporal
Estudos Transversais
Fatores Etários
Estatísticas não Paramétricas
Pessoa de Meia-Idade
Obesidade/fisiopatologia
Limites: Humanos
Masculino
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


  2 / 204 LILACS  
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Id: lil-777319
Autor: Yuksel, Ozgur Haki; Verit, Ayhan; Sahin, Aytac; Urkmez, Ahmet; Uruc, Fatih.
Título: White blood cell counts and neutrophil to lymphocyte ratio in the diagnosis of testicular cancer: a simple secondary serum tumor marker
Fonte: Int. braz. j. urol;42(1):53-59, Jan.-Feb. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Purpose The aim of the study was to investigate white blood cell counts and neutrophil to lymphocyte ratio (NLR) as markers of systemic inflammation in the diagnosis of localized testicular cancer as a malignancy with initially low volume. Materials and Methods Thirty-six patients with localized testicular cancer with a mean age of 34.22±14.89 years and 36 healthy controls with a mean age of 26.67±2.89 years were enrolled in the study. White blood cell counts and NLR were calculated from complete blood cell counts. Results White blood cell counts and NLR were statistically significantly higher in patients with testicular cancer compared with the control group (p<0.0001 for all). Conclusions Both white blood cell counts and NLR can be used as a simple test in the diagnosis of testicular cancer besides the well-known accurate serum tumor markers as AFP (alpha fetoprotein), hCG (human chorionic gonadotropin) and LDH (lactate dehydrogenase).
Descritores: Neoplasias Testiculares/diagnóstico
Neoplasias Testiculares/sangue
Linfócitos
Neoplasias Embrionárias de Células Germinativas/diagnóstico
Neoplasias Embrionárias de Células Germinativas/sangue
Neutrófilos
-Prognóstico
Valores de Referência
Neoplasias Testiculares/patologia
Varicocele/sangue
Hemoglobinas/análise
Biomarcadores Tumorais/sangue
Estudos de Casos e Controles
Reprodutibilidade dos Testes
Estudos Retrospectivos
Curva ROC
Neoplasias Embrionárias de Células Germinativas/patologia
Estatísticas não Paramétricas
Contagem de Linfócitos
Carga Tumoral
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-1040035
Autor: Cho, Chak-Lam; Ho, Kwan-Lun; Chan, Wayne Kwun-Wai; Chu, Ringo Wing-Hong; Law, In-Chak.
Título: Use of indocyanine green angiography in microsurgical subinguinal varicocelectomy - lessons learned from our initial experience
Fonte: Int. braz. j. urol;43(5):974-979, Sept.-Oct. 2017. graf.
Idioma: en.
Resumo: ABSTRACT Microsurgical subinguinal varicocelectomy (MSV) is generally considered the gold standard nowadays in view of the lower risk of complications and recurrence. To achieve complete ligation of veins while preserving testicular artery (TA) during the procedure remains challenging despite the application of high power optical magnification and micro-Doppler ultrasonography. The use of intraoperative indocyanine green angiography (ICGA) with infrared fluorescence operative micro-scope in MSV potentially lowers the incidence of TA injury and shortens the learning curve of novice surgeons. We present our initial experience in the application of the technique in nine patients and explore the potential of the new adjunct.
Descritores: Procedimentos Cirúrgicos Urogenitais/métodos
Varicocele/cirurgia
Angiografia/métodos
Verde de Indocianina/administração & dosagem
Canal Inguinal/cirurgia
-Varicocele/diagnóstico por imagem
Índice de Gravidade de Doença
Canal Inguinal/diagnóstico por imagem
Período Intraoperatório
Microscopia de Fluorescência
Microcirurgia
Limites: Humanos
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-1040036
Autor: Cocuzza, Marcello.
Título: Editorial Comment: Use of indocyanine green angiography in microsurgical subinguinal varicocelectomy - lessons learned from our initial experience
Fonte: Int. braz. j. urol;43(5):980-981, Sept.-Oct. 2017.
Idioma: en.
Descritores: Varicocele/cirurgia
Verde de Indocianina
-Procedimentos Cirúrgicos Vasculares
Angiografia
Microcirurgia
Limites: Humanos
Tipo de Publ: Comentário
Editorial
Responsável: BR1.1 - BIREME


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Id: biblio-975645
Autor: Bernstein, Ari P; Fram, Ethan B; North, Amanda; Casale, Anthony; Drzewiecki, Beth A.
Título: Does total testicular volume predict testicular volume difference in adolescent males with varicocele?
Fonte: Int. braz. j. urol;44(5):981-986, Sept.-Oct. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Introduction: We evaluated the relationship between total testicular volume (TTV) and testicular volume differential (TVD) in adolescent males with varicocele. Both low TTV and high TVD have been independently associated with higher incidences of infertility later in life, but a predictive relationship between TTV and TVD directly has yet to be described. Materials and Methods: We retrospectively analyzed a database of Tanner 5 boys ages 16-21 who presented with varicocele at a single institution between 2009 and 2017. All patients had a scrotal sonogram prior to surgical intervention. TTV and TVD were calculated for each individual and four non-exclusive groupings of patients were created for statistical analysis. We chose 30 cc as a cut off value for low TTV based on prior studies. Results: 209 patients met our inclusion criteria. Mean age was 18.3 years (16-21, SD 1.7) with a mean total testicular volume of 36 cc (13.5-78.2, SD 11.1). Cut off points of TVD of 20% and TTV of 30 cc were used to separate patients. There were 65 boys (31%) with TTV < 30 cc and 58 boys (28%) with TVD ≥ 20%. Among males with TTV < 30 cc, 23 (35%) had a TVD ≥ 20%. Among males with TTV ≥ 30 cc, 35 (24%) had a TVD ≥ 20%. The relationship between TVD and TTV was found to be non-significant (p > 0.05). Discussion: Adolescent varicoceles continue to pose a challenge to pediatric urologists. The dilemma of over-aggressive treatment has proven difficult to balance with the risk of infertility. We hoped that elucidating the relationship between TTV and TVD could be useful in identifying patients who are at greater risk for infertility while decreasing the need for more intrusive testing, such as semen analysis, in an adolescent population. We looked at the direct relationship between low TTV and high TVD. In our population, there was a non-significant relationship between TTV < 30 cc and TVD ≥ 20% (p > 0.05) indicating that in adolescents with varicocele, TTV and TVD are independent variables. Our study limitations include the inherent user dependent bias of ultrasound measurements and data collection at a single institution with high ethnic diversity, possibly not comparable to all patient populations. Conclusions: Low TTV (< 30 cc) itself is not predictive of high TVD (≥ 20%) in adolescent boys with varicocele, despite their reported independent associations with impaired fertility in other studies.
Descritores: Motilidade Espermática/fisiologia
Testículo/patologia
Varicocele/patologia
-Tamanho do Órgão
Testículo/fisiopatologia
Testículo/diagnóstico por imagem
Varicocele/fisiopatologia
Índice de Gravidade de Doença
Estudos Retrospectivos
Análise do Sêmen
Limites: Humanos
Masculino
Adolescente
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-954037
Autor: Marte, Antonio.
Título: The history of varicocele: from antiquity to the modern ERA
Fonte: Int. braz. j. urol;44(3):563-576, May-June 2018. graf.
Idioma: en.
Resumo: ABSTRACT Men have most likely been affected by varicocele since the assumption of the upright position. In De Medicina, written during the first century AD, Celsus credits the Greeks with the first description of a varicocele, and he recorded his own acute observation: "The veins are swollen and twisted over the testicle, which becomes smaller". Celsus himself is credited with the distinction between varicocele (dilation of surface veins) and "cirsocele" (dilation of deep veins). There has been a long history of treatment attempts and failures, some of which are remarkably strange, that have sometimes cul- minated in tragedy, as in the case of French professor Jacques-Mathieu Delpech (1772-1832). Although some questions regarding the etiopathology and treatment of varico- cele remain unanswered, a succession of more or less conservative attempts involving all medical cultures has been performed throughout history. The report by W.S. Tulloch in 1952 brought varicocele into the era of modern evidence-based medicine, and varicocele surgery finally progressed beyond the aim of merely relieving scrotal pain and swelling. From 1970 to 2000, varicocelectomies gained worldwide attention for the treatment of male infertility. Several innovative procedures to correct varicoceles began to appear in the world's literature as interventional radiology, microsurgery, laparoscopy, and robotics, while comprehensive review articles were also published on the subject of varicocelectomies. Microsurgery is nowadays used worldwide and it can be considered to be the gold standard for correcting infertility linked to varicocele.
Descritores: Varicocele/história
-Escroto/cirurgia
Escroto/irrigação sanguínea
Varicocele/cirurgia
História Antiga
História Medieval
Ilustração Médica/história
Limites: Humanos
Masculino
História do Século XVI
História do Século XVIII
História do Século XIX
História do Século XX
História do Século XXI
Tipo de Publ: Artigo Histórico
Responsável: BR1.1 - BIREME


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Id: biblio-1134237
Autor: Vieiralves, Rodrigo R.
Título: Editorial Comment: Development and validation a task-specific checklist for a microsurgical varicocelectomy simulation model
Fonte: Int. braz. j. urol;46(5):803-804, Sept.-Oct. 2020.
Idioma: en.
Descritores: Varicocele
Lista de Checagem
-Procedimentos Cirúrgicos Vasculares
Limites: Humanos
Masculino
Tipo de Publ: Comentário
Editorial
Responsável: BR1.1 - BIREME


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Id: biblio-1134322
Autor: Esteves, Sandro C; Cocuzza, Marcello S.
Título: The obesity paradox in varicocele - is the protective effect real?
Fonte: Int. braz. j. urol;47(1):20-22, Jan.-Feb. 2021.
Idioma: en.
Descritores: Varicocele
-Índice de Massa Corporal
Fatores de Risco
Obesidade/complicações
Limites: Humanos
Masculino
Tipo de Publ: Comentário
Editorial
Responsável: BR1.1 - BIREME


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Id: biblio-1134333
Autor: Xiao-Bin, Guo; Fang-Lei, Wu; Hui, Xia; Cheng, Yang; Zhi-Xuan, Cai; Zhi-Peng, Huang; Cun-Dong, Liu; Wen-Bin, Guo.
Título: The association between body mass index and varicocele: A meta-analysis
Fonte: Int. braz. j. urol;47(1):8-19, Jan.-Feb. 2021. tab, graf.
Idioma: en.
Projeto: Guangdong Provincial Science and Technology Programme.
Resumo: ABSTRACT Objective: Recently, several studies have found that obesity had a protective effect against varicocele, but no meta-analysis has confirmed this finding. Therefore, we conducted this meta-analysis to investigate the association between body mass index (BMI) and varicocele. Material and Methods: We searched for studies in PubMed, Science Direct and the Cochrane Library from inception until February 2018. The association between BMI and varicocele was assessed by pooling the odds ratios (ORs). Results: Eleven eligible studies with a total study population of 1.376.658 participants were included in our analysis. According to BMI, the subjects were defined as belonging to the obese, overweight and underweight groups. Our results showed that the obese group had a lower risk of varicocele when compared with the normal weight group (odds ratio [OR] 0.46, 95% confidence intervals [CIs] 0.37-0.58). Additionally, an overweight BMI had a protective effect against varicocele (OR 0.70, 95% CIs, 0.56-0.86). However, underweight patients had a more than 30% higher risk of varicocele (OR 1.31, 95% CI, 1.04-1.64). Furthermore, there was no publication bias in any of the analyses. Conclusions: Our study demonstrates that BMI is negatively associated with the presence of varicocele.
Descritores: Varicocele/epidemiologia
-Índice de Massa Corporal
Razão de Chances
Sobrepeso/complicações
Sobrepeso/epidemiologia
Obesidade/complicações
Limites: Humanos
Masculino
Tipo de Publ: Revisão
Metanálise
Responsável: BR1.1 - BIREME


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Id: biblio-1154474
Autor: Jeremias, Jessica Timóteo; Belardin, Larissa Berloffa; Okada, Fatima Kazue; Antoniassi, Mariana P; Fraietta, Renato; Bertolla, Ricardo Pimenta; Intasqui, Paula.
Título: Oxidative origin of sperm DNA fragmentation in the adult varicocele
Fonte: Int. braz. j. urol;47(2):275-283, Mar.-Apr. 2021. tab, graf.
Idioma: en.
Projeto: Ministério da Ciência, Tecnologia e Inovação Conselho Nacional de Desenvolvimento Científico e Tecnológico; . Fundação de Amparo à Pesquisa do Estado de São Paulo.
Resumo: ABSTRACT Purpose: Sperm DNA fragmentation is a major cellular mechanism underlying varicocele-related male infertility. However, the type of DNA fragmentation - whether oxidative or of another nature - remains unknown. Thus, the aim of this study was to evaluate single- and double-stranded sperm DNA fragmentation, and oxidative-induced sperm DNA damage in men with varicocele. Materials and Methods: A cross-sectional study was performed, including 94 normozoospermic adults, of which 39 men without varicocele (controls) and 55 men with varicocele grades II or III, uni- or bilaterally. All men collected semen by masturbation. After semen analysis, the remaining volume was used for evaluation of three types of sperm DNA damage: (i) total DNA fragmentation, using an alkaline comet assay, (ii) double-stranded DNA fragmentation, using a neutral comet assay, and (iii) oxidative DNA damage, using an alkaline comet assay associated with the DNA glycosylase formamidopyrimidine enzyme. In each assay, percentage of sperm with any degree of DNA fragmentation, and with high DNA fragmentation were compared between the groups using an unpaired Student's t test or a Mann-Whitney test. Results: The varicocele group presented a higher rate of sperm with fragmented DNA (both any and high DNA fragmentation), considering single-stranded DNA fragmentation, double-stranded DNA fragmentation, or a combination of both, as well as oxidative- induced DNA fragmentation. Conclusions: Patients with varicocele have an increase in sperm DNA fragmentation levels, particularly in oxidative stress-induced sperm DNA damage.
Descritores: Varicocele/genética
Infertilidade Masculina/genética
-Motilidade Espermática
Espermatozoides
Estudos Transversais
Estresse Oxidativo
Fragmentação do DNA
Limites: Humanos
Masculino
Adulto
Responsável: BR1.1 - BIREME



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